Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QET5_LEIMA

TriTrypDb:

LmjF.16.0840 , LMJLV39_160014100 , LMJSD75_160013900

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QET5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QET5

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018026	peptidyl-lysine monomethylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.536
CLV_C14_Caspase3-7	546	550	PF00656	0.601
CLV_C14_Caspase3-7	592	596	PF00656	0.545
CLV_C14_Caspase3-7	783	787	PF00656	0.620
CLV_C14_Caspase3-7	92	96	PF00656	0.688
CLV_MEL_PAP_1	274	280	PF00089	0.663
CLV_NRD_NRD_1	130	132	PF00675	0.538
CLV_NRD_NRD_1	174	176	PF00675	0.720
CLV_NRD_NRD_1	310	312	PF00675	0.498
CLV_NRD_NRD_1	454	456	PF00675	0.703
CLV_NRD_NRD_1	532	534	PF00675	0.708
CLV_NRD_NRD_1	577	579	PF00675	0.698
CLV_NRD_NRD_1	62	64	PF00675	0.511
CLV_NRD_NRD_1	670	672	PF00675	0.513
CLV_PCSK_FUR_1	128	132	PF00082	0.538
CLV_PCSK_FUR_1	172	176	PF00082	0.666
CLV_PCSK_KEX2_1	130	132	PF00082	0.538
CLV_PCSK_KEX2_1	174	176	PF00082	0.727
CLV_PCSK_KEX2_1	310	312	PF00082	0.551
CLV_PCSK_KEX2_1	577	579	PF00082	0.698
CLV_PCSK_KEX2_1	670	672	PF00082	0.513
CLV_PCSK_PC7_1	126	132	PF00082	0.533
CLV_PCSK_SKI1_1	311	315	PF00082	0.540
CLV_PCSK_SKI1_1	460	464	PF00082	0.646
CLV_PCSK_SKI1_1	560	564	PF00082	0.566
DEG_APCC_DBOX_1	559	567	PF00400	0.622
DEG_APCC_DBOX_1	611	619	PF00400	0.632
DEG_SCF_FBW7_1	626	633	PF00400	0.710
DEG_SCF_FBW7_1	714	719	PF00400	0.499
DOC_CDC14_PxL_1	520	528	PF14671	0.682
DOC_CKS1_1	711	716	PF01111	0.675
DOC_CYCLIN_RxL_1	775	786	PF00134	0.619
DOC_MAPK_FxFP_2	390	393	PF00069	0.529
DOC_MAPK_gen_1	467	475	PF00069	0.674
DOC_MAPK_gen_1	533	540	PF00069	0.774
DOC_PP1_RVXF_1	729	736	PF00149	0.440
DOC_PP2B_LxvP_1	521	524	PF13499	0.736
DOC_PP4_FxxP_1	390	393	PF00568	0.529
DOC_PP4_FxxP_1	711	714	PF00568	0.627
DOC_USP7_MATH_1	112	116	PF00917	0.487
DOC_USP7_MATH_1	146	150	PF00917	0.467
DOC_USP7_MATH_1	187	191	PF00917	0.626
DOC_USP7_MATH_1	276	280	PF00917	0.731
DOC_USP7_MATH_1	29	33	PF00917	0.522
DOC_USP7_MATH_1	357	361	PF00917	0.718
DOC_USP7_MATH_1	409	413	PF00917	0.493
DOC_USP7_MATH_1	435	439	PF00917	0.607
DOC_USP7_MATH_1	548	552	PF00917	0.712
DOC_USP7_MATH_1	55	59	PF00917	0.481
DOC_USP7_MATH_1	589	593	PF00917	0.620
DOC_USP7_MATH_1	706	710	PF00917	0.560
DOC_USP7_MATH_1	716	720	PF00917	0.637
DOC_USP7_MATH_1	781	785	PF00917	0.545
DOC_USP7_MATH_1	84	88	PF00917	0.703
DOC_WW_Pin1_4	237	242	PF00397	0.781
DOC_WW_Pin1_4	266	271	PF00397	0.732
DOC_WW_Pin1_4	353	358	PF00397	0.721
DOC_WW_Pin1_4	613	618	PF00397	0.546
DOC_WW_Pin1_4	626	631	PF00397	0.604
DOC_WW_Pin1_4	642	647	PF00397	0.415
DOC_WW_Pin1_4	697	702	PF00397	0.572
DOC_WW_Pin1_4	710	715	PF00397	0.586
LIG_14-3-3_CanoR_1	116	123	PF00244	0.544
LIG_14-3-3_CanoR_1	289	295	PF00244	0.625
LIG_14-3-3_CanoR_1	296	302	PF00244	0.518
LIG_14-3-3_CanoR_1	348	357	PF00244	0.556
LIG_14-3-3_CanoR_1	57	67	PF00244	0.428
LIG_14-3-3_CanoR_1	718	728	PF00244	0.578
LIG_14-3-3_CanoR_1	767	772	PF00244	0.678
LIG_Actin_WH2_2	160	176	PF00022	0.573
LIG_Actin_WH2_2	502	519	PF00022	0.559
LIG_Actin_WH2_2	690	706	PF00022	0.592
LIG_AP2alpha_1	402	406	PF02296	0.482
LIG_APCC_ABBA_1	399	404	PF00400	0.476
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_BIR_III_4	547	551	PF00653	0.719
LIG_BRCT_BRCA1_1	386	390	PF00533	0.433
LIG_CaM_NSCaTE_8	634	641	PF13499	0.536
LIG_CSL_BTD_1	711	714	PF09270	0.627
LIG_deltaCOP1_diTrp_1	212	219	PF00928	0.504
LIG_deltaCOP1_diTrp_1	394	402	PF00928	0.447
LIG_deltaCOP1_diTrp_1	666	672	PF00928	0.515
LIG_deltaCOP1_diTrp_1	675	680	PF00928	0.558
LIG_deltaCOP1_diTrp_1	772	779	PF00928	0.565
LIG_eIF4E_1	503	509	PF01652	0.490
LIG_FHA_1	103	109	PF00498	0.569
LIG_FHA_1	148	154	PF00498	0.456
LIG_FHA_1	330	336	PF00498	0.569
LIG_FHA_1	394	400	PF00498	0.473
LIG_FHA_1	40	46	PF00498	0.452
LIG_FHA_1	428	434	PF00498	0.758
LIG_FHA_1	463	469	PF00498	0.637
LIG_FHA_1	535	541	PF00498	0.758
LIG_FHA_1	568	574	PF00498	0.592
LIG_FHA_1	643	649	PF00498	0.535
LIG_FHA_1	751	757	PF00498	0.683
LIG_FHA_1	766	772	PF00498	0.608
LIG_FHA_2	247	253	PF00498	0.680
LIG_FHA_2	631	637	PF00498	0.643
LIG_LIR_Apic_2	387	393	PF02991	0.510
LIG_LIR_Apic_2	709	714	PF02991	0.629
LIG_LIR_Gen_1	290	299	PF02991	0.596
LIG_LIR_Gen_1	394	405	PF02991	0.445
LIG_LIR_Gen_1	480	491	PF02991	0.522
LIG_LIR_Gen_1	737	746	PF02991	0.555
LIG_LIR_Gen_1	772	782	PF02991	0.553
LIG_LIR_LC3C_4	725	730	PF02991	0.600
LIG_LIR_Nem_3	115	121	PF02991	0.561
LIG_LIR_Nem_3	290	294	PF02991	0.597
LIG_LIR_Nem_3	404	408	PF02991	0.436
LIG_LIR_Nem_3	480	486	PF02991	0.567
LIG_LIR_Nem_3	674	680	PF02991	0.588
LIG_LIR_Nem_3	683	688	PF02991	0.575
LIG_LIR_Nem_3	772	777	PF02991	0.572
LIG_LIR_Nem_3	790	795	PF02991	0.604
LIG_MYND_1	518	522	PF01753	0.583
LIG_MYND_1	539	543	PF01753	0.698
LIG_NRBOX	634	640	PF00104	0.615
LIG_NRBOX	9	15	PF00104	0.462
LIG_PCNA_PIPBox_1	773	782	PF02747	0.548
LIG_PCNA_yPIPBox_3	767	780	PF02747	0.649
LIG_Pex14_1	287	291	PF04695	0.614
LIG_Pex14_1	735	739	PF04695	0.503
LIG_Pex14_2	378	382	PF04695	0.462
LIG_Pex14_2	402	406	PF04695	0.482
LIG_SH2_CRK	164	168	PF00017	0.501
LIG_SH2_CRK	227	231	PF00017	0.506
LIG_SH2_CRK	611	615	PF00017	0.609
LIG_SH2_GRB2like	227	230	PF00017	0.508
LIG_SH2_GRB2like	405	408	PF00017	0.432
LIG_SH2_GRB2like	739	742	PF00017	0.545
LIG_SH2_NCK_1	503	507	PF00017	0.626
LIG_SH2_PTP2	156	159	PF00017	0.444
LIG_SH2_PTP2	291	294	PF00017	0.604
LIG_SH2_STAP1	227	231	PF00017	0.506
LIG_SH2_STAP1	481	485	PF00017	0.565
LIG_SH2_STAT3	481	484	PF00017	0.495
LIG_SH2_STAT5	156	159	PF00017	0.444
LIG_SH2_STAT5	209	212	PF00017	0.525
LIG_SH2_STAT5	281	284	PF00017	0.599
LIG_SH2_STAT5	291	294	PF00017	0.572
LIG_SH2_STAT5	391	394	PF00017	0.579
LIG_SH2_STAT5	405	408	PF00017	0.331
LIG_SH2_STAT5	739	742	PF00017	0.539
LIG_SH2_STAT5	792	795	PF00017	0.553
LIG_SH3_1	611	617	PF00018	0.601
LIG_SH3_3	231	237	PF00018	0.599
LIG_SH3_3	267	273	PF00018	0.703
LIG_SH3_3	420	426	PF00018	0.742
LIG_SH3_3	485	491	PF00018	0.523
LIG_SH3_3	536	542	PF00018	0.711
LIG_SH3_3	611	617	PF00018	0.601
LIG_SH3_3	645	651	PF00018	0.555
LIG_SH3_5	401	405	PF00018	0.431
LIG_SUMO_SIM_anti_2	504	510	PF11976	0.576
LIG_SUMO_SIM_anti_2	725	731	PF11976	0.598
LIG_TRAF2_1	183	186	PF00917	0.793
LIG_TRAF2_1	788	791	PF00917	0.524
LIG_TRFH_1	514	518	PF08558	0.528
LIG_TYR_ITIM	154	159	PF00017	0.444
LIG_Vh1_VBS_1	552	570	PF01044	0.612
MOD_CDK_SPxK_1	712	718	PF00069	0.608
MOD_CDK_SPxxK_3	697	704	PF00069	0.598
MOD_CK1_1	149	155	PF00069	0.541
MOD_CK1_1	2	8	PF00069	0.594
MOD_CK1_1	259	265	PF00069	0.661
MOD_CK1_1	279	285	PF00069	0.511
MOD_CK1_1	290	296	PF00069	0.558
MOD_CK1_1	352	358	PF00069	0.747
MOD_CK1_1	412	418	PF00069	0.497
MOD_CK1_1	568	574	PF00069	0.670
MOD_CK1_1	58	64	PF00069	0.423
MOD_CK1_1	710	716	PF00069	0.648
MOD_CK1_1	719	725	PF00069	0.579
MOD_CK2_1	116	122	PF00069	0.587
MOD_CK2_1	187	193	PF00069	0.643
MOD_CK2_1	246	252	PF00069	0.602
MOD_CK2_1	501	507	PF00069	0.493
MOD_CK2_1	654	660	PF00069	0.610
MOD_CK2_1	719	725	PF00069	0.617
MOD_CK2_1	794	800	PF00069	0.700
MOD_Cter_Amidation	531	534	PF01082	0.711
MOD_GlcNHglycan	1	4	PF01048	0.684
MOD_GlcNHglycan	175	178	PF01048	0.778
MOD_GlcNHglycan	189	192	PF01048	0.713
MOD_GlcNHglycan	22	25	PF01048	0.522
MOD_GlcNHglycan	261	264	PF01048	0.754
MOD_GlcNHglycan	278	281	PF01048	0.663
MOD_GlcNHglycan	284	287	PF01048	0.603
MOD_GlcNHglycan	567	570	PF01048	0.681
MOD_GlcNHglycan	639	642	PF01048	0.599
MOD_GlcNHglycan	682	685	PF01048	0.683
MOD_GlcNHglycan	721	724	PF01048	0.569
MOD_GlcNHglycan	758	761	PF01048	0.603
MOD_GlcNHglycan	97	100	PF01048	0.598
MOD_GSK3_1	112	119	PF00069	0.518
MOD_GSK3_1	122	129	PF00069	0.500
MOD_GSK3_1	185	192	PF00069	0.736
MOD_GSK3_1	203	210	PF00069	0.586
MOD_GSK3_1	259	266	PF00069	0.710
MOD_GSK3_1	349	356	PF00069	0.738
MOD_GSK3_1	458	465	PF00069	0.702
MOD_GSK3_1	486	493	PF00069	0.577
MOD_GSK3_1	512	519	PF00069	0.549
MOD_GSK3_1	561	568	PF00069	0.616
MOD_GSK3_1	626	633	PF00069	0.641
MOD_GSK3_1	650	657	PF00069	0.586
MOD_GSK3_1	706	713	PF00069	0.612
MOD_GSK3_1	752	759	PF00069	0.681
MOD_GSK3_1	85	92	PF00069	0.706
MOD_N-GLC_1	263	268	PF02516	0.807
MOD_N-GLC_1	412	417	PF02516	0.490
MOD_N-GLC_1	686	691	PF02516	0.632
MOD_N-GLC_1	740	745	PF02516	0.631
MOD_N-GLC_1	89	94	PF02516	0.720
MOD_N-GLC_1	95	100	PF02516	0.684
MOD_NEK2_1	173	178	PF00069	0.716
MOD_NEK2_1	297	302	PF00069	0.605
MOD_NEK2_1	434	439	PF00069	0.599
MOD_NEK2_1	561	566	PF00069	0.652
MOD_NEK2_1	680	685	PF00069	0.594
MOD_NEK2_2	512	517	PF00069	0.558
MOD_PIKK_1	357	363	PF00454	0.789
MOD_PIKK_1	561	567	PF00454	0.622
MOD_PK_1	256	262	PF00069	0.731
MOD_PK_1	767	773	PF00069	0.671
MOD_PKA_1	534	540	PF00069	0.659
MOD_PKA_2	165	171	PF00069	0.524
MOD_PKA_2	173	179	PF00069	0.644
MOD_PKA_2	276	282	PF00069	0.783
MOD_PKA_2	486	492	PF00069	0.539
MOD_PKA_2	516	522	PF00069	0.624
MOD_PKA_2	717	723	PF00069	0.614
MOD_Plk_1	185	191	PF00069	0.745
MOD_Plk_1	393	399	PF00069	0.515
MOD_Plk_1	716	722	PF00069	0.576
MOD_Plk_2-3	654	660	PF00069	0.593
MOD_Plk_2-3	794	800	PF00069	0.657
MOD_Plk_4	149	155	PF00069	0.369
MOD_Plk_4	256	262	PF00069	0.755
MOD_Plk_4	381	387	PF00069	0.410
MOD_Plk_4	412	418	PF00069	0.550
MOD_Plk_4	516	522	PF00069	0.571
MOD_Plk_4	548	554	PF00069	0.709
MOD_Plk_4	599	605	PF00069	0.591
MOD_Plk_4	630	636	PF00069	0.590
MOD_Plk_4	707	713	PF00069	0.568
MOD_ProDKin_1	237	243	PF00069	0.785
MOD_ProDKin_1	266	272	PF00069	0.728
MOD_ProDKin_1	353	359	PF00069	0.720
MOD_ProDKin_1	613	619	PF00069	0.545
MOD_ProDKin_1	626	632	PF00069	0.596
MOD_ProDKin_1	642	648	PF00069	0.413
MOD_ProDKin_1	697	703	PF00069	0.565
MOD_ProDKin_1	710	716	PF00069	0.592
MOD_SUMO_for_1	138	141	PF00179	0.520
MOD_SUMO_rev_2	616	626	PF00179	0.614
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.755
TRG_DiLeu_BaLyEn_6	723	728	PF01217	0.632
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.508
TRG_ENDOCYTIC_2	156	159	PF00928	0.444
TRG_ENDOCYTIC_2	164	167	PF00928	0.486
TRG_ENDOCYTIC_2	227	230	PF00928	0.508
TRG_ENDOCYTIC_2	291	294	PF00928	0.604
TRG_ENDOCYTIC_2	503	506	PF00928	0.500
TRG_ENDOCYTIC_2	739	742	PF00928	0.621
TRG_ER_diArg_1	127	130	PF00400	0.528
TRG_ER_diArg_1	172	175	PF00400	0.771
TRG_ER_diArg_1	576	578	PF00400	0.676
TRG_ER_diArg_1	669	671	PF00400	0.512
TRG_NLS_MonoExtN_4	530	537	PF00514	0.670
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	778	783	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I059	Leptomonas seymouri	52%	99%
A0A1X0NQD9	Trypanosomatidae	26%	100%
A0A3S7WTX8	Leishmania donovani	92%	100%
A4H8K8	Leishmania braziliensis	74%	100%
E9AGN5	Leishmania infantum	92%	100%
E9AQP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%