Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEX5_LEIMA

TriTrypDb:

LmjF.16.0450 , LMJLV39_160009900 , LMJSD75_160009800

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

Q4QEX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEX5

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.604
CLV_NRD_NRD_1	32	34	PF00675	0.468
CLV_PCSK_KEX2_1	122	124	PF00082	0.539
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.539
CLV_PCSK_SKI1_1	4	8	PF00082	0.516
CLV_PCSK_SKI1_1	99	103	PF00082	0.516
DEG_APCC_DBOX_1	131	139	PF00400	0.383
DEG_SCF_FBW7_1	71	78	PF00400	0.685
DOC_MAPK_MEF2A_6	132	140	PF00069	0.449
DOC_USP7_MATH_1	177	181	PF00917	0.525

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I779	Leptomonas seymouri	60%	98%
A0A0S4JEF8	Bodo saltans	40%	100%
A0A1X0NHP7	Trypanosomatidae	50%	100%
A0A3S7WTT8	Leishmania donovani	96%	100%
A0A422N958	Trypanosoma rangeli	45%	91%
A4H8G9	Leishmania braziliensis	84%	91%
A4HWU3	Leishmania infantum	95%	100%
C9ZW39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AQK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5D515	Trypanosoma cruzi	44%	100%

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