TP6A_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

meiotic recombination protein SPO11, putative

Species:

Leishmania major

UniProt:

Q4QEV6_LEIMA

TriTrypDb:

LmjF.16.0630 , LMJLV39_160011700 , LMJSD75_160011500

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000228	nuclear chromosome	6	2
GO:0005694	chromosome	5	6
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QEV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEV6

Function

Biological processes
Term	Name	Level	Count
GO:0000706	meiotic DNA double-strand break processing	3	2
GO:0000729	DNA double-strand break processing	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007131	reciprocal meiotic recombination	3	2
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0022402	cell cycle process	2	2
GO:0022414	reproductive process	1	2
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0035825	homologous recombination	6	2
GO:0042138	meiotic DNA double-strand break formation	4	2
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0061982	meiosis I cell cycle process	3	2
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0140527	reciprocal homologous recombination	7	2
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1903046	meiotic cell cycle process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003676	nucleic acid binding	3	6
GO:0003677	DNA binding	4	6
GO:0003824	catalytic activity	1	6
GO:0003916	DNA topoisomerase activity	3	6
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0008094	ATP-dependent activity, acting on DNA	2	6
GO:0016853	isomerase activity	2	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140097	catalytic activity, acting on DNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6
GO:0140657	ATP-dependent activity	1	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.615
CLV_C14_Caspase3-7	501	505	PF00656	0.558
CLV_NRD_NRD_1	127	129	PF00675	0.437
CLV_NRD_NRD_1	27	29	PF00675	0.376
CLV_NRD_NRD_1	344	346	PF00675	0.445
CLV_NRD_NRD_1	502	504	PF00675	0.487
CLV_NRD_NRD_1	543	545	PF00675	0.665
CLV_NRD_NRD_1	627	629	PF00675	0.699
CLV_NRD_NRD_1	647	649	PF00675	0.277
CLV_NRD_NRD_1	68	70	PF00675	0.700
CLV_PCSK_KEX2_1	127	129	PF00082	0.437
CLV_PCSK_KEX2_1	27	29	PF00082	0.376
CLV_PCSK_KEX2_1	344	346	PF00082	0.445
CLV_PCSK_KEX2_1	418	420	PF00082	0.532
CLV_PCSK_KEX2_1	46	48	PF00082	0.534
CLV_PCSK_KEX2_1	502	504	PF00082	0.500
CLV_PCSK_KEX2_1	542	544	PF00082	0.701
CLV_PCSK_KEX2_1	626	628	PF00082	0.666
CLV_PCSK_KEX2_1	647	649	PF00082	0.423
CLV_PCSK_KEX2_1	67	69	PF00082	0.707
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.505
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.522
CLV_PCSK_PC7_1	414	420	PF00082	0.489
CLV_PCSK_SKI1_1	122	126	PF00082	0.677
CLV_PCSK_SKI1_1	283	287	PF00082	0.632
CLV_PCSK_SKI1_1	344	348	PF00082	0.448
CLV_PCSK_SKI1_1	46	50	PF00082	0.555
CLV_Separin_Metazoa	24	28	PF03568	0.400
DEG_APCC_DBOX_1	133	141	PF00400	0.308
DEG_APCC_DBOX_1	320	328	PF00400	0.364
DEG_APCC_DBOX_1	343	351	PF00400	0.444
DEG_SCF_TRCP1_1	420	425	PF00400	0.574
DOC_CDC14_PxL_1	396	404	PF14671	0.451
DOC_MAPK_gen_1	184	192	PF00069	0.308
DOC_MAPK_gen_1	27	33	PF00069	0.378
DOC_MAPK_MEF2A_6	326	333	PF00069	0.370
DOC_MAPK_RevD_3	31	47	PF00069	0.442
DOC_PP2B_LxvP_1	183	186	PF13499	0.308
DOC_PP2B_LxvP_1	41	44	PF13499	0.523
DOC_PP4_FxxP_1	298	301	PF00568	0.360
DOC_USP7_MATH_1	123	127	PF00917	0.659
DOC_USP7_MATH_1	258	262	PF00917	0.705
DOC_USP7_MATH_1	379	383	PF00917	0.568
DOC_USP7_MATH_1	386	390	PF00917	0.553
DOC_USP7_MATH_1	461	465	PF00917	0.664
DOC_USP7_MATH_1	467	471	PF00917	0.733
DOC_USP7_MATH_1	490	494	PF00917	0.671
DOC_USP7_MATH_1	521	525	PF00917	0.633
DOC_USP7_UBL2_3	530	534	PF12436	0.557
DOC_WW_Pin1_4	438	443	PF00397	0.802
DOC_WW_Pin1_4	486	491	PF00397	0.577
DOC_WW_Pin1_4	522	527	PF00397	0.625
DOC_WW_Pin1_4	6	11	PF00397	0.461
LIG_14-3-3_CanoR_1	122	130	PF00244	0.490
LIG_14-3-3_CanoR_1	164	172	PF00244	0.406
LIG_14-3-3_CanoR_1	276	285	PF00244	0.622
LIG_14-3-3_CanoR_1	288	298	PF00244	0.432
LIG_14-3-3_CanoR_1	377	386	PF00244	0.584
LIG_14-3-3_CanoR_1	520	526	PF00244	0.480
LIG_14-3-3_CanoR_1	554	558	PF00244	0.596
LIG_14-3-3_CanoR_1	568	572	PF00244	0.686
LIG_14-3-3_CanoR_1	580	584	PF00244	0.467
LIG_14-3-3_CanoR_1	595	599	PF00244	0.307
LIG_14-3-3_CanoR_1	86	96	PF00244	0.584
LIG_Actin_WH2_2	505	522	PF00022	0.360
LIG_EVH1_2	633	637	PF00568	0.451
LIG_FHA_1	166	172	PF00498	0.395
LIG_FHA_1	379	385	PF00498	0.418
LIG_FHA_1	407	413	PF00498	0.441
LIG_FHA_1	615	621	PF00498	0.468
LIG_FHA_2	152	158	PF00498	0.308
LIG_FHA_2	276	282	PF00498	0.561
LIG_FHA_2	499	505	PF00498	0.465
LIG_Integrin_RGD_1	149	151	PF01839	0.340
LIG_LIR_Apic_2	394	400	PF02991	0.447
LIG_LIR_Apic_2	603	609	PF02991	0.500
LIG_LIR_Gen_1	157	166	PF02991	0.308
LIG_LIR_Gen_1	2	13	PF02991	0.468
LIG_LIR_LC3C_4	230	235	PF02991	0.422
LIG_LIR_Nem_3	141	147	PF02991	0.457
LIG_LIR_Nem_3	157	163	PF02991	0.264
LIG_LIR_Nem_3	2	8	PF02991	0.470
LIG_LIR_Nem_3	393	399	PF02991	0.587
LIG_LIR_Nem_3	401	407	PF02991	0.424
LIG_MYND_1	325	329	PF01753	0.357
LIG_NRBOX	36	42	PF00104	0.483
LIG_NRBOX	514	520	PF00104	0.494
LIG_SH2_CRK	160	164	PF00017	0.308
LIG_SH2_CRK	606	610	PF00017	0.529
LIG_SH2_CRK	72	76	PF00017	0.652
LIG_SH2_GRB2like	610	613	PF00017	0.433
LIG_SH2_NCK_1	606	610	PF00017	0.529
LIG_SH2_STAP1	610	614	PF00017	0.456
LIG_SH2_STAT5	199	202	PF00017	0.419
LIG_SH2_STAT5	32	35	PF00017	0.380
LIG_SH2_STAT5	606	609	PF00017	0.457
LIG_SH3_3	429	435	PF00018	0.640
LIG_SH3_3	91	97	PF00018	0.662
LIG_SH3_CIN85_PxpxPR_1	71	76	PF14604	0.573
LIG_SUMO_SIM_par_1	136	142	PF11976	0.384
LIG_SUMO_SIM_par_1	306	311	PF11976	0.325
LIG_TRAF2_1	219	222	PF00917	0.521
LIG_TYR_ITIM	158	163	PF00017	0.308
LIG_UBA3_1	40	46	PF00899	0.503
MOD_CK1_1	126	132	PF00069	0.512
MOD_CK1_1	261	267	PF00069	0.629
MOD_CK1_1	272	278	PF00069	0.620
MOD_CK1_1	289	295	PF00069	0.539
MOD_CK1_1	391	397	PF00069	0.432
MOD_CK1_1	463	469	PF00069	0.605
MOD_CK1_1	489	495	PF00069	0.632
MOD_CK1_1	567	573	PF00069	0.527
MOD_CK2_1	1	7	PF00069	0.488
MOD_CK2_1	275	281	PF00069	0.568
MOD_CK2_1	547	553	PF00069	0.594
MOD_Cter_Amidation	540	543	PF01082	0.575
MOD_GlcNHglycan	229	232	PF01048	0.414
MOD_GlcNHglycan	254	257	PF01048	0.638
MOD_GlcNHglycan	271	274	PF01048	0.659
MOD_GlcNHglycan	288	291	PF01048	0.645
MOD_GlcNHglycan	388	391	PF01048	0.596
MOD_GlcNHglycan	420	423	PF01048	0.591
MOD_GlcNHglycan	424	427	PF01048	0.645
MOD_GlcNHglycan	429	432	PF01048	0.574
MOD_GlcNHglycan	465	468	PF01048	0.579
MOD_GlcNHglycan	476	479	PF01048	0.622
MOD_GlcNHglycan	559	562	PF01048	0.596
MOD_GlcNHglycan	62	65	PF01048	0.598
MOD_GlcNHglycan	89	92	PF01048	0.703
MOD_GSK3_1	122	129	PF00069	0.437
MOD_GSK3_1	252	259	PF00069	0.778
MOD_GSK3_1	261	268	PF00069	0.518
MOD_GSK3_1	271	278	PF00069	0.651
MOD_GSK3_1	418	425	PF00069	0.594
MOD_GSK3_1	452	459	PF00069	0.733
MOD_GSK3_1	463	470	PF00069	0.604
MOD_GSK3_1	474	481	PF00069	0.679
MOD_GSK3_1	486	493	PF00069	0.520
MOD_GSK3_1	553	560	PF00069	0.573
MOD_N-GLC_1	172	177	PF02516	0.308
MOD_N-GLC_1	261	266	PF02516	0.582
MOD_N-GLC_2	303	305	PF02516	0.384
MOD_NEK2_1	1	6	PF00069	0.569
MOD_NEK2_1	233	238	PF00069	0.448
MOD_NEK2_1	257	262	PF00069	0.579
MOD_NEK2_1	263	268	PF00069	0.536
MOD_NEK2_1	269	274	PF00069	0.607
MOD_NEK2_1	36	41	PF00069	0.478
MOD_NEK2_1	445	450	PF00069	0.754
MOD_NEK2_1	614	619	PF00069	0.505
MOD_PIKK_1	151	157	PF00454	0.411
MOD_PIKK_1	165	171	PF00454	0.231
MOD_PIKK_1	632	638	PF00454	0.510
MOD_PKA_1	418	424	PF00069	0.553
MOD_PKA_2	126	132	PF00069	0.406
MOD_PKA_2	275	281	PF00069	0.685
MOD_PKA_2	418	424	PF00069	0.588
MOD_PKA_2	553	559	PF00069	0.680
MOD_PKA_2	567	573	PF00069	0.655
MOD_PKA_2	579	585	PF00069	0.433
MOD_PKA_2	594	600	PF00069	0.384
MOD_Plk_1	172	178	PF00069	0.308
MOD_Plk_1	445	451	PF00069	0.563
MOD_Plk_4	233	239	PF00069	0.401
MOD_Plk_4	36	42	PF00069	0.503
MOD_Plk_4	547	553	PF00069	0.651
MOD_Plk_4	579	585	PF00069	0.439
MOD_Plk_4	616	622	PF00069	0.552
MOD_ProDKin_1	438	444	PF00069	0.802
MOD_ProDKin_1	486	492	PF00069	0.576
MOD_ProDKin_1	522	528	PF00069	0.628
MOD_ProDKin_1	6	12	PF00069	0.461
MOD_SUMO_for_1	598	601	PF00179	0.369
TRG_DiLeu_BaEn_4	221	227	PF01217	0.470
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.388
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.554
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.249
TRG_ENDOCYTIC_2	159	162	PF00928	0.331
TRG_ENDOCYTIC_2	396	399	PF00928	0.574
TRG_ER_diArg_1	206	209	PF00400	0.370
TRG_ER_diArg_1	26	28	PF00400	0.384
TRG_ER_diArg_1	344	346	PF00400	0.411
TRG_ER_diArg_1	435	438	PF00400	0.580
TRG_ER_diArg_1	542	544	PF00400	0.572
TRG_ER_diArg_1	625	628	PF00400	0.601
TRG_ER_diArg_1	646	648	PF00400	0.485
TRG_ER_diArg_1	66	69	PF00400	0.671
TRG_NES_CRM1_1	19	35	PF08389	0.370
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C1	Leptomonas seymouri	37%	97%
A0A3S7WTW1	Leishmania donovani	87%	100%
A4H8I5	Leishmania braziliensis	69%	100%
E9AQM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%