Putative metallopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COP9 signalosome complex subunit 5, putative

Species:

Leishmania major

UniProt:

Q4QET4_LEIMA

TriTrypDb:

LmjF.16.0850 , LMJLV39_160014200 , LMJSD75_160014000

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0008180	COP9 signalosome	3	7
GO:0032991	protein-containing complex	1	7
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	7

Expansion

Sequence features

Q4QET4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QET4

Function

Biological processes
Term	Name	Level	Count
GO:0000338	protein deneddylation	6	2
GO:0006508	proteolysis	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	7
GO:0070646	protein modification by small protein removal	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	7
GO:0004222	metalloendopeptidase activity	5	7
GO:0005488	binding	1	7
GO:0008233	peptidase activity	3	7
GO:0008237	metallopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	2
GO:0019784	deNEDDylase activity	5	2
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.590
CLV_C14_Caspase3-7	281	285	PF00656	0.402
CLV_C14_Caspase3-7	372	376	PF00656	0.654
CLV_NRD_NRD_1	149	151	PF00675	0.302
CLV_NRD_NRD_1	449	451	PF00675	0.573
CLV_PCSK_KEX2_1	149	151	PF00082	0.302
CLV_PCSK_KEX2_1	436	438	PF00082	0.763
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.631
CLV_PCSK_SKI1_1	79	83	PF00082	0.363
CLV_Separin_Metazoa	396	400	PF03568	0.458
DEG_SCF_FBW7_1	20	26	PF00400	0.581
DOC_CKS1_1	20	25	PF01111	0.763
DOC_CKS1_1	43	48	PF01111	0.435
DOC_CYCLIN_yCln2_LP_2	302	308	PF00134	0.481
DOC_MAPK_gen_1	58	67	PF00069	0.389
DOC_MAPK_HePTP_8	290	302	PF00069	0.497
DOC_MAPK_MEF2A_6	270	278	PF00069	0.373
DOC_MAPK_MEF2A_6	293	302	PF00069	0.496
DOC_PP4_FxxP_1	120	123	PF00568	0.302
DOC_PP4_FxxP_1	247	250	PF00568	0.514
DOC_USP7_MATH_1	227	231	PF00917	0.684
DOC_USP7_MATH_1	23	27	PF00917	0.649
DOC_USP7_MATH_1	331	335	PF00917	0.524
DOC_USP7_MATH_1	37	41	PF00917	0.362
DOC_USP7_MATH_1	89	93	PF00917	0.305
DOC_USP7_MATH_1	9	13	PF00917	0.633
DOC_WW_Pin1_4	19	24	PF00397	0.681
DOC_WW_Pin1_4	237	242	PF00397	0.554
DOC_WW_Pin1_4	337	342	PF00397	0.613
DOC_WW_Pin1_4	4	9	PF00397	0.619
DOC_WW_Pin1_4	42	47	PF00397	0.507
LIG_14-3-3_CanoR_1	223	232	PF00244	0.583
LIG_14-3-3_CanoR_1	277	287	PF00244	0.408
LIG_14-3-3_CanoR_1	437	445	PF00244	0.604
LIG_AP2alpha_2	188	190	PF02296	0.362
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	300	304	PF00533	0.439
LIG_BRCT_BRCA1_1	455	459	PF00533	0.609
LIG_BRCT_BRCA1_1	63	67	PF00533	0.415
LIG_CtBP_PxDLS_1	297	301	PF00389	0.427
LIG_deltaCOP1_diTrp_1	41	48	PF00928	0.467
LIG_EH1_1	98	106	PF00400	0.302
LIG_FHA_1	392	398	PF00498	0.508
LIG_FHA_2	246	252	PF00498	0.609
LIG_FHA_2	439	445	PF00498	0.537
LIG_HP1_1	189	193	PF01393	0.346
LIG_LIR_Apic_2	117	123	PF02991	0.302
LIG_LIR_Apic_2	245	250	PF02991	0.613
LIG_LIR_Apic_2	251	256	PF02991	0.564
LIG_LIR_Apic_2	40	46	PF02991	0.402
LIG_LIR_Gen_1	188	198	PF02991	0.399
LIG_LIR_Gen_1	403	413	PF02991	0.578
LIG_LIR_Gen_1	45	54	PF02991	0.520
LIG_LIR_Gen_1	452	459	PF02991	0.598
LIG_LIR_Gen_1	64	75	PF02991	0.196
LIG_LIR_Nem_3	188	193	PF02991	0.375
LIG_LIR_Nem_3	403	408	PF02991	0.562
LIG_LIR_Nem_3	452	458	PF02991	0.594
LIG_LIR_Nem_3	64	70	PF02991	0.405
LIG_MLH1_MIPbox_1	63	67	PF16413	0.415
LIG_PCNA_PIPBox_1	102	111	PF02747	0.302
LIG_Pex14_1	44	48	PF04695	0.468
LIG_Pex14_2	455	459	PF04695	0.609
LIG_Pex14_2	62	66	PF04695	0.393
LIG_SH2_CRK	253	257	PF00017	0.547
LIG_SH2_STAP1	168	172	PF00017	0.302
LIG_SH2_STAT5	144	147	PF00017	0.311
LIG_SH3_3	191	197	PF00018	0.341
LIG_SH3_3	2	8	PF00018	0.562
LIG_SH3_3	302	308	PF00018	0.520
LIG_SUMO_SIM_par_1	296	301	PF11976	0.429
LIG_SUMO_SIM_par_1	389	394	PF11976	0.554
LIG_TRAF2_1	466	469	PF00917	0.662
MOD_CDK_SPxxK_3	4	11	PF00069	0.620
MOD_CK1_1	13	19	PF00069	0.588
MOD_CK1_1	4	10	PF00069	0.619
MOD_CK1_1	439	445	PF00069	0.735
MOD_CK1_1	454	460	PF00069	0.499
MOD_CK2_1	107	113	PF00069	0.318
MOD_CK2_1	124	130	PF00069	0.325
MOD_CK2_1	438	444	PF00069	0.536
MOD_GlcNHglycan	12	15	PF01048	0.532
MOD_GlcNHglycan	172	175	PF01048	0.302
MOD_GlcNHglycan	225	228	PF01048	0.636
MOD_GlcNHglycan	229	232	PF01048	0.661
MOD_GlcNHglycan	25	28	PF01048	0.541
MOD_GlcNHglycan	280	283	PF01048	0.453
MOD_GlcNHglycan	316	319	PF01048	0.576
MOD_GlcNHglycan	324	327	PF01048	0.541
MOD_GlcNHglycan	366	369	PF01048	0.636
MOD_GlcNHglycan	371	374	PF01048	0.586
MOD_GlcNHglycan	375	379	PF01048	0.516
MOD_GSK3_1	114	121	PF00069	0.302
MOD_GSK3_1	166	173	PF00069	0.302
MOD_GSK3_1	176	183	PF00069	0.302
MOD_GSK3_1	18	25	PF00069	0.607
MOD_GSK3_1	200	207	PF00069	0.439
MOD_GSK3_1	221	228	PF00069	0.727
MOD_GSK3_1	296	303	PF00069	0.481
MOD_GSK3_1	333	340	PF00069	0.552
MOD_GSK3_1	453	460	PF00069	0.545
MOD_GSK3_1	66	73	PF00069	0.320
MOD_GSK3_1	9	16	PF00069	0.614
MOD_N-GLC_1	242	247	PF02516	0.552
MOD_NEK2_1	1	6	PF00069	0.620
MOD_NEK2_1	116	121	PF00069	0.302
MOD_NEK2_1	298	303	PF00069	0.481
MOD_NEK2_1	32	37	PF00069	0.556
MOD_NEK2_1	358	363	PF00069	0.626
MOD_NEK2_1	458	463	PF00069	0.618
MOD_NEK2_1	66	71	PF00069	0.375
MOD_NEK2_1	74	79	PF00069	0.265
MOD_NEK2_1	82	87	PF00069	0.234
MOD_NEK2_2	166	171	PF00069	0.302
MOD_NEK2_2	204	209	PF00069	0.423
MOD_PIKK_1	13	19	PF00454	0.620
MOD_PIKK_1	134	140	PF00454	0.302
MOD_PIKK_1	176	182	PF00454	0.302
MOD_PIKK_1	89	95	PF00454	0.302
MOD_PKA_1	436	442	PF00069	0.574
MOD_PKA_2	10	16	PF00069	0.630
MOD_PKA_2	436	442	PF00069	0.608
MOD_PKB_1	223	231	PF00069	0.580
MOD_PKB_1	399	407	PF00069	0.497
MOD_Plk_1	129	135	PF00069	0.300
MOD_Plk_1	242	248	PF00069	0.563
MOD_Plk_1	451	457	PF00069	0.626
MOD_Plk_4	454	460	PF00069	0.605
MOD_Plk_4	61	67	PF00069	0.435
MOD_ProDKin_1	19	25	PF00069	0.677
MOD_ProDKin_1	237	243	PF00069	0.556
MOD_ProDKin_1	337	343	PF00069	0.613
MOD_ProDKin_1	4	10	PF00069	0.619
MOD_ProDKin_1	42	48	PF00069	0.510
TRG_AP2beta_CARGO_1	452	462	PF09066	0.571
TRG_DiLeu_BaEn_1	100	105	PF01217	0.302
TRG_DiLeu_BaEn_1	403	408	PF01217	0.500
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.532
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.572
TRG_ENDOCYTIC_2	168	171	PF00928	0.352
TRG_ENDOCYTIC_2	271	274	PF00928	0.355
TRG_ER_diArg_1	149	151	PF00400	0.302
TRG_ER_diArg_1	398	401	PF00400	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD30	Leptomonas seymouri	58%	100%
A0A3Q8IAE8	Leishmania donovani	94%	97%
A4H8K9	Leishmania braziliensis	78%	100%
A4HWY1	Leishmania infantum	94%	100%
E9AQP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%