Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEX5_LEIMA

TriTrypDb:

LmjF.16.0450 , LMJLV39_160009900 , LMJSD75_160009800

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QEX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.604
CLV_NRD_NRD_1	32	34	PF00675	0.468
CLV_PCSK_KEX2_1	122	124	PF00082	0.539
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.539
CLV_PCSK_SKI1_1	4	8	PF00082	0.516
CLV_PCSK_SKI1_1	99	103	PF00082	0.516
DEG_APCC_DBOX_1	131	139	PF00400	0.383
DEG_SCF_FBW7_1	71	78	PF00400	0.685
DOC_MAPK_MEF2A_6	132	140	PF00069	0.449
DOC_USP7_MATH_1	177	181	PF00917	0.525
DOC_WW_Pin1_4	71	76	PF00397	0.666
LIG_14-3-3_CanoR_1	11	21	PF00244	0.714
LIG_14-3-3_CanoR_1	63	68	PF00244	0.657
LIG_Actin_WH2_2	160	178	PF00022	0.434
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_DLG_GKlike_1	63	71	PF00625	0.664
LIG_FHA_1	135	141	PF00498	0.375
LIG_FHA_2	204	210	PF00498	0.535
LIG_FHA_2	53	59	PF00498	0.745
LIG_LIR_Apic_2	19	24	PF02991	0.753
LIG_LIR_Gen_1	170	177	PF02991	0.484
LIG_LIR_Gen_1	55	65	PF02991	0.748
LIG_LIR_Nem_3	170	175	PF02991	0.488
LIG_LIR_Nem_3	55	60	PF02991	0.748
LIG_LIR_Nem_3	86	91	PF02991	0.638
LIG_PDZ_Class_2	229	234	PF00595	0.449
LIG_SH2_CRK	172	176	PF00017	0.485
LIG_SH2_STAP1	77	81	PF00017	0.737
LIG_SH2_STAT5	77	80	PF00017	0.674
LIG_SH2_STAT5	84	87	PF00017	0.622
LIG_SH3_3	138	144	PF00018	0.385
LIG_SH3_3	210	216	PF00018	0.381
LIG_SH3_3	94	100	PF00018	0.690
LIG_TYR_ITIM	82	87	PF00017	0.732
LIG_UBA3_1	101	108	PF00899	0.650
LIG_UBA3_1	116	122	PF00899	0.641
MOD_CK1_1	14	20	PF00069	0.686
MOD_CK1_1	178	184	PF00069	0.511
MOD_CK2_1	203	209	PF00069	0.511
MOD_CK2_1	63	69	PF00069	0.672
MOD_GlcNHglycan	16	19	PF01048	0.459
MOD_GlcNHglycan	177	180	PF01048	0.736
MOD_GlcNHglycan	183	186	PF01048	0.734
MOD_GlcNHglycan	8	11	PF01048	0.546
MOD_GSK3_1	157	164	PF00069	0.477
MOD_GSK3_1	177	184	PF00069	0.312
MOD_GSK3_1	6	13	PF00069	0.717
MOD_GSK3_1	71	78	PF00069	0.678
MOD_LATS_1	61	67	PF00433	0.656
MOD_NEK2_1	147	152	PF00069	0.561
MOD_NEK2_1	175	180	PF00069	0.532
MOD_NEK2_1	39	44	PF00069	0.754
MOD_NEK2_1	6	11	PF00069	0.664
MOD_NEK2_2	203	208	PF00069	0.551
MOD_PKA_2	10	16	PF00069	0.708
MOD_Plk_4	26	32	PF00069	0.742
MOD_ProDKin_1	71	77	PF00069	0.668
TRG_ENDOCYTIC_2	172	175	PF00928	0.469
TRG_ENDOCYTIC_2	84	87	PF00928	0.731

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I779	Leptomonas seymouri	60%	98%
A0A0S4JEF8	Bodo saltans	40%	100%
A0A1X0NHP7	Trypanosomatidae	50%	100%
A0A3S7WTT8	Leishmania donovani	96%	100%
A0A422N958	Trypanosoma rangeli	45%	91%
A4H8G9	Leishmania braziliensis	84%	91%
A4HWU3	Leishmania infantum	95%	100%
C9ZW39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AQK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5D515	Trypanosoma cruzi	44%	100%