ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QEU4_LEIMA

TriTrypDb:

LmjF.16.0750 , LMJLV39_160013000 , LMJSD75_160012800

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.654
CLV_C14_Caspase3-7	290	294	PF00656	0.590
CLV_C14_Caspase3-7	321	325	PF00656	0.440
CLV_C14_Caspase3-7	338	342	PF00656	0.456
CLV_C14_Caspase3-7	368	372	PF00656	0.597
CLV_C14_Caspase3-7	451	455	PF00656	0.508
CLV_C14_Caspase3-7	490	494	PF00656	0.639
CLV_C14_Caspase3-7	558	562	PF00656	0.614
CLV_NRD_NRD_1	552	554	PF00675	0.561
CLV_NRD_NRD_1	586	588	PF00675	0.557
CLV_PCSK_FUR_1	583	587	PF00082	0.496
CLV_PCSK_KEX2_1	551	553	PF00082	0.565
CLV_PCSK_KEX2_1	585	587	PF00082	0.570
CLV_PCSK_KEX2_1	68	70	PF00082	0.434
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.427
CLV_PCSK_SKI1_1	213	217	PF00082	0.555
CLV_PCSK_SKI1_1	230	234	PF00082	0.255
CLV_PCSK_SKI1_1	25	29	PF00082	0.481
CLV_PCSK_SKI1_1	252	256	PF00082	0.468
CLV_PCSK_SKI1_1	425	429	PF00082	0.483
CLV_PCSK_SKI1_1	51	55	PF00082	0.345
DEG_Nend_Nbox_1	1	3	PF02207	0.375
DEG_SCF_FBW7_1	15	20	PF00400	0.420
DEG_SPOP_SBC_1	365	369	PF00917	0.573
DEG_SPOP_SBC_1	487	491	PF00917	0.648
DEG_SPOP_SBC_1	555	559	PF00917	0.616
DOC_CYCLIN_RxL_1	21	30	PF00134	0.411
DOC_CYCLIN_RxL_1	420	432	PF00134	0.455
DOC_MAPK_DCC_7	44	52	PF00069	0.392
DOC_MAPK_MEF2A_6	44	52	PF00069	0.399
DOC_PP1_RVXF_1	565	572	PF00149	0.429
DOC_PP4_MxPP_1	177	180	PF00568	0.453
DOC_USP7_MATH_1	109	113	PF00917	0.750
DOC_USP7_MATH_1	155	159	PF00917	0.595
DOC_USP7_MATH_1	200	204	PF00917	0.704
DOC_USP7_MATH_1	206	210	PF00917	0.650
DOC_USP7_MATH_1	289	293	PF00917	0.548
DOC_USP7_MATH_1	555	559	PF00917	0.640
DOC_WW_Pin1_4	104	109	PF00397	0.715
DOC_WW_Pin1_4	13	18	PF00397	0.388
DOC_WW_Pin1_4	293	298	PF00397	0.565
DOC_WW_Pin1_4	305	310	PF00397	0.366
DOC_WW_Pin1_4	446	451	PF00397	0.325
DOC_WW_Pin1_4	466	471	PF00397	0.499
LIG_14-3-3_CanoR_1	213	218	PF00244	0.437
LIG_14-3-3_CanoR_1	69	78	PF00244	0.453
LIG_14-3-3_CterR_2	598	603	PF00244	0.542
LIG_APCC_ABBA_1	50	55	PF00400	0.392
LIG_BIR_III_2	328	332	PF00653	0.414
LIG_BIR_III_4	114	118	PF00653	0.494
LIG_BIR_III_4	199	203	PF00653	0.605
LIG_BIR_III_4	288	292	PF00653	0.535
LIG_EVH1_2	461	465	PF00568	0.404
LIG_FHA_1	116	122	PF00498	0.356
LIG_FHA_1	294	300	PF00498	0.545
LIG_FHA_1	57	63	PF00498	0.408
LIG_FHA_2	336	342	PF00498	0.454
LIG_FHA_2	488	494	PF00498	0.655
LIG_LIR_Gen_1	132	142	PF02991	0.469
LIG_LIR_Gen_1	265	275	PF02991	0.407
LIG_LIR_Nem_3	132	138	PF02991	0.498
LIG_LIR_Nem_3	186	191	PF02991	0.431
LIG_LIR_Nem_3	265	270	PF02991	0.402
LIG_LIR_Nem_3	359	365	PF02991	0.427
LIG_LIR_Nem_3	72	78	PF02991	0.442
LIG_LYPXL_S_1	74	78	PF13949	0.432
LIG_LYPXL_yS_3	75	78	PF13949	0.435
LIG_MYND_1	76	80	PF01753	0.436
LIG_NRBOX	270	276	PF00104	0.376
LIG_NRBOX	532	538	PF00104	0.385
LIG_Pex14_1	49	53	PF04695	0.338
LIG_Pex14_1	71	75	PF04695	0.369
LIG_Pex14_2	2	6	PF04695	0.355
LIG_Pex14_2	358	362	PF04695	0.366
LIG_PTAP_UEV_1	151	156	PF05743	0.637
LIG_SH2_STAT3	191	194	PF00017	0.470
LIG_SH2_STAT3	31	34	PF00017	0.451
LIG_SH2_STAT5	120	123	PF00017	0.340
LIG_SH2_STAT5	26	29	PF00017	0.391
LIG_SH2_STAT5	31	34	PF00017	0.404
LIG_SH3_3	100	106	PF00018	0.739
LIG_SH3_3	149	155	PF00018	0.643
LIG_SH3_3	277	283	PF00018	0.532
LIG_SH3_3	303	309	PF00018	0.418
LIG_SH3_3	450	456	PF00018	0.425
LIG_TRAF2_1	184	187	PF00917	0.480
MOD_CDK_SPK_2	466	471	PF00069	0.451
MOD_CDK_SPxK_1	15	21	PF00069	0.422
MOD_CK1_1	209	215	PF00069	0.504
MOD_CK1_1	367	373	PF00069	0.709
MOD_CK1_1	491	497	PF00069	0.627
MOD_CK1_1	539	545	PF00069	0.449
MOD_CK1_1	554	560	PF00069	0.487
MOD_Cter_Amidation	66	69	PF01082	0.391
MOD_GlcNHglycan	152	155	PF01048	0.734
MOD_GlcNHglycan	208	211	PF01048	0.609
MOD_GlcNHglycan	264	267	PF01048	0.297
MOD_GlcNHglycan	287	292	PF01048	0.654
MOD_GlcNHglycan	490	493	PF01048	0.654
MOD_GlcNHglycan	553	556	PF01048	0.538
MOD_GSK3_1	11	18	PF00069	0.389
MOD_GSK3_1	209	216	PF00069	0.568
MOD_GSK3_1	258	265	PF00069	0.460
MOD_GSK3_1	289	296	PF00069	0.639
MOD_GSK3_1	301	308	PF00069	0.328
MOD_GSK3_1	361	368	PF00069	0.594
MOD_GSK3_1	403	410	PF00069	0.411
MOD_GSK3_1	487	494	PF00069	0.651
MOD_GSK3_1	551	558	PF00069	0.579
MOD_GSK3_1	596	603	PF00069	0.562
MOD_LATS_1	148	154	PF00433	0.591
MOD_LATS_1	23	29	PF00433	0.479
MOD_NEK2_1	11	16	PF00069	0.381
MOD_NEK2_1	129	134	PF00069	0.365
MOD_NEK2_1	27	32	PF00069	0.453
MOD_NEK2_1	301	306	PF00069	0.395
MOD_NEK2_1	374	379	PF00069	0.490
MOD_NEK2_1	438	443	PF00069	0.396
MOD_NEK2_1	512	517	PF00069	0.667
MOD_NEK2_1	536	541	PF00069	0.405
MOD_OFUCOSY	416	423	PF10250	0.283
MOD_PIKK_1	200	206	PF00454	0.672
MOD_PIKK_1	403	409	PF00454	0.416
MOD_PIKK_1	438	444	PF00454	0.571
MOD_PIKK_1	69	75	PF00454	0.447
MOD_PKA_1	551	557	PF00069	0.504
MOD_PKA_2	512	518	PF00069	0.448
MOD_PKA_2	551	557	PF00069	0.504
MOD_PKA_2	597	603	PF00069	0.574
MOD_Plk_4	115	121	PF00069	0.412
MOD_ProDKin_1	104	110	PF00069	0.716
MOD_ProDKin_1	13	19	PF00069	0.396
MOD_ProDKin_1	293	299	PF00069	0.548
MOD_ProDKin_1	305	311	PF00069	0.367
MOD_ProDKin_1	446	452	PF00069	0.335
MOD_ProDKin_1	466	472	PF00069	0.517
MOD_SUMO_rev_2	398	406	PF00179	0.419
TRG_DiLeu_BaEn_1	432	437	PF01217	0.539
TRG_ENDOCYTIC_2	26	29	PF00928	0.391
TRG_ENDOCYTIC_2	75	78	PF00928	0.359
TRG_ER_diArg_1	130	133	PF00400	0.377
TRG_ER_diArg_1	394	397	PF00400	0.484
TRG_ER_diArg_1	551	553	PF00400	0.561
TRG_ER_diArg_1	583	586	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z9	Leptomonas seymouri	52%	100%
A0A3S7WTW8	Leishmania donovani	93%	100%
A4H8J7	Leishmania braziliensis	81%	99%
A4HWX2	Leishmania infantum	94%	100%
E9AQN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%