Pyridoxal-dependent decarboxylase conserved domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pyridoxal-dependent decarboxylase conserved domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEX8_LEIMA

TriTrypDb:

LmjF.16.0420 , LMJLV39_160009600 , LMJSD75_160009600

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEX8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044281	small molecule metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0016829	lyase activity	2	10
GO:0016830	carbon-carbon lyase activity	3	10
GO:0016831	carboxy-lyase activity	4	2
GO:0019842	vitamin binding	3	10
GO:0030170	pyridoxal phosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0070279	vitamin B6 binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.364
CLV_C14_Caspase3-7	59	63	PF00656	0.605
CLV_MEL_PAP_1	379	385	PF00089	0.498
CLV_NRD_NRD_1	302	304	PF00675	0.430
CLV_PCSK_KEX2_1	143	145	PF00082	0.574
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.411
CLV_PCSK_SKI1_1	109	113	PF00082	0.275
CLV_PCSK_SKI1_1	288	292	PF00082	0.671
CLV_PCSK_SKI1_1	391	395	PF00082	0.658
CLV_PCSK_SKI1_1	418	422	PF00082	0.456
CLV_PCSK_SKI1_1	43	47	PF00082	0.588
DEG_APCC_DBOX_1	365	373	PF00400	0.515
DEG_APCC_DBOX_1	390	398	PF00400	0.478
DEG_COP1_1	261	272	PF00400	0.374
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DEG_SCF_FBW7_1	54	59	PF00400	0.556
DEG_SPOP_SBC_1	18	22	PF00917	0.580
DOC_CKS1_1	323	328	PF01111	0.490
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.370
DOC_MAPK_MEF2A_6	482	491	PF00069	0.524
DOC_MAPK_MEF2A_6	499	506	PF00069	0.377
DOC_MAPK_RevD_3	129	144	PF00069	0.367
DOC_PP2B_LxvP_1	146	149	PF13499	0.514
DOC_PP2B_LxvP_1	510	513	PF13499	0.605
DOC_USP7_MATH_1	150	154	PF00917	0.408
DOC_USP7_MATH_1	19	23	PF00917	0.519
DOC_USP7_MATH_1	237	241	PF00917	0.479
DOC_USP7_MATH_1	258	262	PF00917	0.525
DOC_USP7_MATH_1	458	462	PF00917	0.593
DOC_USP7_MATH_1	47	51	PF00917	0.664
DOC_USP7_MATH_1	54	58	PF00917	0.611
DOC_WW_Pin1_4	281	286	PF00397	0.593
DOC_WW_Pin1_4	322	327	PF00397	0.499
DOC_WW_Pin1_4	334	339	PF00397	0.474
DOC_WW_Pin1_4	441	446	PF00397	0.564
DOC_WW_Pin1_4	463	468	PF00397	0.674
DOC_WW_Pin1_4	52	57	PF00397	0.644
LIG_14-3-3_CanoR_1	104	113	PF00244	0.302
LIG_14-3-3_CanoR_1	135	141	PF00244	0.370
LIG_14-3-3_CanoR_1	288	297	PF00244	0.390
LIG_14-3-3_CanoR_1	316	321	PF00244	0.545
LIG_14-3-3_CanoR_1	382	390	PF00244	0.602
LIG_14-3-3_CanoR_1	554	559	PF00244	0.458
LIG_deltaCOP1_diTrp_1	343	347	PF00928	0.441
LIG_Dynein_DLC8_1	133	139	PF01221	0.334
LIG_FHA_1	135	141	PF00498	0.388
LIG_FHA_1	323	329	PF00498	0.491
LIG_FHA_1	355	361	PF00498	0.440
LIG_FHA_1	425	431	PF00498	0.448
LIG_FHA_1	74	80	PF00498	0.362
LIG_FHA_1	82	88	PF00498	0.320
LIG_FHA_2	39	45	PF00498	0.531
LIG_FHA_2	419	425	PF00498	0.475
LIG_FHA_2	57	63	PF00498	0.617
LIG_FHA_2	68	74	PF00498	0.381
LIG_Integrin_RGD_1	398	400	PF01839	0.505
LIG_LIR_Gen_1	73	82	PF02991	0.447
LIG_LIR_Nem_3	505	509	PF02991	0.585
LIG_LIR_Nem_3	73	78	PF02991	0.457
LIG_LYPXL_S_1	188	192	PF13949	0.237
LIG_LYPXL_yS_3	189	192	PF13949	0.237
LIG_RPA_C_Fungi	427	439	PF08784	0.477
LIG_SH2_CRK	278	282	PF00017	0.670
LIG_SH2_CRK	75	79	PF00017	0.429
LIG_SH2_NCK_1	257	261	PF00017	0.371
LIG_SH2_STAP1	106	110	PF00017	0.240
LIG_SH2_STAP1	169	173	PF00017	0.303
LIG_SH2_STAP1	68	72	PF00017	0.522
LIG_SH2_STAP1	75	79	PF00017	0.414
LIG_SH2_STAT5	113	116	PF00017	0.360
LIG_SH2_STAT5	547	550	PF00017	0.646
LIG_SH2_STAT5	75	78	PF00017	0.457
LIG_SH3_1	13	19	PF00018	0.488
LIG_SH3_3	13	19	PF00018	0.686
LIG_SH3_3	238	244	PF00018	0.536
LIG_SH3_3	263	269	PF00018	0.414
LIG_SH3_3	279	285	PF00018	0.585
LIG_SH3_3	333	339	PF00018	0.462
LIG_SH3_3	370	376	PF00018	0.706
LIG_SUMO_SIM_anti_2	206	213	PF11976	0.251
LIG_SUMO_SIM_par_1	375	381	PF11976	0.531
LIG_SUMO_SIM_par_1	508	515	PF11976	0.536
LIG_SUMO_SIM_par_1	75	81	PF11976	0.364
LIG_TYR_ITIM	276	281	PF00017	0.565
LIG_WRC_WIRS_1	194	199	PF05994	0.354
MOD_CDK_SPxxK_3	281	288	PF00069	0.448
MOD_CK1_1	153	159	PF00069	0.554
MOD_CK1_1	199	205	PF00069	0.381
MOD_CK1_1	284	290	PF00069	0.573
MOD_CK1_1	337	343	PF00069	0.482
MOD_CK1_1	463	469	PF00069	0.606
MOD_CK1_1	543	549	PF00069	0.589
MOD_CK2_1	337	343	PF00069	0.449
MOD_CK2_1	38	44	PF00069	0.533
MOD_CK2_1	67	73	PF00069	0.407
MOD_DYRK1A_RPxSP_1	52	56	PF00069	0.546
MOD_GlcNHglycan	10	13	PF01048	0.749
MOD_GlcNHglycan	101	104	PF01048	0.464
MOD_GlcNHglycan	198	201	PF01048	0.380
MOD_GlcNHglycan	383	386	PF01048	0.461
MOD_GlcNHglycan	454	457	PF01048	0.588
MOD_GlcNHglycan	460	463	PF01048	0.576
MOD_GlcNHglycan	472	475	PF01048	0.490
MOD_GlcNHglycan	528	531	PF01048	0.680
MOD_GlcNHglycan	540	543	PF01048	0.478
MOD_GSK3_1	2	9	PF00069	0.658
MOD_GSK3_1	258	265	PF00069	0.335
MOD_GSK3_1	267	274	PF00069	0.372
MOD_GSK3_1	284	291	PF00069	0.539
MOD_GSK3_1	48	55	PF00069	0.596
MOD_GSK3_1	554	561	PF00069	0.559
MOD_GSK3_1	81	88	PF00069	0.388
MOD_NEK2_1	262	267	PF00069	0.315
MOD_NEK2_1	558	563	PF00069	0.619
MOD_NEK2_1	67	72	PF00069	0.389
MOD_NEK2_1	78	83	PF00069	0.323
MOD_NEK2_2	354	359	PF00069	0.381
MOD_PIKK_1	134	140	PF00454	0.444
MOD_PIKK_1	251	257	PF00454	0.309
MOD_PIKK_1	81	87	PF00454	0.385
MOD_PKA_2	134	140	PF00069	0.495
MOD_PKA_2	381	387	PF00069	0.456
MOD_Plk_1	403	409	PF00069	0.467
MOD_Plk_1	424	430	PF00069	0.565
MOD_Plk_4	237	243	PF00069	0.350
MOD_Plk_4	262	268	PF00069	0.381
MOD_Plk_4	543	549	PF00069	0.586
MOD_Plk_4	73	79	PF00069	0.351
MOD_ProDKin_1	281	287	PF00069	0.591
MOD_ProDKin_1	322	328	PF00069	0.495
MOD_ProDKin_1	334	340	PF00069	0.474
MOD_ProDKin_1	441	447	PF00069	0.566
MOD_ProDKin_1	463	469	PF00069	0.674
MOD_ProDKin_1	52	58	PF00069	0.647
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.251
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.507
TRG_ENDOCYTIC_2	189	192	PF00928	0.237
TRG_ENDOCYTIC_2	278	281	PF00928	0.626
TRG_ENDOCYTIC_2	75	78	PF00928	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL2	Leptomonas seymouri	45%	77%
A0A1X0P0L1	Trypanosomatidae	29%	83%
A0A3Q8IDL2	Leishmania donovani	92%	100%
A0A3R7K963	Trypanosoma rangeli	35%	100%
A4H8G7	Leishmania braziliensis	76%	100%
A4HWU0	Leishmania infantum	92%	100%
C9ZW41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	94%
E9AQJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q16S21	Aedes aegypti	24%	100%