Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QET2_LEIMA

TriTrypDb:

LmjF.16.0870 , LMJLV39_160014400 , LMJSD75_160014200

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QET2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QET2

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	517	521	PF00656	0.389
CLV_NRD_NRD_1	197	199	PF00675	0.555
CLV_NRD_NRD_1	349	351	PF00675	0.587
CLV_NRD_NRD_1	442	444	PF00675	0.389
CLV_NRD_NRD_1	640	642	PF00675	0.374
CLV_PCSK_KEX2_1	197	199	PF00082	0.520
CLV_PCSK_KEX2_1	349	351	PF00082	0.587
CLV_PCSK_KEX2_1	442	444	PF00082	0.389
CLV_PCSK_KEX2_1	662	664	PF00082	0.324
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.358

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE38	Leptomonas seymouri	66%	100%
A0A0S4JLW5	Bodo saltans	36%	90%
A0A3S5H6X9	Leishmania donovani	94%	100%
A4H8L1	Leishmania braziliensis	76%	100%
A4HWY3	Leishmania infantum	94%	100%
C9ZW20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AQP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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