ER-golgi trafficking TRAPP I complex 85 kDa subunit-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QES3_LEIMA

TriTrypDb:

LmjF.16.0970 , LMJLV39_160015500 , LMJSD75_160015300

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QES3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QES3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.558
CLV_C14_Caspase3-7	278	282	PF00656	0.429
CLV_C14_Caspase3-7	508	512	PF00656	0.513
CLV_C14_Caspase3-7	589	593	PF00656	0.397
CLV_MEL_PAP_1	438	444	PF00089	0.453
CLV_NRD_NRD_1	164	166	PF00675	0.525
CLV_NRD_NRD_1	172	174	PF00675	0.554
CLV_NRD_NRD_1	310	312	PF00675	0.738
CLV_NRD_NRD_1	427	429	PF00675	0.513
CLV_NRD_NRD_1	606	608	PF00675	0.559
CLV_NRD_NRD_1	647	649	PF00675	0.629
CLV_NRD_NRD_1	743	745	PF00675	0.538
CLV_PCSK_FUR_1	645	649	PF00082	0.620
CLV_PCSK_KEX2_1	164	166	PF00082	0.469
CLV_PCSK_KEX2_1	172	174	PF00082	0.492
CLV_PCSK_KEX2_1	197	199	PF00082	0.636
CLV_PCSK_KEX2_1	310	312	PF00082	0.722
CLV_PCSK_KEX2_1	427	429	PF00082	0.513
CLV_PCSK_KEX2_1	496	498	PF00082	0.548
CLV_PCSK_KEX2_1	606	608	PF00082	0.542
CLV_PCSK_KEX2_1	647	649	PF00082	0.624
CLV_PCSK_KEX2_1	743	745	PF00082	0.483
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.636
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.548
CLV_PCSK_PC7_1	492	498	PF00082	0.365
CLV_PCSK_SKI1_1	121	125	PF00082	0.553
CLV_PCSK_SKI1_1	247	251	PF00082	0.652
CLV_PCSK_SKI1_1	428	432	PF00082	0.573
CLV_PCSK_SKI1_1	452	456	PF00082	0.701
CLV_PCSK_SKI1_1	462	466	PF00082	0.535
CLV_PCSK_SKI1_1	480	484	PF00082	0.489
CLV_PCSK_SKI1_1	57	61	PF00082	0.492
CLV_PCSK_SKI1_1	704	708	PF00082	0.462
DEG_APCC_DBOX_1	475	483	PF00400	0.462
DEG_APCC_DBOX_1	56	64	PF00400	0.486
DEG_APCC_DBOX_1	657	665	PF00400	0.583
DOC_CYCLIN_RxL_1	244	253	PF00134	0.646
DOC_CYCLIN_RxL_1	476	484	PF00134	0.453
DOC_CYCLIN_RxL_1	701	710	PF00134	0.441
DOC_MAPK_gen_1	623	630	PF00069	0.520
DOC_MAPK_MEF2A_6	476	485	PF00069	0.451
DOC_MAPK_MEF2A_6	751	759	PF00069	0.520
DOC_PP1_RVXF_1	460	466	PF00149	0.498
DOC_PP1_RVXF_1	536	542	PF00149	0.453
DOC_PP1_RVXF_1	565	571	PF00149	0.566
DOC_PP2B_LxvP_1	679	682	PF13499	0.670
DOC_PP4_FxxP_1	364	367	PF00568	0.404
DOC_USP7_MATH_1	236	240	PF00917	0.778
DOC_USP7_MATH_1	327	331	PF00917	0.704
DOC_USP7_MATH_1	4	8	PF00917	0.373
DOC_USP7_MATH_1	44	48	PF00917	0.475
DOC_USP7_MATH_1	530	534	PF00917	0.553
DOC_USP7_MATH_1	657	661	PF00917	0.568
DOC_WW_Pin1_4	199	204	PF00397	0.738
DOC_WW_Pin1_4	418	423	PF00397	0.633
DOC_WW_Pin1_4	440	445	PF00397	0.567
DOC_WW_Pin1_4	695	700	PF00397	0.391
DOC_WW_Pin1_4	95	100	PF00397	0.596
LIG_14-3-3_CanoR_1	32	38	PF00244	0.490
LIG_14-3-3_CanoR_1	42	52	PF00244	0.541
LIG_14-3-3_CanoR_1	476	480	PF00244	0.398
LIG_14-3-3_CanoR_1	492	496	PF00244	0.360
LIG_14-3-3_CanoR_1	538	548	PF00244	0.570
LIG_14-3-3_CanoR_1	658	662	PF00244	0.665
LIG_14-3-3_CanoR_1	743	749	PF00244	0.415
LIG_APCC_ABBA_1	431	436	PF00400	0.564
LIG_BIR_II_1	1	5	PF00653	0.368
LIG_BIR_III_2	211	215	PF00653	0.550
LIG_BIR_III_3	1	5	PF00653	0.481
LIG_BIR_III_4	218	222	PF00653	0.616
LIG_Clathr_ClatBox_1	249	253	PF01394	0.574
LIG_eIF4E_1	387	393	PF01652	0.489
LIG_EVH1_1	519	523	PF00568	0.521
LIG_FHA_1	155	161	PF00498	0.511
LIG_FHA_1	202	208	PF00498	0.656
LIG_FHA_1	278	284	PF00498	0.400
LIG_FHA_1	296	302	PF00498	0.588
LIG_FHA_1	335	341	PF00498	0.600
LIG_FHA_1	476	482	PF00498	0.373
LIG_FHA_1	53	59	PF00498	0.446
LIG_FHA_1	612	618	PF00498	0.535
LIG_FHA_2	103	109	PF00498	0.715
LIG_FHA_2	156	162	PF00498	0.392
LIG_FHA_2	20	26	PF00498	0.504
LIG_FHA_2	312	318	PF00498	0.718
LIG_FHA_2	32	38	PF00498	0.383
LIG_FHA_2	399	405	PF00498	0.523
LIG_FHA_2	681	687	PF00498	0.629
LIG_Integrin_isoDGR_2	78	80	PF01839	0.600
LIG_LIR_Apic_2	362	367	PF02991	0.403
LIG_LIR_Gen_1	265	274	PF02991	0.391
LIG_LIR_Gen_1	351	361	PF02991	0.492
LIG_LIR_Gen_1	499	509	PF02991	0.439
LIG_LIR_Nem_3	245	249	PF02991	0.559
LIG_LIR_Nem_3	265	269	PF02991	0.196
LIG_LIR_Nem_3	351	357	PF02991	0.398
LIG_LIR_Nem_3	368	372	PF02991	0.405
LIG_LIR_Nem_3	384	389	PF02991	0.403
LIG_LIR_Nem_3	421	426	PF02991	0.619
LIG_LIR_Nem_3	493	498	PF02991	0.413
LIG_LIR_Nem_3	499	505	PF02991	0.427
LIG_LIR_Nem_3	585	590	PF02991	0.383
LIG_LIR_Nem_3	726	732	PF02991	0.453
LIG_LIR_Nem_3	88	93	PF02991	0.656
LIG_LYPXL_S_1	89	93	PF13949	0.684
LIG_LYPXL_yS_3	729	732	PF13949	0.526
LIG_LYPXL_yS_3	90	93	PF13949	0.686
LIG_MAD2	462	470	PF02301	0.507
LIG_MYND_1	525	529	PF01753	0.573
LIG_NRBOX	478	484	PF00104	0.452
LIG_PCNA_PIPBox_1	708	717	PF02747	0.467
LIG_PCNA_yPIPBox_3	24	32	PF02747	0.562
LIG_PCNA_yPIPBox_3	704	715	PF02747	0.508
LIG_Pex14_2	17	21	PF04695	0.447
LIG_Pex14_2	584	588	PF04695	0.387
LIG_PTAP_UEV_1	681	686	PF05743	0.551
LIG_RPA_C_Fungi	505	517	PF08784	0.477
LIG_SH2_CRK	246	250	PF00017	0.587
LIG_SH2_CRK	354	358	PF00017	0.542
LIG_SH2_STAP1	152	156	PF00017	0.411
LIG_SH2_STAP1	354	358	PF00017	0.427
LIG_SH2_STAP1	372	376	PF00017	0.362
LIG_SH2_STAP1	387	391	PF00017	0.393
LIG_SH2_STAP1	498	502	PF00017	0.467
LIG_SH2_STAT3	166	169	PF00017	0.554
LIG_SH2_STAT5	154	157	PF00017	0.497
LIG_SH2_STAT5	166	169	PF00017	0.582
LIG_SH2_STAT5	365	368	PF00017	0.391
LIG_SH3_2	682	687	PF14604	0.610
LIG_SH3_3	429	435	PF00018	0.552
LIG_SH3_3	461	467	PF00018	0.487
LIG_SH3_3	517	523	PF00018	0.557
LIG_SH3_3	679	685	PF00018	0.594
LIG_SH3_3	755	761	PF00018	0.552
LIG_SUMO_SIM_anti_2	549	558	PF11976	0.578
LIG_SUMO_SIM_par_1	248	253	PF11976	0.591
LIG_SUMO_SIM_par_1	549	558	PF11976	0.578
LIG_TRAF2_1	190	193	PF00917	0.666
LIG_TRAF2_1	22	25	PF00917	0.565
LIG_TRAF2_1	558	561	PF00917	0.628
LIG_TRAF2_1	6	9	PF00917	0.498
LIG_Vh1_VBS_1	269	287	PF01044	0.273
LIG_WRC_WIRS_1	502	507	PF05994	0.431
MOD_CK1_1	237	243	PF00069	0.675
MOD_CK1_1	43	49	PF00069	0.522
MOD_CK1_1	53	59	PF00069	0.425
MOD_CK1_1	554	560	PF00069	0.512
MOD_CK1_1	660	666	PF00069	0.593
MOD_CK2_1	102	108	PF00069	0.659
MOD_CK2_1	19	25	PF00069	0.578
MOD_CK2_1	272	278	PF00069	0.458
MOD_CK2_1	311	317	PF00069	0.676
MOD_CK2_1	398	404	PF00069	0.509
MOD_CK2_1	418	424	PF00069	0.533
MOD_CK2_1	555	561	PF00069	0.598
MOD_CK2_1	643	649	PF00069	0.510
MOD_CK2_1	680	686	PF00069	0.581
MOD_CK2_1	713	719	PF00069	0.393
MOD_CK2_1	744	750	PF00069	0.511
MOD_GlcNHglycan	108	111	PF01048	0.654
MOD_GlcNHglycan	139	142	PF01048	0.471
MOD_GlcNHglycan	238	242	PF01048	0.755
MOD_GlcNHglycan	287	290	PF01048	0.488
MOD_GlcNHglycan	300	304	PF01048	0.556
MOD_GlcNHglycan	329	332	PF01048	0.736
MOD_GlcNHglycan	42	45	PF01048	0.540
MOD_GlcNHglycan	446	449	PF01048	0.503
MOD_GlcNHglycan	507	510	PF01048	0.487
MOD_GlcNHglycan	555	560	PF01048	0.581
MOD_GlcNHglycan	563	566	PF01048	0.530
MOD_GlcNHglycan	572	575	PF01048	0.360
MOD_GlcNHglycan	649	652	PF01048	0.446
MOD_GlcNHglycan	715	718	PF01048	0.416
MOD_GSK3_1	102	109	PF00069	0.688
MOD_GSK3_1	119	126	PF00069	0.567
MOD_GSK3_1	137	144	PF00069	0.474
MOD_GSK3_1	15	22	PF00069	0.541
MOD_GSK3_1	252	259	PF00069	0.523
MOD_GSK3_1	295	302	PF00069	0.637
MOD_GSK3_1	321	328	PF00069	0.656
MOD_GSK3_1	381	388	PF00069	0.407
MOD_GSK3_1	394	401	PF00069	0.519
MOD_GSK3_1	40	47	PF00069	0.478
MOD_GSK3_1	440	447	PF00069	0.457
MOD_GSK3_1	501	508	PF00069	0.521
MOD_GSK3_1	551	558	PF00069	0.526
MOD_GSK3_1	593	600	PF00069	0.533
MOD_GSK3_1	643	650	PF00069	0.482
MOD_N-GLC_1	102	107	PF02516	0.661
MOD_NEK2_1	106	111	PF00069	0.588
MOD_NEK2_1	123	128	PF00069	0.543
MOD_NEK2_1	155	160	PF00069	0.468
MOD_NEK2_1	299	304	PF00069	0.546
MOD_NEK2_1	475	480	PF00069	0.316
MOD_NEK2_1	501	506	PF00069	0.553
MOD_NEK2_1	52	57	PF00069	0.454
MOD_NEK2_1	539	544	PF00069	0.643
MOD_NEK2_1	694	699	PF00069	0.454
MOD_NEK2_1	707	712	PF00069	0.452
MOD_NEK2_1	94	99	PF00069	0.645
MOD_NEK2_2	336	341	PF00069	0.636
MOD_NEK2_2	385	390	PF00069	0.401
MOD_NEK2_2	530	535	PF00069	0.543
MOD_NEK2_2	593	598	PF00069	0.446
MOD_NEK2_2	657	662	PF00069	0.634
MOD_NEK2_2	666	671	PF00069	0.700
MOD_PIKK_1	123	129	PF00454	0.507
MOD_PIKK_1	19	25	PF00454	0.486
MOD_PIKK_1	192	198	PF00454	0.687
MOD_PIKK_1	252	258	PF00454	0.580
MOD_PIKK_1	305	311	PF00454	0.711
MOD_PKA_1	647	653	PF00069	0.540
MOD_PKA_1	743	749	PF00069	0.345
MOD_PKA_2	304	310	PF00069	0.677
MOD_PKA_2	31	37	PF00069	0.555
MOD_PKA_2	321	327	PF00069	0.759
MOD_PKA_2	475	481	PF00069	0.347
MOD_PKA_2	491	497	PF00069	0.392
MOD_PKA_2	647	653	PF00069	0.603
MOD_PKA_2	657	663	PF00069	0.649
MOD_PKA_2	743	749	PF00069	0.500
MOD_PKA_2	79	85	PF00069	0.624
MOD_PKB_1	645	653	PF00069	0.535
MOD_Plk_1	102	108	PF00069	0.678
MOD_Plk_1	348	354	PF00069	0.415
MOD_Plk_1	398	404	PF00069	0.531
MOD_Plk_1	490	496	PF00069	0.356
MOD_Plk_1	702	708	PF00069	0.490
MOD_Plk_1	9	15	PF00069	0.498
MOD_Plk_4	119	125	PF00069	0.516
MOD_Plk_4	141	147	PF00069	0.462
MOD_Plk_4	272	278	PF00069	0.413
MOD_Plk_4	279	285	PF00069	0.350
MOD_Plk_4	381	387	PF00069	0.452
MOD_Plk_4	44	50	PF00069	0.429
MOD_Plk_4	501	507	PF00069	0.553
MOD_Plk_4	530	536	PF00069	0.574
MOD_Plk_4	702	708	PF00069	0.477
MOD_Plk_4	744	750	PF00069	0.472
MOD_Plk_4	85	91	PF00069	0.699
MOD_Plk_4	9	15	PF00069	0.461
MOD_ProDKin_1	199	205	PF00069	0.741
MOD_ProDKin_1	418	424	PF00069	0.632
MOD_ProDKin_1	440	446	PF00069	0.568
MOD_ProDKin_1	695	701	PF00069	0.390
MOD_ProDKin_1	95	101	PF00069	0.598
TRG_DiLeu_BaEn_1	69	74	PF01217	0.601
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.580
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.403
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.521
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.455
TRG_ENDOCYTIC_2	152	155	PF00928	0.502
TRG_ENDOCYTIC_2	246	249	PF00928	0.568
TRG_ENDOCYTIC_2	354	357	PF00928	0.472
TRG_ENDOCYTIC_2	386	389	PF00928	0.385
TRG_ENDOCYTIC_2	434	437	PF00928	0.559
TRG_ENDOCYTIC_2	498	501	PF00928	0.429
TRG_ENDOCYTIC_2	502	505	PF00928	0.417
TRG_ENDOCYTIC_2	587	590	PF00928	0.440
TRG_ENDOCYTIC_2	729	732	PF00928	0.427
TRG_ENDOCYTIC_2	90	93	PF00928	0.686
TRG_ER_diArg_1	163	165	PF00400	0.554
TRG_ER_diArg_1	310	312	PF00400	0.639
TRG_ER_diArg_1	426	428	PF00400	0.511
TRG_ER_diArg_1	577	580	PF00400	0.462
TRG_ER_diArg_1	605	607	PF00400	0.574
TRG_ER_diArg_1	613	616	PF00400	0.517
TRG_ER_diArg_1	644	647	PF00400	0.564
TRG_ER_diArg_1	738	741	PF00400	0.567
TRG_ER_diArg_1	743	745	PF00400	0.574
TRG_NES_CRM1_1	589	602	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6V3	Leptomonas seymouri	57%	100%
A0A0S4JIN6	Bodo saltans	24%	100%
A0A1X0NZ87	Trypanosomatidae	28%	100%
A0A3Q8ICJ8	Leishmania donovani	94%	100%
A0A422NAP0	Trypanosoma rangeli	28%	100%
A4H8M1	Leishmania braziliensis	80%	100%
A4HWZ2	Leishmania infantum	94%	100%
C9ZW10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AQQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B3X0	Trypanosoma cruzi	24%	100%