eIF2A domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor eIF2A, putative

Species:

Leishmania major

UniProt:

Q4QEV0_LEIMA

TriTrypDb:

LmjF.16.0690 , LMJLV39_160012400 , LMJSD75_160012200

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0015935	small ribosomal subunit	4	2
GO:0022627	cytosolic small ribosomal subunit	5	2
GO:0032991	protein-containing complex	1	2
GO:0044391	ribosomal subunit	3	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QEV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEV0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	2
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0043022	ribosome binding	4	2
GO:0044877	protein-containing complex binding	2	2
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.282
CLV_NRD_NRD_1	138	140	PF00675	0.359
CLV_NRD_NRD_1	523	525	PF00675	0.589
CLV_NRD_NRD_1	549	551	PF00675	0.717
CLV_PCSK_KEX2_1	119	121	PF00082	0.400
CLV_PCSK_KEX2_1	138	140	PF00082	0.359
CLV_PCSK_KEX2_1	523	525	PF00082	0.589
CLV_PCSK_KEX2_1	548	550	PF00082	0.662
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.396
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.662
CLV_PCSK_SKI1_1	231	235	PF00082	0.449
CLV_PCSK_SKI1_1	244	248	PF00082	0.445
CLV_PCSK_SKI1_1	312	316	PF00082	0.223
CLV_PCSK_SKI1_1	466	470	PF00082	0.248
DEG_SPOP_SBC_1	60	64	PF00917	0.465
DOC_MAPK_gen_1	11	18	PF00069	0.297
DOC_MAPK_gen_1	450	459	PF00069	0.432
DOC_MAPK_MEF2A_6	11	20	PF00069	0.373
DOC_PP4_FxxP_1	275	278	PF00568	0.473
DOC_PP4_FxxP_1	90	93	PF00568	0.424
DOC_USP7_MATH_1	176	180	PF00917	0.620
DOC_USP7_MATH_1	415	419	PF00917	0.493
DOC_USP7_UBL2_3	238	242	PF12436	0.328
DOC_WW_Pin1_4	101	106	PF00397	0.448
DOC_WW_Pin1_4	118	123	PF00397	0.553
DOC_WW_Pin1_4	274	279	PF00397	0.525
DOC_WW_Pin1_4	329	334	PF00397	0.440
DOC_WW_Pin1_4	492	497	PF00397	0.488
LIG_14-3-3_CanoR_1	244	249	PF00244	0.441
LIG_14-3-3_CanoR_1	312	319	PF00244	0.527
LIG_14-3-3_CanoR_1	347	353	PF00244	0.439
LIG_14-3-3_CanoR_1	466	475	PF00244	0.506
LIG_14-3-3_CanoR_1	83	87	PF00244	0.423
LIG_APCC_ABBA_1	18	23	PF00400	0.374
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_BRCT_BRCA1_1	438	442	PF00533	0.443
LIG_BRCT_BRCA1_1	444	448	PF00533	0.441
LIG_BRCT_BRCA1_1	99	103	PF00533	0.391
LIG_CSL_BTD_1	275	278	PF09270	0.473
LIG_FHA_1	106	112	PF00498	0.333
LIG_FHA_1	199	205	PF00498	0.479
LIG_FHA_1	245	251	PF00498	0.299
LIG_FHA_1	299	305	PF00498	0.488
LIG_FHA_1	411	417	PF00498	0.479
LIG_FHA_1	60	66	PF00498	0.342
LIG_FHA_2	149	155	PF00498	0.348
LIG_FHA_2	183	189	PF00498	0.554
LIG_FHA_2	323	329	PF00498	0.490
LIG_FHA_2	332	338	PF00498	0.442
LIG_FHA_2	360	366	PF00498	0.418
LIG_FHA_2	64	70	PF00498	0.467
LIG_LIR_Apic_2	249	254	PF02991	0.241
LIG_LIR_Apic_2	273	278	PF02991	0.438
LIG_LIR_Apic_2	88	93	PF02991	0.430
LIG_LIR_Gen_1	112	117	PF02991	0.411
LIG_LIR_Gen_1	279	287	PF02991	0.512
LIG_LIR_Gen_1	438	448	PF02991	0.469
LIG_LIR_Gen_1	64	75	PF02991	0.477
LIG_LIR_Gen_1	85	94	PF02991	0.478
LIG_LIR_Nem_3	247	251	PF02991	0.477
LIG_LIR_Nem_3	279	285	PF02991	0.512
LIG_LIR_Nem_3	297	302	PF02991	0.418
LIG_LIR_Nem_3	391	395	PF02991	0.418
LIG_LIR_Nem_3	438	443	PF02991	0.469
LIG_LIR_Nem_3	445	451	PF02991	0.433
LIG_LIR_Nem_3	469	475	PF02991	0.432
LIG_LIR_Nem_3	64	70	PF02991	0.429
LIG_LIR_Nem_3	85	89	PF02991	0.502
LIG_LYPXL_yS_3	472	475	PF13949	0.432
LIG_NRBOX	334	340	PF00104	0.438
LIG_Pex14_2	86	90	PF04695	0.399
LIG_SH2_CRK	251	255	PF00017	0.332
LIG_SH2_CRK	299	303	PF00017	0.418
LIG_SH2_CRK	395	399	PF00017	0.469
LIG_SH2_CRK	440	444	PF00017	0.514
LIG_SH2_CRK	509	513	PF00017	0.557
LIG_SH2_NCK_1	223	227	PF00017	0.466
LIG_SH2_NCK_1	395	399	PF00017	0.463
LIG_SH2_PTP2	282	285	PF00017	0.512
LIG_SH2_STAP1	67	71	PF00017	0.322
LIG_SH2_STAT3	21	24	PF00017	0.256
LIG_SH2_STAT5	109	112	PF00017	0.452
LIG_SH2_STAT5	156	159	PF00017	0.297
LIG_SH2_STAT5	282	285	PF00017	0.512
LIG_SH2_STAT5	38	41	PF00017	0.501
LIG_SH2_STAT5	67	70	PF00017	0.443
LIG_SH3_1	531	537	PF00018	0.599
LIG_SH3_3	154	160	PF00018	0.434
LIG_SH3_3	48	54	PF00018	0.467
LIG_SH3_3	531	537	PF00018	0.626
LIG_SH3_3	89	95	PF00018	0.480
LIG_SH3_4	238	245	PF00018	0.340
LIG_SH3_4	503	510	PF00018	0.565
LIG_SUMO_SIM_anti_2	2	7	PF11976	0.362
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.409
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.420
LIG_SUMO_SIM_par_1	305	311	PF11976	0.376
LIG_TRAF2_1	185	188	PF00917	0.617
LIG_TRAF2_1	499	502	PF00917	0.688
LIG_TYR_ITIM	65	70	PF00017	0.311
LIG_UBA3_1	233	238	PF00899	0.301
LIG_UBA3_1	338	344	PF00899	0.387
LIG_UBA3_1	5	12	PF00899	0.358
LIG_WRPW_2	237	240	PF00400	0.312
MOD_CDK_SPK_2	101	106	PF00069	0.387
MOD_CDK_SPK_2	492	497	PF00069	0.497
MOD_CK1_1	174	180	PF00069	0.587
MOD_CK1_1	294	300	PF00069	0.277
MOD_CK1_1	410	416	PF00069	0.414
MOD_CK1_1	85	91	PF00069	0.430
MOD_CK2_1	124	130	PF00069	0.359
MOD_CK2_1	148	154	PF00069	0.344
MOD_CK2_1	182	188	PF00069	0.475
MOD_CK2_1	24	30	PF00069	0.399
MOD_CK2_1	331	337	PF00069	0.387
MOD_CK2_1	359	365	PF00069	0.222
MOD_CK2_1	63	69	PF00069	0.453
MOD_DYRK1A_RPxSP_1	492	496	PF00069	0.465
MOD_GlcNHglycan	278	281	PF01048	0.296
MOD_GlcNHglycan	292	296	PF01048	0.270
MOD_GlcNHglycan	384	387	PF01048	0.399
MOD_GlcNHglycan	417	421	PF01048	0.365
MOD_GSK3_1	105	112	PF00069	0.311
MOD_GSK3_1	124	131	PF00069	0.474
MOD_GSK3_1	171	178	PF00069	0.549
MOD_GSK3_1	187	194	PF00069	0.707
MOD_GSK3_1	270	277	PF00069	0.251
MOD_GSK3_1	294	301	PF00069	0.262
MOD_GSK3_1	308	315	PF00069	0.383
MOD_GSK3_1	416	423	PF00069	0.342
MOD_GSK3_1	442	449	PF00069	0.383
MOD_GSK3_1	59	66	PF00069	0.452
MOD_GSK3_1	97	104	PF00069	0.333
MOD_N-GLC_1	124	129	PF02516	0.409
MOD_N-GLC_1	204	209	PF02516	0.463
MOD_N-GLC_1	410	415	PF02516	0.338
MOD_N-GLC_2	348	350	PF02516	0.387
MOD_NEK2_1	172	177	PF00069	0.523
MOD_NEK2_1	310	315	PF00069	0.315
MOD_NEK2_1	382	387	PF00069	0.252
MOD_NEK2_1	442	447	PF00069	0.303
MOD_NEK2_2	124	129	PF00069	0.409
MOD_NEK2_2	246	251	PF00069	0.323
MOD_PIKK_1	526	532	PF00454	0.522
MOD_PIKK_1	541	547	PF00454	0.549
MOD_PKA_2	36	42	PF00069	0.410
MOD_PKA_2	52	58	PF00069	0.331
MOD_PKA_2	82	88	PF00069	0.434
MOD_Plk_1	12	18	PF00069	0.367
MOD_Plk_1	124	130	PF00069	0.410
MOD_Plk_1	410	416	PF00069	0.368
MOD_Plk_2-3	191	197	PF00069	0.606
MOD_Plk_2-3	322	328	PF00069	0.387
MOD_Plk_4	105	111	PF00069	0.247
MOD_Plk_4	12	18	PF00069	0.353
MOD_Plk_4	124	130	PF00069	0.410
MOD_Plk_4	176	182	PF00069	0.626
MOD_Plk_4	270	276	PF00069	0.252
MOD_Plk_4	294	300	PF00069	0.282
MOD_Plk_4	348	354	PF00069	0.255
MOD_Plk_4	443	449	PF00069	0.299
MOD_Plk_4	538	544	PF00069	0.585
MOD_Plk_4	85	91	PF00069	0.437
MOD_ProDKin_1	101	107	PF00069	0.443
MOD_ProDKin_1	118	124	PF00069	0.542
MOD_ProDKin_1	274	280	PF00069	0.405
MOD_ProDKin_1	329	335	PF00069	0.286
MOD_ProDKin_1	492	498	PF00069	0.497
MOD_SUMO_for_1	287	290	PF00179	0.255
MOD_SUMO_for_1	319	322	PF00179	0.387
MOD_SUMO_rev_2	311	319	PF00179	0.263
MOD_SUMO_rev_2	495	504	PF00179	0.535
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.474
TRG_ENDOCYTIC_2	113	116	PF00928	0.396
TRG_ENDOCYTIC_2	282	285	PF00928	0.387
TRG_ENDOCYTIC_2	299	302	PF00928	0.255
TRG_ENDOCYTIC_2	440	443	PF00928	0.387
TRG_ENDOCYTIC_2	472	475	PF00928	0.274
TRG_ENDOCYTIC_2	67	70	PF00928	0.316
TRG_ER_diArg_1	137	139	PF00400	0.327
TRG_ER_diArg_1	450	453	PF00400	0.274
TRG_ER_diArg_1	522	524	PF00400	0.579
TRG_ER_diLys_1	546	551	PF00400	0.603
TRG_NES_CRM1_1	308	322	PF08389	0.387
TRG_NLS_MonoCore_2	545	550	PF00514	0.599
TRG_NLS_MonoExtC_3	545	550	PF00514	0.599
TRG_NLS_MonoExtN_4	546	551	PF00514	0.716
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC7	Leptomonas seymouri	76%	100%
A0A1X0NNW1	Trypanosomatidae	50%	99%
A0A3S5H6X4	Leishmania donovani	95%	100%
A0A422N2R4	Trypanosoma rangeli	51%	100%
A4H8J1	Leishmania braziliensis	87%	100%
A4HWW6	Leishmania infantum	95%	100%
C9ZPL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AQM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O74965	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	96%
Q4QRJ7	Danio rerio	25%	95%
Q54PV7	Dictyostelium discoideum	27%	91%
Q5ZKC1	Gallus gallus	24%	94%
Q7ZY11	Xenopus laevis	24%	95%
Q8BJW6	Mus musculus	25%	95%
Q9BY44	Homo sapiens	23%	94%
Q9VNX8	Drosophila melanogaster	27%	86%
V5BCM0	Trypanosoma cruzi	52%	100%