Membrane transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane transport protein, putative

Species:

Leishmania major

UniProt:

Q4QET9_LEIMA

TriTrypDb:

LmjF.16.0800 , LMJLV39_160013700 , LMJSD75_160013500

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QET9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QET9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0009914	hormone transport	4	8
GO:0009987	cellular process	1	8
GO:0010817	regulation of hormone levels	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0055085	transmembrane transport	2	8
GO:0060918	auxin transport	5	8
GO:0065007	biological regulation	1	8
GO:0065008	regulation of biological quality	2	8
GO:0080162	endoplasmic reticulum to cytosol auxin transport	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	337	341	PF00656	0.506
CLV_C14_Caspase3-7	631	635	PF00656	0.558
CLV_NRD_NRD_1	106	108	PF00675	0.582
CLV_NRD_NRD_1	144	146	PF00675	0.611
CLV_NRD_NRD_1	312	314	PF00675	0.215
CLV_NRD_NRD_1	385	387	PF00675	0.249
CLV_NRD_NRD_1	494	496	PF00675	0.390
CLV_PCSK_KEX2_1	144	146	PF00082	0.653
CLV_PCSK_KEX2_1	268	270	PF00082	0.308
CLV_PCSK_KEX2_1	312	314	PF00082	0.215
CLV_PCSK_KEX2_1	385	387	PF00082	0.250
CLV_PCSK_KEX2_1	393	395	PF00082	0.258
CLV_PCSK_KEX2_1	494	496	PF00082	0.385
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.653
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.287
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.278
CLV_PCSK_PC7_1	389	395	PF00082	0.278
CLV_PCSK_SKI1_1	252	256	PF00082	0.314
CLV_PCSK_SKI1_1	261	265	PF00082	0.337
CLV_PCSK_SKI1_1	471	475	PF00082	0.314
CLV_PCSK_SKI1_1	596	600	PF00082	0.388
CLV_PCSK_SKI1_1	646	650	PF00082	0.389
CLV_PCSK_SKI1_1	714	718	PF00082	0.309
CLV_PCSK_SKI1_1	722	726	PF00082	0.258
DEG_Nend_UBRbox_2	1	3	PF02207	0.597
DEG_SPOP_SBC_1	331	335	PF00917	0.545
DEG_SPOP_SBC_1	529	533	PF00917	0.514
DOC_ANK_TNKS_1	509	516	PF00023	0.478
DOC_CKS1_1	404	409	PF01111	0.514
DOC_CYCLIN_RxL_1	593	602	PF00134	0.584
DOC_MAPK_DCC_7	145	155	PF00069	0.389
DOC_MAPK_DCC_7	471	481	PF00069	0.486
DOC_MAPK_gen_1	107	114	PF00069	0.344
DOC_MAPK_gen_1	255	265	PF00069	0.477
DOC_MAPK_gen_1	393	401	PF00069	0.478
DOC_MAPK_HePTP_8	654	666	PF00069	0.346
DOC_MAPK_MEF2A_6	107	114	PF00069	0.344
DOC_MAPK_MEF2A_6	13	22	PF00069	0.357
DOC_MAPK_MEF2A_6	146	155	PF00069	0.370
DOC_MAPK_MEF2A_6	320	328	PF00069	0.415
DOC_MAPK_MEF2A_6	57	65	PF00069	0.567
DOC_MAPK_MEF2A_6	657	666	PF00069	0.346
DOC_MAPK_MEF2A_6	66	73	PF00069	0.432
DOC_MAPK_MEF2A_6	688	696	PF00069	0.304
DOC_PP1_RVXF_1	720	727	PF00149	0.446
DOC_PP2B_LxvP_1	175	178	PF13499	0.314
DOC_PP2B_LxvP_1	281	284	PF13499	0.514
DOC_PP2B_LxvP_1	698	701	PF13499	0.371
DOC_USP7_MATH_1	331	335	PF00917	0.531
DOC_USP7_MATH_1	529	533	PF00917	0.590
DOC_USP7_MATH_1	536	540	PF00917	0.440
DOC_USP7_MATH_1	703	707	PF00917	0.307
DOC_USP7_UBL2_3	142	146	PF12436	0.508
DOC_USP7_UBL2_3	252	256	PF12436	0.462
DOC_WW_Pin1_4	130	135	PF00397	0.485
DOC_WW_Pin1_4	403	408	PF00397	0.473
DOC_WW_Pin1_4	472	477	PF00397	0.516
DOC_WW_Pin1_4	658	663	PF00397	0.458
LIG_14-3-3_CanoR_1	145	151	PF00244	0.326
LIG_14-3-3_CanoR_1	320	328	PF00244	0.549
LIG_14-3-3_CanoR_1	362	371	PF00244	0.502
LIG_14-3-3_CanoR_1	450	458	PF00244	0.482
LIG_14-3-3_CanoR_1	463	467	PF00244	0.495
LIG_14-3-3_CanoR_1	494	503	PF00244	0.415
LIG_14-3-3_CanoR_1	638	643	PF00244	0.580
LIG_Actin_WH2_2	629	645	PF00022	0.609
LIG_BRCT_BRCA1_1	157	161	PF00533	0.343
LIG_BRCT_BRCA1_1	214	218	PF00533	0.286
LIG_BRCT_BRCA1_1	474	478	PF00533	0.514
LIG_CtBP_PxDLS_1	103	107	PF00389	0.382
LIG_EH1_1	39	47	PF00400	0.346
LIG_FHA_1	201	207	PF00498	0.279
LIG_FHA_1	23	29	PF00498	0.446
LIG_FHA_1	276	282	PF00498	0.497
LIG_FHA_1	340	346	PF00498	0.517
LIG_FHA_1	398	404	PF00498	0.578
LIG_FHA_1	637	643	PF00498	0.588
LIG_FHA_2	165	171	PF00498	0.343
LIG_FHA_2	411	417	PF00498	0.442
LIG_FHA_2	576	582	PF00498	0.587
LIG_FHA_2	618	624	PF00498	0.694
LIG_FHA_2	629	635	PF00498	0.553
LIG_LIR_Apic_2	497	503	PF02991	0.415
LIG_LIR_Gen_1	113	124	PF02991	0.401
LIG_LIR_Gen_1	149	157	PF02991	0.316
LIG_LIR_Gen_1	215	226	PF02991	0.255
LIG_LIR_Gen_1	319	328	PF02991	0.413
LIG_LIR_Gen_1	368	377	PF02991	0.460
LIG_LIR_Gen_1	379	388	PF02991	0.398
LIG_LIR_Gen_1	465	473	PF02991	0.541
LIG_LIR_Gen_1	475	486	PF02991	0.435
LIG_LIR_Gen_1	558	568	PF02991	0.610
LIG_LIR_Gen_1	665	673	PF02991	0.355
LIG_LIR_Gen_1	7	16	PF02991	0.346
LIG_LIR_Gen_1	717	728	PF02991	0.497
LIG_LIR_Nem_3	113	119	PF02991	0.325
LIG_LIR_Nem_3	149	155	PF02991	0.366
LIG_LIR_Nem_3	158	164	PF02991	0.309
LIG_LIR_Nem_3	224	230	PF02991	0.298
LIG_LIR_Nem_3	232	238	PF02991	0.414
LIG_LIR_Nem_3	319	324	PF02991	0.413
LIG_LIR_Nem_3	368	374	PF02991	0.460
LIG_LIR_Nem_3	398	404	PF02991	0.460
LIG_LIR_Nem_3	465	469	PF02991	0.556
LIG_LIR_Nem_3	475	481	PF02991	0.449
LIG_LIR_Nem_3	551	556	PF02991	0.691
LIG_LIR_Nem_3	558	563	PF02991	0.611
LIG_LIR_Nem_3	663	669	PF02991	0.423
LIG_LIR_Nem_3	7	11	PF02991	0.346
LIG_LIR_Nem_3	707	713	PF02991	0.416
LIG_LIR_Nem_3	89	95	PF02991	0.337
LIG_LIR_Nem_3	96	102	PF02991	0.368
LIG_LYPXL_yS_3	553	556	PF13949	0.626
LIG_PDZ_Class_1	744	749	PF00595	0.321
LIG_Pex14_2	667	671	PF04695	0.371
LIG_PTB_Apo_2	34	41	PF02174	0.321
LIG_Rb_pABgroove_1	110	118	PF01858	0.343
LIG_REV1ctd_RIR_1	90	96	PF16727	0.379
LIG_SH2_CRK	116	120	PF00017	0.299
LIG_SH2_CRK	99	103	PF00017	0.359
LIG_SH2_NCK_1	116	120	PF00017	0.403
LIG_SH2_PTP2	152	155	PF00017	0.325
LIG_SH2_PTP2	227	230	PF00017	0.357
LIG_SH2_STAP1	190	194	PF00017	0.345
LIG_SH2_STAP1	369	373	PF00017	0.478
LIG_SH2_STAP1	430	434	PF00017	0.556
LIG_SH2_STAP1	442	446	PF00017	0.449
LIG_SH2_STAP1	569	573	PF00017	0.615
LIG_SH2_STAT3	573	576	PF00017	0.631
LIG_SH2_STAT5	152	155	PF00017	0.325
LIG_SH2_STAT5	227	230	PF00017	0.289
LIG_SH2_STAT5	238	241	PF00017	0.276
LIG_SH2_STAT5	325	328	PF00017	0.478
LIG_SH2_STAT5	437	440	PF00017	0.482
LIG_SH2_STAT5	728	731	PF00017	0.298
LIG_SH2_STAT5	745	748	PF00017	0.306
LIG_SH3_3	199	205	PF00018	0.262
LIG_SH3_3	325	331	PF00018	0.415
LIG_SH3_3	551	557	PF00018	0.670
LIG_SUMO_SIM_anti_2	519	525	PF11976	0.548
LIG_SUMO_SIM_anti_2	60	65	PF11976	0.548
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.276
LIG_SUMO_SIM_anti_2	689	695	PF11976	0.357
LIG_SUMO_SIM_par_1	152	159	PF11976	0.312
LIG_SUMO_SIM_par_1	203	210	PF11976	0.286
LIG_SUMO_SIM_par_1	68	74	PF11976	0.322
LIG_SUMO_SIM_par_1	692	697	PF11976	0.357
LIG_TRAF2_1	620	623	PF00917	0.714
LIG_TRFH_1	553	557	PF08558	0.663
LIG_TRFH_1	93	97	PF08558	0.287
LIG_TYR_ITIM	114	119	PF00017	0.395
LIG_TYR_ITIM	150	155	PF00017	0.340
LIG_UBA3_1	259	268	PF00899	0.504
LIG_UBA3_1	668	675	PF00899	0.431
LIG_UBA3_1	91	98	PF00899	0.288
MOD_CDK_SPxxK_3	130	137	PF00069	0.469
MOD_CDK_SPxxK_3	403	410	PF00069	0.478
MOD_CK1_1	132	138	PF00069	0.471
MOD_CK1_1	207	213	PF00069	0.286
MOD_CK1_1	214	220	PF00069	0.277
MOD_CK1_1	303	309	PF00069	0.415
MOD_CK1_1	31	37	PF00069	0.296
MOD_CK1_1	329	335	PF00069	0.531
MOD_CK1_1	339	345	PF00069	0.511
MOD_CK1_1	376	382	PF00069	0.451
MOD_CK1_1	516	522	PF00069	0.504
MOD_CK1_1	589	595	PF00069	0.629
MOD_CK1_1	609	615	PF00069	0.604
MOD_CK1_1	74	80	PF00069	0.371
MOD_CK2_1	164	170	PF00069	0.348
MOD_CK2_1	340	346	PF00069	0.496
MOD_CK2_1	420	426	PF00069	0.478
MOD_CK2_1	450	456	PF00069	0.496
MOD_CK2_1	575	581	PF00069	0.603
MOD_CK2_1	617	623	PF00069	0.707
MOD_Cter_Amidation	391	394	PF01082	0.278
MOD_GlcNHglycan	223	226	PF01048	0.483
MOD_GlcNHglycan	240	243	PF01048	0.243
MOD_GlcNHglycan	290	293	PF01048	0.370
MOD_GlcNHglycan	365	368	PF01048	0.367
MOD_GlcNHglycan	390	393	PF01048	0.362
MOD_GlcNHglycan	452	455	PF01048	0.363
MOD_GlcNHglycan	532	535	PF01048	0.293
MOD_GlcNHglycan	538	541	PF01048	0.490
MOD_GlcNHglycan	608	611	PF01048	0.465
MOD_GlcNHglycan	79	82	PF01048	0.384
MOD_GlcNHglycan	99	102	PF01048	0.512
MOD_GSK3_1	128	135	PF00069	0.473
MOD_GSK3_1	200	207	PF00069	0.262
MOD_GSK3_1	24	31	PF00069	0.347
MOD_GSK3_1	275	282	PF00069	0.474
MOD_GSK3_1	326	333	PF00069	0.560
MOD_GSK3_1	336	343	PF00069	0.568
MOD_GSK3_1	350	357	PF00069	0.461
MOD_GSK3_1	363	370	PF00069	0.552
MOD_GSK3_1	372	379	PF00069	0.500
MOD_GSK3_1	406	413	PF00069	0.493
MOD_GSK3_1	448	455	PF00069	0.469
MOD_GSK3_1	46	53	PF00069	0.284
MOD_GSK3_1	513	520	PF00069	0.481
MOD_GSK3_1	658	665	PF00069	0.371
MOD_GSK3_1	682	689	PF00069	0.385
MOD_GSK3_1	699	706	PF00069	0.357
MOD_GSK3_1	737	744	PF00069	0.357
MOD_N-GLC_1	340	345	PF02516	0.340
MOD_N-GLC_1	704	709	PF02516	0.357
MOD_NEK2_1	221	226	PF00069	0.294
MOD_NEK2_1	229	234	PF00069	0.322
MOD_NEK2_1	373	378	PF00069	0.547
MOD_NEK2_1	4	9	PF00069	0.346
MOD_NEK2_1	40	45	PF00069	0.368
MOD_NEK2_1	420	425	PF00069	0.415
MOD_NEK2_1	46	51	PF00069	0.332
MOD_NEK2_1	52	57	PF00069	0.438
MOD_NEK2_1	528	533	PF00069	0.504
MOD_NEK2_1	584	589	PF00069	0.616
MOD_NEK2_1	599	604	PF00069	0.664
MOD_NEK2_1	65	70	PF00069	0.545
MOD_NEK2_1	686	691	PF00069	0.394
MOD_NEK2_1	737	742	PF00069	0.400
MOD_NEK2_2	397	402	PF00069	0.478
MOD_NEK2_2	662	667	PF00069	0.321
MOD_PIKK_1	195	201	PF00454	0.304
MOD_PIKK_1	275	281	PF00454	0.462
MOD_PIKK_1	283	289	PF00454	0.462
MOD_PIKK_1	319	325	PF00454	0.478
MOD_PIKK_1	379	385	PF00454	0.514
MOD_PK_1	146	152	PF00069	0.376
MOD_PKA_1	145	151	PF00069	0.392
MOD_PKA_1	494	500	PF00069	0.415
MOD_PKA_1	628	634	PF00069	0.646
MOD_PKA_2	117	123	PF00069	0.379
MOD_PKA_2	319	325	PF00069	0.494
MOD_PKA_2	388	394	PF00069	0.482
MOD_PKA_2	462	468	PF00069	0.556
MOD_PKA_2	494	500	PF00069	0.415
MOD_PKA_2	65	71	PF00069	0.504
MOD_PKA_2	682	688	PF00069	0.394
MOD_Plk_1	340	346	PF00069	0.469
MOD_Plk_1	397	403	PF00069	0.478
MOD_Plk_1	686	692	PF00069	0.304
MOD_Plk_1	704	710	PF00069	0.357
MOD_Plk_2-3	117	123	PF00069	0.412
MOD_Plk_4	204	210	PF00069	0.277
MOD_Plk_4	4	10	PF00069	0.341
MOD_Plk_4	41	47	PF00069	0.317
MOD_Plk_4	462	468	PF00069	0.568
MOD_Plk_4	477	483	PF00069	0.420
MOD_Plk_4	517	523	PF00069	0.437
MOD_Plk_4	589	595	PF00069	0.620
MOD_Plk_4	599	605	PF00069	0.653
MOD_Plk_4	628	634	PF00069	0.643
MOD_Plk_4	65	71	PF00069	0.495
MOD_Plk_4	662	668	PF00069	0.337
MOD_Plk_4	686	692	PF00069	0.281
MOD_Plk_4	704	710	PF00069	0.357
MOD_Plk_4	731	737	PF00069	0.315
MOD_Plk_4	741	747	PF00069	0.324
MOD_ProDKin_1	130	136	PF00069	0.486
MOD_ProDKin_1	403	409	PF00069	0.473
MOD_ProDKin_1	472	478	PF00069	0.516
MOD_ProDKin_1	658	664	PF00069	0.458
MOD_SUMO_for_1	440	443	PF00179	0.504
MOD_SUMO_rev_2	443	449	PF00179	0.504
TRG_DiLeu_BaEn_1	558	563	PF01217	0.625
TRG_DiLeu_BaEn_4	558	564	PF01217	0.601
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.504
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.478
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.635
TRG_ENDOCYTIC_2	116	119	PF00928	0.291
TRG_ENDOCYTIC_2	152	155	PF00928	0.325
TRG_ENDOCYTIC_2	227	230	PF00928	0.298
TRG_ENDOCYTIC_2	325	328	PF00928	0.415
TRG_ENDOCYTIC_2	437	440	PF00928	0.438
TRG_ENDOCYTIC_2	553	556	PF00928	0.626
TRG_ENDOCYTIC_2	713	716	PF00928	0.558
TRG_ENDOCYTIC_2	99	102	PF00928	0.358
TRG_ER_diArg_1	312	314	PF00400	0.415
TRG_ER_diArg_1	384	386	PF00400	0.486
TRG_ER_diArg_1	493	495	PF00400	0.585
TRG_ER_diArg_1	542	545	PF00400	0.688
TRG_NES_CRM1_1	579	591	PF08389	0.595
TRG_NLS_MonoCore_2	143	148	PF00514	0.463
TRG_NLS_MonoExtN_4	142	149	PF00514	0.472
TRG_NLS_MonoExtN_4	252	259	PF00514	0.475
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.262
TRG_Pf-PMV_PEXEL_1	312	317	PF00026	0.215
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL2	Leptomonas seymouri	52%	100%
A0A3S5H6X7	Leishmania donovani	90%	100%
A4H8K4	Leishmania braziliensis	67%	99%
A4HWX7	Leishmania infantum	91%	100%
C9ZW27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AQN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%