Transmembrane protein 231

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEY0_LEIMA

TriTrypDb:

LmjF.16.0400 , LMJLV39_160009400 , LMJSD75_160009400

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QEY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEY0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.360
CLV_C14_Caspase3-7	228	232	PF00656	0.499
CLV_C14_Caspase3-7	247	251	PF00656	0.524
CLV_C14_Caspase3-7	254	258	PF00656	0.588
CLV_NRD_NRD_1	13	15	PF00675	0.397
CLV_NRD_NRD_1	165	167	PF00675	0.637
CLV_NRD_NRD_1	189	191	PF00675	0.651
CLV_PCSK_KEX2_1	13	15	PF00082	0.397
CLV_PCSK_KEX2_1	165	167	PF00082	0.622
CLV_PCSK_KEX2_1	189	191	PF00082	0.702
CLV_PCSK_SKI1_1	155	159	PF00082	0.556
CLV_PCSK_SKI1_1	195	199	PF00082	0.681
DEG_APCC_DBOX_1	154	162	PF00400	0.370
DEG_SPOP_SBC_1	225	229	PF00917	0.497
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.367
DOC_MAPK_gen_1	13	23	PF00069	0.546
DOC_MAPK_gen_1	165	173	PF00069	0.452
DOC_MAPK_gen_1	284	292	PF00069	0.439
DOC_MAPK_JIP1_4	284	290	PF00069	0.433
DOC_MAPK_MEF2A_6	165	173	PF00069	0.420
DOC_MAPK_MEF2A_6	284	292	PF00069	0.439
DOC_MAPK_NFAT4_5	166	174	PF00069	0.336
DOC_PP1_RVXF_1	168	174	PF00149	0.500
DOC_PP2B_LxvP_1	288	291	PF13499	0.472
DOC_PP2B_PxIxI_1	314	320	PF00149	0.363
DOC_USP7_MATH_1	253	257	PF00917	0.573
DOC_USP7_MATH_1	31	35	PF00917	0.513
DOC_WW_Pin1_4	173	178	PF00397	0.438
DOC_WW_Pin1_4	205	210	PF00397	0.572
DOC_WW_Pin1_4	75	80	PF00397	0.606
LIG_14-3-3_CanoR_1	17	21	PF00244	0.605
LIG_14-3-3_CanoR_1	170	174	PF00244	0.434
LIG_14-3-3_CanoR_1	189	194	PF00244	0.426
LIG_14-3-3_CanoR_1	40	44	PF00244	0.514
LIG_14-3-3_CanoR_1	94	101	PF00244	0.494
LIG_AP2alpha_2	275	277	PF02296	0.506
LIG_BIR_II_1	1	5	PF00653	0.752
LIG_BIR_III_4	202	206	PF00653	0.368
LIG_BRCT_BRCA1_1	177	181	PF00533	0.424
LIG_BRCT_BRCA1_1	309	313	PF00533	0.445
LIG_CaMK_CASK_1	241	246	PF00069	0.558
LIG_Clathr_ClatBox_1	301	305	PF01394	0.301
LIG_deltaCOP1_diTrp_1	305	313	PF00928	0.342
LIG_eIF4E_1	324	330	PF01652	0.513
LIG_FHA_1	30	36	PF00498	0.483
LIG_FHA_2	226	232	PF00498	0.566
LIG_LIR_Apic_2	293	298	PF02991	0.518
LIG_LIR_Gen_1	178	188	PF02991	0.427
LIG_LIR_Gen_1	19	28	PF02991	0.363
LIG_LIR_Gen_1	48	57	PF02991	0.528
LIG_LIR_Gen_1	99	108	PF02991	0.439
LIG_LIR_Nem_3	102	108	PF02991	0.422
LIG_LIR_Nem_3	178	184	PF02991	0.423
LIG_LIR_Nem_3	19	23	PF02991	0.363
LIG_LIR_Nem_3	274	280	PF02991	0.434
LIG_LIR_Nem_3	310	314	PF02991	0.407
LIG_LIR_Nem_3	33	39	PF02991	0.355
LIG_LIR_Nem_3	48	53	PF02991	0.468
LIG_Pex14_1	327	331	PF04695	0.411
LIG_Pex14_2	321	325	PF04695	0.397
LIG_Pex14_2	60	64	PF04695	0.540
LIG_Pex14_2	7	11	PF04695	0.570
LIG_SH2_CRK	105	109	PF00017	0.427
LIG_SH2_CRK	295	299	PF00017	0.510
LIG_SH2_CRK	338	342	PF00017	0.411
LIG_SH2_CRK	50	54	PF00017	0.428
LIG_SH2_NCK_1	338	342	PF00017	0.389
LIG_SH2_STAP1	101	105	PF00017	0.518
LIG_SH2_STAT5	101	104	PF00017	0.527
LIG_SH2_STAT5	156	159	PF00017	0.396
LIG_SH2_STAT5	324	327	PF00017	0.459
LIG_SH2_STAT5	334	337	PF00017	0.353
LIG_SH2_STAT5	338	341	PF00017	0.328
LIG_SH2_STAT5	37	40	PF00017	0.501
LIG_SH3_3	116	122	PF00018	0.400
LIG_SH3_3	273	279	PF00018	0.518
LIG_SH3_3	309	315	PF00018	0.429
LIG_SH3_3	41	47	PF00018	0.487
LIG_TYR_ITIM	332	337	PF00017	0.411
MOD_CDK_SPxxK_3	205	212	PF00069	0.585
MOD_CK1_1	256	262	PF00069	0.472
MOD_CK2_1	39	45	PF00069	0.477
MOD_CK2_1	77	83	PF00069	0.536
MOD_CK2_1	93	99	PF00069	0.510
MOD_CMANNOS	308	311	PF00535	0.556
MOD_CMANNOS	64	67	PF00535	0.742
MOD_Cter_Amidation	163	166	PF01082	0.574
MOD_GlcNHglycan	138	141	PF01048	0.838
MOD_GlcNHglycan	253	256	PF01048	0.769
MOD_GlcNHglycan	270	273	PF01048	0.724
MOD_GlcNHglycan	342	345	PF01048	0.453
MOD_GlcNHglycan	79	82	PF01048	0.745
MOD_GSK3_1	169	176	PF00069	0.426
MOD_GSK3_1	336	343	PF00069	0.411
MOD_GSK3_1	85	92	PF00069	0.548
MOD_NEK2_1	21	26	PF00069	0.481
MOD_NEK2_1	224	229	PF00069	0.443
MOD_NEK2_1	29	34	PF00069	0.339
MOD_NEK2_1	340	345	PF00069	0.660
MOD_NEK2_1	89	94	PF00069	0.556
MOD_NEK2_2	31	36	PF00069	0.411
MOD_PIKK_1	99	105	PF00454	0.475
MOD_PK_1	189	195	PF00069	0.505
MOD_PK_1	286	292	PF00069	0.466
MOD_PKA_1	189	195	PF00069	0.505
MOD_PKA_2	136	142	PF00069	0.612
MOD_PKA_2	16	22	PF00069	0.605
MOD_PKA_2	169	175	PF00069	0.435
MOD_PKA_2	188	194	PF00069	0.424
MOD_PKA_2	39	45	PF00069	0.532
MOD_PKA_2	93	99	PF00069	0.510
MOD_PKB_1	284	292	PF00069	0.439
MOD_Plk_4	16	22	PF00069	0.534
MOD_Plk_4	169	175	PF00069	0.429
MOD_Plk_4	31	37	PF00069	0.411
MOD_Plk_4	336	342	PF00069	0.452
MOD_Plk_4	85	91	PF00069	0.517
MOD_ProDKin_1	173	179	PF00069	0.433
MOD_ProDKin_1	205	211	PF00069	0.578
MOD_ProDKin_1	75	81	PF00069	0.604
TRG_ENDOCYTIC_2	101	104	PF00928	0.419
TRG_ENDOCYTIC_2	105	108	PF00928	0.363
TRG_ENDOCYTIC_2	334	337	PF00928	0.360
TRG_ENDOCYTIC_2	338	341	PF00928	0.345
TRG_ENDOCYTIC_2	36	39	PF00928	0.362
TRG_ENDOCYTIC_2	50	53	PF00928	0.454
TRG_ER_diArg_1	116	119	PF00400	0.451
TRG_ER_diArg_1	12	14	PF00400	0.594
TRG_ER_diArg_1	152	155	PF00400	0.377
TRG_ER_diArg_1	165	167	PF00400	0.405
TRG_ER_diArg_1	188	190	PF00400	0.497
TRG_ER_diArg_1	283	286	PF00400	0.383
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0F8	Leptomonas seymouri	38%	93%
A0A3S7WTU6	Leishmania donovani	85%	100%
A4H8G5	Leishmania braziliensis	61%	100%
E9AGN1	Leishmania infantum	85%	100%
E9AQJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%