Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEW8_LEIMA

TriTrypDb:

LmjF.16.0520 , LMJLV39_160010700 , LMJSD75_160010600

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.503
CLV_NRD_NRD_1	3	5	PF00675	0.575
CLV_PCSK_KEX2_1	166	168	PF00082	0.395
CLV_PCSK_KEX2_1	3	5	PF00082	0.575
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.395
CLV_PCSK_SKI1_1	128	132	PF00082	0.459
CLV_PCSK_SKI1_1	162	166	PF00082	0.520
CLV_PCSK_SKI1_1	203	207	PF00082	0.422
CLV_PCSK_SKI1_1	230	234	PF00082	0.526
CLV_PCSK_SKI1_1	255	259	PF00082	0.504
DEG_APCC_DBOX_1	229	237	PF00400	0.450
DEG_Nend_Nbox_1	1	3	PF02207	0.670
DEG_SPOP_SBC_1	32	36	PF00917	0.582
DOC_MAPK_gen_1	128	136	PF00069	0.437
DOC_PP1_RVXF_1	253	260	PF00149	0.494
DOC_PP1_RVXF_1	65	72	PF00149	0.515
DOC_USP7_UBL2_3	162	166	PF12436	0.384
DOC_WW_Pin1_4	264	269	PF00397	0.595
DOC_WW_Pin1_4	303	308	PF00397	0.508
DOC_WW_Pin1_4	313	318	PF00397	0.678
DOC_WW_Pin1_4	323	328	PF00397	0.662
LIG_14-3-3_CanoR_1	167	176	PF00244	0.551
LIG_14-3-3_CanoR_1	4	13	PF00244	0.602
LIG_Actin_WH2_2	203	221	PF00022	0.422
LIG_Actin_WH2_2	285	300	PF00022	0.529
LIG_FHA_1	248	254	PF00498	0.412
LIG_FHA_1	284	290	PF00498	0.596
LIG_FHA_1	87	93	PF00498	0.585
LIG_FHA_2	133	139	PF00498	0.328
LIG_FHA_2	256	262	PF00498	0.565
LIG_FHA_2	304	310	PF00498	0.531
LIG_FHA_2	70	76	PF00498	0.427
LIG_FHA_2	85	91	PF00498	0.382
LIG_FHA_2	93	99	PF00498	0.420
LIG_LIR_Gen_1	91	102	PF02991	0.527
LIG_LIR_Nem_3	124	130	PF02991	0.411
LIG_LIR_Nem_3	79	84	PF02991	0.405
LIG_LIR_Nem_3	91	97	PF02991	0.454
LIG_PCNA_yPIPBox_3	184	193	PF02747	0.324
LIG_Rb_LxCxE_1	272	290	PF01857	0.647
LIG_SH2_NCK_1	246	250	PF00017	0.518
LIG_SH2_NCK_1	94	98	PF00017	0.438
LIG_SH2_STAP1	137	141	PF00017	0.329
LIG_SH2_STAT3	176	179	PF00017	0.531
LIG_SH2_STAT5	176	179	PF00017	0.488
LIG_SH2_STAT5	94	97	PF00017	0.434
LIG_SH3_3	60	66	PF00018	0.504
LIG_SUMO_SIM_anti_2	24	29	PF11976	0.631
LIG_TRAF2_1	45	48	PF00917	0.452
LIG_TYR_ITIM	92	97	PF00017	0.501
LIG_UBA3_1	235	243	PF00899	0.562
LIG_WRC_WIRS_1	133	138	PF05994	0.341
LIG_WRC_WIRS_1	156	161	PF05994	0.418
MOD_CK1_1	132	138	PF00069	0.468
MOD_CK1_1	31	37	PF00069	0.505
MOD_CK1_1	316	322	PF00069	0.710
MOD_CK1_1	42	48	PF00069	0.483
MOD_CK2_1	132	138	PF00069	0.384
MOD_CK2_1	42	48	PF00069	0.511
MOD_CK2_1	92	98	PF00069	0.469
MOD_GlcNHglycan	169	172	PF01048	0.441
MOD_GlcNHglycan	30	33	PF01048	0.534
MOD_GlcNHglycan	41	44	PF01048	0.595
MOD_GSK3_1	11	18	PF00069	0.581
MOD_GSK3_1	28	35	PF00069	0.601
MOD_NEK2_1	122	127	PF00069	0.420
MOD_NEK2_1	172	177	PF00069	0.550
MOD_NEK2_1	197	202	PF00069	0.426
MOD_NEK2_1	28	33	PF00069	0.585
MOD_NEK2_1	76	81	PF00069	0.383
MOD_NEK2_1	84	89	PF00069	0.366
MOD_NEK2_2	137	142	PF00069	0.439
MOD_PKA_2	122	128	PF00069	0.528
MOD_Plk_1	137	143	PF00069	0.429
MOD_Plk_1	154	160	PF00069	0.483
MOD_Plk_1	92	98	PF00069	0.440
MOD_Plk_2-3	290	296	PF00069	0.603
MOD_Plk_2-3	93	99	PF00069	0.511
MOD_Plk_4	129	135	PF00069	0.388
MOD_Plk_4	137	143	PF00069	0.312
MOD_Plk_4	172	178	PF00069	0.476
MOD_ProDKin_1	264	270	PF00069	0.598
MOD_ProDKin_1	303	309	PF00069	0.506
MOD_ProDKin_1	313	319	PF00069	0.696
MOD_SUMO_rev_2	124	133	PF00179	0.495
TRG_DiLeu_BaEn_1	295	300	PF01217	0.540
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.588
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.350
TRG_ENDOCYTIC_2	94	97	PF00928	0.498
TRG_ER_diArg_1	2	4	PF00400	0.571
TRG_ER_diArg_1	78	81	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY5	Leptomonas seymouri	73%	100%
A0A0S4J0C5	Bodo saltans	41%	100%
A0A1X0NZ39	Trypanosomatidae	53%	100%
A0A3R7MGA8	Trypanosoma rangeli	51%	99%
A0A3S5H6X2	Leishmania donovani	94%	100%
A4H8H8	Leishmania braziliensis	81%	100%
A4HWV0	Leishmania infantum	94%	100%
C9ZW37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	98%
E9AQL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B947	Trypanosoma cruzi	51%	100%