Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEX7_LEIMA

TriTrypDb:

LmjF.16.0430 , LMJLV39_160009700 , LMJSD75_160009700

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.597
CLV_C14_Caspase3-7	172	176	PF00656	0.615
CLV_NRD_NRD_1	133	135	PF00675	0.487
CLV_NRD_NRD_1	140	142	PF00675	0.470
CLV_NRD_NRD_1	15	17	PF00675	0.655
CLV_NRD_NRD_1	9	11	PF00675	0.721
CLV_PCSK_KEX2_1	133	135	PF00082	0.498
CLV_PCSK_KEX2_1	15	17	PF00082	0.657
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.654
CLV_PCSK_SKI1_1	146	150	PF00082	0.625
DOC_MAPK_gen_1	138	147	PF00069	0.621
DOC_MAPK_gen_1	14	23	PF00069	0.584
DOC_MAPK_gen_1	158	167	PF00069	0.537
DOC_USP7_MATH_1	27	31	PF00917	0.636
DOC_USP7_MATH_1	39	43	PF00917	0.488
DOC_USP7_MATH_1	59	63	PF00917	0.568
DOC_USP7_MATH_1	67	71	PF00917	0.593
DOC_USP7_MATH_1	80	84	PF00917	0.651
DOC_USP7_MATH_1	85	89	PF00917	0.616
DOC_USP7_UBL2_3	11	15	PF12436	0.574
DOC_USP7_UBL2_3	138	142	PF12436	0.532
DOC_WW_Pin1_4	76	81	PF00397	0.733
LIG_14-3-3_CanoR_1	160	165	PF00244	0.537
LIG_14-3-3_CanoR_1	31	37	PF00244	0.543
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_BRCT_BRCA1_1	29	33	PF00533	0.589
LIG_BRCT_BRCA1_1	86	90	PF00533	0.574
LIG_FHA_1	33	39	PF00498	0.531
LIG_FHA_2	118	124	PF00498	0.664
LIG_LIR_Apic_2	105	111	PF02991	0.452
LIG_LIR_Gen_1	30	39	PF02991	0.576
LIG_LIR_Gen_1	53	59	PF02991	0.595
LIG_LIR_Gen_1	96	107	PF02991	0.477
LIG_LIR_Nem_3	126	131	PF02991	0.547
LIG_LIR_Nem_3	30	36	PF02991	0.584
LIG_LIR_Nem_3	53	58	PF02991	0.612
LIG_LIR_Nem_3	87	93	PF02991	0.569
LIG_LIR_Nem_3	96	102	PF02991	0.349
LIG_RPA_C_Fungi	26	38	PF08784	0.639
LIG_SH2_SRC	55	58	PF00017	0.421
LIG_SH3_3	149	155	PF00018	0.665
LIG_SH3_3	33	39	PF00018	0.495
LIG_TRAF2_1	112	115	PF00917	0.487
LIG_TRAF2_2	45	50	PF00917	0.597
LIG_UBA3_1	98	106	PF00899	0.538
MOD_CK1_1	168	174	PF00069	0.678
MOD_CK1_1	63	69	PF00069	0.640
MOD_CK1_1	76	82	PF00069	0.729
MOD_CK1_1	83	89	PF00069	0.661
MOD_CK2_1	109	115	PF00069	0.490
MOD_Cter_Amidation	12	15	PF01082	0.582
MOD_GlcNHglycan	62	65	PF01048	0.595
MOD_GlcNHglycan	69	72	PF01048	0.611
MOD_GlcNHglycan	73	76	PF01048	0.598
MOD_GlcNHglycan	87	90	PF01048	0.637
MOD_GSK3_1	165	172	PF00069	0.701
MOD_GSK3_1	27	34	PF00069	0.597
MOD_GSK3_1	59	66	PF00069	0.608
MOD_GSK3_1	67	74	PF00069	0.629
MOD_GSK3_1	76	83	PF00069	0.650
MOD_NEK2_1	167	172	PF00069	0.700
MOD_PKA_2	21	27	PF00069	0.538
MOD_PKA_2	39	45	PF00069	0.596
MOD_Plk_4	160	166	PF00069	0.564
MOD_Plk_4	50	56	PF00069	0.624
MOD_ProDKin_1	76	82	PF00069	0.731
MOD_SUMO_for_1	148	151	PF00179	0.659
MOD_SUMO_rev_2	130	140	PF00179	0.535
TRG_ENDOCYTIC_2	55	58	PF00928	0.566
TRG_ER_diArg_1	20	23	PF00400	0.529
TRG_NLS_MonoCore_2	13	18	PF00514	0.656
TRG_NLS_MonoExtC_3	13	18	PF00514	0.605
TRG_NLS_MonoExtN_4	11	18	PF00514	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B0	Leptomonas seymouri	62%	100%
A0A0S4JAB3	Bodo saltans	43%	100%
A0A1X0P0C9	Trypanosomatidae	53%	100%
A0A3R7M9R7	Trypanosoma rangeli	58%	100%
A0A3S7WTU8	Leishmania donovani	86%	100%
A4H8G8	Leishmania braziliensis	75%	100%
A4HWU1	Leishmania infantum	86%	100%
C9ZW40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AQK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%