Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEU7_LEIMA

TriTrypDb:

LmjF.16.0720 , LMJLV39_160012700 , LMJSD75_160012500

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

Q4QEU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	495	499	PF00656	0.742
CLV_NRD_NRD_1	10	12	PF00675	0.609
CLV_NRD_NRD_1	290	292	PF00675	0.452
CLV_NRD_NRD_1	348	350	PF00675	0.373
CLV_NRD_NRD_1	518	520	PF00675	0.591
CLV_PCSK_KEX2_1	123	125	PF00082	0.599
CLV_PCSK_KEX2_1	290	292	PF00082	0.452
CLV_PCSK_KEX2_1	348	350	PF00082	0.373
CLV_PCSK_KEX2_1	518	520	PF00082	0.591
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.599
CLV_PCSK_SKI1_1	464	468	PF00082	0.533
DEG_APCC_DBOX_1	471	479	PF00400	0.539
DEG_MDM2_SWIB_1	135	142	PF02201	0.313
DEG_Nend_UBRbox_1	1	4	PF02207	0.525
DEG_SPOP_SBC_1	180	184	PF00917	0.404
DEG_SPOP_SBC_1	89	93	PF00917	0.607
DOC_CKS1_1	334	339	PF01111	0.460
DOC_CYCLIN_RxL_1	226	234	PF00134	0.421
DOC_CYCLIN_RxL_1	345	353	PF00134	0.368
DOC_MAPK_gen_1	123	133	PF00069	0.606
DOC_MAPK_JIP1_4	186	192	PF00069	0.451
DOC_MAPK_MEF2A_6	126	135	PF00069	0.602
DOC_MAPK_RevD_3	276	291	PF00069	0.435
DOC_PP2B_LxvP_1	209	212	PF13499	0.607
DOC_USP7_MATH_1	181	185	PF00917	0.501
DOC_USP7_MATH_1	243	247	PF00917	0.445
DOC_USP7_MATH_1	386	390	PF00917	0.518
DOC_USP7_MATH_1	398	402	PF00917	0.381
DOC_USP7_MATH_1	483	487	PF00917	0.549
DOC_USP7_MATH_1	505	509	PF00917	0.593
DOC_USP7_MATH_2	505	511	PF00917	0.522
DOC_WW_Pin1_4	109	114	PF00397	0.671
DOC_WW_Pin1_4	333	338	PF00397	0.462
LIG_14-3-3_CanoR_1	178	187	PF00244	0.388
LIG_14-3-3_CanoR_1	42	48	PF00244	0.506
LIG_14-3-3_CanoR_1	470	476	PF00244	0.540
LIG_14-3-3_CanoR_1	518	525	PF00244	0.608
LIG_14-3-3_CanoR_1	77	87	PF00244	0.528
LIG_Actin_WH2_2	149	166	PF00022	0.386
LIG_Actin_WH2_2	459	474	PF00022	0.471
LIG_BIR_III_2	498	502	PF00653	0.544
LIG_BRCT_BRCA1_1	131	135	PF00533	0.460
LIG_eIF4E_1	409	415	PF01652	0.399
LIG_FHA_1	153	159	PF00498	0.443
LIG_FHA_1	180	186	PF00498	0.461
LIG_FHA_1	225	231	PF00498	0.383
LIG_FHA_1	357	363	PF00498	0.416
LIG_FHA_1	453	459	PF00498	0.578
LIG_FHA_1	520	526	PF00498	0.577
LIG_FHA_2	411	417	PF00498	0.439
LIG_FHA_2	490	496	PF00498	0.650
LIG_FHA_2	51	57	PF00498	0.543
LIG_FHA_2	519	525	PF00498	0.560
LIG_Integrin_RGD_1	496	498	PF01839	0.534
LIG_LIR_Gen_1	143	153	PF02991	0.300
LIG_LIR_Gen_1	200	209	PF02991	0.473
LIG_LIR_Nem_3	132	138	PF02991	0.458
LIG_LIR_Nem_3	143	148	PF02991	0.307
LIG_LIR_Nem_3	200	204	PF02991	0.472
LIG_LIR_Nem_3	359	363	PF02991	0.515
LIG_LIR_Nem_3	401	405	PF02991	0.308
LIG_NRBOX	137	143	PF00104	0.321
LIG_PDZ_Class_1	538	543	PF00595	0.542
LIG_Pex14_1	44	48	PF04695	0.508
LIG_Pex14_2	135	139	PF04695	0.457
LIG_SH2_GRB2like	409	412	PF00017	0.364
LIG_SH2_NCK_1	383	387	PF00017	0.637
LIG_SH2_NCK_1	534	538	PF00017	0.392
LIG_SH2_SRC	431	434	PF00017	0.415
LIG_SH2_STAT5	360	363	PF00017	0.600
LIG_SH2_STAT5	409	412	PF00017	0.364
LIG_SH2_STAT5	431	434	PF00017	0.415
LIG_SH3_3	210	216	PF00018	0.545
LIG_SH3_3	29	35	PF00018	0.725
LIG_SUMO_SIM_anti_2	143	151	PF11976	0.302
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.469
LIG_SUMO_SIM_par_1	159	166	PF11976	0.273
LIG_SUMO_SIM_par_1	22	28	PF11976	0.626
LIG_SUMO_SIM_par_1	229	234	PF11976	0.402
LIG_SUMO_SIM_par_1	60	65	PF11976	0.496
LIG_TRAF2_1	53	56	PF00917	0.582
MOD_CK1_1	111	117	PF00069	0.675
MOD_CK1_1	19	25	PF00069	0.615
MOD_CK1_1	260	266	PF00069	0.321
MOD_CK1_1	364	370	PF00069	0.481
MOD_CK1_1	508	514	PF00069	0.708
MOD_CK1_1	78	84	PF00069	0.700
MOD_CK2_1	191	197	PF00069	0.608
MOD_CK2_1	410	416	PF00069	0.446
MOD_CK2_1	489	495	PF00069	0.645
MOD_CK2_1	50	56	PF00069	0.513
MOD_CK2_1	511	517	PF00069	0.590
MOD_CK2_1	518	524	PF00069	0.483
MOD_CK2_1	79	85	PF00069	0.493
MOD_GlcNHglycan	21	24	PF01048	0.643
MOD_GlcNHglycan	232	236	PF01048	0.530
MOD_GlcNHglycan	294	297	PF01048	0.444
MOD_GlcNHglycan	328	331	PF01048	0.652
MOD_GlcNHglycan	377	380	PF01048	0.536
MOD_GlcNHglycan	388	391	PF01048	0.724
MOD_GlcNHglycan	485	488	PF01048	0.589
MOD_GlcNHglycan	513	516	PF01048	0.546
MOD_GlcNHglycan	81	84	PF01048	0.691
MOD_GlcNHglycan	98	101	PF01048	0.647
MOD_GSK3_1	105	112	PF00069	0.636
MOD_GSK3_1	148	155	PF00069	0.375
MOD_GSK3_1	15	22	PF00069	0.534
MOD_GSK3_1	159	166	PF00069	0.368
MOD_GSK3_1	211	218	PF00069	0.576
MOD_GSK3_1	219	226	PF00069	0.521
MOD_GSK3_1	243	250	PF00069	0.436
MOD_GSK3_1	253	260	PF00069	0.303
MOD_GSK3_1	311	318	PF00069	0.346
MOD_GSK3_1	447	454	PF00069	0.523
MOD_GSK3_1	479	486	PF00069	0.508
MOD_GSK3_1	507	514	PF00069	0.559
MOD_GSK3_1	519	526	PF00069	0.523
MOD_GSK3_1	75	82	PF00069	0.598
MOD_GSK3_1	89	96	PF00069	0.546
MOD_N-GLC_1	257	262	PF02516	0.437
MOD_N-GLC_1	410	415	PF02516	0.365
MOD_N-GLC_1	483	488	PF02516	0.723
MOD_NEK2_1	15	20	PF00069	0.634
MOD_NEK2_1	152	157	PF00069	0.388
MOD_NEK2_1	163	168	PF00069	0.297
MOD_NEK2_1	204	209	PF00069	0.467
MOD_NEK2_1	231	236	PF00069	0.381
MOD_NEK2_1	247	252	PF00069	0.370
MOD_NEK2_1	350	355	PF00069	0.309
MOD_NEK2_1	356	361	PF00069	0.345
MOD_NEK2_1	385	390	PF00069	0.580
MOD_NEK2_1	410	415	PF00069	0.365
MOD_NEK2_1	449	454	PF00069	0.546
MOD_NEK2_1	479	484	PF00069	0.552
MOD_NEK2_1	7	12	PF00069	0.518
MOD_NEK2_1	73	78	PF00069	0.520
MOD_NEK2_1	88	93	PF00069	0.577
MOD_NEK2_2	181	186	PF00069	0.398
MOD_NEK2_2	224	229	PF00069	0.418
MOD_NEK2_2	43	48	PF00069	0.466
MOD_NEK2_2	459	464	PF00069	0.566
MOD_PIKK_1	505	511	PF00454	0.733
MOD_PKA_1	518	524	PF00069	0.567
MOD_PKA_2	163	169	PF00069	0.331
MOD_PKA_2	375	381	PF00069	0.528
MOD_PKA_2	440	446	PF00069	0.491
MOD_PKA_2	471	477	PF00069	0.550
MOD_PKA_2	518	524	PF00069	0.633
MOD_Plk_1	260	266	PF00069	0.343
MOD_Plk_1	364	370	PF00069	0.476
MOD_Plk_1	410	416	PF00069	0.370
MOD_Plk_4	243	249	PF00069	0.395
MOD_Plk_4	356	362	PF00069	0.405
MOD_Plk_4	410	416	PF00069	0.446
MOD_Plk_4	43	49	PF00069	0.507
MOD_Plk_4	508	514	PF00069	0.690
MOD_ProDKin_1	109	115	PF00069	0.671
MOD_ProDKin_1	333	339	PF00069	0.460
MOD_SUMO_rev_2	430	436	PF00179	0.409
TRG_DiLeu_BaEn_1	524	529	PF01217	0.468
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.363
TRG_ENDOCYTIC_2	360	363	PF00928	0.576
TRG_ER_diArg_1	289	291	PF00400	0.451
TRG_ER_diArg_1	347	349	PF00400	0.489
TRG_ER_diArg_1	518	520	PF00400	0.591
TRG_NLS_MonoExtC_3	10	16	PF00514	0.512
TRG_NLS_MonoExtC_3	122	128	PF00514	0.555
TRG_NLS_MonoExtN_4	9	15	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	174	179	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG7	Leptomonas seymouri	36%	100%
A0A3S5H6X5	Leishmania donovani	85%	100%
A4H8J4	Leishmania braziliensis	68%	100%
A4HWW9	Leishmania infantum	86%	100%
E9AQN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%