Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QET7_LEIMA

TriTrypDb:

LmjF.16.0820 , LMJLV39_160013900 , LMJSD75_160013700

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QET7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QET7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.748
CLV_NRD_NRD_1	16	18	PF00675	0.537
CLV_NRD_NRD_1	171	173	PF00675	0.619
CLV_NRD_NRD_1	254	256	PF00675	0.633
CLV_NRD_NRD_1	294	296	PF00675	0.733
CLV_NRD_NRD_1	305	307	PF00675	0.594
CLV_NRD_NRD_1	36	38	PF00675	0.576
CLV_NRD_NRD_1	370	372	PF00675	0.783
CLV_NRD_NRD_1	389	391	PF00675	0.735
CLV_NRD_NRD_1	90	92	PF00675	0.662
CLV_PCSK_FUR_1	252	256	PF00082	0.590
CLV_PCSK_FUR_1	292	296	PF00082	0.735
CLV_PCSK_KEX2_1	16	18	PF00082	0.537
CLV_PCSK_KEX2_1	171	173	PF00082	0.707
CLV_PCSK_KEX2_1	254	256	PF00082	0.633
CLV_PCSK_KEX2_1	292	294	PF00082	0.724
CLV_PCSK_KEX2_1	305	307	PF00082	0.580
CLV_PCSK_KEX2_1	389	391	PF00082	0.744
CLV_PCSK_KEX2_1	58	60	PF00082	0.530
CLV_PCSK_KEX2_1	645	647	PF00082	0.729
CLV_PCSK_KEX2_1	90	92	PF00082	0.662
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.530
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.542
CLV_PCSK_PC7_1	12	18	PF00082	0.396
CLV_PCSK_SKI1_1	12	16	PF00082	0.500
CLV_PCSK_SKI1_1	433	437	PF00082	0.571
CLV_PCSK_SKI1_1	642	646	PF00082	0.544
DEG_APCC_DBOX_1	67	75	PF00400	0.491
DEG_Nend_UBRbox_4	1	3	PF02207	0.568
DEG_SPOP_SBC_1	186	190	PF00917	0.776
DEG_SPOP_SBC_1	277	281	PF00917	0.707
DEG_SPOP_SBC_1	363	367	PF00917	0.625
DOC_ANK_TNKS_1	254	261	PF00023	0.632
DOC_CKS1_1	351	356	PF01111	0.741
DOC_MAPK_gen_1	58	65	PF00069	0.511
DOC_MAPK_MEF2A_6	58	65	PF00069	0.511
DOC_PP1_RVXF_1	236	242	PF00149	0.693
DOC_PP1_RVXF_1	506	512	PF00149	0.550
DOC_PP2B_LxvP_1	579	582	PF13499	0.791
DOC_PP4_FxxP_1	115	118	PF00568	0.649
DOC_PP4_FxxP_1	351	354	PF00568	0.722
DOC_USP7_MATH_1	184	188	PF00917	0.729
DOC_USP7_MATH_1	209	213	PF00917	0.758
DOC_USP7_MATH_1	299	303	PF00917	0.660
DOC_USP7_MATH_1	385	389	PF00917	0.677
DOC_USP7_MATH_1	485	489	PF00917	0.752
DOC_USP7_MATH_1	559	563	PF00917	0.609
DOC_USP7_MATH_1	667	671	PF00917	0.628
DOC_WW_Pin1_4	119	124	PF00397	0.668
DOC_WW_Pin1_4	201	206	PF00397	0.763
DOC_WW_Pin1_4	266	271	PF00397	0.746
DOC_WW_Pin1_4	295	300	PF00397	0.760
DOC_WW_Pin1_4	308	313	PF00397	0.602
DOC_WW_Pin1_4	324	329	PF00397	0.618
DOC_WW_Pin1_4	339	344	PF00397	0.821
DOC_WW_Pin1_4	350	355	PF00397	0.787
DOC_WW_Pin1_4	383	388	PF00397	0.765
DOC_WW_Pin1_4	569	574	PF00397	0.749
DOC_WW_Pin1_4	588	593	PF00397	0.519
LIG_14-3-3_CanoR_1	142	150	PF00244	0.620
LIG_14-3-3_CanoR_1	179	186	PF00244	0.795
LIG_14-3-3_CanoR_1	278	287	PF00244	0.707
LIG_14-3-3_CanoR_1	293	299	PF00244	0.614
LIG_14-3-3_CanoR_1	305	311	PF00244	0.622
LIG_14-3-3_CanoR_1	364	369	PF00244	0.689
LIG_14-3-3_CanoR_1	389	395	PF00244	0.739
LIG_14-3-3_CanoR_1	409	417	PF00244	0.367
LIG_14-3-3_CanoR_1	468	474	PF00244	0.513
LIG_14-3-3_CanoR_1	508	514	PF00244	0.545
LIG_14-3-3_CanoR_1	662	671	PF00244	0.671
LIG_14-3-3_CanoR_1	90	94	PF00244	0.606
LIG_APCC_ABBA_1	440	445	PF00400	0.634
LIG_BIR_III_2	120	124	PF00653	0.687
LIG_BRCT_BRCA1_1	188	192	PF00533	0.786
LIG_BRCT_BRCA1_1	296	300	PF00533	0.729
LIG_BRCT_BRCA1_1	341	345	PF00533	0.748
LIG_BRCT_BRCA1_1	42	46	PF00533	0.536
LIG_BRCT_BRCA1_1	582	586	PF00533	0.554
LIG_BRCT_BRCA1_1	669	673	PF00533	0.516
LIG_Clathr_ClatBox_1	441	445	PF01394	0.533
LIG_deltaCOP1_diTrp_1	532	536	PF00928	0.584
LIG_EH1_1	131	139	PF00400	0.593
LIG_eIF4E_1	132	138	PF01652	0.587
LIG_EVH1_1	351	355	PF00568	0.565
LIG_FHA_1	363	369	PF00498	0.673
LIG_FHA_1	500	506	PF00498	0.485
LIG_FHA_1	575	581	PF00498	0.800
LIG_FHA_1	621	627	PF00498	0.558
LIG_FHA_2	368	374	PF00498	0.801
LIG_FHA_2	510	516	PF00498	0.503
LIG_LIR_Apic_2	114	118	PF02991	0.658
LIG_LIR_Apic_2	350	354	PF02991	0.721
LIG_LIR_Gen_1	160	168	PF02991	0.569
LIG_LIR_Gen_1	259	270	PF02991	0.670
LIG_LIR_Gen_1	483	490	PF02991	0.770
LIG_LIR_Gen_1	512	520	PF02991	0.503
LIG_LIR_Gen_1	532	541	PF02991	0.589
LIG_LIR_Gen_1	607	613	PF02991	0.689
LIG_LIR_Nem_3	144	150	PF02991	0.515
LIG_LIR_Nem_3	160	166	PF02991	0.471
LIG_LIR_Nem_3	259	265	PF02991	0.695
LIG_LIR_Nem_3	321	326	PF02991	0.808
LIG_LIR_Nem_3	512	516	PF02991	0.507
LIG_LIR_Nem_3	532	536	PF02991	0.482
LIG_LIR_Nem_3	607	612	PF02991	0.754
LIG_MYND_1	324	328	PF01753	0.645
LIG_MYND_1	578	582	PF01753	0.718
LIG_NRP_CendR_1	676	677	PF00754	0.626
LIG_PCNA_APIM_2	10	16	PF02747	0.392
LIG_Pex14_1	147	151	PF04695	0.514
LIG_Pex14_2	42	46	PF04695	0.536
LIG_Pex14_2	469	473	PF04695	0.639
LIG_Rb_pABgroove_1	432	440	PF01858	0.499
LIG_SH2_CRK	210	214	PF00017	0.572
LIG_SH2_GRB2like	139	142	PF00017	0.509
LIG_SH2_GRB2like	198	201	PF00017	0.569
LIG_SH2_PTP2	456	459	PF00017	0.605
LIG_SH2_STAT5	13	16	PF00017	0.462
LIG_SH2_STAT5	132	135	PF00017	0.489
LIG_SH2_STAT5	139	142	PF00017	0.494
LIG_SH2_STAT5	163	166	PF00017	0.431
LIG_SH2_STAT5	198	201	PF00017	0.569
LIG_SH2_STAT5	456	459	PF00017	0.488
LIG_SH2_STAT5	463	466	PF00017	0.451
LIG_SH3_1	223	229	PF00018	0.726
LIG_SH3_1	346	352	PF00018	0.581
LIG_SH3_3	223	229	PF00018	0.804
LIG_SH3_3	346	352	PF00018	0.741
LIG_SH3_3	476	482	PF00018	0.576
LIG_SH3_3	60	66	PF00018	0.473
LIG_SUMO_SIM_anti_2	432	439	PF11976	0.402
LIG_TRAF2_1	83	86	PF00917	0.449
LIG_WW_3	353	357	PF00397	0.772
MOD_CDC14_SPxK_1	386	389	PF00782	0.806
MOD_CDK_SPK_2	119	124	PF00069	0.649
MOD_CDK_SPxK_1	350	356	PF00069	0.778
MOD_CDK_SPxK_1	383	389	PF00069	0.814
MOD_CDK_SPxxK_3	339	346	PF00069	0.711
MOD_CDK_SPxxK_3	383	390	PF00069	0.814
MOD_CK1_1	154	160	PF00069	0.433
MOD_CK1_1	187	193	PF00069	0.808
MOD_CK1_1	276	282	PF00069	0.713
MOD_CK1_1	298	304	PF00069	0.798
MOD_CK1_1	308	314	PF00069	0.638
MOD_CK1_1	344	350	PF00069	0.709
MOD_CK1_1	367	373	PF00069	0.800
MOD_CK1_1	392	398	PF00069	0.699
MOD_CK1_1	403	409	PF00069	0.626
MOD_CK1_1	471	477	PF00069	0.639
MOD_CK1_1	493	499	PF00069	0.591
MOD_CK1_1	561	567	PF00069	0.741
MOD_CK1_1	590	596	PF00069	0.752
MOD_CK1_1	663	669	PF00069	0.642
MOD_CK2_1	601	607	PF00069	0.732
MOD_Cter_Amidation	88	91	PF01082	0.653
MOD_DYRK1A_RPxSP_1	295	299	PF00069	0.644
MOD_DYRK1A_RPxSP_1	339	343	PF00069	0.744
MOD_GlcNHglycan	151	154	PF01048	0.528
MOD_GlcNHglycan	157	160	PF01048	0.482
MOD_GlcNHglycan	182	185	PF01048	0.702
MOD_GlcNHglycan	189	192	PF01048	0.713
MOD_GlcNHglycan	244	247	PF01048	0.800
MOD_GlcNHglycan	266	269	PF01048	0.760
MOD_GlcNHglycan	313	316	PF01048	0.746
MOD_GlcNHglycan	320	323	PF01048	0.815
MOD_GlcNHglycan	346	349	PF01048	0.798
MOD_GlcNHglycan	405	408	PF01048	0.735
MOD_GlcNHglycan	412	415	PF01048	0.585
MOD_GlcNHglycan	487	490	PF01048	0.571
MOD_GlcNHglycan	561	564	PF01048	0.666
MOD_GlcNHglycan	665	668	PF01048	0.745
MOD_GlcNHglycan	86	90	PF01048	0.642
MOD_GSK3_1	107	114	PF00069	0.696
MOD_GSK3_1	151	158	PF00069	0.508
MOD_GSK3_1	180	187	PF00069	0.708
MOD_GSK3_1	260	267	PF00069	0.750
MOD_GSK3_1	273	280	PF00069	0.565
MOD_GSK3_1	294	301	PF00069	0.731
MOD_GSK3_1	306	313	PF00069	0.635
MOD_GSK3_1	318	325	PF00069	0.728
MOD_GSK3_1	363	370	PF00069	0.719
MOD_GSK3_1	385	392	PF00069	0.710
MOD_GSK3_1	485	492	PF00069	0.640
MOD_GSK3_1	663	670	PF00069	0.513
MOD_GSK3_1	85	92	PF00069	0.705
MOD_LATS_1	26	32	PF00433	0.475
MOD_N-GLC_1	401	406	PF02516	0.510
MOD_N-GLC_1	499	504	PF02516	0.483
MOD_NEK2_1	22	27	PF00069	0.594
MOD_NEK2_1	273	278	PF00069	0.758
MOD_NEK2_1	318	323	PF00069	0.810
MOD_NEK2_1	362	367	PF00069	0.747
MOD_NEK2_1	469	474	PF00069	0.584
MOD_NEK2_1	509	514	PF00069	0.387
MOD_NEK2_1	587	592	PF00069	0.758
MOD_NEK2_1	608	613	PF00069	0.687
MOD_PIKK_1	151	157	PF00454	0.557
MOD_PIKK_1	30	36	PF00454	0.594
MOD_PIKK_1	98	104	PF00454	0.800
MOD_PKA_1	294	300	PF00069	0.704
MOD_PKA_1	305	311	PF00069	0.608
MOD_PKA_1	389	395	PF00069	0.810
MOD_PKA_2	141	147	PF00069	0.630
MOD_PKA_2	178	184	PF00069	0.794
MOD_PKA_2	277	283	PF00069	0.745
MOD_PKA_2	294	300	PF00069	0.485
MOD_PKA_2	305	311	PF00069	0.608
MOD_PKA_2	363	369	PF00069	0.773
MOD_PKA_2	389	395	PF00069	0.768
MOD_PKA_2	601	607	PF00069	0.718
MOD_PKA_2	663	669	PF00069	0.668
MOD_PKA_2	67	73	PF00069	0.492
MOD_PKA_2	89	95	PF00069	0.627
MOD_PKB_1	292	300	PF00069	0.707
MOD_PKB_1	339	347	PF00069	0.635
MOD_Plk_1	401	407	PF00069	0.616
MOD_Plk_1	61	67	PF00069	0.510
MOD_Plk_4	111	117	PF00069	0.566
MOD_Plk_4	133	139	PF00069	0.593
MOD_Plk_4	392	398	PF00069	0.766
MOD_Plk_4	494	500	PF00069	0.635
MOD_Plk_4	608	614	PF00069	0.688
MOD_Plk_4	77	83	PF00069	0.417
MOD_ProDKin_1	119	125	PF00069	0.667
MOD_ProDKin_1	201	207	PF00069	0.762
MOD_ProDKin_1	266	272	PF00069	0.741
MOD_ProDKin_1	295	301	PF00069	0.761
MOD_ProDKin_1	308	314	PF00069	0.604
MOD_ProDKin_1	324	330	PF00069	0.619
MOD_ProDKin_1	339	345	PF00069	0.824
MOD_ProDKin_1	350	356	PF00069	0.817
MOD_ProDKin_1	383	389	PF00069	0.766
MOD_ProDKin_1	569	575	PF00069	0.747
MOD_ProDKin_1	588	594	PF00069	0.522
TRG_DiLeu_BaEn_1	542	547	PF01217	0.474
TRG_DiLeu_BaLyEn_6	575	580	PF01217	0.724
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.404
TRG_ENDOCYTIC_2	163	166	PF00928	0.549
TRG_ENDOCYTIC_2	210	213	PF00928	0.571
TRG_ENDOCYTIC_2	427	430	PF00928	0.498
TRG_ENDOCYTIC_2	456	459	PF00928	0.488
TRG_ENDOCYTIC_2	484	487	PF00928	0.747
TRG_ER_diArg_1	15	17	PF00400	0.531
TRG_ER_diArg_1	171	173	PF00400	0.661
TRG_ER_diArg_1	251	254	PF00400	0.762
TRG_ER_diArg_1	291	294	PF00400	0.737
TRG_ER_diArg_1	305	307	PF00400	0.556
TRG_ER_diArg_1	662	665	PF00400	0.645
TRG_ER_diArg_1	675	677	PF00400	0.711
TRG_NES_CRM1_1	432	448	PF08389	0.473
TRG_NES_CRM1_1	545	558	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	651	656	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8H2	Leptomonas seymouri	40%	100%
A0A3S5H6X8	Leishmania donovani	87%	100%
A4H8K6	Leishmania braziliensis	62%	100%
A4HWX9	Leishmania infantum	87%	100%
E9AQP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	93%