Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEV3_LEIMA

TriTrypDb:

LmjF.16.0660 , LMJLV39_160012100 , LMJSD75_160011900

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.536
CLV_NRD_NRD_1	162	164	PF00675	0.580
CLV_NRD_NRD_1	371	373	PF00675	0.636
CLV_NRD_NRD_1	396	398	PF00675	0.499
CLV_NRD_NRD_1	461	463	PF00675	0.557
CLV_NRD_NRD_1	517	519	PF00675	0.608
CLV_NRD_NRD_1	53	55	PF00675	0.595
CLV_NRD_NRD_1	66	68	PF00675	0.583
CLV_PCSK_FUR_1	51	55	PF00082	0.613
CLV_PCSK_KEX2_1	301	303	PF00082	0.492
CLV_PCSK_KEX2_1	411	413	PF00082	0.538
CLV_PCSK_KEX2_1	461	463	PF00082	0.584
CLV_PCSK_KEX2_1	509	511	PF00082	0.629
CLV_PCSK_KEX2_1	517	519	PF00082	0.590
CLV_PCSK_KEX2_1	53	55	PF00082	0.619
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.492
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.603
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.629
CLV_PCSK_SKI1_1	148	152	PF00082	0.644
CLV_PCSK_SKI1_1	491	495	PF00082	0.613
CLV_Separin_Metazoa	108	112	PF03568	0.567
DEG_APCC_DBOX_1	553	561	PF00400	0.639
DEG_Nend_UBRbox_1	1	4	PF02207	0.579
DEG_SPOP_SBC_1	274	278	PF00917	0.689
DOC_MAPK_gen_1	461	468	PF00069	0.567
DOC_MAPK_gen_1	486	495	PF00069	0.517
DOC_MAPK_gen_1	51	59	PF00069	0.544
DOC_MAPK_gen_1	67	73	PF00069	0.549
DOC_MAPK_MEF2A_6	24	32	PF00069	0.497
DOC_PP2B_LxvP_1	11	14	PF13499	0.617
DOC_USP7_MATH_1	274	278	PF00917	0.757
DOC_USP7_MATH_1	346	350	PF00917	0.637
DOC_USP7_MATH_1	392	396	PF00917	0.611
DOC_USP7_MATH_1	407	411	PF00917	0.488
LIG_14-3-3_CanoR_1	136	141	PF00244	0.598
LIG_14-3-3_CanoR_1	280	288	PF00244	0.591
LIG_14-3-3_CanoR_1	341	350	PF00244	0.565
LIG_14-3-3_CanoR_1	397	406	PF00244	0.615
LIG_14-3-3_CanoR_1	412	417	PF00244	0.572
LIG_14-3-3_CanoR_1	430	438	PF00244	0.537
LIG_Actin_WH2_2	196	214	PF00022	0.521
LIG_BRCT_BRCA1_1	409	413	PF00533	0.392
LIG_DLG_GKlike_1	136	144	PF00625	0.629
LIG_FHA_1	115	121	PF00498	0.535
LIG_FHA_1	206	212	PF00498	0.641
LIG_FHA_1	240	246	PF00498	0.495
LIG_FHA_1	274	280	PF00498	0.652
LIG_FHA_1	282	288	PF00498	0.523
LIG_FHA_1	323	329	PF00498	0.550
LIG_FHA_1	44	50	PF00498	0.588
LIG_FHA_2	140	146	PF00498	0.600
LIG_FHA_2	164	170	PF00498	0.580
LIG_FHA_2	413	419	PF00498	0.526
LIG_FHA_2	59	65	PF00498	0.509
LIG_LIR_Gen_1	410	419	PF02991	0.389
LIG_LIR_Gen_1	450	459	PF02991	0.564
LIG_LIR_Gen_1	535	545	PF02991	0.625
LIG_LIR_Nem_3	410	416	PF02991	0.389
LIG_LIR_Nem_3	450	456	PF02991	0.566
LIG_LIR_Nem_3	535	540	PF02991	0.621
LIG_NRBOX	6	12	PF00104	0.644
LIG_PCNA_yPIPBox_3	2	11	PF02747	0.531
LIG_SH2_CRK	38	42	PF00017	0.579
LIG_SH2_NCK_1	453	457	PF00017	0.571
LIG_SH2_SRC	453	456	PF00017	0.585
LIG_SH2_SRC	98	101	PF00017	0.599
LIG_SH2_STAP1	38	42	PF00017	0.474
LIG_SH2_STAT5	98	101	PF00017	0.572
LIG_SUMO_SIM_anti_2	244	249	PF11976	0.559
LIG_TRAF2_1	166	169	PF00917	0.599
LIG_TRAF2_1	365	368	PF00917	0.567
LIG_TRAF2_1	415	418	PF00917	0.495
LIG_TRAF2_1	441	444	PF00917	0.535
MOD_CK1_1	139	145	PF00069	0.609
MOD_CK1_1	272	278	PF00069	0.752
MOD_CK1_1	391	397	PF00069	0.577
MOD_CK2_1	139	145	PF00069	0.595
MOD_CK2_1	149	155	PF00069	0.514
MOD_CK2_1	163	169	PF00069	0.526
MOD_CK2_1	280	286	PF00069	0.588
MOD_CK2_1	346	352	PF00069	0.629
MOD_CK2_1	412	418	PF00069	0.510
MOD_CK2_1	429	435	PF00069	0.527
MOD_CK2_1	444	450	PF00069	0.547
MOD_GlcNHglycan	262	265	PF01048	0.738
MOD_GlcNHglycan	272	275	PF01048	0.685
MOD_GlcNHglycan	306	310	PF01048	0.508
MOD_GlcNHglycan	344	347	PF01048	0.599
MOD_GlcNHglycan	390	393	PF01048	0.598
MOD_GlcNHglycan	394	397	PF01048	0.571
MOD_GlcNHglycan	400	403	PF01048	0.540
MOD_GlcNHglycan	421	424	PF01048	0.577
MOD_GlcNHglycan	446	449	PF01048	0.603
MOD_GSK3_1	235	242	PF00069	0.604
MOD_GSK3_1	266	273	PF00069	0.680
MOD_GSK3_1	342	349	PF00069	0.627
MOD_GSK3_1	388	395	PF00069	0.577
MOD_GSK3_1	407	414	PF00069	0.329
MOD_N-GLC_1	239	244	PF02516	0.600
MOD_NEK2_1	360	365	PF00069	0.605
MOD_NEK2_1	468	473	PF00069	0.614
MOD_NEK2_1	71	76	PF00069	0.548
MOD_NEK2_1	83	88	PF00069	0.525
MOD_PIKK_1	187	193	PF00454	0.585
MOD_PIKK_1	239	245	PF00454	0.483
MOD_PIKK_1	58	64	PF00454	0.559
MOD_PK_1	489	495	PF00069	0.560
MOD_PKA_1	163	169	PF00069	0.461
MOD_PKA_1	411	417	PF00069	0.427
MOD_PKA_2	187	193	PF00069	0.416
MOD_PKA_2	266	272	PF00069	0.733
MOD_PKA_2	323	329	PF00069	0.456
MOD_PKA_2	388	394	PF00069	0.601
MOD_PKA_2	411	417	PF00069	0.600
MOD_PKA_2	429	435	PF00069	0.497
MOD_Plk_1	305	311	PF00069	0.497
MOD_Plk_1	367	373	PF00069	0.577
MOD_Plk_1	489	495	PF00069	0.521
MOD_Plk_2-3	429	435	PF00069	0.620
MOD_SUMO_for_1	485	488	PF00179	0.532
MOD_SUMO_rev_2	159	166	PF00179	0.593
MOD_SUMO_rev_2	297	303	PF00179	0.516
MOD_SUMO_rev_2	358	366	PF00179	0.629
MOD_SUMO_rev_2	414	422	PF00179	0.503
TRG_DiLeu_BaEn_1	490	495	PF01217	0.362
TRG_DiLeu_BaEn_3	226	232	PF01217	0.593
TRG_DiLeu_BaEn_4	107	113	PF01217	0.587
TRG_DiLeu_BaEn_4	47	53	PF01217	0.512
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.477
TRG_ENDOCYTIC_2	38	41	PF00928	0.579
TRG_ENDOCYTIC_2	453	456	PF00928	0.577
TRG_ENDOCYTIC_2	463	466	PF00928	0.601
TRG_ER_diArg_1	110	113	PF00400	0.565
TRG_ER_diArg_1	21	24	PF00400	0.597
TRG_ER_diArg_1	228	231	PF00400	0.552
TRG_ER_diArg_1	461	463	PF00400	0.584
TRG_ER_diArg_1	51	54	PF00400	0.602
TRG_ER_diArg_1	517	519	PF00400	0.606
TRG_NES_CRM1_1	104	115	PF08389	0.567
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBD3	Leptomonas seymouri	68%	91%
A0A0S4JEJ6	Bodo saltans	36%	95%
A0A1X0NNU4	Trypanosomatidae	39%	98%
A0A3S7WTX4	Leishmania donovani	93%	100%
A0A422MW68	Trypanosoma rangeli	39%	98%
A4H8I8	Leishmania braziliensis	83%	100%
A4HWW5	Leishmania infantum	93%	100%
C9ZPQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AQM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AX96	Trypanosoma cruzi	39%	98%