Fe-S_biosyn domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iron-sulfur assembly protein 1, putative

Species:

Leishmania major

UniProt:

Q4QET6_LEIMA

TriTrypDb:

LmjF.16.0830 , LMJLV39_160014000 , LMJSD75_160013800

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QET6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QET6

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0019538	protein metabolic process	3	2
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	11
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.474
CLV_NRD_NRD_1	193	195	PF00675	0.272
CLV_PCSK_KEX2_1	134	136	PF00082	0.498
CLV_PCSK_KEX2_1	153	155	PF00082	0.390
CLV_PCSK_KEX2_1	17	19	PF00082	0.615
CLV_PCSK_KEX2_1	192	194	PF00082	0.272
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.593
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.584
CLV_PCSK_PC7_1	188	194	PF00082	0.272
CLV_PCSK_SKI1_1	142	146	PF00082	0.453
CLV_PCSK_SKI1_1	153	157	PF00082	0.442
CLV_PCSK_SKI1_1	17	21	PF00082	0.741
CLV_PCSK_SKI1_1	215	219	PF00082	0.320
DEG_Nend_UBRbox_3	1	3	PF02207	0.595
DEG_SPOP_SBC_1	28	32	PF00917	0.704
DOC_CKS1_1	146	151	PF01111	0.484
DOC_CYCLIN_RxL_1	14	23	PF00134	0.614
DOC_CYCLIN_RxL_1	153	163	PF00134	0.510
DOC_PP1_RVXF_1	133	140	PF00149	0.533
DOC_PP2B_LxvP_1	106	109	PF13499	0.573
DOC_PP4_FxxP_1	267	270	PF00568	0.458
DOC_USP7_MATH_1	113	117	PF00917	0.724
DOC_USP7_MATH_1	160	164	PF00917	0.593
DOC_USP7_MATH_1	174	178	PF00917	0.654
DOC_USP7_MATH_1	210	214	PF00917	0.529
DOC_USP7_MATH_1	217	221	PF00917	0.549
DOC_USP7_MATH_1	24	28	PF00917	0.656
DOC_USP7_MATH_1	35	39	PF00917	0.717
DOC_USP7_MATH_1	46	50	PF00917	0.722
DOC_USP7_MATH_1	95	99	PF00917	0.744
DOC_USP7_UBL2_3	264	268	PF12436	0.543
DOC_USP7_UBL2_3	63	67	PF12436	0.613
DOC_WW_Pin1_4	127	132	PF00397	0.496
DOC_WW_Pin1_4	145	150	PF00397	0.381
DOC_WW_Pin1_4	170	175	PF00397	0.626
DOC_WW_Pin1_4	215	220	PF00397	0.548
DOC_WW_Pin1_4	69	74	PF00397	0.713
LIG_BIR_III_2	120	124	PF00653	0.651
LIG_FHA_1	1	7	PF00498	0.612
LIG_FHA_1	56	62	PF00498	0.648
LIG_FHA_1	69	75	PF00498	0.504
LIG_FHA_2	250	256	PF00498	0.458
LIG_FHA_2	257	263	PF00498	0.458
LIG_LIR_Apic_2	266	270	PF02991	0.458
LIG_LIR_Apic_2	77	81	PF02991	0.641
LIG_LIR_LC3C_4	228	232	PF02991	0.518
LIG_LIR_Nem_3	244	250	PF02991	0.525
LIG_LIR_Nem_3	280	285	PF02991	0.406
LIG_SH2_SRC	248	251	PF00017	0.458
LIG_SH2_STAP1	199	203	PF00017	0.458
LIG_SH2_STAT5	157	160	PF00017	0.371
LIG_SH2_STAT5	201	204	PF00017	0.458
LIG_SH2_STAT5	206	209	PF00017	0.458
LIG_SH2_STAT5	248	251	PF00017	0.458
LIG_SH2_STAT5	256	259	PF00017	0.458
LIG_SH3_3	143	149	PF00018	0.523
LIG_SxIP_EBH_1	67	79	PF03271	0.624
LIG_TRFH_1	145	149	PF08558	0.377
LIG_WRC_WIRS_1	62	67	PF05994	0.525
MOD_CDK_SPxxK_3	127	134	PF00069	0.490
MOD_CDK_SPxxK_3	215	222	PF00069	0.543
MOD_CDK_SPxxK_3	69	76	PF00069	0.682
MOD_CK1_1	177	183	PF00069	0.586
MOD_CK1_1	197	203	PF00069	0.396
MOD_CK1_1	221	227	PF00069	0.453
MOD_CK1_1	27	33	PF00069	0.673
MOD_CK1_1	38	44	PF00069	0.786
MOD_CK1_1	49	55	PF00069	0.677
MOD_CK1_1	97	103	PF00069	0.541
MOD_CK2_1	113	119	PF00069	0.532
MOD_CK2_1	256	262	PF00069	0.550
MOD_CK2_1	74	80	PF00069	0.762
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.478
MOD_GlcNHglycan	166	169	PF01048	0.566
MOD_GlcNHglycan	196	199	PF01048	0.222
MOD_GlcNHglycan	208	211	PF01048	0.280
MOD_GlcNHglycan	212	215	PF01048	0.303
MOD_GlcNHglycan	26	29	PF01048	0.603
MOD_GlcNHglycan	48	51	PF01048	0.722
MOD_GlcNHglycan	97	100	PF01048	0.576
MOD_GSK3_1	160	167	PF00069	0.515
MOD_GSK3_1	170	177	PF00069	0.506
MOD_GSK3_1	20	27	PF00069	0.630
MOD_GSK3_1	206	213	PF00069	0.525
MOD_GSK3_1	217	224	PF00069	0.423
MOD_GSK3_1	35	42	PF00069	0.714
MOD_GSK3_1	48	55	PF00069	0.547
MOD_N-GLC_1	36	41	PF02516	0.775
MOD_N-GLC_1	46	51	PF02516	0.631
MOD_NEK2_1	1	6	PF00069	0.696
MOD_NEK2_1	19	24	PF00069	0.755
MOD_NEK2_1	61	66	PF00069	0.685
MOD_PIKK_1	55	61	PF00454	0.737
MOD_PKA_2	113	119	PF00069	0.573
MOD_PKA_2	39	45	PF00069	0.730
MOD_PKA_2	68	74	PF00069	0.677
MOD_PKB_1	192	200	PF00069	0.472
MOD_Plk_4	1	7	PF00069	0.604
MOD_Plk_4	278	284	PF00069	0.532
MOD_ProDKin_1	127	133	PF00069	0.493
MOD_ProDKin_1	145	151	PF00069	0.374
MOD_ProDKin_1	170	176	PF00069	0.629
MOD_ProDKin_1	215	221	PF00069	0.548
MOD_ProDKin_1	69	75	PF00069	0.716
TRG_ENDOCYTIC_2	62	65	PF00928	0.674
TRG_ER_diArg_1	152	154	PF00400	0.376
TRG_ER_diArg_1	191	194	PF00400	0.484
TRG_ER_diArg_1	83	86	PF00400	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U6	Leptomonas seymouri	65%	100%
A0A1X0NZ22	Trypanosomatidae	59%	100%
A0A3Q8IAJ0	Leishmania donovani	93%	100%
A0A422NDJ9	Trypanosoma rangeli	50%	100%
A4H8K7	Leishmania braziliensis	76%	100%
A4HWY0	Leishmania infantum	93%	100%
C9ZW24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AQP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BHL1	Trypanosoma cruzi	49%	91%