Polysacc_synt_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QET8_LEIMA

TriTrypDb:

LmjF.16.0810 , LMJLV39_160013800 , LMJSD75_160013600

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QET8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QET8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.544
CLV_C14_Caspase3-7	412	416	PF00656	0.282
CLV_C14_Caspase3-7	597	601	PF00656	0.581
CLV_MEL_PAP_1	313	319	PF00089	0.676
CLV_NRD_NRD_1	127	129	PF00675	0.571
CLV_NRD_NRD_1	15	17	PF00675	0.414
CLV_NRD_NRD_1	292	294	PF00675	0.486
CLV_NRD_NRD_1	315	317	PF00675	0.684
CLV_NRD_NRD_1	387	389	PF00675	0.560
CLV_NRD_NRD_1	434	436	PF00675	0.547
CLV_NRD_NRD_1	571	573	PF00675	0.386
CLV_NRD_NRD_1	584	586	PF00675	0.266
CLV_NRD_NRD_1	69	71	PF00675	0.658
CLV_PCSK_FUR_1	13	17	PF00082	0.425
CLV_PCSK_KEX2_1	127	129	PF00082	0.558
CLV_PCSK_KEX2_1	15	17	PF00082	0.368
CLV_PCSK_KEX2_1	315	317	PF00082	0.684
CLV_PCSK_KEX2_1	364	366	PF00082	0.496
CLV_PCSK_KEX2_1	387	389	PF00082	0.583
CLV_PCSK_KEX2_1	434	436	PF00082	0.547
CLV_PCSK_KEX2_1	584	586	PF00082	0.418
CLV_PCSK_KEX2_1	68	70	PF00082	0.639
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.567
CLV_PCSK_SKI1_1	24	28	PF00082	0.355
CLV_PCSK_SKI1_1	272	276	PF00082	0.539
CLV_PCSK_SKI1_1	294	298	PF00082	0.482
CLV_PCSK_SKI1_1	306	310	PF00082	0.563
CLV_PCSK_SKI1_1	364	368	PF00082	0.509
CLV_PCSK_SKI1_1	463	467	PF00082	0.482
CLV_PCSK_SKI1_1	584	588	PF00082	0.398
CLV_Separin_Metazoa	336	340	PF03568	0.300
DEG_SPOP_SBC_1	186	190	PF00917	0.566
DEG_SPOP_SBC_1	247	251	PF00917	0.482
DOC_CYCLIN_RxL_1	290	298	PF00134	0.342
DOC_CYCLIN_RxL_1	361	373	PF00134	0.316
DOC_MAPK_DCC_7	294	304	PF00069	0.305
DOC_MAPK_gen_1	127	133	PF00069	0.439
DOC_MAPK_gen_1	293	299	PF00069	0.286
DOC_MAPK_gen_1	361	369	PF00069	0.273
DOC_MAPK_gen_1	584	593	PF00069	0.492
DOC_MAPK_gen_1	68	77	PF00069	0.402
DOC_MAPK_JIP1_4	404	410	PF00069	0.345
DOC_MAPK_MEF2A_6	32	41	PF00069	0.460
DOC_PP1_RVXF_1	363	370	PF00149	0.307
DOC_PP1_RVXF_1	424	430	PF00149	0.313
DOC_PP1_RVXF_1	520	526	PF00149	0.588
DOC_PP2B_LxvP_1	112	115	PF13499	0.504
DOC_PP4_FxxP_1	34	37	PF00568	0.413
DOC_PP4_MxPP_1	1	4	PF00568	0.641
DOC_USP7_MATH_1	180	184	PF00917	0.497
DOC_USP7_MATH_1	185	189	PF00917	0.541
DOC_USP7_MATH_1	198	202	PF00917	0.487
DOC_USP7_MATH_1	223	227	PF00917	0.464
DOC_USP7_MATH_1	230	234	PF00917	0.454
DOC_USP7_MATH_1	76	80	PF00917	0.509
DOC_USP7_MATH_1	93	97	PF00917	0.448
DOC_WW_Pin1_4	160	165	PF00397	0.478
DOC_WW_Pin1_4	194	199	PF00397	0.404
DOC_WW_Pin1_4	234	239	PF00397	0.553
DOC_WW_Pin1_4	33	38	PF00397	0.325
DOC_WW_Pin1_4	476	481	PF00397	0.300
LIG_14-3-3_CanoR_1	272	282	PF00244	0.381
LIG_14-3-3_CanoR_1	315	320	PF00244	0.399
LIG_14-3-3_CanoR_1	339	348	PF00244	0.320
LIG_14-3-3_CanoR_1	419	427	PF00244	0.350
LIG_14-3-3_CanoR_1	53	61	PF00244	0.318
LIG_14-3-3_CanoR_1	572	582	PF00244	0.635
LIG_14-3-3_CanoR_1	585	593	PF00244	0.447
LIG_Actin_WH2_2	292	308	PF00022	0.334
LIG_BRCT_BRCA1_1	109	113	PF00533	0.473
LIG_BRCT_BRCA1_1	22	26	PF00533	0.492
LIG_BRCT_BRCA1_1	4	8	PF00533	0.749
LIG_BRCT_BRCA1_1	42	46	PF00533	0.202
LIG_Clathr_ClatBox_1	408	412	PF01394	0.267
LIG_FHA_1	239	245	PF00498	0.506
LIG_FHA_1	249	255	PF00498	0.444
LIG_FHA_1	307	313	PF00498	0.427
LIG_FHA_1	325	331	PF00498	0.313
LIG_FHA_1	374	380	PF00498	0.348
LIG_FHA_1	526	532	PF00498	0.565
LIG_FHA_1	542	548	PF00498	0.638
LIG_FHA_2	163	169	PF00498	0.337
LIG_FHA_2	238	244	PF00498	0.508
LIG_FHA_2	397	403	PF00498	0.392
LIG_FHA_2	484	490	PF00498	0.348
LIG_HP1_1	37	41	PF01393	0.312
LIG_LIR_Apic_2	31	37	PF02991	0.538
LIG_LIR_Apic_2	55	61	PF02991	0.366
LIG_LIR_Gen_1	250	258	PF02991	0.477
LIG_LIR_Gen_1	36	46	PF02991	0.324
LIG_LIR_Gen_1	505	515	PF02991	0.603
LIG_LIR_Gen_1	534	541	PF02991	0.601
LIG_LIR_Nem_3	169	175	PF02991	0.310
LIG_LIR_Nem_3	250	256	PF02991	0.439
LIG_LIR_Nem_3	342	348	PF02991	0.291
LIG_LIR_Nem_3	36	41	PF02991	0.335
LIG_LIR_Nem_3	421	427	PF02991	0.313
LIG_LIR_Nem_3	43	49	PF02991	0.360
LIG_LIR_Nem_3	505	510	PF02991	0.528
LIG_LIR_Nem_3	534	539	PF02991	0.538
LIG_MLH1_MIPbox_1	22	26	PF16413	0.564
LIG_PCNA_yPIPBox_3	315	329	PF02747	0.427
LIG_Pex14_1	462	466	PF04695	0.284
LIG_SH2_CRK	172	176	PF00017	0.302
LIG_SH2_PTP2	38	41	PF00017	0.413
LIG_SH2_PTP2	58	61	PF00017	0.242
LIG_SH2_SRC	177	180	PF00017	0.372
LIG_SH2_SRC	550	553	PF00017	0.503
LIG_SH2_STAP1	291	295	PF00017	0.298
LIG_SH2_STAP1	406	410	PF00017	0.274
LIG_SH2_STAT5	177	180	PF00017	0.329
LIG_SH2_STAT5	253	256	PF00017	0.386
LIG_SH2_STAT5	38	41	PF00017	0.381
LIG_SH2_STAT5	385	388	PF00017	0.377
LIG_SH2_STAT5	49	52	PF00017	0.274
LIG_SH2_STAT5	550	553	PF00017	0.508
LIG_SH2_STAT5	58	61	PF00017	0.242
LIG_SH3_3	376	382	PF00018	0.377
LIG_SH3_3	442	448	PF00018	0.359
LIG_SH3_3	474	480	PF00018	0.338
LIG_SH3_3	535	541	PF00018	0.523
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.402
LIG_SUMO_SIM_anti_2	407	412	PF11976	0.327
LIG_SUMO_SIM_par_1	407	412	PF11976	0.271
LIG_TRAF2_1	61	64	PF00917	0.448
LIG_TYR_ITIM	170	175	PF00017	0.364
LIG_WRC_WIRS_1	484	489	PF05994	0.353
MOD_CDK_SPK_2	194	199	PF00069	0.505
MOD_CDK_SPxxK_3	160	167	PF00069	0.489
MOD_CK1_1	134	140	PF00069	0.433
MOD_CK1_1	160	166	PF00069	0.590
MOD_CK1_1	205	211	PF00069	0.637
MOD_CK1_1	214	220	PF00069	0.558
MOD_CK1_1	226	232	PF00069	0.726
MOD_CK1_1	237	243	PF00069	0.680
MOD_CK1_1	373	379	PF00069	0.491
MOD_CK1_1	479	485	PF00069	0.324
MOD_CK1_1	534	540	PF00069	0.474
MOD_CK1_1	594	600	PF00069	0.645
MOD_CK2_1	114	120	PF00069	0.477
MOD_CK2_1	185	191	PF00069	0.571
MOD_CK2_1	214	220	PF00069	0.697
MOD_CK2_1	237	243	PF00069	0.683
MOD_CK2_1	396	402	PF00069	0.499
MOD_CMANNOS	579	582	PF00535	0.422
MOD_GlcNHglycan	143	146	PF01048	0.576
MOD_GlcNHglycan	148	151	PF01048	0.524
MOD_GlcNHglycan	183	186	PF01048	0.693
MOD_GlcNHglycan	217	220	PF01048	0.776
MOD_GlcNHglycan	225	228	PF01048	0.602
MOD_GlcNHglycan	232	235	PF01048	0.736
MOD_GlcNHglycan	333	336	PF01048	0.350
MOD_GlcNHglycan	42	45	PF01048	0.381
MOD_GlcNHglycan	530	534	PF01048	0.495
MOD_GlcNHglycan	95	98	PF01048	0.606
MOD_GSK3_1	181	188	PF00069	0.615
MOD_GSK3_1	194	201	PF00069	0.626
MOD_GSK3_1	203	210	PF00069	0.579
MOD_GSK3_1	211	218	PF00069	0.486
MOD_GSK3_1	226	233	PF00069	0.668
MOD_GSK3_1	234	241	PF00069	0.693
MOD_GSK3_1	369	376	PF00069	0.495
MOD_GSK3_1	475	482	PF00069	0.311
MOD_GSK3_1	483	490	PF00069	0.364
MOD_GSK3_1	525	532	PF00069	0.417
MOD_N-GLC_1	373	378	PF02516	0.484
MOD_N-GLC_1	396	401	PF02516	0.589
MOD_N-GLC_1	534	539	PF02516	0.483
MOD_N-GLC_2	278	280	PF02516	0.355
MOD_N-GLC_2	440	442	PF02516	0.463
MOD_NEK2_1	295	300	PF00069	0.483
MOD_NEK2_1	369	374	PF00069	0.378
MOD_NEK2_1	40	45	PF00069	0.360
MOD_NEK2_1	487	492	PF00069	0.466
MOD_NEK2_1	571	576	PF00069	0.586
MOD_NEK2_1	591	596	PF00069	0.560
MOD_NEK2_1	77	82	PF00069	0.519
MOD_NEK2_2	171	176	PF00069	0.426
MOD_NEK2_2	340	345	PF00069	0.468
MOD_PIKK_1	273	279	PF00454	0.466
MOD_PIKK_1	306	312	PF00454	0.529
MOD_PIKK_1	419	425	PF00454	0.379
MOD_PIKK_1	573	579	PF00454	0.487
MOD_PIKK_1	591	597	PF00454	0.509
MOD_PKA_1	315	321	PF00069	0.605
MOD_PKA_1	584	590	PF00069	0.626
MOD_PKA_2	141	147	PF00069	0.632
MOD_PKA_2	20	26	PF00069	0.573
MOD_PKA_2	315	321	PF00069	0.493
MOD_PKA_2	418	424	PF00069	0.433
MOD_PKA_2	52	58	PF00069	0.447
MOD_PKA_2	571	577	PF00069	0.571
MOD_PKA_2	584	590	PF00069	0.433
MOD_Plk_1	208	214	PF00069	0.579
MOD_Plk_1	373	379	PF00069	0.443
MOD_Plk_1	534	540	PF00069	0.416
MOD_Plk_1	541	547	PF00069	0.424
MOD_Plk_4	211	217	PF00069	0.612
MOD_Plk_4	308	314	PF00069	0.566
MOD_Plk_4	324	330	PF00069	0.267
MOD_Plk_4	355	361	PF00069	0.448
MOD_Plk_4	479	485	PF00069	0.343
MOD_ProDKin_1	160	166	PF00069	0.611
MOD_ProDKin_1	194	200	PF00069	0.508
MOD_ProDKin_1	234	240	PF00069	0.712
MOD_ProDKin_1	33	39	PF00069	0.325
MOD_ProDKin_1	476	482	PF00069	0.300
MOD_SUMO_for_1	502	505	PF00179	0.468
MOD_SUMO_rev_2	400	405	PF00179	0.470
TRG_ENDOCYTIC_2	172	175	PF00928	0.365
TRG_ENDOCYTIC_2	253	256	PF00928	0.542
TRG_ENDOCYTIC_2	345	348	PF00928	0.475
TRG_ENDOCYTIC_2	38	41	PF00928	0.325
TRG_ENDOCYTIC_2	406	409	PF00928	0.338
TRG_ENDOCYTIC_2	424	427	PF00928	0.480
TRG_ER_diArg_1	126	128	PF00400	0.474
TRG_ER_diArg_1	13	16	PF00400	0.507
TRG_ER_diArg_1	314	316	PF00400	0.608
TRG_ER_diArg_1	386	388	PF00400	0.442
TRG_ER_diArg_1	433	435	PF00400	0.425
TRG_ER_diArg_1	583	585	PF00400	0.486
TRG_ER_diArg_1	59	62	PF00400	0.458
TRG_ER_diArg_1	68	70	PF00400	0.510
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R7	Leptomonas seymouri	66%	100%
A0A0S4IJV1	Bodo saltans	37%	100%
A0A1X0NZ16	Trypanosomatidae	45%	100%
A0A3Q8IJ17	Leishmania donovani	96%	100%
A4H8K5	Leishmania braziliensis	82%	100%
A4HWX8	Leishmania infantum	96%	100%
C9ZW26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AQP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5D930	Trypanosoma cruzi	48%	100%