Methyltransf_11 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QES4_LEIMA

TriTrypDb:

LmjF.16.0960 , LMJLV39_160015400 , LMJSD75_160015200

Length:

488

Annotations

LeishMANIAdb annotations

Homologous to yeast mitochondrial OMS1 methyltransferase, but many Kinetoplastid homologs lack the transit signal.. One sub-group of these proteins have an N-terminal membrane anchor, while others might possess an internal Tm segment potentially targeted to mitochondria.. Localization: Mitochondrial (by homology) / Others (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QES4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QES4

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.370
CLV_NRD_NRD_1	120	122	PF00675	0.781
CLV_NRD_NRD_1	201	203	PF00675	0.721
CLV_NRD_NRD_1	213	215	PF00675	0.679
CLV_NRD_NRD_1	283	285	PF00675	0.598
CLV_NRD_NRD_1	295	297	PF00675	0.606
CLV_NRD_NRD_1	437	439	PF00675	0.506
CLV_NRD_NRD_1	478	480	PF00675	0.687
CLV_NRD_NRD_1	71	73	PF00675	0.524
CLV_PCSK_FUR_1	69	73	PF00082	0.535
CLV_PCSK_KEX2_1	120	122	PF00082	0.703
CLV_PCSK_KEX2_1	201	203	PF00082	0.738
CLV_PCSK_KEX2_1	215	217	PF00082	0.664
CLV_PCSK_KEX2_1	283	285	PF00082	0.575
CLV_PCSK_KEX2_1	295	297	PF00082	0.617
CLV_PCSK_KEX2_1	312	314	PF00082	0.576
CLV_PCSK_KEX2_1	437	439	PF00082	0.496
CLV_PCSK_KEX2_1	71	73	PF00082	0.522
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.664
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.666
CLV_PCSK_PC7_1	291	297	PF00082	0.674
CLV_PCSK_SKI1_1	210	214	PF00082	0.735
CLV_PCSK_SKI1_1	399	403	PF00082	0.543
CLV_PCSK_SKI1_1	72	76	PF00082	0.534
DEG_APCC_DBOX_1	346	354	PF00400	0.460
DEG_APCC_KENBOX_2	142	146	PF00400	0.461
DEG_Nend_UBRbox_1	1	4	PF02207	0.692
DOC_CKS1_1	229	234	PF01111	0.471
DOC_MAPK_gen_1	392	402	PF00069	0.282
DOC_MAPK_gen_1	41	50	PF00069	0.422
DOC_MAPK_gen_1	434	442	PF00069	0.285
DOC_PP2B_LxvP_1	28	31	PF13499	0.446
DOC_PP4_FxxP_1	380	383	PF00568	0.296
DOC_USP7_MATH_1	126	130	PF00917	0.571
DOC_USP7_MATH_1	244	248	PF00917	0.569
DOC_USP7_MATH_1	316	320	PF00917	0.517
DOC_USP7_MATH_1	321	325	PF00917	0.481
DOC_USP7_MATH_1	364	368	PF00917	0.334
DOC_USP7_MATH_1	465	469	PF00917	0.411
DOC_USP7_UBL2_3	395	399	PF12436	0.362
DOC_USP7_UBL2_3	43	47	PF12436	0.428
DOC_USP7_UBL2_3	449	453	PF12436	0.390
DOC_WW_Pin1_4	228	233	PF00397	0.466
LIG_14-3-3_CanoR_1	307	311	PF00244	0.484
LIG_14-3-3_CanoR_1	41	46	PF00244	0.450
LIG_BRCT_BRCA1_1	451	455	PF00533	0.451
LIG_Clathr_ClatBox_1	400	404	PF01394	0.296
LIG_CtBP_PxDLS_1	335	339	PF00389	0.525
LIG_deltaCOP1_diTrp_1	448	455	PF00928	0.425
LIG_deltaCOP1_diTrp_1	470	475	PF00928	0.517
LIG_DLG_GKlike_1	41	48	PF00625	0.450
LIG_FHA_1	9	15	PF00498	0.355
LIG_FHA_2	194	200	PF00498	0.463
LIG_FHA_2	222	228	PF00498	0.469
LIG_FHA_2	234	240	PF00498	0.456
LIG_FHA_2	368	374	PF00498	0.272
LIG_LIR_Apic_2	379	383	PF02991	0.282
LIG_LIR_Gen_1	365	375	PF02991	0.282
LIG_LIR_Gen_1	44	53	PF02991	0.371
LIG_LIR_Gen_1	470	477	PF02991	0.513
LIG_LIR_Nem_3	365	371	PF02991	0.282
LIG_LIR_Nem_3	44	48	PF02991	0.369
LIG_LIR_Nem_3	470	475	PF02991	0.428
LIG_LIR_Nem_3	62	67	PF02991	0.334
LIG_PCNA_yPIPBox_3	426	440	PF02747	0.282
LIG_PTB_Apo_2	92	99	PF02174	0.428
LIG_PTB_Phospho_1	92	98	PF10480	0.429
LIG_SH2_CRK	45	49	PF00017	0.376
LIG_SH2_NCK_1	181	185	PF00017	0.416
LIG_SH2_SRC	181	184	PF00017	0.416
LIG_SH2_SRC	460	463	PF00017	0.369
LIG_SH2_STAT3	136	139	PF00017	0.475
LIG_SH2_STAT5	103	106	PF00017	0.456
LIG_SH2_STAT5	22	25	PF00017	0.333
LIG_SH2_STAT5	34	37	PF00017	0.397
LIG_SH2_STAT5	460	463	PF00017	0.306
LIG_SH2_STAT5	64	67	PF00017	0.368
LIG_SH3_3	329	335	PF00018	0.497
LIG_SH3_3	390	396	PF00018	0.282
LIG_SH3_4	395	402	PF00018	0.362
LIG_SUMO_SIM_par_1	399	404	PF11976	0.282
LIG_TRAF2_1	224	227	PF00917	0.513
LIG_TRAF2_1	236	239	PF00917	0.550
LIG_TRAF2_1	468	471	PF00917	0.491
LIG_UBA3_1	137	143	PF00899	0.470
LIG_UBA3_1	400	407	PF00899	0.282
LIG_WRC_WIRS_1	377	382	PF05994	0.296
LIG_WW_1	31	34	PF00397	0.448
MOD_CK1_1	246	252	PF00069	0.551
MOD_CK1_1	367	373	PF00069	0.271
MOD_CK1_1	443	449	PF00069	0.353
MOD_CK2_1	221	227	PF00069	0.460
MOD_CK2_1	231	237	PF00069	0.448
MOD_CK2_1	321	327	PF00069	0.539
MOD_CK2_1	465	471	PF00069	0.396
MOD_CMANNOS	428	431	PF00535	0.482
MOD_Cter_Amidation	118	121	PF01082	0.672
MOD_GlcNHglycan	128	131	PF01048	0.741
MOD_GlcNHglycan	154	158	PF01048	0.573
MOD_GlcNHglycan	19	22	PF01048	0.430
MOD_GlcNHglycan	206	209	PF01048	0.761
MOD_GlcNHglycan	233	236	PF01048	0.688
MOD_GlcNHglycan	317	321	PF01048	0.748
MOD_GlcNHglycan	442	445	PF01048	0.553
MOD_GSK3_1	126	133	PF00069	0.552
MOD_GSK3_1	242	249	PF00069	0.521
MOD_GSK3_1	8	15	PF00069	0.334
MOD_LATS_1	405	411	PF00433	0.362
MOD_N-GLC_1	131	136	PF02516	0.679
MOD_N-GLC_1	32	37	PF02516	0.699
MOD_N-GLC_1	321	326	PF02516	0.712
MOD_NEK2_1	159	164	PF00069	0.337
MOD_NEK2_1	17	22	PF00069	0.351
MOD_NEK2_1	242	247	PF00069	0.555
MOD_NEK2_1	455	460	PF00069	0.325
MOD_NEK2_1	65	70	PF00069	0.329
MOD_PIKK_1	121	127	PF00454	0.600
MOD_PIKK_1	193	199	PF00454	0.539
MOD_PIKK_1	244	250	PF00454	0.570
MOD_PKA_2	186	192	PF00069	0.480
MOD_PKA_2	306	312	PF00069	0.493
MOD_PKA_2	440	446	PF00069	0.360
MOD_Plk_1	131	137	PF00069	0.471
MOD_Plk_1	277	283	PF00069	0.465
MOD_Plk_1	32	38	PF00069	0.493
MOD_Plk_1	364	370	PF00069	0.307
MOD_Plk_1	388	394	PF00069	0.274
MOD_Plk_2-3	221	227	PF00069	0.532
MOD_Plk_4	12	18	PF00069	0.336
MOD_Plk_4	132	138	PF00069	0.455
MOD_Plk_4	306	312	PF00069	0.475
MOD_Plk_4	367	373	PF00069	0.272
MOD_ProDKin_1	228	234	PF00069	0.469
MOD_SUMO_rev_2	446	455	PF00179	0.449
MOD_SUMO_rev_2	49	58	PF00179	0.373
TRG_DiLeu_BaEn_1	327	332	PF01217	0.525
TRG_DiLeu_BaEn_2	236	242	PF01217	0.546
TRG_DiLeu_BaEn_3	305	311	PF01217	0.500
TRG_DiLeu_BaEn_4	237	243	PF01217	0.549
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.454
TRG_ENDOCYTIC_2	45	48	PF00928	0.367
TRG_ENDOCYTIC_2	466	469	PF00928	0.500
TRG_ENDOCYTIC_2	64	67	PF00928	0.355
TRG_ER_diArg_1	201	203	PF00400	0.422
TRG_ER_diArg_1	213	216	PF00400	0.532
TRG_ER_diArg_1	294	296	PF00400	0.452
TRG_ER_diArg_1	436	438	PF00400	0.285
TRG_ER_diArg_1	70	72	PF00400	0.324
TRG_ER_diArg_1	81	84	PF00400	0.332
TRG_NLS_Bipartite_1	201	219	PF00514	0.434
TRG_NLS_Bipartite_1	295	316	PF00514	0.447
TRG_NLS_MonoCore_2	213	218	PF00514	0.532
TRG_NLS_MonoExtC_3	311	317	PF00514	0.485
TRG_NLS_MonoExtN_4	214	219	PF00514	0.531
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	343	348	PF00026	0.669
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8I0	Leptomonas seymouri	74%	100%
A0A1X0NZ02	Trypanosomatidae	46%	100%
A0A3Q8I9F7	Leishmania donovani	96%	100%
A0A3R7NGZ3	Trypanosoma rangeli	48%	100%
A4H8M0	Leishmania braziliensis	85%	100%
A4HWZ1	Leishmania infantum	95%	100%
C9ZW11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AQQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5ANK2	Trypanosoma cruzi	47%	100%