Sucrose-phosphate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sucrose-phosphate synthase-like protein

Species:

Leishmania major

UniProt:

Q4QES5_LEIMA

TriTrypDb:

LmjF.16.0950 , LMJLV39_160015300 , LMJSD75_160015100

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QES5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QES5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0008194	UDP-glycosyltransferase activity	4	6
GO:0016740	transferase activity	2	8
GO:0016757	glycosyltransferase activity	3	8
GO:0016758	hexosyltransferase activity	4	6
GO:0035251	UDP-glucosyltransferase activity	5	6
GO:0046524	sucrose-phosphate synthase activity	6	6
GO:0046527	glucosyltransferase activity	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.473
CLV_NRD_NRD_1	324	326	PF00675	0.459
CLV_PCSK_KEX2_1	117	119	PF00082	0.517
CLV_PCSK_KEX2_1	140	142	PF00082	0.474
CLV_PCSK_KEX2_1	293	295	PF00082	0.409
CLV_PCSK_KEX2_1	310	312	PF00082	0.479
CLV_PCSK_KEX2_1	83	85	PF00082	0.506
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.517
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.409
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.545
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.560
CLV_PCSK_SKI1_1	185	189	PF00082	0.507
CLV_PCSK_SKI1_1	310	314	PF00082	0.466
CLV_PCSK_SKI1_1	422	426	PF00082	0.493
DOC_CKS1_1	53	58	PF01111	0.580
DOC_MAPK_DCC_7	141	151	PF00069	0.503
DOC_MAPK_DCC_7	63	73	PF00069	0.547
DOC_MAPK_gen_1	113	123	PF00069	0.517
DOC_MAPK_gen_1	307	317	PF00069	0.521
DOC_MAPK_HePTP_8	111	123	PF00069	0.513
DOC_MAPK_MEF2A_6	114	123	PF00069	0.512
DOC_MAPK_MEF2A_6	310	317	PF00069	0.535
DOC_MAPK_NFAT4_5	310	318	PF00069	0.535
DOC_PP1_RVXF_1	279	286	PF00149	0.409
DOC_PP4_FxxP_1	128	131	PF00568	0.431
DOC_PP4_FxxP_1	343	346	PF00568	0.409
DOC_USP7_MATH_1	35	39	PF00917	0.497
DOC_USP7_MATH_1	359	363	PF00917	0.460
DOC_USP7_MATH_1	79	83	PF00917	0.591
DOC_USP7_UBL2_3	113	117	PF12436	0.511
DOC_WW_Pin1_4	220	225	PF00397	0.503
DOC_WW_Pin1_4	258	263	PF00397	0.486
DOC_WW_Pin1_4	380	385	PF00397	0.409
DOC_WW_Pin1_4	52	57	PF00397	0.523
LIG_14-3-3_CanoR_1	265	274	PF00244	0.520
LIG_14-3-3_CanoR_1	311	316	PF00244	0.418
LIG_14-3-3_CanoR_1	84	89	PF00244	0.508
LIG_Actin_WH2_2	324	341	PF00022	0.377
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	194	198	PF00533	0.501
LIG_Clathr_ClatBox_1	373	377	PF01394	0.409
LIG_deltaCOP1_diTrp_1	4	8	PF00928	0.500
LIG_FHA_1	103	109	PF00498	0.552
LIG_FHA_1	182	188	PF00498	0.529
LIG_FHA_1	189	195	PF00498	0.524
LIG_FHA_1	322	328	PF00498	0.542
LIG_FHA_1	333	339	PF00498	0.436
LIG_FHA_1	381	387	PF00498	0.409
LIG_FHA_2	355	361	PF00498	0.409
LIG_FHA_2	407	413	PF00498	0.480
LIG_FHA_2	53	59	PF00498	0.605
LIG_FHA_2	87	93	PF00498	0.534
LIG_LIR_Apic_2	12	18	PF02991	0.510
LIG_LIR_Apic_2	340	346	PF02991	0.466
LIG_LIR_Gen_1	207	216	PF02991	0.514
LIG_LIR_Gen_1	330	338	PF02991	0.535
LIG_LIR_Gen_1	4	10	PF02991	0.441
LIG_LIR_Gen_1	415	426	PF02991	0.535
LIG_LIR_Gen_1	82	93	PF02991	0.517
LIG_LIR_Nem_3	105	110	PF02991	0.504
LIG_LIR_Nem_3	207	211	PF02991	0.467
LIG_LIR_Nem_3	330	336	PF02991	0.481
LIG_LIR_Nem_3	368	374	PF02991	0.409
LIG_LIR_Nem_3	4	8	PF02991	0.442
LIG_LIR_Nem_3	415	421	PF02991	0.521
LIG_LIR_Nem_3	60	65	PF02991	0.493
LIG_Pex14_2	208	212	PF04695	0.462
LIG_Pex14_2	285	289	PF04695	0.409
LIG_Pex14_2	371	375	PF04695	0.409
LIG_SH2_CRK	227	231	PF00017	0.534
LIG_SH2_CRK	279	283	PF00017	0.463
LIG_SH2_CRK	333	337	PF00017	0.464
LIG_SH2_CRK	418	422	PF00017	0.463
LIG_SH2_GRB2like	163	166	PF00017	0.465
LIG_SH2_NCK_1	356	360	PF00017	0.535
LIG_SH2_SRC	65	68	PF00017	0.555
LIG_SH2_STAP1	163	167	PF00017	0.525
LIG_SH2_STAP1	279	283	PF00017	0.463
LIG_SH2_STAT5	110	113	PF00017	0.521
LIG_SH2_STAT5	328	331	PF00017	0.382
LIG_SH2_STAT5	356	359	PF00017	0.463
LIG_SH2_STAT5	96	99	PF00017	0.531
LIG_SH3_1	210	216	PF00018	0.529
LIG_SH3_2	171	176	PF14604	0.559
LIG_SH3_3	144	150	PF00018	0.496
LIG_SH3_3	168	174	PF00018	0.569
LIG_SH3_3	197	203	PF00018	0.513
LIG_SH3_3	210	216	PF00018	0.480
LIG_TRAF2_1	89	92	PF00917	0.525
LIG_TRFH_1	212	216	PF08558	0.597
LIG_TRFH_1	342	346	PF08558	0.409
MOD_CDK_SPxxK_3	258	265	PF00069	0.421
MOD_CDK_SPxxK_3	52	59	PF00069	0.614
MOD_CK1_1	321	327	PF00069	0.433
MOD_CK1_1	446	452	PF00069	0.482
MOD_CK2_1	300	306	PF00069	0.463
MOD_CK2_1	363	369	PF00069	0.409
MOD_CK2_1	406	412	PF00069	0.456
MOD_CK2_1	446	452	PF00069	0.542
MOD_CK2_1	86	92	PF00069	0.512
MOD_Cter_Amidation	115	118	PF01082	0.538
MOD_GlcNHglycan	194	197	PF01048	0.424
MOD_GlcNHglycan	200	203	PF01048	0.453
MOD_GlcNHglycan	24	27	PF01048	0.541
MOD_GlcNHglycan	389	392	PF01048	0.409
MOD_GSK3_1	188	195	PF00069	0.490
MOD_GSK3_1	359	366	PF00069	0.497
MOD_GSK3_1	43	50	PF00069	0.438
MOD_NEK2_1	188	193	PF00069	0.484
MOD_NEK2_1	198	203	PF00069	0.525
MOD_NEK2_1	255	260	PF00069	0.568
MOD_NEK2_1	338	343	PF00069	0.463
MOD_NEK2_1	457	462	PF00069	0.551
MOD_NEK2_2	359	364	PF00069	0.457
MOD_PIKK_1	255	261	PF00454	0.630
MOD_PIKK_1	318	324	PF00454	0.535
MOD_PIKK_1	345	351	PF00454	0.463
MOD_PIKK_1	446	452	PF00454	0.509
MOD_PK_1	294	300	PF00069	0.456
MOD_PKA_1	443	449	PF00069	0.527
MOD_PKA_2	181	187	PF00069	0.530
MOD_Plk_1	255	261	PF00069	0.620
MOD_Plk_1	359	365	PF00069	0.535
MOD_Plk_1	91	97	PF00069	0.543
MOD_Plk_2-3	92	98	PF00069	0.539
MOD_Plk_4	294	300	PF00069	0.463
MOD_Plk_4	311	317	PF00069	0.409
MOD_Plk_4	338	344	PF00069	0.450
MOD_Plk_4	359	365	PF00069	0.477
MOD_Plk_4	43	49	PF00069	0.499
MOD_ProDKin_1	220	226	PF00069	0.500
MOD_ProDKin_1	258	264	PF00069	0.477
MOD_ProDKin_1	380	386	PF00069	0.409
MOD_ProDKin_1	52	58	PF00069	0.528
MOD_SUMO_rev_2	303	312	PF00179	0.535
MOD_SUMO_rev_2	427	432	PF00179	0.463
TRG_DiLeu_BaEn_1	369	374	PF01217	0.409
TRG_DiLeu_BaEn_1	400	405	PF01217	0.496
TRG_DiLeu_BaEn_2	102	108	PF01217	0.507
TRG_ENDOCYTIC_2	178	181	PF00928	0.461
TRG_ENDOCYTIC_2	227	230	PF00928	0.535
TRG_ENDOCYTIC_2	252	255	PF00928	0.500
TRG_ENDOCYTIC_2	279	282	PF00928	0.463
TRG_ENDOCYTIC_2	328	331	PF00928	0.374
TRG_ENDOCYTIC_2	333	336	PF00928	0.374
TRG_ENDOCYTIC_2	418	421	PF00928	0.463
TRG_ER_diArg_1	140	142	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	325	330	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL5	Leptomonas seymouri	81%	100%
A0A0R6YAV9	Leishmania donovani	97%	100%
A0A0S4JKT8	Bodo saltans	47%	85%
A4H8L9	Leishmania braziliensis	90%	94%
A4HWZ0	Leishmania infantum	97%	100%
E9AQQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%