Charged multivesicular body protein 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Snf7, putative

Species:

Leishmania major

UniProt:

Q4QES7_LEIMA

TriTrypDb:

LmjF.16.0930 , LMJLV39_160015100 , LMJSD75_160014900

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	3
GO:0005768	endosome	7	3
GO:0005770	late endosome	8	3
GO:0005771	multivesicular body	9	3
GO:0031410	cytoplasmic vesicle	6	3
GO:0031982	vesicle	4	3
GO:0032991	protein-containing complex	1	3
GO:0036452	ESCRT complex	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0097708	intracellular vesicle	5	3
GO:0098796	membrane protein complex	2	3
GO:0110165	cellular anatomical entity	1	3
GO:0009898	cytoplasmic side of plasma membrane	4	1
GO:0098552	side of membrane	2	1
GO:0098562	cytoplasmic side of membrane	3	1

Expansion

Sequence features

Q4QES7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QES7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	17
GO:0006900	vesicle budding from membrane	5	3
GO:0006996	organelle organization	4	3
GO:0007034	vacuolar transport	4	17
GO:0009987	cellular process	1	17
GO:0016043	cellular component organization	3	3
GO:0016050	vesicle organization	5	3
GO:0016192	vesicle-mediated transport	4	3
GO:0016197	endosomal transport	4	3
GO:0032509	endosome transport via multivesicular body sorting pathway	5	3
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	3
GO:0045324	late endosome to vacuole transport	5	3
GO:0046907	intracellular transport	3	17
GO:0051179	localization	1	17
GO:0051234	establishment of localization	2	17
GO:0051641	cellular localization	2	17
GO:0051649	establishment of localization in cell	3	17
GO:0061024	membrane organization	4	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:0071985	multivesicular body sorting pathway	5	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.404
CLV_NRD_NRD_1	43	45	PF00675	0.295
CLV_NRD_NRD_1	66	68	PF00675	0.320
CLV_PCSK_KEX2_1	66	68	PF00082	0.289
CLV_PCSK_KEX2_1	74	76	PF00082	0.328
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.328
CLV_PCSK_PC7_1	62	68	PF00082	0.319
CLV_PCSK_SKI1_1	48	52	PF00082	0.318
CLV_PCSK_SKI1_1	67	71	PF00082	0.285
CLV_Separin_Metazoa	165	169	PF03568	0.386
DEG_APCC_DBOX_1	66	74	PF00400	0.319
DOC_CKS1_1	21	26	PF01111	0.472
DOC_MAPK_DCC_7	178	188	PF00069	0.404
DOC_MAPK_gen_1	27	34	PF00069	0.401
DOC_MAPK_gen_1	44	51	PF00069	0.386
DOC_MAPK_gen_1	56	63	PF00069	0.393
DOC_MAPK_MEF2A_6	27	34	PF00069	0.319
DOC_MAPK_NFAT4_5	27	35	PF00069	0.319
DOC_PP2B_LxvP_1	186	189	PF13499	0.575
DOC_USP7_MATH_1	139	143	PF00917	0.281
DOC_USP7_MATH_1	17	21	PF00917	0.606
DOC_USP7_MATH_1	78	82	PF00917	0.354
DOC_USP7_UBL2_3	199	203	PF12436	0.666
DOC_WW_Pin1_4	20	25	PF00397	0.489
LIG_BIR_III_2	212	216	PF00653	0.528
LIG_eIF4E_1	46	52	PF01652	0.184
LIG_FHA_1	188	194	PF00498	0.550
LIG_FHA_1	85	91	PF00498	0.294
LIG_FHA_2	21	27	PF00498	0.503
LIG_LIR_Gen_1	99	110	PF02991	0.294
LIG_LIR_Nem_3	59	63	PF02991	0.423
LIG_LIR_Nem_3	99	105	PF02991	0.294
LIG_SH2_NCK_1	46	50	PF00017	0.294
LIG_SH2_SRC	210	213	PF00017	0.495
LIG_SH2_STAP1	210	214	PF00017	0.493
LIG_SH2_STAP1	46	50	PF00017	0.275
LIG_SH2_STAT5	71	74	PF00017	0.294
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.469
LIG_SUMO_SIM_anti_2	81	88	PF11976	0.404
LIG_SUMO_SIM_par_1	125	131	PF11976	0.406
LIG_TRAF2_1	142	145	PF00917	0.319
LIG_TRAF2_1	179	182	PF00917	0.184
MOD_CDK_SPxxK_3	20	27	PF00069	0.479
MOD_CK1_1	173	179	PF00069	0.423
MOD_CK1_1	20	26	PF00069	0.557
MOD_CK1_1	81	87	PF00069	0.319
MOD_CK2_1	139	145	PF00069	0.319
MOD_GlcNHglycan	171	175	PF01048	0.386
MOD_GSK3_1	96	103	PF00069	0.396
MOD_N-GLC_1	184	189	PF02516	0.587
MOD_NEK2_1	170	175	PF00069	0.423
MOD_NEK2_1	3	8	PF00069	0.569
MOD_PIKK_1	100	106	PF00454	0.354
MOD_PIKK_1	151	157	PF00454	0.401
MOD_PIKK_1	17	23	PF00454	0.636
MOD_PIKK_1	173	179	PF00454	0.438
MOD_PIKK_1	78	84	PF00454	0.325
MOD_PIKK_1	8	14	PF00454	0.644
MOD_PKA_2	195	201	PF00069	0.635
MOD_PKA_2	3	9	PF00069	0.584
MOD_Plk_1	100	106	PF00069	0.376
MOD_Plk_1	17	23	PF00069	0.533
MOD_Plk_1	184	190	PF00069	0.709
MOD_ProDKin_1	20	26	PF00069	0.482
MOD_SUMO_for_1	73	76	PF00179	0.319
TRG_DiLeu_BaEn_1	47	52	PF01217	0.184
TRG_ENDOCYTIC_2	46	49	PF00928	0.354
TRG_NES_CRM1_1	119	133	PF08389	0.281
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5W8	Leptomonas seymouri	35%	97%
A0A0N1ILA5	Leptomonas seymouri	67%	100%
A0A0S4JI05	Bodo saltans	27%	91%
A0A1X0NZJ9	Trypanosomatidae	55%	100%
A0A1X0P4I7	Trypanosomatidae	34%	97%
A0A3Q8IJN8	Leishmania donovani	35%	98%
A0A3R7NQB4	Trypanosoma rangeli	33%	96%
A0A3S7WU01	Leishmania donovani	94%	100%
A0A422NAN8	Trypanosoma rangeli	55%	100%
A4H8L7	Leishmania braziliensis	81%	99%
A4HPQ2	Leishmania braziliensis	34%	98%
A4HWY8	Leishmania infantum	94%	100%
A4ID11	Leishmania infantum	35%	98%
C9ZW12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D0A8G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	96%
E9AQQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9ATG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	98%
O94318	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	97%
P0C0A3	Mus musculus	30%	100%
Q04272	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4Q130	Leishmania major	33%	100%
Q503V0	Danio rerio	33%	100%
Q54KZ4	Dictyostelium discoideum	32%	100%
Q5R861	Pongo abelii	32%	100%
Q5ZL55	Gallus gallus	32%	100%
Q8GXN6	Arabidopsis thaliana	28%	100%
Q96FZ7	Homo sapiens	32%	100%
Q9FY89	Arabidopsis thaliana	26%	100%