Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEV2_LEIMA

TriTrypDb:

LmjF.16.0670 , LMJLV39_160012200 , LMJSD75_160012000

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.598
CLV_C14_Caspase3-7	82	86	PF00656	0.559
CLV_NRD_NRD_1	267	269	PF00675	0.369
CLV_NRD_NRD_1	277	279	PF00675	0.276
CLV_NRD_NRD_1	344	346	PF00675	0.576
CLV_NRD_NRD_1	5	7	PF00675	0.599
CLV_PCSK_KEX2_1	267	269	PF00082	0.369
CLV_PCSK_KEX2_1	277	279	PF00082	0.276
CLV_PCSK_KEX2_1	344	346	PF00082	0.576
CLV_PCSK_KEX2_1	5	7	PF00082	0.599
CLV_PCSK_KEX2_1	535	537	PF00082	0.587
CLV_PCSK_KEX2_1	669	671	PF00082	0.515
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.587
CLV_PCSK_PC1ET2_1	669	671	PF00082	0.516
CLV_PCSK_SKI1_1	111	115	PF00082	0.564
CLV_PCSK_SKI1_1	118	122	PF00082	0.636
CLV_PCSK_SKI1_1	202	206	PF00082	0.625
CLV_PCSK_SKI1_1	267	271	PF00082	0.403
CLV_PCSK_SKI1_1	277	281	PF00082	0.290
CLV_PCSK_SKI1_1	320	324	PF00082	0.441
DEG_COP1_1	573	581	PF00400	0.526
DEG_Nend_Nbox_1	1	3	PF02207	0.620
DEG_SCF_FBW7_1	567	574	PF00400	0.604
DEG_SPOP_SBC_1	297	301	PF00917	0.325
DEG_SPOP_SBC_1	571	575	PF00917	0.649
DOC_CYCLIN_RxL_1	115	124	PF00134	0.556
DOC_CYCLIN_RxL_1	28	39	PF00134	0.595
DOC_PP4_FxxP_1	269	272	PF00568	0.304
DOC_PP4_FxxP_1	581	584	PF00568	0.526
DOC_PP4_MxPP_1	569	572	PF00568	0.572
DOC_USP7_MATH_1	116	120	PF00917	0.548
DOC_USP7_MATH_1	259	263	PF00917	0.369
DOC_USP7_MATH_1	410	414	PF00917	0.494
DOC_USP7_MATH_1	438	442	PF00917	0.618
DOC_USP7_MATH_1	551	555	PF00917	0.655
DOC_USP7_MATH_1	563	567	PF00917	0.501
DOC_USP7_MATH_1	572	576	PF00917	0.559
DOC_USP7_MATH_2	443	449	PF00917	0.574
DOC_WW_Pin1_4	217	222	PF00397	0.566
DOC_WW_Pin1_4	234	239	PF00397	0.529
DOC_WW_Pin1_4	268	273	PF00397	0.304
DOC_WW_Pin1_4	41	46	PF00397	0.614
DOC_WW_Pin1_4	510	515	PF00397	0.471
DOC_WW_Pin1_4	567	572	PF00397	0.677
LIG_14-3-3_CanoR_1	125	131	PF00244	0.703
LIG_14-3-3_CanoR_1	140	147	PF00244	0.559
LIG_14-3-3_CanoR_1	202	207	PF00244	0.788
LIG_14-3-3_CanoR_1	320	325	PF00244	0.446
LIG_14-3-3_CanoR_1	337	347	PF00244	0.550
LIG_APCC_ABBA_1	634	639	PF00400	0.429
LIG_BIR_III_2	235	239	PF00653	0.492
LIG_BRCT_BRCA1_1	371	375	PF00533	0.469
LIG_Clathr_ClatBox_1	307	311	PF01394	0.369
LIG_CtBP_PxDLS_1	353	357	PF00389	0.361
LIG_FHA_1	112	118	PF00498	0.496
LIG_FHA_1	195	201	PF00498	0.549
LIG_FHA_1	284	290	PF00498	0.371
LIG_FHA_1	297	303	PF00498	0.267
LIG_FHA_1	323	329	PF00498	0.459
LIG_FHA_1	349	355	PF00498	0.452
LIG_FHA_1	364	370	PF00498	0.489
LIG_FHA_1	493	499	PF00498	0.356
LIG_FHA_1	511	517	PF00498	0.410
LIG_FHA_1	631	637	PF00498	0.388
LIG_FHA_1	96	102	PF00498	0.730
LIG_FHA_2	133	139	PF00498	0.557
LIG_FHA_2	321	327	PF00498	0.485
LIG_FHA_2	37	43	PF00498	0.531
LIG_FHA_2	421	427	PF00498	0.557
LIG_FHA_2	619	625	PF00498	0.587
LIG_FHA_2	80	86	PF00498	0.719
LIG_Integrin_RGD_1	546	548	PF01839	0.614
LIG_LIR_Apic_2	580	584	PF02991	0.549
LIG_LIR_Gen_1	468	476	PF02991	0.511
LIG_LIR_Nem_3	372	378	PF02991	0.457
LIG_LIR_Nem_3	468	473	PF02991	0.502
LIG_MAD2	530	538	PF02301	0.527
LIG_NRBOX	116	122	PF00104	0.617
LIG_PCNA_yPIPBox_3	648	658	PF02747	0.439
LIG_Pex14_2	269	273	PF04695	0.304
LIG_Rb_LxCxE_1	181	201	PF01857	0.609
LIG_SH2_CRK	506	510	PF00017	0.437
LIG_SH2_GRB2like	458	461	PF00017	0.412
LIG_SH2_NCK_1	459	463	PF00017	0.477
LIG_SH2_STAP1	36	40	PF00017	0.605
LIG_SH2_STAP1	431	435	PF00017	0.552
LIG_SH2_STAT5	502	505	PF00017	0.440
LIG_SH3_2	29	34	PF14604	0.544
LIG_SH3_3	238	244	PF00018	0.488
LIG_SH3_3	26	32	PF00018	0.615
LIG_SH3_3	624	630	PF00018	0.518
LIG_SUMO_SIM_anti_2	591	596	PF11976	0.534
LIG_SUMO_SIM_par_1	285	293	PF11976	0.369
LIG_SUMO_SIM_par_1	96	104	PF11976	0.536
LIG_TRAF2_1	443	446	PF00917	0.583
LIG_TYR_ITIM	456	461	PF00017	0.363
LIG_UBA3_1	524	530	PF00899	0.347
MOD_CDK_SPK_2	217	222	PF00069	0.562
MOD_CK1_1	124	130	PF00069	0.581
MOD_CK1_1	255	261	PF00069	0.325
MOD_CK1_1	339	345	PF00069	0.585
MOD_CK1_1	412	418	PF00069	0.484
MOD_CK1_1	448	454	PF00069	0.593
MOD_CK1_1	554	560	PF00069	0.583
MOD_CK2_1	132	138	PF00069	0.579
MOD_CK2_1	139	145	PF00069	0.674
MOD_CK2_1	175	181	PF00069	0.618
MOD_CK2_1	237	243	PF00069	0.545
MOD_CK2_1	259	265	PF00069	0.394
MOD_CK2_1	320	326	PF00069	0.446
MOD_CMANNOS	497	500	PF00535	0.350
MOD_GlcNHglycan	128	131	PF01048	0.620
MOD_GlcNHglycan	165	168	PF01048	0.618
MOD_GlcNHglycan	224	227	PF01048	0.679
MOD_GlcNHglycan	24	27	PF01048	0.557
MOD_GlcNHglycan	257	260	PF01048	0.266
MOD_GlcNHglycan	261	264	PF01048	0.340
MOD_GlcNHglycan	560	563	PF01048	0.603
MOD_GlcNHglycan	574	577	PF01048	0.587
MOD_GlcNHglycan	609	612	PF01048	0.612
MOD_GSK3_1	121	128	PF00069	0.600
MOD_GSK3_1	255	262	PF00069	0.390
MOD_GSK3_1	359	366	PF00069	0.471
MOD_GSK3_1	412	419	PF00069	0.614
MOD_GSK3_1	551	558	PF00069	0.569
MOD_GSK3_1	563	570	PF00069	0.723
MOD_GSK3_1	612	619	PF00069	0.584
MOD_GSK3_1	95	102	PF00069	0.756
MOD_LATS_1	123	129	PF00433	0.656
MOD_N-GLC_1	337	342	PF02516	0.463
MOD_NEK2_1	1	6	PF00069	0.607
MOD_NEK2_1	121	126	PF00069	0.572
MOD_NEK2_1	215	220	PF00069	0.621
MOD_NEK2_1	273	278	PF00069	0.369
MOD_NEK2_1	296	301	PF00069	0.383
MOD_NEK2_1	310	315	PF00069	0.262
MOD_NEK2_1	363	368	PF00069	0.482
MOD_PIKK_1	79	85	PF00454	0.669
MOD_PKA_2	124	130	PF00069	0.725
MOD_PKA_2	139	145	PF00069	0.653
MOD_PKA_2	336	342	PF00069	0.450
MOD_PKA_2	555	561	PF00069	0.577
MOD_PKB_1	335	343	PF00069	0.531
MOD_Plk_1	310	316	PF00069	0.304
MOD_Plk_1	427	433	PF00069	0.537
MOD_Plk_1	95	101	PF00069	0.554
MOD_Plk_2-3	139	145	PF00069	0.565
MOD_Plk_4	116	122	PF00069	0.688
MOD_Plk_4	283	289	PF00069	0.265
MOD_Plk_4	298	304	PF00069	0.358
MOD_Plk_4	404	410	PF00069	0.592
MOD_Plk_4	412	418	PF00069	0.577
MOD_Plk_4	493	499	PF00069	0.367
MOD_ProDKin_1	217	223	PF00069	0.569
MOD_ProDKin_1	234	240	PF00069	0.527
MOD_ProDKin_1	268	274	PF00069	0.304
MOD_ProDKin_1	41	47	PF00069	0.617
MOD_ProDKin_1	510	516	PF00069	0.459
MOD_ProDKin_1	567	573	PF00069	0.679
TRG_DiLeu_BaEn_1	292	297	PF01217	0.369
TRG_DiLeu_BaEn_2	264	270	PF01217	0.369
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.355
TRG_ENDOCYTIC_2	458	461	PF00928	0.352
TRG_ER_diArg_1	267	269	PF00400	0.369
TRG_ER_diArg_1	330	333	PF00400	0.464
TRG_ER_diArg_1	343	345	PF00400	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUK6	Leptomonas seymouri	34%	100%
A0A3S7WTX7	Leishmania donovani	86%	100%
A4H8I9	Leishmania braziliensis	61%	100%
E9AGN3	Leishmania infantum	86%	100%
E9AQM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%