Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEX9_LEIMA

TriTrypDb:

LmjF.16.0410 , LMJLV39_160009500 , LMJSD75_160009500

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.785
CLV_C14_Caspase3-7	483	487	PF00656	0.780
CLV_C14_Caspase3-7	536	540	PF00656	0.551
CLV_NRD_NRD_1	158	160	PF00675	0.533
CLV_NRD_NRD_1	361	363	PF00675	0.747
CLV_NRD_NRD_1	445	447	PF00675	0.636
CLV_NRD_NRD_1	545	547	PF00675	0.785
CLV_PCSK_KEX2_1	157	159	PF00082	0.560
CLV_PCSK_KEX2_1	210	212	PF00082	0.421
CLV_PCSK_KEX2_1	320	322	PF00082	0.582
CLV_PCSK_KEX2_1	374	376	PF00082	0.804
CLV_PCSK_KEX2_1	444	446	PF00082	0.661
CLV_PCSK_KEX2_1	544	546	PF00082	0.672
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.560
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.467
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.572
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.804
CLV_PCSK_SKI1_1	136	140	PF00082	0.433
CLV_PCSK_SKI1_1	284	288	PF00082	0.409
CLV_PCSK_SKI1_1	327	331	PF00082	0.435
CLV_PCSK_SKI1_1	406	410	PF00082	0.700
DEG_Nend_Nbox_1	1	3	PF02207	0.513
DEG_SPOP_SBC_1	338	342	PF00917	0.590
DOC_CKS1_1	276	281	PF01111	0.550
DOC_CKS1_1	71	76	PF01111	0.330
DOC_CYCLIN_yClb5_NLxxxL_5	184	193	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.535
DOC_MAPK_gen_1	243	252	PF00069	0.518
DOC_MAPK_MEF2A_6	190	197	PF00069	0.401
DOC_MAPK_MEF2A_6	245	254	PF00069	0.467
DOC_MAPK_MEF2A_6	69	78	PF00069	0.476
DOC_PP2B_LxvP_1	145	148	PF13499	0.563
DOC_PP2B_LxvP_1	193	196	PF13499	0.355
DOC_USP7_MATH_1	101	105	PF00917	0.738
DOC_USP7_MATH_1	16	20	PF00917	0.494
DOC_USP7_MATH_1	291	295	PF00917	0.533
DOC_USP7_MATH_1	339	343	PF00917	0.748
DOC_USP7_MATH_1	389	393	PF00917	0.782
DOC_USP7_MATH_1	429	433	PF00917	0.669
DOC_USP7_MATH_1	456	460	PF00917	0.761
DOC_USP7_MATH_1	471	475	PF00917	0.479
DOC_USP7_MATH_1	480	484	PF00917	0.581
DOC_USP7_MATH_1	490	494	PF00917	0.465
DOC_USP7_MATH_1	518	522	PF00917	0.728
DOC_USP7_MATH_1	534	538	PF00917	0.621
DOC_USP7_MATH_1	551	555	PF00917	0.622
DOC_USP7_UBL2_3	370	374	PF12436	0.733
DOC_WW_Pin1_4	275	280	PF00397	0.553
DOC_WW_Pin1_4	45	50	PF00397	0.601
DOC_WW_Pin1_4	469	474	PF00397	0.674
DOC_WW_Pin1_4	476	481	PF00397	0.608
DOC_WW_Pin1_4	61	66	PF00397	0.311
DOC_WW_Pin1_4	70	75	PF00397	0.299
DOC_WW_Pin1_4	85	90	PF00397	0.428
DOC_WW_Pin1_4	97	102	PF00397	0.654
LIG_14-3-3_CanoR_1	136	145	PF00244	0.413
LIG_14-3-3_CanoR_1	15	21	PF00244	0.684
LIG_14-3-3_CanoR_1	211	219	PF00244	0.495
LIG_14-3-3_CanoR_1	229	235	PF00244	0.566
LIG_14-3-3_CanoR_1	295	302	PF00244	0.393
LIG_14-3-3_CanoR_1	303	308	PF00244	0.470
LIG_14-3-3_CanoR_1	400	408	PF00244	0.694
LIG_14-3-3_CanoR_1	418	426	PF00244	0.421
LIG_14-3-3_CanoR_1	431	441	PF00244	0.553
LIG_Actin_WH2_2	423	440	PF00022	0.681
LIG_BRCT_BRCA1_1	247	251	PF00533	0.478
LIG_deltaCOP1_diTrp_1	168	174	PF00928	0.506
LIG_eIF4E_1	265	271	PF01652	0.362
LIG_FHA_1	116	122	PF00498	0.636
LIG_FHA_1	142	148	PF00498	0.574
LIG_FHA_1	179	185	PF00498	0.387
LIG_FHA_1	22	28	PF00498	0.612
LIG_FHA_1	239	245	PF00498	0.527
LIG_FHA_1	303	309	PF00498	0.561
LIG_FHA_1	34	40	PF00498	0.453
LIG_FHA_1	62	68	PF00498	0.426
LIG_FHA_1	71	77	PF00498	0.315
LIG_FHA_2	23	29	PF00498	0.578
LIG_FHA_2	339	345	PF00498	0.648
LIG_FHA_2	418	424	PF00498	0.620
LIG_FHA_2	46	52	PF00498	0.476
LIG_Integrin_isoDGR_2	227	229	PF01839	0.434
LIG_LIR_Gen_1	168	179	PF02991	0.387
LIG_LIR_Gen_1	262	273	PF02991	0.463
LIG_LIR_Gen_1	73	83	PF02991	0.338
LIG_LIR_Nem_3	168	174	PF02991	0.433
LIG_LIR_Nem_3	191	197	PF02991	0.483
LIG_LIR_Nem_3	248	254	PF02991	0.366
LIG_LIR_Nem_3	262	268	PF02991	0.373
LIG_LIR_Nem_3	317	322	PF02991	0.424
LIG_LIR_Nem_3	402	408	PF02991	0.765
LIG_LIR_Nem_3	66	71	PF02991	0.343
LIG_LIR_Nem_3	73	78	PF02991	0.352
LIG_MAD2	57	65	PF02301	0.518
LIG_MYND_1	476	480	PF01753	0.643
LIG_NRBOX	66	72	PF00104	0.414
LIG_PCNA_yPIPBox_3	283	295	PF02747	0.389
LIG_PDZ_Class_2	570	575	PF00595	0.659
LIG_Pex14_1	315	319	PF04695	0.416
LIG_RPA_C_Fungi	154	166	PF08784	0.511
LIG_SH2_CRK	319	323	PF00017	0.415
LIG_SH2_CRK	68	72	PF00017	0.458
LIG_SH2_PTP2	194	197	PF00017	0.462
LIG_SH2_STAT5	194	197	PF00017	0.462
LIG_SH2_STAT5	265	268	PF00017	0.370
LIG_SH2_STAT5	407	410	PF00017	0.571
LIG_SH2_STAT5	63	66	PF00017	0.385
LIG_SH2_STAT5	72	75	PF00017	0.325
LIG_SH3_3	124	130	PF00018	0.610
LIG_SH3_3	231	237	PF00018	0.600
LIG_SH3_3	467	473	PF00018	0.798
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.404
LIG_TRAF2_1	421	424	PF00917	0.588
LIG_TRAF2_1	43	46	PF00917	0.525
LIG_TRAF2_1	449	452	PF00917	0.652
LIG_TYR_ITIM	263	268	PF00017	0.382
MOD_CDC14_SPxK_1	479	482	PF00782	0.654
MOD_CDK_SPxK_1	476	482	PF00069	0.683
MOD_CK1_1	108	114	PF00069	0.598
MOD_CK1_1	342	348	PF00069	0.742
MOD_CK1_1	432	438	PF00069	0.652
MOD_CK1_1	460	466	PF00069	0.722
MOD_CK1_1	474	480	PF00069	0.487
MOD_CK1_1	481	487	PF00069	0.679
MOD_CK1_1	528	534	PF00069	0.665
MOD_CK1_1	537	543	PF00069	0.583
MOD_CK1_1	61	67	PF00069	0.393
MOD_CK1_1	99	105	PF00069	0.708
MOD_CK2_1	169	175	PF00069	0.346
MOD_CK2_1	22	28	PF00069	0.663
MOD_CK2_1	236	242	PF00069	0.484
MOD_CK2_1	338	344	PF00069	0.671
MOD_CK2_1	389	395	PF00069	0.746
MOD_CK2_1	417	423	PF00069	0.496
MOD_CK2_1	446	452	PF00069	0.708
MOD_CK2_1	45	51	PF00069	0.492
MOD_CK2_1	469	475	PF00069	0.726
MOD_CK2_1	526	532	PF00069	0.808
MOD_Cter_Amidation	155	158	PF01082	0.547
MOD_Cter_Amidation	372	375	PF01082	0.732
MOD_GlcNHglycan	101	104	PF01048	0.724
MOD_GlcNHglycan	105	108	PF01048	0.735
MOD_GlcNHglycan	171	174	PF01048	0.354
MOD_GlcNHglycan	212	215	PF01048	0.524
MOD_GlcNHglycan	280	283	PF01048	0.526
MOD_GlcNHglycan	344	347	PF01048	0.726
MOD_GlcNHglycan	382	385	PF01048	0.710
MOD_GlcNHglycan	454	457	PF01048	0.676
MOD_GlcNHglycan	464	469	PF01048	0.795
MOD_GlcNHglycan	536	539	PF01048	0.672
MOD_GlcNHglycan	60	63	PF01048	0.512
MOD_GSK3_1	105	112	PF00069	0.748
MOD_GSK3_1	115	122	PF00069	0.707
MOD_GSK3_1	206	213	PF00069	0.541
MOD_GSK3_1	291	298	PF00069	0.411
MOD_GSK3_1	338	345	PF00069	0.691
MOD_GSK3_1	351	358	PF00069	0.527
MOD_GSK3_1	373	380	PF00069	0.782
MOD_GSK3_1	390	397	PF00069	0.552
MOD_GSK3_1	452	459	PF00069	0.686
MOD_GSK3_1	460	467	PF00069	0.597
MOD_GSK3_1	47	54	PF00069	0.527
MOD_GSK3_1	474	481	PF00069	0.807
MOD_GSK3_1	524	531	PF00069	0.658
MOD_GSK3_1	551	558	PF00069	0.624
MOD_GSK3_1	95	102	PF00069	0.705
MOD_N-GLC_1	342	347	PF02516	0.764
MOD_NEK2_1	22	27	PF00069	0.589
MOD_NEK2_1	302	307	PF00069	0.474
MOD_NEK2_1	308	313	PF00069	0.439
MOD_NEK2_1	96	101	PF00069	0.706
MOD_PIKK_1	481	487	PF00454	0.628
MOD_PKA_1	210	216	PF00069	0.530
MOD_PKA_1	362	368	PF00069	0.734
MOD_PKA_1	446	452	PF00069	0.645
MOD_PKA_2	16	22	PF00069	0.715
MOD_PKA_2	210	216	PF00069	0.530
MOD_PKA_2	302	308	PF00069	0.467
MOD_PKA_2	399	405	PF00069	0.682
MOD_PKA_2	417	423	PF00069	0.421
MOD_PKA_2	432	438	PF00069	0.554
MOD_PKA_2	481	487	PF00069	0.709
MOD_PKA_2	491	497	PF00069	0.658
MOD_PKB_1	243	251	PF00069	0.472
MOD_PKB_1	444	452	PF00069	0.672
MOD_Plk_1	390	396	PF00069	0.679
MOD_Plk_1	414	420	PF00069	0.624
MOD_Plk_1	464	470	PF00069	0.785
MOD_Plk_2-3	6	12	PF00069	0.600
MOD_Plk_4	303	309	PF00069	0.555
MOD_Plk_4	457	463	PF00069	0.544
MOD_Plk_4	63	69	PF00069	0.447
MOD_ProDKin_1	275	281	PF00069	0.554
MOD_ProDKin_1	45	51	PF00069	0.598
MOD_ProDKin_1	469	475	PF00069	0.678
MOD_ProDKin_1	476	482	PF00069	0.611
MOD_ProDKin_1	61	67	PF00069	0.307
MOD_ProDKin_1	70	76	PF00069	0.308
MOD_ProDKin_1	85	91	PF00069	0.438
MOD_ProDKin_1	97	103	PF00069	0.654
MOD_SUMO_for_1	514	517	PF00179	0.675
MOD_SUMO_for_1	552	555	PF00179	0.552
TRG_DiLeu_BaEn_1	242	247	PF01217	0.486
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.463
TRG_ENDOCYTIC_2	194	197	PF00928	0.462
TRG_ENDOCYTIC_2	265	268	PF00928	0.370
TRG_ENDOCYTIC_2	319	322	PF00928	0.405
TRG_ENDOCYTIC_2	405	408	PF00928	0.720
TRG_ENDOCYTIC_2	68	71	PF00928	0.344
TRG_ENDOCYTIC_2	72	75	PF00928	0.332
TRG_ER_diArg_1	14	17	PF00400	0.599
TRG_ER_diArg_1	158	160	PF00400	0.533
TRG_ER_diArg_1	243	246	PF00400	0.542
TRG_ER_diArg_1	430	433	PF00400	0.498
TRG_ER_diArg_1	444	446	PF00400	0.480
TRG_ER_diArg_1	543	546	PF00400	0.663
TRG_ER_diArg_1	55	58	PF00400	0.540
TRG_NES_CRM1_1	191	207	PF08389	0.352
TRG_NLS_Bipartite_1	362	378	PF00514	0.727
TRG_NLS_MonoExtC_3	445	450	PF00514	0.711
TRG_NLS_MonoExtN_4	444	450	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X8	Leptomonas seymouri	61%	86%
A0A1X0NZC8	Trypanosomatidae	40%	95%
A0A3S7WTU1	Leishmania donovani	93%	100%
A0A422N971	Trypanosoma rangeli	42%	96%
A4H8G6	Leishmania braziliensis	83%	100%
A4HWT9	Leishmania infantum	93%	100%
C9ZPR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AQJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B948	Trypanosoma cruzi	37%	100%