Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QEX0_LEIMA

TriTrypDb:

LmjF.16.0500 , LMJLV39_160010500 , LMJSD75_160010400

Length:

215

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 18
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

Q4QEX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.548
CLV_NRD_NRD_1	28	30	PF00675	0.573
CLV_PCSK_SKI1_1	5	9	PF00082	0.265
CLV_PCSK_SKI1_1	67	71	PF00082	0.703
CLV_PCSK_SKI1_1	75	79	PF00082	0.583
DEG_APCC_DBOX_1	4	12	PF00400	0.421
DEG_Nend_UBRbox_1	1	4	PF02207	0.535
DOC_CYCLIN_RxL_1	72	82	PF00134	0.279
DOC_MAPK_gen_1	2	11	PF00069	0.536
DOC_MAPK_MEF2A_6	2	11	PF00069	0.502
DOC_MAPK_MEF2A_6	73	81	PF00069	0.275
DOC_PP1_RVXF_1	73	79	PF00149	0.333
DOC_PP2B_LxvP_1	150	153	PF13499	0.312
DOC_WW_Pin1_4	52	57	PF00397	0.381
LIG_FHA_1	112	118	PF00498	0.479
LIG_FHA_1	14	20	PF00498	0.451
LIG_FHA_1	146	152	PF00498	0.482
LIG_FHA_1	178	184	PF00498	0.307
LIG_FHA_1	64	70	PF00498	0.387
LIG_FHA_2	53	59	PF00498	0.321
LIG_GBD_Chelix_1	116	124	PF00786	0.476
LIG_LIR_Gen_1	119	129	PF02991	0.333
LIG_LIR_LC3C_4	180	183	PF02991	0.230
LIG_LIR_Nem_3	119	124	PF02991	0.311
LIG_LIR_Nem_3	162	167	PF02991	0.292
LIG_NBox_RRM_1	125	135	PF00076	0.198
LIG_Pex14_2	121	125	PF04695	0.326
LIG_Pex14_2	137	141	PF04695	0.296
LIG_Pex14_2	174	178	PF04695	0.366
LIG_SH2_STAP1	107	111	PF00017	0.688
LIG_SH2_STAP1	65	69	PF00017	0.417
LIG_SH2_STAT5	65	68	PF00017	0.466
LIG_SUMO_SIM_anti_2	126	131	PF11976	0.317
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.352
LIG_UBA3_1	23	30	PF00899	0.436
LIG_UBA3_1	69	73	PF00899	0.297
MOD_CK1_1	112	118	PF00069	0.582
MOD_CK1_1	32	38	PF00069	0.526
MOD_CK1_1	49	55	PF00069	0.398
MOD_CK1_1	82	88	PF00069	0.300
MOD_CK2_1	52	58	PF00069	0.519
MOD_GlcNHglycan	111	114	PF01048	0.330
MOD_GlcNHglycan	81	84	PF01048	0.379
MOD_GSK3_1	101	108	PF00069	0.486
MOD_GSK3_1	112	119	PF00069	0.503
MOD_GSK3_1	188	195	PF00069	0.586
MOD_GSK3_1	46	53	PF00069	0.369
MOD_GSK3_1	59	66	PF00069	0.329
MOD_N-GLC_1	143	148	PF02516	0.624
MOD_N-GLC_1	32	37	PF02516	0.663
MOD_N-GLC_1	46	51	PF02516	0.548
MOD_NEK2_1	116	121	PF00069	0.325
MOD_NEK2_1	123	128	PF00069	0.328
MOD_NEK2_1	130	135	PF00069	0.336
MOD_NEK2_1	177	182	PF00069	0.319
MOD_NEK2_1	59	64	PF00069	0.406
MOD_NEK2_1	79	84	PF00069	0.277
MOD_PIKK_1	188	194	PF00454	0.659
MOD_PKA_1	29	35	PF00069	0.336
MOD_Plk_1	46	52	PF00069	0.355
MOD_Plk_4	112	118	PF00069	0.535
MOD_Plk_4	131	137	PF00069	0.245
MOD_Plk_4	177	183	PF00069	0.301
MOD_Plk_4	19	25	PF00069	0.373
MOD_Plk_4	46	52	PF00069	0.353
MOD_Plk_4	82	88	PF00069	0.352
MOD_ProDKin_1	52	58	PF00069	0.382
TRG_DiLeu_BaEn_1	162	167	PF01217	0.297
TRG_ENDOCYTIC_2	158	161	PF00928	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	32%	100%
A0A0N0P3Z6	Leptomonas seymouri	31%	95%
A0A0N0P4D5	Leptomonas seymouri	32%	100%
A0A0N1HU04	Leptomonas seymouri	29%	69%
A0A0N1PD13	Leptomonas seymouri	24%	92%
A0A3Q8IIZ2	Leishmania donovani	78%	97%
A0A3R7KFR8	Trypanosoma rangeli	26%	100%
A0A3S5H6X1	Leishmania donovani	34%	100%
A0A3S7WTU4	Leishmania donovani	28%	100%
A4H8H3	Leishmania braziliensis	34%	100%
A4H8H5	Leishmania braziliensis	31%	100%
A4H8H6	Leishmania braziliensis	44%	97%
A4HWU5	Leishmania infantum	28%	100%
A4HWU7	Leishmania infantum	34%	100%
A4HWU8	Leishmania infantum	78%	97%
E9AQK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AQK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AQK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4QEX1	Leishmania major	34%	100%
Q4QEX3	Leishmania major	32%	100%