Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QET3_LEIMA

TriTrypDb:

LmjF.16.0860 , LMJLV39_160014300 , LMJSD75_160014100

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QET3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QET3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	233	235	PF00675	0.464
CLV_PCSK_KEX2_1	227	229	PF00082	0.530
CLV_PCSK_KEX2_1	233	235	PF00082	0.461
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.561
CLV_PCSK_SKI1_1	140	144	PF00082	0.532
CLV_PCSK_SKI1_1	244	248	PF00082	0.374
DEG_Nend_Nbox_1	1	3	PF02207	0.515
DEG_SPOP_SBC_1	61	65	PF00917	0.773
DOC_CKS1_1	38	43	PF01111	0.530
DOC_MAPK_gen_1	233	239	PF00069	0.494
DOC_MAPK_MEF2A_6	114	122	PF00069	0.539
DOC_PP4_FxxP_1	191	194	PF00568	0.562
DOC_SPAK_OSR1_1	234	238	PF12202	0.494
DOC_USP7_MATH_1	106	110	PF00917	0.603
DOC_USP7_MATH_1	130	134	PF00917	0.722
DOC_USP7_MATH_1	171	175	PF00917	0.682
DOC_USP7_MATH_1	217	221	PF00917	0.654
DOC_USP7_MATH_1	84	88	PF00917	0.552
DOC_USP7_UBL2_3	110	114	PF12436	0.715
DOC_WW_Pin1_4	16	21	PF00397	0.553
DOC_WW_Pin1_4	190	195	PF00397	0.555
DOC_WW_Pin1_4	37	42	PF00397	0.526
LIG_14-3-3_CanoR_1	119	123	PF00244	0.506
LIG_14-3-3_CanoR_1	172	182	PF00244	0.662
LIG_14-3-3_CanoR_1	244	254	PF00244	0.446
LIG_Actin_WH2_2	39	55	PF00022	0.531
LIG_BIR_III_2	152	156	PF00653	0.499
LIG_BRCT_BRCA1_1	145	149	PF00533	0.498
LIG_BRCT_BRCA1_1	150	154	PF00533	0.600
LIG_BRCT_BRCA1_1	192	196	PF00533	0.561
LIG_Clathr_ClatBox_1	2	6	PF01394	0.513
LIG_FHA_1	139	145	PF00498	0.534
LIG_FHA_1	32	38	PF00498	0.442
LIG_FHA_2	181	187	PF00498	0.682
LIG_LIR_Apic_2	188	194	PF02991	0.558
LIG_LIR_Gen_1	40	48	PF02991	0.513
LIG_LIR_Gen_1	81	90	PF02991	0.524
LIG_LIR_Nem_3	40	46	PF02991	0.513
LIG_PTB_Apo_2	36	43	PF02174	0.551
LIG_SH2_CRK	229	233	PF00017	0.577
LIG_SH2_CRK	27	31	PF00017	0.500
LIG_SH2_STAP1	27	31	PF00017	0.500
LIG_SH3_3	123	129	PF00018	0.585
LIG_SH3_4	110	117	PF00018	0.681
LIG_SUMO_SIM_anti_2	205	212	PF11976	0.498
LIG_SUMO_SIM_par_1	1	6	PF11976	0.514
LIG_SUMO_SIM_par_1	140	146	PF11976	0.521
LIG_TRAF2_1	48	51	PF00917	0.642
LIG_UBA3_1	1	8	PF00899	0.513
LIG_WRC_WIRS_1	144	149	PF05994	0.482
MOD_CDC14_SPxK_1	19	22	PF00782	0.557
MOD_CDK_SPxK_1	16	22	PF00069	0.562
MOD_CK1_1	174	180	PF00069	0.752
MOD_CK1_1	199	205	PF00069	0.520
MOD_CK1_1	219	225	PF00069	0.480
MOD_CK1_1	63	69	PF00069	0.681
MOD_CK1_1	70	76	PF00069	0.675
MOD_CK2_1	130	136	PF00069	0.686
MOD_CK2_1	180	186	PF00069	0.704
MOD_GlcNHglycan	199	202	PF01048	0.652
MOD_GlcNHglycan	219	222	PF01048	0.447
MOD_GlcNHglycan	58	61	PF01048	0.636
MOD_GlcNHglycan	66	69	PF01048	0.628
MOD_GlcNHglycan	86	89	PF01048	0.564
MOD_GSK3_1	143	150	PF00069	0.465
MOD_GSK3_1	157	164	PF00069	0.586
MOD_GSK3_1	173	180	PF00069	0.569
MOD_GSK3_1	212	219	PF00069	0.660
MOD_GSK3_1	56	63	PF00069	0.682
MOD_GSK3_1	67	74	PF00069	0.655
MOD_N-GLC_1	147	152	PF02516	0.519
MOD_NEK2_1	138	143	PF00069	0.569
MOD_NEK2_1	196	201	PF00069	0.513
MOD_NEK2_1	213	218	PF00069	0.548
MOD_NEK2_1	62	67	PF00069	0.665
MOD_PKA_2	118	124	PF00069	0.506
MOD_PKA_2	171	177	PF00069	0.678
MOD_Plk_1	185	191	PF00069	0.601
MOD_Plk_4	113	119	PF00069	0.556
MOD_Plk_4	204	210	PF00069	0.603
MOD_ProDKin_1	16	22	PF00069	0.555
MOD_ProDKin_1	190	196	PF00069	0.556
MOD_ProDKin_1	37	43	PF00069	0.528
MOD_SUMO_for_1	78	81	PF00179	0.598
MOD_SUMO_rev_2	45	55	PF00179	0.517
MOD_SUMO_rev_2	93	101	PF00179	0.642
TRG_DiLeu_BaEn_1	249	254	PF01217	0.535
TRG_DiLeu_BaEn_3	249	255	PF01217	0.530
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.484
TRG_ENDOCYTIC_2	27	30	PF00928	0.507
TRG_ER_diArg_1	232	234	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5G6	Leptomonas seymouri	50%	100%
A0A3Q8IAC4	Leishmania donovani	93%	100%
A4H8L0	Leishmania braziliensis	74%	100%
A4HWY2	Leishmania infantum	93%	100%
E9AQP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	81%