LeishMANIAdb
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Dihydroorotate dehydrogenase (fumarate)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dihydroorotate dehydrogenase (fumarate)
Gene product:
dihydroorotate dehydrogenase (fumarate)
Species:
Leishmania major
UniProt:
Q4QEW7_LEIMA
TriTrypDb:
LmjF.16.0530 , LMJLV39_160010800 , LMJSD75_160010700
Length:
320

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 2
GO:0005737 cytoplasm 2 11
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

Q4QEW7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEW7

PDB structure(s): 3gye_A , 3gye_B , 3gz3_A , 3gz3_B , 3mhu_A , 3mhu_B , 3mjy_A , 3mjy_B , 3tjx_A , 3tjx_B , 3tq0_A , 3tq0_B , 3tro_A , 3tro_B , 4ef8_A , 4ef8_B , 4ef9_A , 4ef9_B , 4wzh_A , 4wzh_B , 6dgs_A , 6dgs_B , 6dwg_A , 6dwg_B , 6ebs_A , 6ebs_B , 7mx6_AAA , 7mx6_BBB , 7myd_AAA , 7myd_BBB

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 2
GO:0006106 fumarate metabolic process 7 2
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006206 pyrimidine nucleobase metabolic process 5 3
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process 7 3
GO:0006220 pyrimidine nucleotide metabolic process 5 11
GO:0006221 pyrimidine nucleotide biosynthetic process 6 11
GO:0006222 UMP biosynthetic process 8 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006753 nucleoside phosphate metabolic process 4 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009112 nucleobase metabolic process 4 3
GO:0009117 nucleotide metabolic process 5 11
GO:0009123 nucleoside monophosphate metabolic process 5 11
GO:0009124 nucleoside monophosphate biosynthetic process 6 11
GO:0009129 pyrimidine nucleoside monophosphate metabolic process 6 11
GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process 7 11
GO:0009156 ribonucleoside monophosphate biosynthetic process 7 11
GO:0009161 ribonucleoside monophosphate metabolic process 6 11
GO:0009165 nucleotide biosynthetic process 6 11
GO:0009173 pyrimidine ribonucleoside monophosphate metabolic process 7 11
GO:0009174 pyrimidine ribonucleoside monophosphate biosynthetic process 8 11
GO:0009218 pyrimidine ribonucleotide metabolic process 6 11
GO:0009220 pyrimidine ribonucleotide biosynthetic process 7 11
GO:0009259 ribonucleotide metabolic process 5 11
GO:0009260 ribonucleotide biosynthetic process 6 11
GO:0009987 cellular process 1 11
GO:0018130 heterocycle biosynthetic process 4 11
GO:0019438 aromatic compound biosynthetic process 4 11
GO:0019637 organophosphate metabolic process 3 11
GO:0019693 ribose phosphate metabolic process 4 11
GO:0019752 carboxylic acid metabolic process 5 2
GO:0019856 pyrimidine nucleobase biosynthetic process 6 3
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034654 nucleobase-containing compound biosynthetic process 4 11
GO:0043436 oxoacid metabolic process 4 2
GO:0043648 dicarboxylic acid metabolic process 6 2
GO:0044205 'de novo' UMP biosynthetic process 9 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044271 cellular nitrogen compound biosynthetic process 4 11
GO:0044281 small molecule metabolic process 2 11
GO:0046049 UMP metabolic process 7 11
GO:0046112 nucleobase biosynthetic process 5 3
GO:0046390 ribose phosphate biosynthetic process 5 11
GO:0046483 heterocycle metabolic process 3 11
GO:0055086 nucleobase-containing small molecule metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0072527 pyrimidine-containing compound metabolic process 4 11
GO:0072528 pyrimidine-containing compound biosynthetic process 5 11
GO:0090407 organophosphate biosynthetic process 4 11
GO:1901135 carbohydrate derivative metabolic process 3 11
GO:1901137 carbohydrate derivative biosynthetic process 4 11
GO:1901293 nucleoside phosphate biosynthetic process 5 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901362 organic cyclic compound biosynthetic process 4 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901566 organonitrogen compound biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 3
GO:0003824 catalytic activity 1 11
GO:0004152 dihydroorotate dehydrogenase activity 4 11
GO:0005488 binding 1 3
GO:0016491 oxidoreductase activity 2 11
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 11
GO:0036094 small molecule binding 2 3
GO:0097159 organic cyclic compound binding 2 3
GO:1901265 nucleoside phosphate binding 3 3
GO:1901363 heterocyclic compound binding 2 3
GO:1990663 dihydroorotate dehydrogenase (fumarate) activity 5 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 239 241 PF00675 0.281
CLV_PCSK_KEX2_1 112 114 PF00082 0.359
CLV_PCSK_KEX2_1 239 241 PF00082 0.281
CLV_PCSK_KEX2_1 297 299 PF00082 0.305
CLV_PCSK_PC1ET2_1 112 114 PF00082 0.414
CLV_PCSK_PC1ET2_1 297 299 PF00082 0.305
CLV_PCSK_SKI1_1 224 228 PF00082 0.272
CLV_PCSK_SKI1_1 244 248 PF00082 0.182
CLV_PCSK_SKI1_1 93 97 PF00082 0.290
DEG_APCC_DBOX_1 147 155 PF00400 0.281
DOC_CYCLIN_yClb1_LxF_4 242 247 PF00134 0.324
DOC_MAPK_gen_1 239 247 PF00069 0.281
DOC_MAPK_JIP1_4 93 99 PF00069 0.278
DOC_MAPK_MEF2A_6 121 129 PF00069 0.302
DOC_MAPK_MEF2A_6 92 99 PF00069 0.316
DOC_PP1_RVXF_1 185 191 PF00149 0.381
DOC_PP1_RVXF_1 242 248 PF00149 0.300
DOC_PP4_FxxP_1 12 15 PF00568 0.300
DOC_USP7_MATH_1 264 268 PF00917 0.281
DOC_USP7_MATH_1 37 41 PF00917 0.345
DOC_USP7_MATH_1 63 67 PF00917 0.300
DOC_WW_Pin1_4 44 49 PF00397 0.424
DOC_WW_Pin1_4 53 58 PF00397 0.414
LIG_14-3-3_CanoR_1 148 158 PF00244 0.447
LIG_14-3-3_CanoR_1 285 294 PF00244 0.359
LIG_14-3-3_CanoR_1 298 303 PF00244 0.393
LIG_APCC_ABBA_1 166 171 PF00400 0.281
LIG_BIR_II_1 1 5 PF00653 0.302
LIG_EH_1 13 17 PF12763 0.300
LIG_eIF4E_1 90 96 PF01652 0.300
LIG_FHA_1 205 211 PF00498 0.300
LIG_FHA_1 25 31 PF00498 0.280
LIG_FHA_1 285 291 PF00498 0.372
LIG_FHA_1 45 51 PF00498 0.254
LIG_FHA_2 23 29 PF00498 0.291
LIG_FHA_2 252 258 PF00498 0.392
LIG_FHA_2 299 305 PF00498 0.361
LIG_LIR_Apic_2 11 15 PF02991 0.300
LIG_LIR_Gen_1 143 151 PF02991 0.300
LIG_LIR_Gen_1 171 179 PF02991 0.346
LIG_LIR_Gen_1 256 266 PF02991 0.282
LIG_LIR_Gen_1 281 291 PF02991 0.272
LIG_LIR_Gen_1 56 67 PF02991 0.313
LIG_LIR_Nem_3 171 175 PF02991 0.389
LIG_LIR_Nem_3 184 188 PF02991 0.226
LIG_LIR_Nem_3 256 262 PF02991 0.282
LIG_LIR_Nem_3 281 286 PF02991 0.262
LIG_LIR_Nem_3 56 62 PF02991 0.278
LIG_LIR_Nem_3 78 83 PF02991 0.329
LIG_Pex14_2 12 16 PF04695 0.324
LIG_PTB_Apo_2 6 13 PF02174 0.394
LIG_PTB_Apo_2 71 78 PF02174 0.289
LIG_SH2_CRK 59 63 PF00017 0.304
LIG_SH2_PTP2 225 228 PF00017 0.281
LIG_SH2_STAP1 142 146 PF00017 0.346
LIG_SH2_STAT5 169 172 PF00017 0.489
LIG_SH2_STAT5 225 228 PF00017 0.281
LIG_SH2_STAT5 253 256 PF00017 0.359
LIG_SH2_STAT5 80 83 PF00017 0.289
LIG_SH3_2 132 137 PF14604 0.281
LIG_SH3_3 129 135 PF00018 0.281
LIG_SH3_3 161 167 PF00018 0.281
LIG_SH3_3 208 214 PF00018 0.335
LIG_TRAF2_1 26 29 PF00917 0.272
LIG_TRAF2_1 274 277 PF00917 0.236
LIG_UBA3_1 290 297 PF00899 0.445
LIG_Vh1_VBS_1 16 34 PF01044 0.394
MOD_CDK_SPK_2 53 58 PF00069 0.394
MOD_CDK_SPxxK_3 44 51 PF00069 0.414
MOD_CK1_1 100 106 PF00069 0.300
MOD_CK1_1 40 46 PF00069 0.358
MOD_CK1_1 66 72 PF00069 0.281
MOD_CK2_1 100 106 PF00069 0.281
MOD_CK2_1 22 28 PF00069 0.334
MOD_CK2_1 278 284 PF00069 0.215
MOD_CK2_1 298 304 PF00069 0.352
MOD_Cter_Amidation 90 93 PF01082 0.394
MOD_GlcNHglycan 35 38 PF01048 0.288
MOD_GlcNHglycan 99 102 PF01048 0.281
MOD_GSK3_1 189 196 PF00069 0.281
MOD_GSK3_1 308 315 PF00069 0.385
MOD_GSK3_1 31 38 PF00069 0.323
MOD_GSK3_1 40 47 PF00069 0.345
MOD_N-GLC_1 127 132 PF02516 0.281
MOD_N-GLC_1 8 13 PF02516 0.394
MOD_NEK2_1 127 132 PF00069 0.284
MOD_NEK2_1 33 38 PF00069 0.345
MOD_NEK2_1 8 13 PF00069 0.370
MOD_NEK2_1 95 100 PF00069 0.284
MOD_PKA_2 284 290 PF00069 0.346
MOD_Plk_1 8 14 PF00069 0.394
MOD_Plk_2-3 278 284 PF00069 0.215
MOD_Plk_4 206 212 PF00069 0.324
MOD_Plk_4 264 270 PF00069 0.314
MOD_Plk_4 278 284 PF00069 0.306
MOD_Plk_4 37 43 PF00069 0.291
MOD_ProDKin_1 44 50 PF00069 0.424
MOD_ProDKin_1 53 59 PF00069 0.414
TRG_ENDOCYTIC_2 169 172 PF00928 0.281
TRG_ENDOCYTIC_2 299 302 PF00928 0.345
TRG_ENDOCYTIC_2 59 62 PF00928 0.285
TRG_ER_diArg_1 238 240 PF00400 0.281
TRG_ER_FFAT_2 184 196 PF00635 0.302

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJ26 Leptomonas seymouri 81% 100%
A0A0S4J3D1 Bodo saltans 63% 100%
A0A1X0NZ27 Trypanosomatidae 76% 100%
A0A3S7WTV8 Leishmania donovani 96% 100%
A0A422N937 Trypanosoma rangeli 73% 100%
A0AJT8 Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8) 30% 100%
A0KKK9 Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049) 26% 95%
A0QZY9 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 25% 90%
A0RHQ6 Bacillus thuringiensis (strain Al Hakam) 28% 100%
A1ASB3 Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1) 31% 100%
A1UHW0 Mycobacterium sp. (strain KMS) 26% 90%
A1URL3 Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583) 25% 88%
A1W7S6 Acidovorax sp. (strain JS42) 27% 91%
A1WJ81 Verminephrobacter eiseniae (strain EF01-2) 26% 89%
A2RDV3 Streptococcus pyogenes serotype M5 (strain Manfredo) 55% 100%
A2RJT9 Lactococcus lactis subsp. cremoris (strain MG1363) 53% 100%
A3Q1C6 Mycobacterium sp. (strain JLS) 26% 90%
A4G7T7 Herminiimonas arsenicoxydans 27% 92%
A4IM35 Geobacillus thermodenitrificans (strain NG80-2) 33% 100%
A4J560 Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1) 31% 100%
A4QEA4 Corynebacterium glutamicum (strain R) 25% 86%
A4SME2 Aeromonas salmonicida (strain A449) 26% 95%
A4W8V7 Enterobacter sp. (strain 638) 25% 95%
A4XKT6 Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331) 28% 100%
A4Z2G7 Bradyrhizobium sp. (strain ORS 278) 24% 88%
A5EA61 Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) 24% 88%
A5G3H0 Geotalea uraniireducens (strain Rf4) 28% 100%
A5IK84 Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1) 28% 100%
A5UX75 Roseiflexus sp. (strain RS-1) 25% 89%
A5VHS3 Limosilactobacillus reuteri (strain DSM 20016) 30% 100%
A6L5H1 Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154) 28% 100%
A6LB11 Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152) 31% 100%
A6Q8G0 Sulfurovum sp. (strain NBC37-1) 26% 90%
A6T106 Janthinobacterium sp. (strain Marseille) 26% 93%
A6TVS0 Alkaliphilus metalliredigens (strain QYMF) 28% 100%
A6U5U0 Sinorhizobium medicae (strain WSM419) 25% 88%
A7GRK9 Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) 28% 100%
A7HQ77 Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) 28% 92%
A7IBC2 Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) 27% 90%
A7NLW9 Roseiflexus castenholzii (strain DSM 13941 / HLO8) 23% 87%
A7Z4H4 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) 30% 100%
A8FD19 Bacillus pumilus (strain SAFR-032) 30% 100%
A8HZX8 Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571) 25% 90%
A8MIU4 Alkaliphilus oremlandii (strain OhILAs) 28% 100%
A8YVZ9 Lactobacillus helveticus (strain DPC 4571) 31% 100%
A9AJX4 Burkholderia multivorans (strain ATCC 17616 / 249) 24% 93%
A9BJH4 Petrotoga mobilis (strain DSM 10674 / SJ95) 26% 100%
A9BWU2 Delftia acidovorans (strain DSM 14801 / SPH-1) 27% 92%
A9CK85 Agrobacterium fabrum (strain C58 / ATCC 33970) 26% 88%
A9I8M0 Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) 26% 92%
A9KKR5 Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) 29% 100%
A9VTC4 Bacillus mycoides (strain KBAB4) 29% 100%
B0CA74 Acaryochloris marina (strain MBIC 11017) 27% 86%
B0K2E5 Thermoanaerobacter sp. (strain X514) 29% 100%
B0KA32 Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) 28% 100%
B0R808 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 25% 92%
B0RTS3 Xanthomonas campestris pv. campestris (strain B100) 24% 91%
B0TGQ8 Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) 33% 100%
B0U5I1 Xylella fastidiosa (strain M12) 26% 91%
B1GYY3 Endomicrobium trichonymphae 29% 100%
B1I4M6 Desulforudis audaxviator (strain MP104C) 29% 100%
B1MPD4 Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) 26% 91%
B1W464 Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) 27% 86%
B1XV77 Polynucleobacter necessarius subsp. necessarius (strain STIR1) 26% 93%
B1YIR7 Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15) 28% 100%
B2A2U4 Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF) 25% 100%
B2G5A3 Limosilactobacillus reuteri (strain JCM 1112) 30% 100%
B2I9T5 Xylella fastidiosa (strain M23) 26% 91%
B2IU79 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 26% 85%
B2SLB9 Xanthomonas oryzae pv. oryzae (strain PXO99A) 23% 91%
B2UNA2 Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) 26% 92%
B2V726 Sulfurihydrogenibium sp. (strain YO3AOP1) 28% 100%
B3DX48 Methylacidiphilum infernorum (isolate V4) 25% 92%
B3E4T4 Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) 29% 100%
B3PIL8 Cellvibrio japonicus (strain Ueda107) 27% 94%
B5EFU4 Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem) 29% 100%
B5EL46 Acidithiobacillus ferrooxidans (strain ATCC 53993 / BNL-5-31) 29% 88%
B5YJH1 Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87) 29% 100%
B6YRL9 Azobacteroides pseudotrichonymphae genomovar. CFP2 26% 100%
B7GFA1 Anoxybacillus flavithermus (strain DSM 21510 / WK1) 30% 100%
B7H6M0 Bacillus cereus (strain B4264) 28% 100%
B7HLL8 Bacillus cereus (strain AH187) 28% 100%
B7IUP4 Bacillus cereus (strain G9842) 28% 100%
B7J5Q1 Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455) 29% 88%
B7JJX1 Bacillus cereus (strain AH820) 28% 100%
B7JXU8 Rippkaea orientalis (strain PCC 8801) 25% 85%
B7KIU7 Gloeothece citriformis (strain PCC 7424) 24% 85%
B8DDR9 Listeria monocytogenes serotype 4a (strain HCC23) 30% 100%
B8HW33 Cyanothece sp. (strain PCC 7425 / ATCC 29141) 28% 85%
B9DPN4 Staphylococcus carnosus (strain TM300) 27% 100%
B9DUS7 Streptococcus uberis (strain ATCC BAA-854 / 0140J) 56% 100%
B9IVW1 Bacillus cereus (strain Q1) 28% 100%
B9J901 Agrobacterium radiobacter (strain K84 / ATCC BAA-868) 25% 88%
B9M211 Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32) 26% 100%
B9MIU2 Acidovorax ebreus (strain TPSY) 28% 91%
B9MS26 Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) 27% 100%
C0M8R7 Streptococcus equi subsp. equi (strain 4047) 56% 100%
C0MCW6 Streptococcus equi subsp. zooepidemicus (strain H70) 56% 100%
C0QYH6 Brachyspira hyodysenteriae (strain ATCC 49526 / WA1) 27% 100%
C0ZZY4 Rhodococcus erythropolis (strain PR4 / NBRC 100887) 27% 90%
C1EPP8 Bacillus cereus (strain 03BB102) 28% 100%
C1KWD2 Listeria monocytogenes serotype 4b (strain CLIP80459) 31% 100%
C3L742 Bacillus anthracis (strain CDC 684 / NRRL 3495) 28% 100%
C3P654 Bacillus anthracis (strain A0248) 28% 100%
C4XPD6 Solidesulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1) 29% 100%
C5D8Q2 Geobacillus sp. (strain WCH70) 30% 100%
C6BW12 Maridesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIMB 8403 / VKM B-1763) 28% 100%
C6E6N2 Geobacter sp. (strain M21) 29% 100%
C9ZPR4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 73% 100%
E9AGN2 Leishmania infantum 96% 100%
E9AI53 Leishmania braziliensis 85% 100%
E9AQL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
F2MMN9 Enterococcus faecalis (strain ATCC 47077 / OG1RF) 30% 100%
O08358 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 26% 100%
O27281 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 29% 100%
O29513 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 29% 100%
O35435 Mus musculus 27% 81%
O59185 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 28% 100%
O66461 Aquifex aeolicus (strain VF5) 32% 100%
P0DD66 Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) 55% 100%
P0DD67 Streptococcus pyogenes serotype M3 (strain SSI-1) 55% 100%
P0DH74 Enterococcus faecalis (strain ATCC 700802 / V583) 29% 100%
P25889 Escherichia coli (strain K12) 27% 78%
P25996 Bacillus subtilis (strain 168) 31% 100%
P28272 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 55% 100%
P32746 Arabidopsis thaliana 25% 70%
P32747 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 72%
P32748 Drosophila melanogaster 26% 79%
P46539 Bacillus caldolyticus 31% 100%
P54322 Lactococcus lactis subsp. cremoris (strain MG1363) 28% 100%
P57858 Pasteurella multocida (strain Pm70) 25% 94%
P59626 Enterococcus faecalis (strain ATCC 700802 / V583) 51% 100%
P77887 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 34% 100%
Q01YA2 Solibacter usitatus (strain Ellin6076) 32% 100%
Q02127 Homo sapiens 27% 81%
Q038Z3 Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441) 29% 100%
Q03HA9 Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) 29% 100%
Q047M3 Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365 / Lb-18) 31% 100%
Q0AIB4 Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57) 25% 94%
Q0AXG6 Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) 28% 100%
Q0W8E1 Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) 28% 100%
Q113R9 Trichodesmium erythraeum (strain IMS101) 27% 85%
Q11M76 Chelativorans sp. (strain BNC1) 26% 88%
Q129L9 Polaromonas sp. (strain JS666 / ATCC BAA-500) 27% 91%
Q13D13 Rhodopseudomonas palustris (strain BisB5) 25% 88%
Q1B765 Mycobacterium sp. (strain MCS) 26% 90%
Q1D7Y6 Myxococcus xanthus (strain DK1622) 27% 88%
Q1G864 Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14) 31% 100%
Q1GVC1 Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) 25% 90%
Q1J132 Deinococcus geothermalis (strain DSM 11300 / AG-3a) 29% 89%
Q1MLT8 Rhizobium leguminosarum bv. viciae (strain 3841) 24% 88%
Q2GBY1 Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199) 28% 92%
Q2JJF3 Synechococcus sp. (strain JA-2-3B'a(2-13)) 26% 84%
Q2JRL7 Synechococcus sp. (strain JA-3-3Ab) 25% 85%
Q2N6N6 Erythrobacter litoralis (strain HTCC2594) 29% 93%
Q2NU82 Sodalis glossinidius (strain morsitans) 25% 95%
Q2P3M0 Xanthomonas oryzae pv. oryzae (strain MAFF 311018) 23% 91%
Q2RX27 Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) 26% 87%
Q30R79 Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) 23% 91%
Q38X22 Latilactobacillus sakei subsp. sakei (strain 23K) 29% 100%
Q39UK4 Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15) 27% 100%
Q3AC05 Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) 31% 100%
Q3BUJ7 Xanthomonas campestris pv. vesicatoria (strain 85-10) 24% 91%
Q3IU78 Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) 25% 91%
Q3K2G4 Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700) 54% 100%
Q3MDU0 Trichormus variabilis (strain ATCC 29413 / PCC 7937) 26% 85%
Q47RF2 Thermobifida fusca (strain YX) 24% 85%
Q4D3W2 Trypanosoma cruzi (strain CL Brener) 75% 100%
Q4UTX5 Xanthomonas campestris pv. campestris (strain 8004) 24% 91%
Q53ZE5 Lactococcus lactis subsp. cremoris 53% 100%
Q57U83 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 73% 100%
Q58070 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 27% 100%
Q5E9W3 Bos taurus 28% 81%
Q5FJB5 Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) 32% 100%
Q5H0N0 Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85) 23% 91%
Q5JHR7 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 29% 100%
Q5L0U1 Geobacillus kaustophilus (strain HTA426) 32% 100%
Q5LCI2 Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) 29% 100%
Q5R6X6 Pongo abelii 28% 81%
Q5WFJ4 Alkalihalobacillus clausii (strain KSM-K16) 30% 100%
Q5YVM8 Nocardia farcinica (strain IFM 10152) 28% 87%
Q636E2 Bacillus cereus (strain ZK / E33L) 28% 100%
Q63707 Rattus norvegicus 27% 81%
Q64TN0 Bacteroides fragilis (strain YCH46) 29% 100%
Q6A912 Cutibacterium acnes (strain DSM 16379 / KPA171202) 29% 100%
Q6CTX8 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 26% 72%
Q6G4F7 Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) 24% 88%
Q6HET0 Bacillus thuringiensis subsp. konkukian (strain 97-27) 28% 100%
Q6NH79 Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) 25% 88%
Q6SZS6 Kluyveromyces marxianus 25% 72%
Q6V3X0 Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630) 55% 100%
Q71YI3 Listeria monocytogenes serotype 4b (strain F2365) 30% 100%
Q732I5 Bacillus cereus (strain ATCC 10987 / NRS 248) 28% 100%
Q74CB9 Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) 30% 100%
Q74J29 Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) 30% 100%
Q7MVJ6 Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 29% 100%
Q7NC99 Gloeobacter violaceus (strain ATCC 29082 / PCC 7421) 28% 91%
Q7NX17 Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) 26% 93%
Q7XKC8 Oryza sativa subsp. japonica 24% 68%
Q7Z891 Saccharomyces paradoxus 54% 100%
Q7Z892 Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) 57% 100%
Q7Z893 Saccharomyces mikatae 55% 100%
Q7Z894 Saccharomyces bayanus 55% 100%
Q7Z895 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 55% 100%
Q819S5 Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) 28% 100%
Q81WF4 Bacillus anthracis 28% 100%
Q874I4 Candida albicans (strain SC5314 / ATCC MYA-2876) 24% 72%
Q87A77 Xylella fastidiosa (strain Temecula1 / ATCC 700964) 26% 91%
Q8A9C3 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) 29% 100%
Q8CWG1 Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831) 26% 100%
Q8DLB7 Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1) 25% 88%
Q8DQ37 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 30% 100%
Q8DQG9 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 51% 100%
Q8E155 Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) 54% 100%
Q8E6L0 Streptococcus agalactiae serotype III (strain NEM316) 54% 100%
Q8EUY2 Malacoplasma penetrans (strain HF-2) 28% 100%
Q8FTC6 Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) 27% 85%
Q8NQC0 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 25% 86%
Q8P0C0 Streptococcus pyogenes serotype M18 (strain MGAS8232) 55% 100%
Q8P9R0 Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) 24% 91%
Q8PLJ2 Xanthomonas axonopodis pv. citri (strain 306) 24% 91%
Q8PW56 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 30% 100%
Q8R9R7 Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) 28% 100%
Q8RG85 Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) 29% 100%
Q8TT55 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 30% 100%
Q8TXU6 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 29% 100%
Q8U0P6 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 29% 100%
Q8X643 Escherichia coli O157:H7 27% 77%
Q8Y667 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) 30% 100%
Q8YPC6 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 25% 85%
Q8ZNL7 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 25% 78%
Q92AH5 Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) 30% 100%
Q979G6 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 29% 100%
Q97R65 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 30% 100%
Q99Z28 Streptococcus pyogenes serotype M1 55% 100%
Q9CFC9 Lactococcus lactis subsp. lactis (strain IL1403) 54% 100%
Q9CFW8 Lactococcus lactis subsp. lactis (strain IL1403) 28% 100%
Q9F1U7 Flavobacterium lutescens 28% 91%
Q9FB59 Corynebacterium striatum 27% 89%
Q9HL35 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 27% 100%
Q9HMK2 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 25% 92%
Q9K9W1 Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 28% 100%
Q9KXR7 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 29% 87%
Q9LVI9 Arabidopsis thaliana 25% 75%
Q9PAE7 Xylella fastidiosa (strain 9a5c) 26% 91%
Q9RX14 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) 25% 87%
Q9UX04 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 28% 100%
Q9V0Y6 Pyrococcus abyssi (strain GE5 / Orsay) 31% 100%
Q9WYG8 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 28% 100%
Q9X9S0 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 51% 100%
Q9YFI6 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS