TIR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEU2_LEIMA

TriTrypDb:

LmjF.16.0770 , LMJLV39_160013300 , LMJSD75_160013100

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.736
CLV_C14_Caspase3-7	405	409	PF00656	0.590
CLV_C14_Caspase3-7	500	504	PF00656	0.489
CLV_NRD_NRD_1	26	28	PF00675	0.515
CLV_NRD_NRD_1	326	328	PF00675	0.759
CLV_NRD_NRD_1	372	374	PF00675	0.825
CLV_NRD_NRD_1	400	402	PF00675	0.749
CLV_NRD_NRD_1	509	511	PF00675	0.432
CLV_NRD_NRD_1	512	514	PF00675	0.443
CLV_NRD_NRD_1	566	568	PF00675	0.524
CLV_NRD_NRD_1	87	89	PF00675	0.531
CLV_PCSK_FUR_1	510	514	PF00082	0.594
CLV_PCSK_KEX2_1	28	30	PF00082	0.537
CLV_PCSK_KEX2_1	372	374	PF00082	0.825
CLV_PCSK_KEX2_1	509	511	PF00082	0.432
CLV_PCSK_KEX2_1	512	514	PF00082	0.443
CLV_PCSK_KEX2_1	565	567	PF00082	0.531
CLV_PCSK_KEX2_1	590	592	PF00082	0.707
CLV_PCSK_KEX2_1	86	88	PF00082	0.551
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.537
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.721
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.572
CLV_PCSK_PC7_1	562	568	PF00082	0.521
CLV_PCSK_SKI1_1	431	435	PF00082	0.584
CLV_PCSK_SKI1_1	516	520	PF00082	0.402
CLV_PCSK_SKI1_1	87	91	PF00082	0.520
DEG_SPOP_SBC_1	112	116	PF00917	0.748
DOC_CDC14_PxL_1	579	587	PF14671	0.645
DOC_CYCLIN_RxL_1	59	71	PF00134	0.502
DOC_PP2B_LxvP_1	152	155	PF13499	0.703
DOC_PP2B_LxvP_1	315	318	PF13499	0.584
DOC_PP2B_LxvP_1	584	587	PF13499	0.636
DOC_PP4_FxxP_1	3	6	PF00568	0.492
DOC_USP7_MATH_1	128	132	PF00917	0.727
DOC_USP7_MATH_1	141	145	PF00917	0.681
DOC_USP7_MATH_1	147	151	PF00917	0.662
DOC_USP7_MATH_1	15	19	PF00917	0.499
DOC_USP7_MATH_1	227	231	PF00917	0.719
DOC_USP7_MATH_1	279	283	PF00917	0.709
DOC_USP7_MATH_1	326	330	PF00917	0.695
DOC_USP7_MATH_1	377	381	PF00917	0.796
DOC_USP7_MATH_1	433	437	PF00917	0.621
DOC_USP7_MATH_1	50	54	PF00917	0.666
DOC_USP7_MATH_1	593	597	PF00917	0.705
DOC_USP7_MATH_1	602	606	PF00917	0.713
DOC_WW_Pin1_4	1	6	PF00397	0.503
DOC_WW_Pin1_4	114	119	PF00397	0.735
DOC_WW_Pin1_4	143	148	PF00397	0.715
DOC_WW_Pin1_4	217	222	PF00397	0.728
DOC_WW_Pin1_4	223	228	PF00397	0.738
DOC_WW_Pin1_4	243	248	PF00397	0.623
DOC_WW_Pin1_4	250	255	PF00397	0.730
DOC_WW_Pin1_4	359	364	PF00397	0.721
DOC_WW_Pin1_4	7	12	PF00397	0.477
LIG_14-3-3_CanoR_1	104	113	PF00244	0.598
LIG_14-3-3_CanoR_1	122	127	PF00244	0.788
LIG_14-3-3_CanoR_1	233	243	PF00244	0.758
LIG_BRCT_BRCA1_1	503	507	PF00533	0.584
LIG_Clathr_ClatBox_1	529	533	PF01394	0.441
LIG_eIF4E_1	579	585	PF01652	0.483
LIG_FHA_1	108	114	PF00498	0.685
LIG_FHA_1	115	121	PF00498	0.720
LIG_FHA_1	199	205	PF00498	0.726
LIG_FHA_1	244	250	PF00498	0.723
LIG_FHA_1	364	370	PF00498	0.747
LIG_FHA_1	46	52	PF00498	0.601
LIG_FHA_1	496	502	PF00498	0.472
LIG_FHA_1	532	538	PF00498	0.573
LIG_FHA_1	59	65	PF00498	0.526
LIG_FHA_2	190	196	PF00498	0.768
LIG_FHA_2	424	430	PF00498	0.557
LIG_FHA_2	540	546	PF00498	0.475
LIG_FHA_2	88	94	PF00498	0.624
LIG_Integrin_RGD_1	406	408	PF01839	0.703
LIG_LIR_Apic_2	148	154	PF02991	0.710
LIG_LIR_Gen_1	539	546	PF02991	0.452
LIG_LIR_Nem_3	177	183	PF02991	0.747
LIG_LIR_Nem_3	440	446	PF02991	0.618
LIG_LIR_Nem_3	539	543	PF02991	0.426
LIG_MLH1_MIPbox_1	503	507	PF16413	0.619
LIG_MYND_1	343	347	PF01753	0.597
LIG_MYND_1	583	587	PF01753	0.656
LIG_PTB_Apo_2	484	491	PF02174	0.473
LIG_REV1ctd_RIR_1	504	514	PF16727	0.500
LIG_SH2_CRK	183	187	PF00017	0.574
LIG_SH2_CRK	579	583	PF00017	0.478
LIG_SH2_NCK_1	579	583	PF00017	0.478
LIG_SH2_SRC	151	154	PF00017	0.705
LIG_SH2_STAT3	55	58	PF00017	0.526
LIG_SH2_STAT5	151	154	PF00017	0.705
LIG_SH2_STAT5	413	416	PF00017	0.772
LIG_SH2_STAT5	82	85	PF00017	0.502
LIG_SH2_STAT5	97	100	PF00017	0.540
LIG_SH3_3	130	136	PF00018	0.805
LIG_SH3_3	152	158	PF00018	0.686
LIG_SH3_3	242	248	PF00018	0.814
LIG_SH3_3	317	323	PF00018	0.707
LIG_SH3_3	336	342	PF00018	0.516
LIG_SH3_3	371	377	PF00018	0.808
LIG_SH3_3	522	528	PF00018	0.519
LIG_SH3_3	596	602	PF00018	0.674
LIG_SUMO_SIM_anti_2	603	612	PF11976	0.574
LIG_SUMO_SIM_par_1	497	505	PF11976	0.490
LIG_TRAF2_1	426	429	PF00917	0.548
LIG_TRAF2_1	542	545	PF00917	0.478
LIG_UBA3_1	19	28	PF00899	0.512
LIG_UBA3_1	484	492	PF00899	0.472
MOD_CDC14_SPxK_1	146	149	PF00782	0.723
MOD_CDK_SPxK_1	143	149	PF00069	0.721
MOD_CDK_SPxK_1	217	223	PF00069	0.685
MOD_CK1_1	107	113	PF00069	0.650
MOD_CK1_1	140	146	PF00069	0.808
MOD_CK1_1	18	24	PF00069	0.482
MOD_CK1_1	185	191	PF00069	0.750
MOD_CK1_1	241	247	PF00069	0.736
MOD_CK1_1	253	259	PF00069	0.692
MOD_CK1_1	267	273	PF00069	0.580
MOD_CK1_1	277	283	PF00069	0.756
MOD_CK1_1	329	335	PF00069	0.762
MOD_CK1_1	365	371	PF00069	0.815
MOD_CK1_1	4	10	PF00069	0.489
MOD_CK1_1	45	51	PF00069	0.478
MOD_CK1_1	605	611	PF00069	0.679
MOD_CK2_1	189	195	PF00069	0.771
MOD_CK2_1	423	429	PF00069	0.567
MOD_CK2_1	539	545	PF00069	0.477
MOD_CK2_1	589	595	PF00069	0.550
MOD_CK2_1	87	93	PF00069	0.631
MOD_GlcNHglycan	126	129	PF01048	0.727
MOD_GlcNHglycan	130	133	PF01048	0.730
MOD_GlcNHglycan	139	142	PF01048	0.789
MOD_GlcNHglycan	206	209	PF01048	0.776
MOD_GlcNHglycan	240	243	PF01048	0.732
MOD_GlcNHglycan	302	306	PF01048	0.752
MOD_GlcNHglycan	313	318	PF01048	0.625
MOD_GlcNHglycan	331	334	PF01048	0.800
MOD_GlcNHglycan	379	382	PF01048	0.808
MOD_GlcNHglycan	516	519	PF01048	0.522
MOD_GlcNHglycan	591	594	PF01048	0.634
MOD_GlcNHglycan	604	607	PF01048	0.579
MOD_GSK3_1	1	8	PF00069	0.498
MOD_GSK3_1	104	111	PF00069	0.682
MOD_GSK3_1	112	119	PF00069	0.697
MOD_GSK3_1	122	129	PF00069	0.766
MOD_GSK3_1	137	144	PF00069	0.788
MOD_GSK3_1	15	22	PF00069	0.476
MOD_GSK3_1	185	192	PF00069	0.707
MOD_GSK3_1	194	201	PF00069	0.708
MOD_GSK3_1	204	211	PF00069	0.702
MOD_GSK3_1	223	230	PF00069	0.722
MOD_GSK3_1	234	241	PF00069	0.701
MOD_GSK3_1	249	256	PF00069	0.628
MOD_GSK3_1	279	286	PF00069	0.717
MOD_GSK3_1	31	38	PF00069	0.532
MOD_GSK3_1	322	329	PF00069	0.748
MOD_GSK3_1	355	362	PF00069	0.766
MOD_GSK3_1	377	384	PF00069	0.691
MOD_GSK3_1	41	48	PF00069	0.623
MOD_GSK3_1	50	57	PF00069	0.656
MOD_GSK3_1	589	596	PF00069	0.628
MOD_GSK3_1	601	608	PF00069	0.583
MOD_N-GLC_1	223	228	PF02516	0.741
MOD_NEK2_1	126	131	PF00069	0.733
MOD_NEK2_1	19	24	PF00069	0.511
MOD_NEK2_1	467	472	PF00069	0.444
MOD_NEK2_1	49	54	PF00069	0.733
MOD_NEK2_1	514	519	PF00069	0.500
MOD_NEK2_1	531	536	PF00069	0.516
MOD_NEK2_2	182	187	PF00069	0.572
MOD_NEK2_2	228	233	PF00069	0.589
MOD_NEK2_2	50	55	PF00069	0.654
MOD_PIKK_1	234	240	PF00454	0.682
MOD_PIKK_1	433	439	PF00454	0.656
MOD_PIKK_1	5	11	PF00454	0.483
MOD_PIKK_1	54	60	PF00454	0.541
MOD_PKA_1	29	35	PF00069	0.555
MOD_PKA_1	87	93	PF00069	0.631
MOD_PKA_2	121	127	PF00069	0.789
MOD_PKA_2	188	194	PF00069	0.708
MOD_PKA_2	208	214	PF00069	0.580
MOD_PKA_2	228	234	PF00069	0.553
MOD_PKA_2	264	270	PF00069	0.707
MOD_PKA_2	326	332	PF00069	0.681
MOD_PKA_2	87	93	PF00069	0.610
MOD_PKB_1	187	195	PF00069	0.576
MOD_PKB_1	27	35	PF00069	0.547
MOD_Plk_1	447	453	PF00069	0.502
MOD_Plk_2-3	448	454	PF00069	0.519
MOD_Plk_2-3	539	545	PF00069	0.477
MOD_Plk_4	15	21	PF00069	0.503
MOD_Plk_4	175	181	PF00069	0.723
MOD_Plk_4	253	259	PF00069	0.756
MOD_Plk_4	365	371	PF00069	0.780
MOD_Plk_4	448	454	PF00069	0.500
MOD_Plk_4	50	56	PF00069	0.637
MOD_Plk_4	605	611	PF00069	0.576
MOD_ProDKin_1	1	7	PF00069	0.501
MOD_ProDKin_1	114	120	PF00069	0.734
MOD_ProDKin_1	143	149	PF00069	0.716
MOD_ProDKin_1	217	223	PF00069	0.728
MOD_ProDKin_1	243	249	PF00069	0.677
MOD_ProDKin_1	250	256	PF00069	0.732
MOD_ProDKin_1	359	365	PF00069	0.722
MOD_SUMO_for_1	98	101	PF00179	0.650
MOD_SUMO_rev_2	417	426	PF00179	0.758
MOD_SUMO_rev_2	547	557	PF00179	0.483
TRG_DiLeu_BaEn_2	485	491	PF01217	0.455
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.481
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.644
TRG_ENDOCYTIC_2	183	186	PF00928	0.572
TRG_ENDOCYTIC_2	579	582	PF00928	0.476
TRG_ER_diArg_1	186	189	PF00400	0.721
TRG_ER_diArg_1	284	287	PF00400	0.657
TRG_ER_diArg_1	372	374	PF00400	0.825
TRG_ER_diArg_1	509	512	PF00400	0.443
TRG_ER_diArg_1	564	567	PF00400	0.483
TRG_ER_diArg_1	87	89	PF00400	0.531
TRG_NLS_MonoExtN_4	27	32	PF00514	0.539
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS0	Leptomonas seymouri	36%	80%
A0A3Q8IDN2	Leishmania donovani	88%	100%
A4H8J9	Leishmania braziliensis	66%	100%
A4HWX4	Leishmania infantum	88%	100%
E9AQN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%