Nucleolar protein, Nop52 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein,Nop52, putative

Species:

Leishmania major

UniProt:

Q4QET0_LEIMA

TriTrypDb:

LmjF.16.0890 , LMJLV39_160014600 , LMJSD75_160014400

Length:

662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0030684	preribosome	3	11
GO:0030687	preribosome, large subunit precursor	4	2
GO:0030688	preribosome, small subunit precursor	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

Q4QET0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QET0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.467
CLV_NRD_NRD_1	144	146	PF00675	0.577
CLV_NRD_NRD_1	277	279	PF00675	0.274
CLV_NRD_NRD_1	455	457	PF00675	0.367
CLV_NRD_NRD_1	514	516	PF00675	0.394
CLV_NRD_NRD_1	557	559	PF00675	0.493
CLV_NRD_NRD_1	619	621	PF00675	0.524
CLV_NRD_NRD_1	631	633	PF00675	0.482
CLV_NRD_NRD_1	639	641	PF00675	0.544
CLV_NRD_NRD_1	8	10	PF00675	0.508
CLV_PCSK_FUR_1	629	633	PF00082	0.642
CLV_PCSK_KEX2_1	10	12	PF00082	0.567
CLV_PCSK_KEX2_1	128	130	PF00082	0.473
CLV_PCSK_KEX2_1	144	146	PF00082	0.580
CLV_PCSK_KEX2_1	277	279	PF00082	0.404
CLV_PCSK_KEX2_1	306	308	PF00082	0.730
CLV_PCSK_KEX2_1	327	329	PF00082	0.731
CLV_PCSK_KEX2_1	437	439	PF00082	0.348
CLV_PCSK_KEX2_1	455	457	PF00082	0.340
CLV_PCSK_KEX2_1	473	475	PF00082	0.524
CLV_PCSK_KEX2_1	477	479	PF00082	0.555
CLV_PCSK_KEX2_1	48	50	PF00082	0.350
CLV_PCSK_KEX2_1	556	558	PF00082	0.495
CLV_PCSK_KEX2_1	631	633	PF00082	0.565
CLV_PCSK_KEX2_1	639	641	PF00082	0.579
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.654
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.796
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.731
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.348
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.632
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.555
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.369
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.577
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.568
CLV_PCSK_PC7_1	125	131	PF00082	0.484
CLV_PCSK_SKI1_1	246	250	PF00082	0.289
CLV_PCSK_SKI1_1	278	282	PF00082	0.314
CLV_PCSK_SKI1_1	285	289	PF00082	0.314
CLV_PCSK_SKI1_1	324	328	PF00082	0.612
CLV_PCSK_SKI1_1	384	388	PF00082	0.470
CLV_PCSK_SKI1_1	437	441	PF00082	0.396
CLV_PCSK_SKI1_1	528	532	PF00082	0.376
CLV_PCSK_SKI1_1	548	552	PF00082	0.540
CLV_PCSK_SKI1_1	561	565	PF00082	0.480
CLV_PCSK_SKI1_1	581	585	PF00082	0.463
CLV_PCSK_SKI1_1	616	620	PF00082	0.626
CLV_Separin_Metazoa	406	410	PF03568	0.441
DEG_APCC_DBOX_1	573	581	PF00400	0.450
DEG_Nend_UBRbox_1	1	4	PF02207	0.549
DOC_CKS1_1	98	103	PF01111	0.530
DOC_CYCLIN_yClb5_NLxxxL_5	105	113	PF00134	0.460
DOC_MAPK_gen_1	241	249	PF00069	0.313
DOC_MAPK_gen_1	266	275	PF00069	0.289
DOC_MAPK_gen_1	9	17	PF00069	0.553
DOC_MAPK_MEF2A_6	105	113	PF00069	0.567
DOC_PP1_RVXF_1	244	250	PF00149	0.289
DOC_PP2B_LxvP_1	237	240	PF13499	0.349
DOC_PP4_FxxP_1	443	446	PF00568	0.317
DOC_USP7_MATH_1	326	330	PF00917	0.707
DOC_USP7_MATH_1	354	358	PF00917	0.359
DOC_USP7_MATH_1	612	616	PF00917	0.610
DOC_USP7_UBL2_3	2	6	PF12436	0.595
DOC_USP7_UBL2_3	323	327	PF12436	0.738
DOC_USP7_UBL2_3	473	477	PF12436	0.645
DOC_USP7_UBL2_3	593	597	PF12436	0.446
DOC_USP7_UBL2_3	95	99	PF12436	0.577
DOC_WW_Pin1_4	300	305	PF00397	0.720
DOC_WW_Pin1_4	314	319	PF00397	0.673
DOC_WW_Pin1_4	484	489	PF00397	0.489
DOC_WW_Pin1_4	97	102	PF00397	0.530
LIG_14-3-3_CanoR_1	191	196	PF00244	0.463
LIG_14-3-3_CanoR_1	384	393	PF00244	0.392
LIG_14-3-3_CanoR_1	528	538	PF00244	0.411
LIG_14-3-3_CanoR_1	539	547	PF00244	0.470
LIG_14-3-3_CanoR_1	71	79	PF00244	0.453
LIG_APCC_ABBAyCdc20_2	648	654	PF00400	0.575
LIG_BIR_III_4	656	660	PF00653	0.592
LIG_FHA_1	341	347	PF00498	0.672
LIG_FHA_1	369	375	PF00498	0.430
LIG_FHA_1	394	400	PF00498	0.377
LIG_FHA_2	192	198	PF00498	0.414
LIG_FHA_2	645	651	PF00498	0.528
LIG_GBD_Chelix_1	374	382	PF00786	0.362
LIG_IBAR_NPY_1	102	104	PF08397	0.575
LIG_LIR_Apic_2	441	446	PF02991	0.330
LIG_LIR_Gen_1	197	207	PF02991	0.342
LIG_LIR_Gen_1	270	280	PF02991	0.272
LIG_LIR_Gen_1	401	412	PF02991	0.312
LIG_LIR_Gen_1	414	425	PF02991	0.299
LIG_LIR_Nem_3	148	153	PF02991	0.622
LIG_LIR_Nem_3	197	202	PF02991	0.349
LIG_LIR_Nem_3	260	264	PF02991	0.314
LIG_LIR_Nem_3	270	275	PF02991	0.240
LIG_LIR_Nem_3	377	382	PF02991	0.434
LIG_LIR_Nem_3	401	407	PF02991	0.306
LIG_LIR_Nem_3	414	420	PF02991	0.303
LIG_LIR_Nem_3	441	447	PF02991	0.404
LIG_LIR_Nem_3	545	550	PF02991	0.523
LIG_MAD2	438	446	PF02301	0.349
LIG_PCNA_TLS_4	266	273	PF02747	0.404
LIG_PCNA_TLS_4	437	444	PF02747	0.336
LIG_PCNA_yPIPBox_3	351	365	PF02747	0.378
LIG_REV1ctd_RIR_1	510	520	PF16727	0.344
LIG_SH2_CRK	153	157	PF00017	0.582
LIG_SH2_CRK	250	254	PF00017	0.404
LIG_SH2_GRB2like	106	109	PF00017	0.544
LIG_SH2_GRB2like	153	156	PF00017	0.517
LIG_SH2_NCK_1	153	157	PF00017	0.539
LIG_SH2_SRC	153	156	PF00017	0.517
LIG_SH2_STAP1	83	87	PF00017	0.548
LIG_SH2_STAT3	380	383	PF00017	0.343
LIG_SH2_STAT5	215	218	PF00017	0.326
LIG_SH2_STAT5	272	275	PF00017	0.349
LIG_SH2_STAT5	283	286	PF00017	0.454
LIG_SH2_STAT5	364	367	PF00017	0.461
LIG_SH2_STAT5	380	383	PF00017	0.350
LIG_SH2_STAT5	434	437	PF00017	0.376
LIG_SH2_STAT5	68	71	PF00017	0.374
LIG_SH2_STAT5	93	96	PF00017	0.593
LIG_SH3_1	95	101	PF00018	0.577
LIG_SH3_3	333	339	PF00018	0.589
LIG_SH3_3	95	101	PF00018	0.596
LIG_SH3_4	222	229	PF00018	0.271
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.269
LIG_SUMO_SIM_par_1	32	39	PF11976	0.439
LIG_TRAF2_1	121	124	PF00917	0.515
LIG_TYR_ITIM	248	253	PF00017	0.404
MOD_CDC14_SPxK_1	303	306	PF00782	0.593
MOD_CDK_SPxK_1	300	306	PF00069	0.591
MOD_CDK_SPxxK_3	300	307	PF00069	0.721
MOD_CDK_SPxxK_3	314	321	PF00069	0.675
MOD_CK1_1	296	302	PF00069	0.693
MOD_CK1_1	322	328	PF00069	0.648
MOD_CK1_1	388	394	PF00069	0.449
MOD_CK2_1	191	197	PF00069	0.421
MOD_CK2_1	314	320	PF00069	0.780
MOD_CK2_1	529	535	PF00069	0.418
MOD_GlcNHglycan	294	298	PF01048	0.601
MOD_GlcNHglycan	324	327	PF01048	0.680
MOD_GlcNHglycan	346	349	PF01048	0.587
MOD_GlcNHglycan	420	423	PF01048	0.469
MOD_GlcNHglycan	540	543	PF01048	0.521
MOD_GSK3_1	296	303	PF00069	0.673
MOD_GSK3_1	322	329	PF00069	0.717
MOD_GSK3_1	340	347	PF00069	0.580
MOD_GSK3_1	364	371	PF00069	0.506
MOD_GSK3_1	385	392	PF00069	0.480
MOD_GSK3_1	75	82	PF00069	0.335
MOD_NEK2_1	349	354	PF00069	0.438
MOD_NEK2_1	387	392	PF00069	0.519
MOD_NEK2_1	418	423	PF00069	0.424
MOD_NEK2_1	550	555	PF00069	0.591
MOD_PIKK_1	354	360	PF00454	0.360
MOD_PIKK_1	427	433	PF00454	0.405
MOD_PIKK_1	468	474	PF00454	0.559
MOD_PKA_1	306	312	PF00069	0.798
MOD_PKA_1	473	479	PF00069	0.703
MOD_PKA_2	240	246	PF00069	0.335
MOD_PKA_2	306	312	PF00069	0.666
MOD_PKA_2	473	479	PF00069	0.736
MOD_PKA_2	538	544	PF00069	0.522
MOD_PKA_2	70	76	PF00069	0.449
MOD_PKB_1	189	197	PF00069	0.429
MOD_Plk_1	79	85	PF00069	0.531
MOD_Plk_2-3	260	266	PF00069	0.289
MOD_Plk_4	191	197	PF00069	0.442
MOD_ProDKin_1	300	306	PF00069	0.721
MOD_ProDKin_1	314	320	PF00069	0.673
MOD_ProDKin_1	484	490	PF00069	0.480
MOD_ProDKin_1	97	103	PF00069	0.526
MOD_SUMO_for_1	305	308	PF00179	0.699
MOD_SUMO_rev_2	560	566	PF00179	0.611
TRG_ENDOCYTIC_2	106	109	PF00928	0.544
TRG_ENDOCYTIC_2	250	253	PF00928	0.360
TRG_ENDOCYTIC_2	272	275	PF00928	0.314
TRG_ENDOCYTIC_2	283	286	PF00928	0.314
TRG_ER_diArg_1	128	130	PF00400	0.563
TRG_ER_diArg_1	136	139	PF00400	0.597
TRG_ER_diArg_1	276	278	PF00400	0.404
TRG_ER_diArg_1	556	558	PF00400	0.480
TRG_ER_diArg_1	8	11	PF00400	0.555
TRG_NLS_Bipartite_1	620	635	PF00514	0.526
TRG_NLS_MonoCore_2	638	643	PF00514	0.565
TRG_NLS_MonoExtN_4	629	635	PF00514	0.532
TRG_NLS_MonoExtN_4	639	644	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R2	Leptomonas seymouri	67%	98%
A0A0S4JIU4	Bodo saltans	37%	100%
A0A3S7WTZ9	Leishmania donovani	95%	100%
A0A422NDR1	Trypanosoma rangeli	38%	100%
A4H8L2	Leishmania braziliensis	85%	100%
A4HWY4	Leishmania infantum	95%	100%
C9ZW19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AQP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BD23	Trypanosoma cruzi	37%	100%