Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QEV7_LEIMA

TriTrypDb:

LmjF.16.0620 , LMJLV39_160011600 , LMJSD75_160011400

Length:

1136

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.817
CLV_C14_Caspase3-7	373	377	PF00656	0.565
CLV_C14_Caspase3-7	405	409	PF00656	0.606
CLV_C14_Caspase3-7	892	896	PF00656	0.775
CLV_C14_Caspase3-7	958	962	PF00656	0.609
CLV_C14_Caspase3-7	994	998	PF00656	0.597
CLV_NRD_NRD_1	148	150	PF00675	0.724
CLV_NRD_NRD_1	199	201	PF00675	0.587
CLV_NRD_NRD_1	238	240	PF00675	0.830
CLV_NRD_NRD_1	318	320	PF00675	0.674
CLV_NRD_NRD_1	4	6	PF00675	0.774
CLV_NRD_NRD_1	515	517	PF00675	0.585
CLV_NRD_NRD_1	546	548	PF00675	0.766
CLV_NRD_NRD_1	766	768	PF00675	0.649
CLV_NRD_NRD_1	875	877	PF00675	0.610
CLV_PCSK_KEX2_1	240	242	PF00082	0.840
CLV_PCSK_KEX2_1	318	320	PF00082	0.751
CLV_PCSK_KEX2_1	4	6	PF00082	0.774
CLV_PCSK_KEX2_1	515	517	PF00082	0.585
CLV_PCSK_KEX2_1	546	548	PF00082	0.766
CLV_PCSK_KEX2_1	719	721	PF00082	0.579
CLV_PCSK_KEX2_1	766	768	PF00082	0.690
CLV_PCSK_KEX2_1	875	877	PF00082	0.653
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.840
CLV_PCSK_PC1ET2_1	719	721	PF00082	0.575
CLV_PCSK_SKI1_1	1108	1112	PF00082	0.514
CLV_PCSK_SKI1_1	189	193	PF00082	0.794
CLV_PCSK_SKI1_1	243	247	PF00082	0.771
CLV_PCSK_SKI1_1	248	252	PF00082	0.764
CLV_PCSK_SKI1_1	331	335	PF00082	0.630
DEG_SPOP_SBC_1	208	212	PF00917	0.768
DOC_CYCLIN_RxL_1	239	249	PF00134	0.687
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.755
DOC_CYCLIN_yCln2_LP_2	429	435	PF00134	0.702
DOC_MAPK_gen_1	1034	1042	PF00069	0.754
DOC_MAPK_gen_1	331	341	PF00069	0.738
DOC_MAPK_MEF2A_6	1108	1115	PF00069	0.644
DOC_MAPK_MEF2A_6	334	341	PF00069	0.585
DOC_MAPK_MEF2A_6	849	858	PF00069	0.800
DOC_MAPK_NFAT4_5	1108	1116	PF00069	0.603
DOC_PP2B_LxvP_1	1050	1053	PF13499	0.666
DOC_PP2B_LxvP_1	339	342	PF13499	0.712
DOC_PP2B_PxIxI_1	853	859	PF00149	0.567
DOC_PP4_FxxP_1	284	287	PF00568	0.649
DOC_PP4_FxxP_1	470	473	PF00568	0.764
DOC_USP7_MATH_1	116	120	PF00917	0.790
DOC_USP7_MATH_1	224	228	PF00917	0.672
DOC_USP7_MATH_1	35	39	PF00917	0.514
DOC_USP7_MATH_1	371	375	PF00917	0.708
DOC_USP7_MATH_1	380	384	PF00917	0.711
DOC_USP7_MATH_1	583	587	PF00917	0.773
DOC_USP7_MATH_1	675	679	PF00917	0.704
DOC_USP7_MATH_1	705	709	PF00917	0.781
DOC_USP7_MATH_1	884	888	PF00917	0.808
DOC_USP7_MATH_1	889	893	PF00917	0.772
DOC_USP7_MATH_1	89	93	PF00917	0.732
DOC_USP7_MATH_1	899	903	PF00917	0.611
DOC_USP7_MATH_1	94	98	PF00917	0.738
DOC_USP7_MATH_1	951	955	PF00917	0.829
DOC_USP7_MATH_2	913	919	PF00917	0.622
DOC_WW_Pin1_4	106	111	PF00397	0.757
DOC_WW_Pin1_4	1078	1083	PF00397	0.774
DOC_WW_Pin1_4	117	122	PF00397	0.702
DOC_WW_Pin1_4	217	222	PF00397	0.785
DOC_WW_Pin1_4	260	265	PF00397	0.751
DOC_WW_Pin1_4	340	345	PF00397	0.747
DOC_WW_Pin1_4	376	381	PF00397	0.824
DOC_WW_Pin1_4	40	45	PF00397	0.796
DOC_WW_Pin1_4	428	433	PF00397	0.766
DOC_WW_Pin1_4	434	439	PF00397	0.699
DOC_WW_Pin1_4	464	469	PF00397	0.828
DOC_WW_Pin1_4	487	492	PF00397	0.693
DOC_WW_Pin1_4	566	571	PF00397	0.751
DOC_WW_Pin1_4	615	620	PF00397	0.758
DOC_WW_Pin1_4	807	812	PF00397	0.637
DOC_WW_Pin1_4	840	845	PF00397	0.750
DOC_WW_Pin1_4	900	905	PF00397	0.788
DOC_WW_Pin1_4	909	914	PF00397	0.774
DOC_WW_Pin1_4	929	934	PF00397	0.512
LIG_14-3-3_CanoR_1	1089	1093	PF00244	0.659
LIG_14-3-3_CanoR_1	196	204	PF00244	0.587
LIG_14-3-3_CanoR_1	331	337	PF00244	0.749
LIG_14-3-3_CanoR_1	475	483	PF00244	0.653
LIG_14-3-3_CanoR_1	500	505	PF00244	0.621
LIG_14-3-3_CanoR_1	546	550	PF00244	0.767
LIG_14-3-3_CanoR_1	663	671	PF00244	0.740
LIG_14-3-3_CanoR_1	769	774	PF00244	0.665
LIG_14-3-3_CanoR_1	849	853	PF00244	0.799
LIG_14-3-3_CanoR_1	943	951	PF00244	0.795
LIG_14-3-3_CanoR_1	977	983	PF00244	0.679
LIG_14-3-3_CanoR_1	999	1007	PF00244	0.675
LIG_Actin_WH2_2	770	787	PF00022	0.512
LIG_BIR_II_1	1	5	PF00653	0.807
LIG_BIR_III_2	895	899	PF00653	0.757
LIG_BRCT_BRCA1_1	221	225	PF00533	0.647
LIG_BRCT_BRCA1_1	395	399	PF00533	0.682
LIG_BRCT_BRCA1_1	466	470	PF00533	0.812
LIG_DLG_GKlike_1	769	777	PF00625	0.529
LIG_FHA_1	1099	1105	PF00498	0.740
LIG_FHA_1	1128	1134	PF00498	0.750
LIG_FHA_1	124	130	PF00498	0.767
LIG_FHA_1	156	162	PF00498	0.790
LIG_FHA_1	190	196	PF00498	0.796
LIG_FHA_1	210	216	PF00498	0.539
LIG_FHA_1	249	255	PF00498	0.729
LIG_FHA_1	424	430	PF00498	0.743
LIG_FHA_1	475	481	PF00498	0.657
LIG_FHA_1	59	65	PF00498	0.631
LIG_FHA_1	666	672	PF00498	0.773
LIG_FHA_1	696	702	PF00498	0.786
LIG_FHA_1	801	807	PF00498	0.635
LIG_FHA_1	816	822	PF00498	0.588
LIG_FHA_1	970	976	PF00498	0.782
LIG_FHA_1	977	983	PF00498	0.604
LIG_FHA_2	1024	1030	PF00498	0.756
LIG_FHA_2	1093	1099	PF00498	0.611
LIG_FHA_2	435	441	PF00498	0.806
LIG_FHA_2	646	652	PF00498	0.852
LIG_FHA_2	686	692	PF00498	0.758
LIG_Integrin_RGD_1	464	466	PF01839	0.632
LIG_Integrin_RGD_1	589	591	PF01839	0.832
LIG_LIR_Apic_2	1094	1099	PF02991	0.608
LIG_LIR_Apic_2	467	473	PF02991	0.760
LIG_LIR_Gen_1	396	406	PF02991	0.695
LIG_LIR_Gen_1	408	419	PF02991	0.587
LIG_LIR_Gen_1	633	643	PF02991	0.828
LIG_LIR_Gen_1	940	947	PF02991	0.751
LIG_LIR_Gen_1	95	105	PF02991	0.577
LIG_LIR_Nem_3	396	402	PF02991	0.778
LIG_LIR_Nem_3	408	414	PF02991	0.518
LIG_LIR_Nem_3	533	537	PF02991	0.753
LIG_LIR_Nem_3	633	639	PF02991	0.832
LIG_LIR_Nem_3	940	944	PF02991	0.747
LIG_LIR_Nem_3	95	101	PF02991	0.597
LIG_MYND_1	933	937	PF01753	0.713
LIG_SH2_PTP2	636	639	PF00017	0.837
LIG_SH2_STAP1	1131	1135	PF00017	0.752
LIG_SH2_STAT5	636	639	PF00017	0.837
LIG_SH2_STAT5	783	786	PF00017	0.731
LIG_SH3_3	1001	1007	PF00018	0.464
LIG_SH3_3	107	113	PF00018	0.772
LIG_SH3_3	1079	1085	PF00018	0.809
LIG_SH3_3	202	208	PF00018	0.807
LIG_SH3_3	21	27	PF00018	0.713
LIG_SH3_3	266	272	PF00018	0.660
LIG_SH3_3	39	45	PF00018	0.496
LIG_SH3_3	454	460	PF00018	0.793
LIG_SH3_3	786	792	PF00018	0.729
LIG_SH3_3	808	814	PF00018	0.668
LIG_SH3_3	930	936	PF00018	0.792
LIG_SH3_3	983	989	PF00018	0.783
LIG_Sin3_3	415	422	PF02671	0.470
LIG_SUMO_SIM_anti_2	617	624	PF11976	0.742
LIG_TRAF2_1	1007	1010	PF00917	0.687
LIG_TRAF2_1	1095	1098	PF00917	0.762
LIG_TRAF2_1	132	135	PF00917	0.732
LIG_TRAF2_1	912	915	PF00917	0.732
LIG_WW_3	472	476	PF00397	0.763
MOD_CDC14_SPxK_1	343	346	PF00782	0.684
MOD_CDK_SPK_2	807	812	PF00069	0.617
MOD_CDK_SPK_2	929	934	PF00069	0.765
MOD_CDK_SPxK_1	340	346	PF00069	0.692
MOD_CK1_1	1074	1080	PF00069	0.784
MOD_CK1_1	210	216	PF00069	0.780
MOD_CK1_1	220	226	PF00069	0.667
MOD_CK1_1	227	233	PF00069	0.560
MOD_CK1_1	340	346	PF00069	0.674
MOD_CK1_1	487	493	PF00069	0.742
MOD_CK1_1	503	509	PF00069	0.531
MOD_CK1_1	569	575	PF00069	0.805
MOD_CK1_1	58	64	PF00069	0.586
MOD_CK1_1	618	624	PF00069	0.706
MOD_CK1_1	665	671	PF00069	0.657
MOD_CK1_1	678	684	PF00069	0.559
MOD_CK1_1	692	698	PF00069	0.572
MOD_CK1_1	756	762	PF00069	0.770
MOD_CK1_1	843	849	PF00069	0.750
MOD_CK1_1	887	893	PF00069	0.799
MOD_CK1_1	902	908	PF00069	0.669
MOD_CK1_1	92	98	PF00069	0.708
MOD_CK2_1	1091	1097	PF00069	0.761
MOD_CK2_1	169	175	PF00069	0.782
MOD_CK2_1	645	651	PF00069	0.848
MOD_CK2_1	909	915	PF00069	0.743
MOD_CMANNOS	509	512	PF00535	0.735
MOD_Cter_Amidation	2	5	PF01082	0.690
MOD_GlcNHglycan	1	4	PF01048	0.757
MOD_GlcNHglycan	1000	1003	PF01048	0.793
MOD_GlcNHglycan	1059	1062	PF01048	0.808
MOD_GlcNHglycan	1085	1088	PF01048	0.794
MOD_GlcNHglycan	13	16	PF01048	0.608
MOD_GlcNHglycan	165	168	PF01048	0.761
MOD_GlcNHglycan	197	200	PF01048	0.590
MOD_GlcNHglycan	222	225	PF01048	0.788
MOD_GlcNHglycan	226	229	PF01048	0.802
MOD_GlcNHglycan	231	236	PF01048	0.759
MOD_GlcNHglycan	37	40	PF01048	0.531
MOD_GlcNHglycan	382	385	PF01048	0.783
MOD_GlcNHglycan	395	398	PF01048	0.616
MOD_GlcNHglycan	484	489	PF01048	0.831
MOD_GlcNHglycan	502	505	PF01048	0.531
MOD_GlcNHglycan	562	565	PF01048	0.844
MOD_GlcNHglycan	576	579	PF01048	0.602
MOD_GlcNHglycan	585	588	PF01048	0.560
MOD_GlcNHglycan	602	605	PF01048	0.561
MOD_GlcNHglycan	673	676	PF01048	0.733
MOD_GlcNHglycan	677	680	PF01048	0.635
MOD_GlcNHglycan	691	694	PF01048	0.640
MOD_GlcNHglycan	707	710	PF01048	0.575
MOD_GlcNHglycan	761	764	PF01048	0.618
MOD_GlcNHglycan	807	810	PF01048	0.846
MOD_GlcNHglycan	87	90	PF01048	0.614
MOD_GlcNHglycan	870	873	PF01048	0.777
MOD_GlcNHglycan	891	894	PF01048	0.768
MOD_GlcNHglycan	904	907	PF01048	0.617
MOD_GlcNHglycan	929	932	PF01048	0.767
MOD_GlcNHglycan	961	964	PF01048	0.687
MOD_GlcNHglycan	969	972	PF01048	0.596
MOD_GSK3_1	1023	1030	PF00069	0.559
MOD_GSK3_1	1071	1078	PF00069	0.845
MOD_GSK3_1	1088	1095	PF00069	0.588
MOD_GSK3_1	207	214	PF00069	0.793
MOD_GSK3_1	216	223	PF00069	0.652
MOD_GSK3_1	227	234	PF00069	0.584
MOD_GSK3_1	244	251	PF00069	0.545
MOD_GSK3_1	376	383	PF00069	0.808
MOD_GSK3_1	483	490	PF00069	0.760
MOD_GSK3_1	560	567	PF00069	0.841
MOD_GSK3_1	596	603	PF00069	0.718
MOD_GSK3_1	671	678	PF00069	0.727
MOD_GSK3_1	68	75	PF00069	0.787
MOD_GSK3_1	685	692	PF00069	0.542
MOD_GSK3_1	752	759	PF00069	0.743
MOD_GSK3_1	761	768	PF00069	0.650
MOD_GSK3_1	769	776	PF00069	0.627
MOD_GSK3_1	800	807	PF00069	0.798
MOD_GSK3_1	840	847	PF00069	0.770
MOD_GSK3_1	85	92	PF00069	0.543
MOD_GSK3_1	883	890	PF00069	0.758
MOD_N-GLC_1	525	530	PF02516	0.526
MOD_N-GLC_1	899	904	PF02516	0.724
MOD_NEK2_1	1027	1032	PF00069	0.653
MOD_NEK2_1	195	200	PF00069	0.590
MOD_NEK2_1	246	251	PF00069	0.816
MOD_NEK2_1	282	287	PF00069	0.766
MOD_NEK2_1	291	296	PF00069	0.574
MOD_NEK2_1	358	363	PF00069	0.503
MOD_NEK2_1	370	375	PF00069	0.506
MOD_NEK2_1	433	438	PF00069	0.544
MOD_NEK2_1	562	567	PF00069	0.827
MOD_NEK2_1	593	598	PF00069	0.761
MOD_NEK2_1	689	694	PF00069	0.755
MOD_NEK2_1	773	778	PF00069	0.659
MOD_NEK2_1	784	789	PF00069	0.638
MOD_NEK2_1	967	972	PF00069	0.718
MOD_NEK2_2	685	690	PF00069	0.639
MOD_NEK2_2	848	853	PF00069	0.801
MOD_OFUCOSY	753	760	PF10250	0.532
MOD_PIKK_1	441	447	PF00454	0.810
MOD_PIKK_1	55	61	PF00454	0.580
MOD_PIKK_1	80	86	PF00454	0.732
MOD_PIKK_1	949	955	PF00454	0.746
MOD_PK_1	200	206	PF00069	0.590
MOD_PK_1	785	791	PF00069	0.696
MOD_PKA_1	200	206	PF00069	0.590
MOD_PKA_2	1088	1094	PF00069	0.636
MOD_PKA_2	116	122	PF00069	0.728
MOD_PKA_2	195	201	PF00069	0.592
MOD_PKA_2	441	447	PF00069	0.695
MOD_PKA_2	474	480	PF00069	0.656
MOD_PKA_2	545	551	PF00069	0.764
MOD_PKA_2	557	563	PF00069	0.639
MOD_PKA_2	662	668	PF00069	0.749
MOD_PKA_2	765	771	PF00069	0.735
MOD_PKA_2	784	790	PF00069	0.599
MOD_PKA_2	800	806	PF00069	0.528
MOD_PKA_2	848	854	PF00069	0.802
MOD_PKA_2	942	948	PF00069	0.794
MOD_PKA_2	976	982	PF00069	0.637
MOD_PKA_2	998	1004	PF00069	0.678
MOD_PKB_1	767	775	PF00069	0.657
MOD_Plk_1	1028	1034	PF00069	0.778
MOD_Plk_1	124	130	PF00069	0.767
MOD_Plk_1	630	636	PF00069	0.819
MOD_Plk_1	650	656	PF00069	0.523
MOD_Plk_1	665	671	PF00069	0.613
MOD_Plk_1	695	701	PF00069	0.751
MOD_Plk_1	785	791	PF00069	0.696
MOD_Plk_2-3	1071	1077	PF00069	0.733
MOD_Plk_4	200	206	PF00069	0.745
MOD_Plk_4	60	66	PF00069	0.625
MOD_Plk_4	618	624	PF00069	0.699
MOD_Plk_4	94	100	PF00069	0.692
MOD_ProDKin_1	106	112	PF00069	0.761
MOD_ProDKin_1	1078	1084	PF00069	0.775
MOD_ProDKin_1	117	123	PF00069	0.698
MOD_ProDKin_1	217	223	PF00069	0.785
MOD_ProDKin_1	260	266	PF00069	0.754
MOD_ProDKin_1	340	346	PF00069	0.746
MOD_ProDKin_1	376	382	PF00069	0.827
MOD_ProDKin_1	40	46	PF00069	0.800
MOD_ProDKin_1	428	434	PF00069	0.770
MOD_ProDKin_1	464	470	PF00069	0.828
MOD_ProDKin_1	487	493	PF00069	0.692
MOD_ProDKin_1	566	572	PF00069	0.749
MOD_ProDKin_1	615	621	PF00069	0.753
MOD_ProDKin_1	807	813	PF00069	0.637
MOD_ProDKin_1	840	846	PF00069	0.750
MOD_ProDKin_1	900	906	PF00069	0.789
MOD_ProDKin_1	909	915	PF00069	0.775
MOD_ProDKin_1	929	935	PF00069	0.510
MOD_SUMO_for_1	718	721	PF00179	0.614
TRG_DiLeu_BaEn_1	696	701	PF01217	0.597
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.711
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.683
TRG_ENDOCYTIC_2	636	639	PF00928	0.837
TRG_ER_diArg_1	1037	1040	PF00400	0.738
TRG_ER_diArg_1	238	241	PF00400	0.833
TRG_ER_diArg_1	4	6	PF00400	0.774
TRG_ER_diArg_1	515	517	PF00400	0.577
TRG_ER_diArg_1	766	769	PF00400	0.690
TRG_NLS_MonoExtC_3	238	243	PF00514	0.836
TRG_NLS_MonoExtN_4	238	244	PF00514	0.830
TRG_Pf-PMV_PEXEL_1	1025	1029	PF00026	0.756
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	515	520	PF00026	0.692
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.770

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9D3	Leishmania donovani	84%	100%
A4H8I4	Leishmania braziliensis	60%	100%
A4HWW1	Leishmania infantum	84%	100%
E9AQM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%