Uridine/cytidine kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEW4_LEIMA

TriTrypDb:

LmjF.16.0560 , LMJLV39_160011200 , LMJSD75_160011100

Length:

733

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.682
CLV_C14_Caspase3-7	36	40	PF00656	0.434
CLV_C14_Caspase3-7	394	398	PF00656	0.640
CLV_C14_Caspase3-7	522	526	PF00656	0.546
CLV_NRD_NRD_1	145	147	PF00675	0.516
CLV_NRD_NRD_1	214	216	PF00675	0.574
CLV_NRD_NRD_1	223	225	PF00675	0.593
CLV_NRD_NRD_1	293	295	PF00675	0.431
CLV_NRD_NRD_1	300	302	PF00675	0.495
CLV_NRD_NRD_1	415	417	PF00675	0.792
CLV_NRD_NRD_1	435	437	PF00675	0.499
CLV_NRD_NRD_1	699	701	PF00675	0.457
CLV_PCSK_FUR_1	212	216	PF00082	0.620
CLV_PCSK_FUR_1	413	417	PF00082	0.608
CLV_PCSK_KEX2_1	145	147	PF00082	0.516
CLV_PCSK_KEX2_1	212	214	PF00082	0.546
CLV_PCSK_KEX2_1	223	225	PF00082	0.575
CLV_PCSK_KEX2_1	293	295	PF00082	0.431
CLV_PCSK_KEX2_1	300	302	PF00082	0.495
CLV_PCSK_KEX2_1	415	417	PF00082	0.748
CLV_PCSK_KEX2_1	435	437	PF00082	0.499
CLV_PCSK_KEX2_1	699	701	PF00082	0.457
CLV_PCSK_PC7_1	411	417	PF00082	0.604
CLV_PCSK_SKI1_1	293	297	PF00082	0.448
CLV_PCSK_SKI1_1	396	400	PF00082	0.556
CLV_PCSK_SKI1_1	572	576	PF00082	0.543
DEG_APCC_DBOX_1	395	403	PF00400	0.565
DEG_APCC_DBOX_1	569	577	PF00400	0.490
DEG_SCF_FBW7_2	549	556	PF00400	0.626
DEG_SPOP_SBC_1	586	590	PF00917	0.514
DOC_CDC14_PxL_1	135	143	PF14671	0.426
DOC_CKS1_1	296	301	PF01111	0.538
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.358
DOC_MAPK_MEF2A_6	9	16	PF00069	0.355
DOC_PP1_RVXF_1	659	665	PF00149	0.491
DOC_PP2B_LxvP_1	136	139	PF13499	0.468
DOC_PP4_FxxP_1	296	299	PF00568	0.461
DOC_PP4_FxxP_1	407	410	PF00568	0.634
DOC_USP7_MATH_1	172	176	PF00917	0.642
DOC_USP7_MATH_1	308	312	PF00917	0.556
DOC_USP7_MATH_1	418	422	PF00917	0.702
DOC_USP7_MATH_1	445	449	PF00917	0.768
DOC_USP7_MATH_1	512	516	PF00917	0.581
DOC_USP7_MATH_1	585	589	PF00917	0.644
DOC_USP7_MATH_1	591	595	PF00917	0.607
DOC_USP7_MATH_1	85	89	PF00917	0.401
DOC_USP7_MATH_2	234	240	PF00917	0.539
DOC_WW_Pin1_4	115	120	PF00397	0.497
DOC_WW_Pin1_4	167	172	PF00397	0.648
DOC_WW_Pin1_4	230	235	PF00397	0.537
DOC_WW_Pin1_4	295	300	PF00397	0.462
DOC_WW_Pin1_4	37	42	PF00397	0.371
DOC_WW_Pin1_4	380	385	PF00397	0.590
DOC_WW_Pin1_4	400	405	PF00397	0.625
DOC_WW_Pin1_4	453	458	PF00397	0.734
DOC_WW_Pin1_4	544	549	PF00397	0.778
DOC_WW_Pin1_4	587	592	PF00397	0.646
DOC_WW_Pin1_4	616	621	PF00397	0.500
DOC_WW_Pin1_4	669	674	PF00397	0.516
DOC_WW_Pin1_4	94	99	PF00397	0.574
LIG_14-3-3_CanoR_1	212	218	PF00244	0.581
LIG_14-3-3_CanoR_1	271	277	PF00244	0.546
LIG_14-3-3_CanoR_1	544	548	PF00244	0.648
LIG_14-3-3_CanoR_1	663	668	PF00244	0.551
LIG_14-3-3_CanoR_1	75	80	PF00244	0.414
LIG_APCC_ABBA_1	482	487	PF00400	0.512
LIG_BRCT_BRCA1_1	602	606	PF00533	0.507
LIG_CtBP_PxDLS_1	234	238	PF00389	0.545
LIG_FHA_1	11	17	PF00498	0.375
LIG_FHA_1	157	163	PF00498	0.566
LIG_FHA_1	287	293	PF00498	0.411
LIG_FHA_1	361	367	PF00498	0.500
LIG_FHA_1	84	90	PF00498	0.424
LIG_FHA_2	176	182	PF00498	0.705
LIG_FHA_2	392	398	PF00498	0.623
LIG_FHA_2	59	65	PF00498	0.391
LIG_FHA_2	674	680	PF00498	0.574
LIG_FHA_2	718	724	PF00498	0.488
LIG_GBD_Chelix_1	30	38	PF00786	0.405
LIG_Integrin_isoDGR_2	706	708	PF01839	0.472
LIG_Integrin_RGD_1	380	382	PF01839	0.517
LIG_LIR_Apic_2	405	410	PF02991	0.567
LIG_LIR_Gen_1	263	273	PF02991	0.308
LIG_LIR_Gen_1	479	490	PF02991	0.492
LIG_LIR_Nem_3	263	268	PF02991	0.378
LIG_LIR_Nem_3	275	279	PF02991	0.287
LIG_LIR_Nem_3	479	485	PF02991	0.481
LIG_LIR_Nem_3	61	65	PF02991	0.360
LIG_LIR_Nem_3	638	644	PF02991	0.429
LIG_LIR_Nem_3	651	657	PF02991	0.402
LIG_LIR_Nem_3	69	73	PF02991	0.319
LIG_NRP_CendR_1	730	733	PF00754	0.504
LIG_Pex14_1	486	490	PF04695	0.506
LIG_Pex14_2	482	486	PF04695	0.488
LIG_Pex14_2	635	639	PF04695	0.437
LIG_Rb_LxCxE_1	578	595	PF01857	0.560
LIG_REV1ctd_RIR_1	293	298	PF16727	0.445
LIG_SH2_CRK	70	74	PF00017	0.347
LIG_SH2_GRB2like	562	565	PF00017	0.579
LIG_SH2_NCK_1	650	654	PF00017	0.413
LIG_SH2_STAP1	279	283	PF00017	0.328
LIG_SH2_STAP1	637	641	PF00017	0.438
LIG_SH2_STAP1	650	654	PF00017	0.392
LIG_SH2_STAT5	276	279	PF00017	0.421
LIG_SH2_STAT5	306	309	PF00017	0.586
LIG_SH2_STAT5	562	565	PF00017	0.514
LIG_SH2_STAT5	643	646	PF00017	0.441
LIG_SH3_3	228	234	PF00018	0.703
LIG_SH3_3	338	344	PF00018	0.538
LIG_SH3_3	38	44	PF00018	0.358
LIG_SH3_3	406	412	PF00018	0.589
LIG_SH3_3	548	554	PF00018	0.587
LIG_SH3_CIN85_PxpxPR_1	694	699	PF14604	0.574
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.550
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.404
LIG_SUMO_SIM_par_1	233	239	PF11976	0.542
LIG_SUMO_SIM_par_1	456	463	PF11976	0.506
LIG_SUMO_SIM_par_1	85	90	PF11976	0.431
LIG_TRAF2_1	207	210	PF00917	0.609
LIG_TRAF2_1	554	557	PF00917	0.646
LIG_TYR_ITIM	648	653	PF00017	0.402
LIG_TYR_ITIM	68	73	PF00017	0.348
LIG_UBA3_1	135	143	PF00899	0.426
LIG_WW_3	408	412	PF00397	0.583
LIG_WW_3	547	551	PF00397	0.622
MOD_CDC14_SPxK_1	547	550	PF00782	0.624
MOD_CDK_SPK_2	295	300	PF00069	0.462
MOD_CDK_SPxK_1	295	301	PF00069	0.469
MOD_CDK_SPxK_1	544	550	PF00069	0.626
MOD_CDK_SPxxK_3	98	105	PF00069	0.608
MOD_CK1_1	153	159	PF00069	0.740
MOD_CK1_1	175	181	PF00069	0.661
MOD_CK1_1	25	31	PF00069	0.343
MOD_CK1_1	388	394	PF00069	0.714
MOD_CK1_1	448	454	PF00069	0.644
MOD_CK1_1	497	503	PF00069	0.642
MOD_CK1_1	542	548	PF00069	0.590
MOD_CK1_1	624	630	PF00069	0.479
MOD_CK1_1	672	678	PF00069	0.570
MOD_CK2_1	175	181	PF00069	0.700
MOD_CK2_1	230	236	PF00069	0.618
MOD_CK2_1	577	583	PF00069	0.545
MOD_CK2_1	586	592	PF00069	0.537
MOD_CK2_1	673	679	PF00069	0.616
MOD_CK2_1	87	93	PF00069	0.440
MOD_DYRK1A_RPxSP_1	544	548	PF00069	0.582
MOD_GlcNHglycan	107	110	PF01048	0.628
MOD_GlcNHglycan	152	155	PF01048	0.645
MOD_GlcNHglycan	22	25	PF01048	0.380
MOD_GlcNHglycan	238	241	PF01048	0.648
MOD_GlcNHglycan	310	313	PF01048	0.579
MOD_GlcNHglycan	420	423	PF01048	0.633
MOD_GlcNHglycan	431	434	PF01048	0.645
MOD_GlcNHglycan	453	456	PF01048	0.662
MOD_GlcNHglycan	468	471	PF01048	0.430
MOD_GlcNHglycan	472	475	PF01048	0.365
MOD_GlcNHglycan	500	503	PF01048	0.679
MOD_GlcNHglycan	602	605	PF01048	0.607
MOD_GlcNHglycan	623	626	PF01048	0.489
MOD_GlcNHglycan	629	632	PF01048	0.447
MOD_GlcNHglycan	681	684	PF01048	0.572
MOD_GSK3_1	149	156	PF00069	0.623
MOD_GSK3_1	22	29	PF00069	0.350
MOD_GSK3_1	33	40	PF00069	0.397
MOD_GSK3_1	380	387	PF00069	0.628
MOD_GSK3_1	425	432	PF00069	0.662
MOD_GSK3_1	445	452	PF00069	0.681
MOD_GSK3_1	466	473	PF00069	0.576
MOD_GSK3_1	492	499	PF00069	0.569
MOD_GSK3_1	539	546	PF00069	0.741
MOD_GSK3_1	587	594	PF00069	0.582
MOD_GSK3_1	668	675	PF00069	0.621
MOD_GSK3_1	83	90	PF00069	0.426
MOD_GSK3_1	94	101	PF00069	0.676
MOD_N-GLC_1	539	544	PF02516	0.754
MOD_NEK2_1	272	277	PF00069	0.430
MOD_NEK2_1	494	499	PF00069	0.605
MOD_NEK2_1	543	548	PF00069	0.626
MOD_NEK2_1	575	580	PF00069	0.643
MOD_NEK2_2	512	517	PF00069	0.599
MOD_PIKK_1	218	224	PF00454	0.569
MOD_PIKK_1	319	325	PF00454	0.541
MOD_PIKK_1	717	723	PF00454	0.434
MOD_PK_1	213	219	PF00069	0.584
MOD_PK_1	663	669	PF00069	0.556
MOD_PK_1	75	81	PF00069	0.417
MOD_PKA_1	213	219	PF00069	0.584
MOD_PKA_2	213	219	PF00069	0.591
MOD_PKA_2	495	501	PF00069	0.580
MOD_PKA_2	543	549	PF00069	0.648
MOD_PKB_1	661	669	PF00069	0.535
MOD_Plk_1	10	16	PF00069	0.316
MOD_Plk_1	198	204	PF00069	0.597
MOD_Plk_1	319	325	PF00069	0.541
MOD_Plk_1	591	597	PF00069	0.520
MOD_Plk_2-3	191	197	PF00069	0.639
MOD_Plk_4	157	163	PF00069	0.745
MOD_Plk_4	272	278	PF00069	0.430
MOD_Plk_4	618	624	PF00069	0.467
MOD_Plk_4	75	81	PF00069	0.417
MOD_Plk_4	87	93	PF00069	0.399
MOD_ProDKin_1	115	121	PF00069	0.484
MOD_ProDKin_1	167	173	PF00069	0.648
MOD_ProDKin_1	230	236	PF00069	0.538
MOD_ProDKin_1	295	301	PF00069	0.469
MOD_ProDKin_1	37	43	PF00069	0.370
MOD_ProDKin_1	380	386	PF00069	0.591
MOD_ProDKin_1	400	406	PF00069	0.625
MOD_ProDKin_1	453	459	PF00069	0.730
MOD_ProDKin_1	544	550	PF00069	0.779
MOD_ProDKin_1	587	593	PF00069	0.647
MOD_ProDKin_1	616	622	PF00069	0.495
MOD_ProDKin_1	669	675	PF00069	0.517
MOD_ProDKin_1	94	100	PF00069	0.577
TRG_DiLeu_BaEn_1	263	268	PF01217	0.317
TRG_ENDOCYTIC_2	636	639	PF00928	0.436
TRG_ENDOCYTIC_2	641	644	PF00928	0.424
TRG_ENDOCYTIC_2	65	68	PF00928	0.354
TRG_ENDOCYTIC_2	650	653	PF00928	0.398
TRG_ENDOCYTIC_2	70	73	PF00928	0.349
TRG_ER_diArg_1	144	146	PF00400	0.453
TRG_ER_diArg_1	212	215	PF00400	0.616
TRG_ER_diArg_1	292	294	PF00400	0.422
TRG_ER_diArg_1	299	301	PF00400	0.488
TRG_ER_diArg_1	342	345	PF00400	0.529
TRG_ER_diArg_1	350	353	PF00400	0.479
TRG_ER_diArg_1	410	413	PF00400	0.703
TRG_ER_diArg_1	570	573	PF00400	0.465
TRG_ER_diArg_1	661	664	PF00400	0.487
TRG_ER_diArg_1	698	700	PF00400	0.475
TRG_NES_CRM1_1	361	373	PF08389	0.568
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVQ0	Leptomonas seymouri	35%	100%
A0A3S7WTV2	Leishmania donovani	89%	100%
A4H8I1	Leishmania braziliensis	62%	99%
A4HWV3	Leishmania infantum	88%	100%
E9AQL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%