Amastin surface glycofamily protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEX3_LEIMA

TriTrypDb:

LmjF.16.0470 , LMJLV39_160010100 , LMJSD75_160010000

Length:

184

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 18
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

Q4QEX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.419
CLV_NRD_NRD_1	28	30	PF00675	0.571
DEG_Nend_Nbox_1	1	3	PF02207	0.647
DOC_AGCK_PIF_1	118	123	PF00069	0.207
DOC_MAPK_gen_1	29	35	PF00069	0.410
LIG_APCC_ABBA_1	176	181	PF00400	0.284
LIG_FHA_1	146	152	PF00498	0.351
LIG_FHA_1	2	8	PF00498	0.599
LIG_FHA_1	74	80	PF00498	0.431
LIG_GBD_Chelix_1	6	14	PF00786	0.316
LIG_HCF-1_HBM_1	59	62	PF13415	0.271
LIG_LIR_Gen_1	122	131	PF02991	0.385
LIG_LIR_Gen_1	162	172	PF02991	0.271
LIG_LIR_Nem_3	122	126	PF02991	0.353
LIG_LIR_Nem_3	162	167	PF02991	0.319
LIG_LIR_Nem_3	59	65	PF02991	0.463
LIG_SH2_PTP2	158	161	PF00017	0.355
LIG_SH2_STAT5	158	161	PF00017	0.368
LIG_SH2_STAT5	45	48	PF00017	0.389
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.449
LIG_UBA3_1	24	30	PF00899	0.436
LIG_WRC_WIRS_1	120	125	PF05994	0.320
MOD_CK1_1	129	135	PF00069	0.383
MOD_CK1_1	138	144	PF00069	0.316
MOD_GlcNHglycan	137	140	PF01048	0.499
MOD_GSK3_1	73	80	PF00069	0.423
MOD_N-GLC_2	110	112	PF02516	0.225
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	126	131	PF00069	0.346
MOD_PKA_2	66	72	PF00069	0.385
MOD_Plk_1	145	151	PF00069	0.406
MOD_Plk_1	48	54	PF00069	0.354
MOD_Plk_4	111	117	PF00069	0.458
MOD_Plk_4	129	135	PF00069	0.417
TRG_DiLeu_BaEn_1	162	167	PF01217	0.305
TRG_ENDOCYTIC_2	158	161	PF00928	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	43%	100%
A0A0N0P3Z6	Leptomonas seymouri	33%	81%
A0A0N0P4D5	Leptomonas seymouri	31%	88%
A0A1X0P9D7	Trypanosomatidae	29%	86%
A0A3Q8IIZ2	Leishmania donovani	33%	83%
A0A3R7KFR8	Trypanosoma rangeli	30%	100%
A0A3S5H6X1	Leishmania donovani	30%	92%
A0A3S7WTU4	Leishmania donovani	91%	100%
A4H8H3	Leishmania braziliensis	67%	100%
A4H8H5	Leishmania braziliensis	28%	92%
A4H8H6	Leishmania braziliensis	32%	83%
A4HWU5	Leishmania infantum	91%	100%
A4HWU7	Leishmania infantum	30%	92%
A4HWU8	Leishmania infantum	33%	83%
E9AQK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AQK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	89%
E9AQK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4QEX0	Leishmania major	32%	100%
Q4QEX1	Leishmania major	30%	100%