DNA-directed DNA polymerase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEU5_LEIMA

TriTrypDb:

LmjF.16.0740 , LMJLV39_160012900 , LMJSD75_160012700

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	297	301	PF00656	0.672
CLV_C14_Caspase3-7	329	333	PF00656	0.702
CLV_NRD_NRD_1	114	116	PF00675	0.464
CLV_NRD_NRD_1	169	171	PF00675	0.622
CLV_NRD_NRD_1	31	33	PF00675	0.636
CLV_NRD_NRD_1	37	39	PF00675	0.524
CLV_NRD_NRD_1	618	620	PF00675	0.635
CLV_NRD_NRD_1	622	624	PF00675	0.615
CLV_PCSK_FUR_1	111	115	PF00082	0.578
CLV_PCSK_KEX2_1	113	115	PF00082	0.500
CLV_PCSK_KEX2_1	169	171	PF00082	0.622
CLV_PCSK_KEX2_1	31	33	PF00082	0.636
CLV_PCSK_KEX2_1	37	39	PF00082	0.524
CLV_PCSK_KEX2_1	386	388	PF00082	0.611
CLV_PCSK_KEX2_1	618	620	PF00082	0.637
CLV_PCSK_KEX2_1	622	624	PF00082	0.614
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.675
CLV_PCSK_PC7_1	614	620	PF00082	0.564
CLV_PCSK_SKI1_1	337	341	PF00082	0.433
CLV_PCSK_SKI1_1	614	618	PF00082	0.536
DEG_APCC_DBOX_1	336	344	PF00400	0.443
DEG_Nend_Nbox_1	1	3	PF02207	0.807
DEG_SCF_FBW7_1	680	686	PF00400	0.664
DEG_SPOP_SBC_1	513	517	PF00917	0.675
DEG_SPOP_SBC_1	55	59	PF00917	0.602
DOC_ANK_TNKS_1	423	430	PF00023	0.479
DOC_CKS1_1	537	542	PF01111	0.567
DOC_CKS1_1	680	685	PF01111	0.621
DOC_MAPK_DCC_7	88	97	PF00069	0.511
DOC_MAPK_gen_1	251	260	PF00069	0.531
DOC_MAPK_gen_1	639	649	PF00069	0.464
DOC_MAPK_MEF2A_6	254	262	PF00069	0.502
DOC_MAPK_MEF2A_6	650	657	PF00069	0.501
DOC_MAPK_MEF2A_6	88	97	PF00069	0.511
DOC_PP2B_LxvP_1	493	496	PF13499	0.665
DOC_USP7_MATH_1	131	135	PF00917	0.500
DOC_USP7_MATH_1	192	196	PF00917	0.683
DOC_USP7_MATH_1	227	231	PF00917	0.744
DOC_USP7_MATH_1	235	239	PF00917	0.739
DOC_USP7_MATH_1	294	298	PF00917	0.679
DOC_USP7_MATH_1	314	318	PF00917	0.536
DOC_USP7_MATH_1	326	330	PF00917	0.670
DOC_USP7_MATH_1	363	367	PF00917	0.571
DOC_USP7_MATH_1	487	491	PF00917	0.602
DOC_USP7_MATH_1	55	59	PF00917	0.593
DOC_USP7_MATH_1	550	554	PF00917	0.561
DOC_USP7_MATH_1	576	580	PF00917	0.644
DOC_USP7_MATH_1	626	630	PF00917	0.731
DOC_USP7_MATH_1	718	722	PF00917	0.536
DOC_WW_Pin1_4	140	145	PF00397	0.457
DOC_WW_Pin1_4	188	193	PF00397	0.679
DOC_WW_Pin1_4	228	233	PF00397	0.678
DOC_WW_Pin1_4	236	241	PF00397	0.581
DOC_WW_Pin1_4	285	290	PF00397	0.527
DOC_WW_Pin1_4	330	335	PF00397	0.592
DOC_WW_Pin1_4	367	372	PF00397	0.587
DOC_WW_Pin1_4	436	441	PF00397	0.557
DOC_WW_Pin1_4	491	496	PF00397	0.681
DOC_WW_Pin1_4	503	508	PF00397	0.678
DOC_WW_Pin1_4	536	541	PF00397	0.581
DOC_WW_Pin1_4	59	64	PF00397	0.657
DOC_WW_Pin1_4	679	684	PF00397	0.659
DOC_WW_Pin1_4	711	716	PF00397	0.615
DOC_WW_Pin1_4	73	78	PF00397	0.747
DOC_WW_Pin1_4	83	88	PF00397	0.665
LIG_14-3-3_CanoR_1	113	119	PF00244	0.464
LIG_14-3-3_CanoR_1	130	139	PF00244	0.451
LIG_14-3-3_CanoR_1	337	347	PF00244	0.460
LIG_14-3-3_CanoR_1	348	353	PF00244	0.531
LIG_14-3-3_CanoR_1	445	455	PF00244	0.590
LIG_14-3-3_CanoR_1	468	476	PF00244	0.570
LIG_14-3-3_CanoR_1	631	638	PF00244	0.494
LIG_14-3-3_CanoR_1	723	729	PF00244	0.436
LIG_BIR_III_4	223	227	PF00653	0.564
LIG_Clathr_ClatBox_1	479	483	PF01394	0.606
LIG_eIF4E_1	732	738	PF01652	0.419
LIG_FHA_1	141	147	PF00498	0.558
LIG_FHA_1	21	27	PF00498	0.637
LIG_FHA_1	231	237	PF00498	0.596
LIG_FHA_1	279	285	PF00498	0.454
LIG_FHA_1	286	292	PF00498	0.562
LIG_FHA_1	340	346	PF00498	0.487
LIG_FHA_1	354	360	PF00498	0.581
LIG_FHA_1	524	530	PF00498	0.645
LIG_FHA_1	650	656	PF00498	0.503
LIG_FHA_1	664	670	PF00498	0.383
LIG_FHA_1	702	708	PF00498	0.527
LIG_FHA_2	130	136	PF00498	0.370
LIG_FHA_2	339	345	PF00498	0.446
LIG_FHA_2	352	358	PF00498	0.618
LIG_FHA_2	595	601	PF00498	0.649
LIG_Integrin_isoDGR_2	252	254	PF01839	0.571
LIG_LIR_Gen_1	404	415	PF02991	0.542
LIG_LIR_Nem_3	241	247	PF02991	0.438
LIG_LIR_Nem_3	404	410	PF02991	0.539
LIG_LIR_Nem_3	459	464	PF02991	0.503
LIG_LIR_Nem_3	729	735	PF02991	0.425
LIG_LYPXL_yS_3	732	735	PF13949	0.415
LIG_MYND_1	73	77	PF01753	0.560
LIG_PCNA_yPIPBox_3	725	738	PF02747	0.427
LIG_PDZ_Class_2	734	739	PF00595	0.427
LIG_Pex14_1	664	668	PF04695	0.454
LIG_Pex14_2	430	434	PF04695	0.510
LIG_Rb_LxCxE_1	168	191	PF01857	0.557
LIG_SH2_CRK	244	248	PF00017	0.413
LIG_SH2_NCK_1	67	71	PF00017	0.560
LIG_SH2_STAP1	51	55	PF00017	0.596
LIG_SH2_STAT3	673	676	PF00017	0.555
LIG_SH2_STAT5	174	177	PF00017	0.520
LIG_SH2_STAT5	461	464	PF00017	0.495
LIG_SH2_STAT5	668	671	PF00017	0.458
LIG_SH3_1	74	80	PF00018	0.688
LIG_SH3_1	88	94	PF00018	0.472
LIG_SH3_3	159	165	PF00018	0.608
LIG_SH3_3	197	203	PF00018	0.697
LIG_SH3_3	229	235	PF00018	0.612
LIG_SH3_3	288	294	PF00018	0.561
LIG_SH3_3	486	492	PF00018	0.781
LIG_SH3_3	494	500	PF00018	0.766
LIG_SH3_3	534	540	PF00018	0.543
LIG_SH3_3	600	606	PF00018	0.555
LIG_SH3_3	645	651	PF00018	0.443
LIG_SH3_3	74	80	PF00018	0.747
LIG_SH3_3	84	90	PF00018	0.627
LIG_SUMO_SIM_par_1	134	143	PF11976	0.428
LIG_SUMO_SIM_par_1	280	286	PF11976	0.515
LIG_SUMO_SIM_par_1	341	346	PF11976	0.463
LIG_SUMO_SIM_par_1	651	656	PF11976	0.498
LIG_SUMO_SIM_par_1	93	99	PF11976	0.450
LIG_TRAF2_1	117	120	PF00917	0.452
LIG_TRAF2_1	441	444	PF00917	0.594
LIG_WW_3	161	165	PF00397	0.650
LIG_WW_3	292	296	PF00397	0.634
MOD_CDK_SPK_2	503	508	PF00069	0.679
MOD_CDK_SPK_2	711	716	PF00069	0.577
MOD_CDK_SPK_2	83	88	PF00069	0.593
MOD_CDK_SPxxK_3	236	243	PF00069	0.556
MOD_CDK_SPxxK_3	330	337	PF00069	0.554
MOD_CK1_1	105	111	PF00069	0.521
MOD_CK1_1	188	194	PF00069	0.720
MOD_CK1_1	230	236	PF00069	0.636
MOD_CK1_1	238	244	PF00069	0.453
MOD_CK1_1	309	315	PF00069	0.669
MOD_CK1_1	316	322	PF00069	0.612
MOD_CK1_1	351	357	PF00069	0.544
MOD_CK1_1	370	376	PF00069	0.582
MOD_CK1_1	380	386	PF00069	0.636
MOD_CK1_1	517	523	PF00069	0.697
MOD_CK1_1	53	59	PF00069	0.609
MOD_CK1_1	546	552	PF00069	0.646
MOD_CK1_1	594	600	PF00069	0.566
MOD_CK1_1	66	72	PF00069	0.544
MOD_CK1_1	711	717	PF00069	0.546
MOD_CK1_1	96	102	PF00069	0.433
MOD_CK2_1	114	120	PF00069	0.516
MOD_CK2_1	139	145	PF00069	0.446
MOD_CK2_1	351	357	PF00069	0.591
MOD_CK2_1	577	583	PF00069	0.640
MOD_CK2_1	655	661	PF00069	0.473
MOD_DYRK1A_RPxSP_1	285	289	PF00069	0.466
MOD_DYRK1A_RPxSP_1	436	440	PF00069	0.549
MOD_DYRK1A_RPxSP_1	491	495	PF00069	0.578
MOD_GlcNHglycan	103	107	PF01048	0.542
MOD_GlcNHglycan	194	197	PF01048	0.630
MOD_GlcNHglycan	316	319	PF01048	0.668
MOD_GlcNHglycan	365	368	PF01048	0.656
MOD_GlcNHglycan	382	385	PF01048	0.519
MOD_GlcNHglycan	42	45	PF01048	0.614
MOD_GlcNHglycan	508	511	PF01048	0.729
MOD_GlcNHglycan	516	519	PF01048	0.579
MOD_GlcNHglycan	548	551	PF01048	0.684
MOD_GlcNHglycan	558	561	PF01048	0.587
MOD_GlcNHglycan	573	577	PF01048	0.583
MOD_GlcNHglycan	579	582	PF01048	0.731
MOD_GlcNHglycan	597	600	PF01048	0.494
MOD_GlcNHglycan	628	631	PF01048	0.625
MOD_GlcNHglycan	632	635	PF01048	0.567
MOD_GlcNHglycan	656	660	PF01048	0.657
MOD_GlcNHglycan	677	680	PF01048	0.559
MOD_GlcNHglycan	683	686	PF01048	0.630
MOD_GSK3_1	125	132	PF00069	0.362
MOD_GSK3_1	188	195	PF00069	0.650
MOD_GSK3_1	26	33	PF00069	0.583
MOD_GSK3_1	301	308	PF00069	0.797
MOD_GSK3_1	309	316	PF00069	0.635
MOD_GSK3_1	326	333	PF00069	0.721
MOD_GSK3_1	339	346	PF00069	0.411
MOD_GSK3_1	363	370	PF00069	0.588
MOD_GSK3_1	373	380	PF00069	0.656
MOD_GSK3_1	487	494	PF00069	0.593
MOD_GSK3_1	499	506	PF00069	0.577
MOD_GSK3_1	50	57	PF00069	0.628
MOD_GSK3_1	513	520	PF00069	0.642
MOD_GSK3_1	546	553	PF00069	0.648
MOD_GSK3_1	572	579	PF00069	0.631
MOD_GSK3_1	59	66	PF00069	0.581
MOD_GSK3_1	591	598	PF00069	0.519
MOD_GSK3_1	626	633	PF00069	0.695
MOD_GSK3_1	663	670	PF00069	0.504
MOD_GSK3_1	671	678	PF00069	0.532
MOD_GSK3_1	679	686	PF00069	0.590
MOD_N-GLC_1	188	193	PF02516	0.572
MOD_N-GLC_2	448	450	PF02516	0.634
MOD_NEK2_1	139	144	PF00069	0.543
MOD_NEK2_1	26	31	PF00069	0.689
MOD_NEK2_1	343	348	PF00069	0.633
MOD_NEK2_1	430	435	PF00069	0.544
MOD_NEK2_1	555	560	PF00069	0.585
MOD_NEK2_2	701	706	PF00069	0.500
MOD_PIKK_1	373	379	PF00454	0.594
MOD_PIKK_1	663	669	PF00454	0.421
MOD_PIKK_1	672	678	PF00454	0.491
MOD_PIKK_1	699	705	PF00454	0.629
MOD_PIKK_1	75	81	PF00454	0.689
MOD_PK_1	263	269	PF00069	0.493
MOD_PKA_1	114	120	PF00069	0.454
MOD_PKA_2	114	120	PF00069	0.455
MOD_PKA_2	129	135	PF00069	0.425
MOD_PKA_2	185	191	PF00069	0.621
MOD_PKA_2	294	300	PF00069	0.650
MOD_PKA_2	30	36	PF00069	0.607
MOD_PKA_2	444	450	PF00069	0.598
MOD_PKA_2	464	470	PF00069	0.711
MOD_PKA_2	546	552	PF00069	0.579
MOD_PKA_2	630	636	PF00069	0.537
MOD_PKA_2	649	655	PF00069	0.592
MOD_PKA_2	718	724	PF00069	0.501
MOD_PKA_2	9	15	PF00069	0.677
MOD_Plk_1	343	349	PF00069	0.509
MOD_Plk_1	430	436	PF00069	0.552
MOD_Plk_1	591	597	PF00069	0.585
MOD_Plk_1	599	605	PF00069	0.545
MOD_Plk_1	655	661	PF00069	0.427
MOD_Plk_4	263	269	PF00069	0.434
MOD_Plk_4	430	436	PF00069	0.552
MOD_Plk_4	524	530	PF00069	0.599
MOD_Plk_4	550	556	PF00069	0.431
MOD_Plk_4	733	739	PF00069	0.423
MOD_Plk_4	93	99	PF00069	0.496
MOD_ProDKin_1	140	146	PF00069	0.451
MOD_ProDKin_1	188	194	PF00069	0.679
MOD_ProDKin_1	228	234	PF00069	0.675
MOD_ProDKin_1	236	242	PF00069	0.559
MOD_ProDKin_1	285	291	PF00069	0.541
MOD_ProDKin_1	330	336	PF00069	0.575
MOD_ProDKin_1	367	373	PF00069	0.590
MOD_ProDKin_1	436	442	PF00069	0.563
MOD_ProDKin_1	491	497	PF00069	0.680
MOD_ProDKin_1	503	509	PF00069	0.678
MOD_ProDKin_1	536	542	PF00069	0.577
MOD_ProDKin_1	59	65	PF00069	0.661
MOD_ProDKin_1	679	685	PF00069	0.661
MOD_ProDKin_1	711	717	PF00069	0.609
MOD_ProDKin_1	73	79	PF00069	0.749
MOD_ProDKin_1	83	89	PF00069	0.656
TRG_DiLeu_BaEn_2	256	262	PF01217	0.409
TRG_DiLeu_BaLyEn_6	730	735	PF01217	0.430
TRG_ENDOCYTIC_2	244	247	PF00928	0.413
TRG_ENDOCYTIC_2	407	410	PF00928	0.542
TRG_ENDOCYTIC_2	461	464	PF00928	0.495
TRG_ENDOCYTIC_2	732	735	PF00928	0.415
TRG_ER_diArg_1	111	114	PF00400	0.622
TRG_ER_diArg_1	169	172	PF00400	0.625
TRG_ER_diArg_1	2	5	PF00400	0.625
TRG_ER_diArg_1	284	287	PF00400	0.445
TRG_ER_diArg_1	30	32	PF00400	0.578
TRG_ER_diArg_1	452	455	PF00400	0.567
TRG_ER_diArg_1	617	619	PF00400	0.628
TRG_ER_diArg_1	621	623	PF00400	0.618
TRG_NES_CRM1_1	271	283	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A3	Leptomonas seymouri	49%	100%
A0A3Q8IAD7	Leishmania donovani	91%	100%
A4H8J6	Leishmania braziliensis	74%	99%
A4HWX1	Leishmania infantum	91%	100%
E9AQN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%