RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-H2 zinc finger, putative

Species:

Leishmania major

UniProt:

Q4QEV4_LEIMA

TriTrypDb:

LmjF.16.0650 , LMJLV39_160011900 , LMJSD75_160011700

Length:

105

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	9
GO:0000152	nuclear ubiquitin ligase complex	3	9
GO:0005634	nucleus	5	3
GO:0005680	anaphase-promoting complex	4	9
GO:0031461	cullin-RING ubiquitin ligase complex	4	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:0140513	nuclear protein-containing complex	2	9
GO:0140535	intracellular protein-containing complex	2	9
GO:1902494	catalytic complex	2	9
GO:1990234	transferase complex	3	9

Expansion

Sequence features

Q4QEV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEV4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	9
GO:0006511	ubiquitin-dependent protein catabolic process	7	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0007088	regulation of mitotic nuclear division	6	3
GO:0007346	regulation of mitotic cell cycle	5	3
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	9
GO:0009057	macromolecule catabolic process	4	9
GO:0009987	cellular process	1	9
GO:0010564	regulation of cell cycle process	5	3
GO:0010638	positive regulation of organelle organization	6	3
GO:0010965	regulation of mitotic sister chromatid separation	6	3
GO:0016567	protein ubiquitination	7	3
GO:0019538	protein metabolic process	3	9
GO:0019941	modification-dependent protein catabolic process	6	9
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	3
GO:0032446	protein modification by small protein conjugation	6	3
GO:0033043	regulation of organelle organization	5	3
GO:0033044	regulation of chromosome organization	6	3
GO:0033045	regulation of sister chromatid segregation	5	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	3
GO:0043632	modification-dependent macromolecule catabolic process	5	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044248	cellular catabolic process	3	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0044265	obsolete cellular macromolecule catabolic process	4	9
GO:0045787	positive regulation of cell cycle	5	3
GO:0045840	positive regulation of mitotic nuclear division	7	3
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	3
GO:0045931	positive regulation of mitotic cell cycle	6	3
GO:0048518	positive regulation of biological process	3	3
GO:0048522	positive regulation of cellular process	4	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0051128	regulation of cellular component organization	4	3
GO:0051130	positive regulation of cellular component organization	5	3
GO:0051603	proteolysis involved in protein catabolic process	5	9
GO:0051726	regulation of cell cycle	4	3
GO:0051783	regulation of nuclear division	6	3
GO:0051785	positive regulation of nuclear division	7	3
GO:0051983	regulation of chromosome segregation	4	3
GO:0065007	biological regulation	1	3
GO:0070647	protein modification by small protein conjugation or removal	5	3
GO:0071704	organic substance metabolic process	2	9
GO:0090068	positive regulation of cell cycle process	6	3
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901575	organic substance catabolic process	3	9
GO:1901970	positive regulation of mitotic sister chromatid separation	7	3
GO:1901987	regulation of cell cycle phase transition	6	3
GO:1901989	positive regulation of cell cycle phase transition	7	3
GO:1901990	regulation of mitotic cell cycle phase transition	6	3
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	3
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	3
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	3
GO:1905818	regulation of chromosome separation	5	3
GO:1905820	positive regulation of chromosome separation	6	3
GO:0010498	proteasomal protein catabolic process	5	7
GO:0030163	protein catabolic process	4	7
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	7
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	7
GO:0051301	cell division	2	6
GO:1901565	organonitrogen compound catabolic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004842	ubiquitin-protein transferase activity	4	9
GO:0005488	binding	1	14
GO:0005515	protein binding	2	9
GO:0008270	zinc ion binding	6	14
GO:0016740	transferase activity	2	9
GO:0019787	ubiquitin-like protein transferase activity	3	9
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14
GO:0046914	transition metal ion binding	5	14
GO:0061630	ubiquitin protein ligase activity	5	9
GO:0061659	ubiquitin-like protein ligase activity	4	9
GO:0097602	cullin family protein binding	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	48	52	PF00082	0.271
DOC_PP4_FxxP_1	17	20	PF00568	0.433
DOC_USP7_MATH_1	7	11	PF00917	0.552
DOC_WW_Pin1_4	8	13	PF00397	0.474
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BIR_III_1	1	5	PF00653	0.515
LIG_BIR_III_3	1	5	PF00653	0.515
LIG_BRCT_BRCA1_1	72	76	PF00533	0.418
LIG_FHA_1	21	27	PF00498	0.594
LIG_FHA_1	86	92	PF00498	0.431
LIG_LIR_Apic_2	14	20	PF02991	0.450
LIG_LIR_Gen_1	22	33	PF02991	0.496
LIG_LIR_Nem_3	22	28	PF02991	0.486
LIG_SH2_SRC	25	28	PF00017	0.385
LIG_SH2_STAT5	25	28	PF00017	0.491
LIG_TYR_ITSM	21	28	PF00017	0.462
MOD_CK1_1	3	9	PF00069	0.590
MOD_CK2_1	58	64	PF00069	0.447
MOD_GlcNHglycan	48	51	PF01048	0.247
MOD_GSK3_1	3	10	PF00069	0.521
MOD_GSK3_1	34	41	PF00069	0.409
MOD_NEK2_1	26	31	PF00069	0.418
MOD_NEK2_1	56	61	PF00069	0.458
MOD_NEK2_1	85	90	PF00069	0.439
MOD_PKA_2	34	40	PF00069	0.442
MOD_Plk_4	34	40	PF00069	0.384
MOD_ProDKin_1	8	14	PF00069	0.473
TRG_ENDOCYTIC_2	25	28	PF00928	0.484
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V1	Leptomonas seymouri	33%	90%
A0A0N0P965	Leptomonas seymouri	37%	100%
A0A0N1I1Q1	Leptomonas seymouri	57%	100%
A0A0S4JR26	Bodo saltans	38%	100%
A0A0S4KL27	Bodo saltans	30%	96%
A0A1X0NQI6	Trypanosomatidae	32%	100%
A0A3S7WTW3	Leishmania donovani	97%	100%
A0A3S7WYG9	Leishmania donovani	32%	100%
A0A3S7X9W9	Leishmania donovani	37%	100%
A4H8I7	Leishmania braziliensis	91%	100%
A4HDM1	Leishmania braziliensis	34%	88%
A4HNB7	Leishmania braziliensis	37%	100%
A4HWW4	Leishmania infantum	97%	100%
A4IBZ0	Leishmania infantum	37%	100%
C9ZPQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9AFS7	Leishmania major	37%	100%
E9AH68	Leishmania infantum	32%	100%
E9AQM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AX06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	88%
E9B6X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QAH0	Leishmania major	32%	100%
Q54L48	Dictyostelium discoideum	36%	100%
V5BCN0	Trypanosoma cruzi	28%	100%