Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEY3_LEIMA

TriTrypDb:

LmjF.16.0370 , LMJLV39_160009000 , LMJSD75_160009000

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.435
CLV_C14_Caspase3-7	467	471	PF00656	0.454
CLV_C14_Caspase3-7	70	74	PF00656	0.603
CLV_NRD_NRD_1	289	291	PF00675	0.622
CLV_NRD_NRD_1	35	37	PF00675	0.707
CLV_PCSK_FUR_1	33	37	PF00082	0.511
CLV_PCSK_KEX2_1	33	35	PF00082	0.710
CLV_PCSK_KEX2_1	8	10	PF00082	0.640
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.586
CLV_PCSK_SKI1_1	117	121	PF00082	0.518
CLV_PCSK_SKI1_1	128	132	PF00082	0.404
CLV_PCSK_SKI1_1	199	203	PF00082	0.360
CLV_PCSK_SKI1_1	35	39	PF00082	0.589
CLV_PCSK_SKI1_1	56	60	PF00082	0.546
CLV_PCSK_SKI1_1	9	13	PF00082	0.578
DEG_APCC_DBOX_1	13	21	PF00400	0.503
DEG_COP1_1	157	166	PF00400	0.624
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DOC_CYCLIN_RxL_1	125	134	PF00134	0.453
DOC_MAPK_HePTP_8	32	44	PF00069	0.503
DOC_MAPK_MEF2A_6	35	44	PF00069	0.562
DOC_PP4_FxxP_1	252	255	PF00568	0.305
DOC_PP4_FxxP_1	298	301	PF00568	0.451
DOC_USP7_MATH_1	101	105	PF00917	0.365
DOC_USP7_MATH_1	149	153	PF00917	0.670
DOC_USP7_MATH_1	159	163	PF00917	0.536
DOC_USP7_MATH_1	397	401	PF00917	0.632
DOC_USP7_MATH_1	87	91	PF00917	0.609
DOC_WW_Pin1_4	135	140	PF00397	0.701
DOC_WW_Pin1_4	150	155	PF00397	0.532
DOC_WW_Pin1_4	395	400	PF00397	0.637
LIG_14-3-3_CanoR_1	180	186	PF00244	0.430
LIG_14-3-3_CanoR_1	196	202	PF00244	0.412
LIG_14-3-3_CanoR_1	23	32	PF00244	0.599
LIG_14-3-3_CanoR_1	315	325	PF00244	0.524
LIG_14-3-3_CanoR_1	354	358	PF00244	0.411
LIG_14-3-3_CanoR_1	56	64	PF00244	0.511
LIG_Actin_WH2_2	102	119	PF00022	0.428
LIG_BIR_III_4	28	32	PF00653	0.499
LIG_BIR_III_4	404	408	PF00653	0.482
LIG_BRCT_BRCA1_1	247	251	PF00533	0.330
LIG_BRCT_BRCA1_1	410	414	PF00533	0.388
LIG_Clathr_ClatBox_1	207	211	PF01394	0.352
LIG_FHA_1	198	204	PF00498	0.385
LIG_FHA_1	278	284	PF00498	0.615
LIG_FHA_1	353	359	PF00498	0.465
LIG_FHA_1	391	397	PF00498	0.592
LIG_FHA_1	470	476	PF00498	0.454
LIG_FHA_1	53	59	PF00498	0.758
LIG_FHA_1	90	96	PF00498	0.462
LIG_FHA_2	179	185	PF00498	0.389
LIG_FHA_2	68	74	PF00498	0.639
LIG_FHA_2	86	92	PF00498	0.456
LIG_GBD_Chelix_1	44	52	PF00786	0.500
LIG_LIR_Apic_2	249	255	PF02991	0.296
LIG_LIR_Apic_2	297	301	PF02991	0.468
LIG_LIR_Gen_1	329	340	PF02991	0.288
LIG_LIR_Gen_1	365	375	PF02991	0.473
LIG_LIR_Gen_1	408	418	PF02991	0.391
LIG_LIR_Nem_3	211	216	PF02991	0.394
LIG_LIR_Nem_3	329	335	PF02991	0.391
LIG_LIR_Nem_3	365	371	PF02991	0.454
LIG_LIR_Nem_3	408	413	PF02991	0.400
LIG_LYPXL_S_1	38	42	PF13949	0.582
LIG_LYPXL_yS_3	39	42	PF13949	0.581
LIG_NRBOX	126	132	PF00104	0.514
LIG_PCNA_yPIPBox_3	117	131	PF02747	0.481
LIG_Pex14_2	59	63	PF04695	0.630
LIG_SH2_CRK	213	217	PF00017	0.449
LIG_SH2_CRK	332	336	PF00017	0.331
LIG_SH2_CRK	368	372	PF00017	0.408
LIG_SH2_CRK	410	414	PF00017	0.450
LIG_SH2_NCK_1	410	414	PF00017	0.450
LIG_SH2_SRC	213	216	PF00017	0.388
LIG_SH2_STAP1	410	414	PF00017	0.450
LIG_SH2_STAP1	454	458	PF00017	0.398
LIG_SH2_STAT5	326	329	PF00017	0.363
LIG_SH2_STAT5	332	335	PF00017	0.335
LIG_SH3_3	209	215	PF00018	0.450
LIG_SH3_3	276	282	PF00018	0.509
LIG_SH3_3	393	399	PF00018	0.629
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.428
LIG_SUMO_SIM_par_1	129	134	PF11976	0.617
LIG_SUMO_SIM_par_1	198	204	PF11976	0.342
LIG_TRAF2_1	181	184	PF00917	0.399
LIG_TRFH_1	208	212	PF08558	0.424
LIG_TRFH_1	251	255	PF08558	0.330
LIG_TYR_ITIM	37	42	PF00017	0.583
LIG_TYR_ITSM	406	413	PF00017	0.429
LIG_UBA3_1	232	239	PF00899	0.395
MOD_CK1_1	162	168	PF00069	0.659
MOD_CK1_1	331	337	PF00069	0.344
MOD_CK1_1	356	362	PF00069	0.435
MOD_CK1_1	416	422	PF00069	0.406
MOD_CK1_1	43	49	PF00069	0.605
MOD_CK1_1	67	73	PF00069	0.587
MOD_CK1_1	85	91	PF00069	0.563
MOD_CK2_1	178	184	PF00069	0.398
MOD_CK2_1	83	89	PF00069	0.695
MOD_Cter_Amidation	288	291	PF01082	0.623
MOD_GlcNHglycan	133	136	PF01048	0.492
MOD_GlcNHglycan	14	17	PF01048	0.604
MOD_GlcNHglycan	159	162	PF01048	0.619
MOD_GlcNHglycan	186	189	PF01048	0.604
MOD_GlcNHglycan	20	23	PF01048	0.679
MOD_GlcNHglycan	245	248	PF01048	0.392
MOD_GlcNHglycan	265	268	PF01048	0.474
MOD_GlcNHglycan	269	274	PF01048	0.543
MOD_GlcNHglycan	303	306	PF01048	0.380
MOD_GlcNHglycan	319	322	PF01048	0.408
MOD_GlcNHglycan	358	361	PF01048	0.421
MOD_GlcNHglycan	388	391	PF01048	0.599
MOD_GlcNHglycan	399	402	PF01048	0.529
MOD_GlcNHglycan	415	418	PF01048	0.327
MOD_GlcNHglycan	465	469	PF01048	0.466
MOD_GlcNHglycan	66	69	PF01048	0.633
MOD_GlcNHglycan	83	88	PF01048	0.621
MOD_GlcNHglycan	99	102	PF01048	0.381
MOD_GSK3_1	131	138	PF00069	0.557
MOD_GSK3_1	150	157	PF00069	0.479
MOD_GSK3_1	191	198	PF00069	0.502
MOD_GSK3_1	259	266	PF00069	0.521
MOD_GSK3_1	352	359	PF00069	0.443
MOD_GSK3_1	386	393	PF00069	0.552
MOD_GSK3_1	40	47	PF00069	0.628
MOD_GSK3_1	408	415	PF00069	0.419
MOD_GSK3_1	448	455	PF00069	0.498
MOD_GSK3_1	469	476	PF00069	0.459
MOD_GSK3_1	58	65	PF00069	0.549
MOD_GSK3_1	83	90	PF00069	0.623
MOD_GSK3_1	97	104	PF00069	0.468
MOD_N-GLC_1	218	223	PF02516	0.443
MOD_N-GLC_1	75	80	PF02516	0.561
MOD_N-GLC_2	314	316	PF02516	0.343
MOD_NEK2_1	12	17	PF00069	0.745
MOD_NEK2_1	131	136	PF00069	0.484
MOD_NEK2_1	259	264	PF00069	0.593
MOD_NEK2_1	44	49	PF00069	0.685
MOD_NEK2_1	52	57	PF00069	0.571
MOD_NEK2_1	58	63	PF00069	0.500
MOD_PIKK_1	120	126	PF00454	0.454
MOD_PIKK_1	133	139	PF00454	0.510
MOD_PIKK_1	433	439	PF00454	0.527
MOD_PKA_2	179	185	PF00069	0.427
MOD_PKA_2	195	201	PF00069	0.527
MOD_PKA_2	221	227	PF00069	0.414
MOD_PKA_2	24	30	PF00069	0.614
MOD_PKA_2	260	266	PF00069	0.520
MOD_PKA_2	314	320	PF00069	0.531
MOD_PKA_2	353	359	PF00069	0.400
MOD_Plk_1	218	224	PF00069	0.439
MOD_Plk_1	90	96	PF00069	0.546
MOD_Plk_4	221	227	PF00069	0.412
MOD_Plk_4	353	359	PF00069	0.406
MOD_Plk_4	408	414	PF00069	0.476
MOD_Plk_4	58	64	PF00069	0.607
MOD_Plk_4	90	96	PF00069	0.595
MOD_ProDKin_1	135	141	PF00069	0.703
MOD_ProDKin_1	150	156	PF00069	0.533
MOD_ProDKin_1	395	401	PF00069	0.637
MOD_SUMO_for_1	462	465	PF00179	0.514
MOD_SUMO_rev_2	114	119	PF00179	0.519
MOD_SUMO_rev_2	198	208	PF00179	0.358
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.622
TRG_ENDOCYTIC_2	213	216	PF00928	0.388
TRG_ENDOCYTIC_2	332	335	PF00928	0.339
TRG_ENDOCYTIC_2	348	351	PF00928	0.357
TRG_ENDOCYTIC_2	368	371	PF00928	0.399
TRG_ENDOCYTIC_2	39	42	PF00928	0.581
TRG_ENDOCYTIC_2	410	413	PF00928	0.457
TRG_ER_diArg_1	220	223	PF00400	0.466
TRG_ER_diArg_1	32	35	PF00400	0.704
TRG_ER_diArg_1	337	340	PF00400	0.426
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA0	Leptomonas seymouri	51%	100%
A0A3S7WTT1	Leishmania donovani	86%	100%
A4HWT6	Leishmania infantum	86%	100%
E9AQJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%