Peptidyl-prolyl cis-trans isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4QEV5_LEIMA

TriTrypDb:

LmjF.16.0640 , LMJLV39_160011800 , LMJSD75_160011600

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QEV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEV5

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	2
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031399	regulation of protein modification process	6	2
GO:0042325	regulation of phosphorylation	7	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051174	regulation of phosphorus metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1901407	obsolete regulation of phosphorylation of RNA polymerase II C-terminal domain	8	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2
GO:0000413	protein peptidyl-prolyl isomerization	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018208	peptidyl-proline modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	9
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	9
GO:0016853	isomerase activity	2	9
GO:0016859	cis-trans isomerase activity	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.705
CLV_NRD_NRD_1	223	225	PF00675	0.550
CLV_NRD_NRD_1	323	325	PF00675	0.655
CLV_NRD_NRD_1	326	328	PF00675	0.662
CLV_NRD_NRD_1	42	44	PF00675	0.438
CLV_NRD_NRD_1	551	553	PF00675	0.525
CLV_NRD_NRD_1	60	62	PF00675	0.571
CLV_NRD_NRD_1	679	681	PF00675	0.462
CLV_PCSK_FUR_1	324	328	PF00082	0.607
CLV_PCSK_FUR_1	369	373	PF00082	0.629
CLV_PCSK_KEX2_1	221	223	PF00082	0.549
CLV_PCSK_KEX2_1	323	325	PF00082	0.575
CLV_PCSK_KEX2_1	326	328	PF00082	0.597
CLV_PCSK_KEX2_1	371	373	PF00082	0.649
CLV_PCSK_KEX2_1	551	553	PF00082	0.539
CLV_PCSK_KEX2_1	681	683	PF00082	0.474
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.634
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.624
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.506
CLV_PCSK_PC7_1	218	224	PF00082	0.626
CLV_PCSK_PC7_1	677	683	PF00082	0.461
CLV_PCSK_SKI1_1	137	141	PF00082	0.516
CLV_PCSK_SKI1_1	30	34	PF00082	0.445
CLV_PCSK_SKI1_1	356	360	PF00082	0.644
CLV_PCSK_SKI1_1	371	375	PF00082	0.505
CLV_PCSK_SKI1_1	409	413	PF00082	0.442
CLV_PCSK_SKI1_1	48	52	PF00082	0.443
CLV_PCSK_SKI1_1	56	60	PF00082	0.491
CLV_PCSK_SKI1_1	684	688	PF00082	0.569
CLV_Separin_Metazoa	320	324	PF03568	0.445
DEG_SPOP_SBC_1	195	199	PF00917	0.797
DOC_CYCLIN_RxL_1	134	141	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.434
DOC_MAPK_gen_1	218	228	PF00069	0.587
DOC_MAPK_gen_1	43	51	PF00069	0.423
DOC_MAPK_gen_1	677	687	PF00069	0.695
DOC_MAPK_MEF2A_6	221	230	PF00069	0.524
DOC_MAPK_MEF2A_6	307	314	PF00069	0.686
DOC_MAPK_MEF2A_6	476	485	PF00069	0.605
DOC_MAPK_MEF2A_6	562	571	PF00069	0.565
DOC_MAPK_RevD_3	357	372	PF00069	0.587
DOC_PP2B_LxvP_1	228	231	PF13499	0.513
DOC_PP2B_PxIxI_1	480	486	PF00149	0.604
DOC_USP7_MATH_1	183	187	PF00917	0.705
DOC_USP7_MATH_1	191	195	PF00917	0.685
DOC_USP7_MATH_1	233	237	PF00917	0.772
DOC_USP7_MATH_1	249	253	PF00917	0.603
DOC_USP7_MATH_1	262	266	PF00917	0.723
DOC_USP7_MATH_1	461	465	PF00917	0.621
DOC_USP7_MATH_1	470	474	PF00917	0.597
DOC_USP7_MATH_1	94	98	PF00917	0.535
DOC_WW_Pin1_4	269	274	PF00397	0.624
DOC_WW_Pin1_4	498	503	PF00397	0.773
DOC_WW_Pin1_4	6	11	PF00397	0.499
LIG_14-3-3_CanoR_1	145	154	PF00244	0.598
LIG_14-3-3_CanoR_1	178	187	PF00244	0.654
LIG_14-3-3_CanoR_1	292	298	PF00244	0.534
LIG_14-3-3_CanoR_1	356	362	PF00244	0.621
LIG_14-3-3_CanoR_1	372	376	PF00244	0.521
LIG_14-3-3_CanoR_1	409	416	PF00244	0.618
LIG_14-3-3_CanoR_1	443	447	PF00244	0.600
LIG_14-3-3_CanoR_1	456	461	PF00244	0.486
LIG_14-3-3_CanoR_1	551	556	PF00244	0.691
LIG_14-3-3_CanoR_1	614	622	PF00244	0.471
LIG_Actin_WH2_2	307	325	PF00022	0.626
LIG_BIR_III_4	524	528	PF00653	0.546
LIG_FHA_1	116	122	PF00498	0.556
LIG_FHA_1	180	186	PF00498	0.638
LIG_FHA_1	197	203	PF00498	0.605
LIG_FHA_1	309	315	PF00498	0.509
LIG_FHA_1	538	544	PF00498	0.611
LIG_FHA_1	564	570	PF00498	0.468
LIG_FHA_1	73	79	PF00498	0.503
LIG_FHA_2	24	30	PF00498	0.448
LIG_FHA_2	294	300	PF00498	0.558
LIG_FHA_2	457	463	PF00498	0.560
LIG_FHA_2	490	496	PF00498	0.645
LIG_FHA_2	598	604	PF00498	0.447
LIG_FHA_2	614	620	PF00498	0.447
LIG_Integrin_RGD_1	581	583	PF01839	0.621
LIG_LIR_Apic_2	360	364	PF02991	0.639
LIG_LIR_Gen_1	100	111	PF02991	0.547
LIG_LIR_Gen_1	306	315	PF02991	0.500
LIG_LIR_Gen_1	381	391	PF02991	0.607
LIG_LIR_Gen_1	636	644	PF02991	0.471
LIG_LIR_Nem_3	100	106	PF02991	0.539
LIG_LIR_Nem_3	133	139	PF02991	0.483
LIG_LIR_Nem_3	306	312	PF02991	0.505
LIG_LIR_Nem_3	381	387	PF02991	0.575
LIG_LIR_Nem_3	390	395	PF02991	0.566
LIG_LIR_Nem_3	610	615	PF02991	0.520
LIG_LIR_Nem_3	629	635	PF02991	0.368
LIG_LIR_Nem_3	636	640	PF02991	0.447
LIG_LIR_Nem_3	641	647	PF02991	0.447
LIG_MYND_1	16	20	PF01753	0.452
LIG_NRBOX	139	145	PF00104	0.496
LIG_PTB_Apo_2	507	514	PF02174	0.562
LIG_PTB_Phospho_1	507	513	PF10480	0.658
LIG_RPA_C_Fungi	218	230	PF08784	0.486
LIG_SH2_CRK	242	246	PF00017	0.696
LIG_SH2_PTP2	309	312	PF00017	0.588
LIG_SH2_PTP2	384	387	PF00017	0.610
LIG_SH2_PTP2	451	454	PF00017	0.496
LIG_SH2_SRC	242	245	PF00017	0.687
LIG_SH2_SRC	246	249	PF00017	0.690
LIG_SH2_STAT5	246	249	PF00017	0.647
LIG_SH2_STAT5	309	312	PF00017	0.509
LIG_SH2_STAT5	384	387	PF00017	0.610
LIG_SH2_STAT5	451	454	PF00017	0.555
LIG_SH2_STAT5	466	469	PF00017	0.668
LIG_SH2_STAT5	517	520	PF00017	0.552
LIG_SH3_3	11	17	PF00018	0.485
LIG_SH3_3	151	157	PF00018	0.678
LIG_SH3_3	242	248	PF00018	0.677
LIG_SH3_3	382	388	PF00018	0.601
LIG_SH3_3	499	505	PF00018	0.557
LIG_SH3_3	54	60	PF00018	0.493
LIG_SUMO_SIM_anti_2	19	29	PF11976	0.456
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.562
LIG_SUMO_SIM_par_1	181	189	PF11976	0.575
LIG_SUMO_SIM_par_1	85	90	PF11976	0.496
LIG_TRAF2_1	167	170	PF00917	0.510
LIG_TYR_ITIM	630	635	PF00017	0.281
MOD_CK1_1	181	187	PF00069	0.743
MOD_CK1_1	194	200	PF00069	0.549
MOD_CK1_1	250	256	PF00069	0.651
MOD_CK1_1	269	275	PF00069	0.466
MOD_CK1_1	287	293	PF00069	0.561
MOD_CK1_1	397	403	PF00069	0.540
MOD_CK1_1	97	103	PF00069	0.638
MOD_CK2_1	491	497	PF00069	0.630
MOD_CK2_1	498	504	PF00069	0.776
MOD_CK2_1	597	603	PF00069	0.281
MOD_GlcNHglycan	147	150	PF01048	0.621
MOD_GlcNHglycan	249	252	PF01048	0.648
MOD_GlcNHglycan	264	267	PF01048	0.665
MOD_GlcNHglycan	268	271	PF01048	0.484
MOD_GlcNHglycan	278	281	PF01048	0.525
MOD_GlcNHglycan	285	289	PF01048	0.601
MOD_GlcNHglycan	389	392	PF01048	0.600
MOD_GlcNHglycan	400	403	PF01048	0.503
MOD_GlcNHglycan	53	56	PF01048	0.611
MOD_GlcNHglycan	537	540	PF01048	0.685
MOD_GlcNHglycan	543	546	PF01048	0.579
MOD_GlcNHglycan	616	619	PF01048	0.281
MOD_GlcNHglycan	65	68	PF01048	0.639
MOD_GlcNHglycan	95	99	PF01048	0.552
MOD_GSK3_1	174	181	PF00069	0.702
MOD_GSK3_1	19	26	PF00069	0.500
MOD_GSK3_1	191	198	PF00069	0.611
MOD_GSK3_1	262	269	PF00069	0.799
MOD_GSK3_1	272	279	PF00069	0.671
MOD_GSK3_1	371	378	PF00069	0.594
MOD_GSK3_1	393	400	PF00069	0.645
MOD_GSK3_1	452	459	PF00069	0.525
MOD_GSK3_1	531	538	PF00069	0.584
MOD_GSK3_1	6	13	PF00069	0.447
MOD_GSK3_1	662	669	PF00069	0.392
MOD_N-GLC_1	563	568	PF02516	0.473
MOD_N-GLC_2	105	107	PF02516	0.457
MOD_NEK2_1	143	148	PF00069	0.605
MOD_NEK2_1	293	298	PF00069	0.506
MOD_NEK2_1	441	446	PF00069	0.531
MOD_NEK2_1	5	10	PF00069	0.448
MOD_NEK2_1	51	56	PF00069	0.508
MOD_NEK2_1	607	612	PF00069	0.315
MOD_NEK2_1	664	669	PF00069	0.410
MOD_NEK2_1	79	84	PF00069	0.511
MOD_NEK2_2	183	188	PF00069	0.595
MOD_NEK2_2	191	196	PF00069	0.530
MOD_NEK2_2	461	466	PF00069	0.563
MOD_PIKK_1	607	613	PF00454	0.315
MOD_PIKK_1	662	668	PF00454	0.383
MOD_PKA_1	371	377	PF00069	0.621
MOD_PKA_1	551	557	PF00069	0.574
MOD_PKA_2	371	377	PF00069	0.644
MOD_PKA_2	442	448	PF00069	0.607
MOD_PKA_2	551	557	PF00069	0.552
MOD_PKA_2	613	619	PF00069	0.351
MOD_Plk_1	44	50	PF00069	0.421
MOD_Plk_1	461	467	PF00069	0.591
MOD_Plk_1	563	569	PF00069	0.561
MOD_Plk_1	80	86	PF00069	0.533
MOD_Plk_1	94	100	PF00069	0.506
MOD_Plk_2-3	636	642	PF00069	0.297
MOD_Plk_4	278	284	PF00069	0.625
MOD_Plk_4	371	377	PF00069	0.593
MOD_Plk_4	461	467	PF00069	0.513
MOD_Plk_4	551	557	PF00069	0.583
MOD_Plk_4	565	571	PF00069	0.441
MOD_ProDKin_1	269	275	PF00069	0.624
MOD_ProDKin_1	498	504	PF00069	0.777
MOD_ProDKin_1	6	12	PF00069	0.493
MOD_SUMO_rev_2	579	587	PF00179	0.501
MOD_SUMO_rev_2	617	626	PF00179	0.281
TRG_DiLeu_BaEn_1	565	570	PF01217	0.500
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.560
TRG_ENDOCYTIC_2	136	139	PF00928	0.561
TRG_ENDOCYTIC_2	242	245	PF00928	0.697
TRG_ENDOCYTIC_2	309	312	PF00928	0.588
TRG_ENDOCYTIC_2	384	387	PF00928	0.610
TRG_ENDOCYTIC_2	451	454	PF00928	0.541
TRG_ENDOCYTIC_2	632	635	PF00928	0.281
TRG_ER_diArg_1	222	224	PF00400	0.615
TRG_ER_diArg_1	322	324	PF00400	0.655
TRG_ER_diArg_1	325	327	PF00400	0.651
TRG_ER_diArg_1	46	49	PF00400	0.433
TRG_ER_diArg_1	679	682	PF00400	0.463
TRG_NLS_MonoCore_2	220	225	PF00514	0.634
TRG_NLS_MonoExtN_4	218	225	PF00514	0.629
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	546	550	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB00	Leptomonas seymouri	57%	100%
A0A3Q8ICH7	Leishmania donovani	87%	98%
A0A422MVZ8	Trypanosoma rangeli	37%	100%
A4H8I6	Leishmania braziliensis	78%	100%
A4HWW3	Leishmania infantum	87%	98%
C9ZPQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AQM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%