M protein repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QES2_LEIMA

TriTrypDb:

LmjF.16.0980 , LMJLV39_160015600 , LMJSD75_160015400

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QES2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QES2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.447
CLV_C14_Caspase3-7	648	652	PF00656	0.686
CLV_NRD_NRD_1	179	181	PF00675	0.564
CLV_NRD_NRD_1	19	21	PF00675	0.471
CLV_NRD_NRD_1	212	214	PF00675	0.522
CLV_NRD_NRD_1	274	276	PF00675	0.523
CLV_NRD_NRD_1	442	444	PF00675	0.461
CLV_NRD_NRD_1	450	452	PF00675	0.448
CLV_NRD_NRD_1	506	508	PF00675	0.554
CLV_NRD_NRD_1	690	692	PF00675	0.505
CLV_NRD_NRD_1	711	713	PF00675	0.480
CLV_PCSK_KEX2_1	179	181	PF00082	0.514
CLV_PCSK_KEX2_1	19	21	PF00082	0.681
CLV_PCSK_KEX2_1	212	214	PF00082	0.522
CLV_PCSK_KEX2_1	362	364	PF00082	0.566
CLV_PCSK_KEX2_1	442	444	PF00082	0.461
CLV_PCSK_KEX2_1	450	452	PF00082	0.448
CLV_PCSK_KEX2_1	480	482	PF00082	0.469
CLV_PCSK_KEX2_1	506	508	PF00082	0.531
CLV_PCSK_KEX2_1	690	692	PF00082	0.505
CLV_PCSK_KEX2_1	701	703	PF00082	0.487
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.562
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.461
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.522
CLV_PCSK_SKI1_1	137	141	PF00082	0.550
CLV_PCSK_SKI1_1	22	26	PF00082	0.612
CLV_PCSK_SKI1_1	222	226	PF00082	0.671
CLV_PCSK_SKI1_1	243	247	PF00082	0.690
CLV_PCSK_SKI1_1	333	337	PF00082	0.484
CLV_PCSK_SKI1_1	55	59	PF00082	0.417
CLV_PCSK_SKI1_1	61	65	PF00082	0.421
CLV_Separin_Metazoa	283	287	PF03568	0.496
DEG_APCC_DBOX_1	185	193	PF00400	0.555
DEG_APCC_DBOX_1	332	340	PF00400	0.591
DEG_APCC_DBOX_1	60	68	PF00400	0.514
DOC_CYCLIN_RxL_1	19	29	PF00134	0.511
DOC_MAPK_gen_1	19	27	PF00069	0.501
DOC_MAPK_gen_1	248	257	PF00069	0.413
DOC_MAPK_gen_1	275	284	PF00069	0.469
DOC_USP7_MATH_1	726	730	PF00917	0.545
DOC_USP7_MATH_1	8	12	PF00917	0.564
DOC_USP7_UBL2_3	155	159	PF12436	0.648
LIG_14-3-3_CanoR_1	161	167	PF00244	0.600
LIG_14-3-3_CanoR_1	333	341	PF00244	0.529
LIG_14-3-3_CanoR_1	379	385	PF00244	0.528
LIG_14-3-3_CanoR_1	442	446	PF00244	0.559
LIG_14-3-3_CanoR_1	681	689	PF00244	0.532
LIG_BIR_III_4	105	109	PF00653	0.369
LIG_EH1_1	601	609	PF00400	0.397
LIG_FHA_1	108	114	PF00498	0.593
LIG_FHA_1	148	154	PF00498	0.584
LIG_FHA_1	180	186	PF00498	0.486
LIG_FHA_1	362	368	PF00498	0.605
LIG_FHA_1	44	50	PF00498	0.435
LIG_FHA_1	672	678	PF00498	0.498
LIG_FHA_1	94	100	PF00498	0.480
LIG_FHA_2	161	167	PF00498	0.525
LIG_FHA_2	409	415	PF00498	0.443
LIG_FHA_2	681	687	PF00498	0.563
LIG_LIR_Gen_1	70	75	PF02991	0.512
LIG_LIR_Nem_3	70	74	PF02991	0.463
LIG_NRBOX	23	29	PF00104	0.447
LIG_RPA_C_Fungi	451	463	PF08784	0.463
LIG_SH2_STAP1	71	75	PF00017	0.523
LIG_SH2_STAT3	42	45	PF00017	0.426
LIG_SH2_STAT3	663	666	PF00017	0.545
LIG_SH2_STAT5	37	40	PF00017	0.593
LIG_SH2_STAT5	59	62	PF00017	0.415
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.502
LIG_SUMO_SIM_anti_2	281	286	PF11976	0.459
LIG_SUMO_SIM_par_1	23	29	PF11976	0.470
LIG_SUMO_SIM_par_1	372	378	PF11976	0.555
LIG_TRAF2_1	130	133	PF00917	0.463
LIG_TRAF2_1	163	166	PF00917	0.561
LIG_TRAF2_1	197	200	PF00917	0.424
LIG_TRAF2_1	228	231	PF00917	0.645
LIG_TRAF2_1	444	447	PF00917	0.488
LIG_TRAF2_1	684	687	PF00917	0.570
MOD_CK1_1	618	624	PF00069	0.529
MOD_CK1_1	680	686	PF00069	0.613
MOD_CK2_1	160	166	PF00069	0.524
MOD_CK2_1	181	187	PF00069	0.620
MOD_CK2_1	194	200	PF00069	0.508
MOD_CK2_1	362	368	PF00069	0.576
MOD_CK2_1	378	384	PF00069	0.498
MOD_CK2_1	408	414	PF00069	0.437
MOD_CK2_1	441	447	PF00069	0.584
MOD_CK2_1	638	644	PF00069	0.627
MOD_CK2_1	680	686	PF00069	0.613
MOD_Cter_Amidation	710	713	PF01082	0.460
MOD_GlcNHglycan	364	367	PF01048	0.545
MOD_GlcNHglycan	380	383	PF01048	0.424
MOD_GlcNHglycan	635	638	PF01048	0.719
MOD_GSK3_1	309	316	PF00069	0.589
MOD_GSK3_1	327	334	PF00069	0.491
MOD_GSK3_1	401	408	PF00069	0.495
MOD_GSK3_1	676	683	PF00069	0.525
MOD_NEK2_1	192	197	PF00069	0.461
MOD_NEK2_1	261	266	PF00069	0.470
MOD_NEK2_1	406	411	PF00069	0.479
MOD_NEK2_1	537	542	PF00069	0.467
MOD_NEK2_1	615	620	PF00069	0.530
MOD_NEK2_1	632	637	PF00069	0.489
MOD_NEK2_1	671	676	PF00069	0.500
MOD_NEK2_1	677	682	PF00069	0.502
MOD_NEK2_1	696	701	PF00069	0.491
MOD_PIKK_1	137	143	PF00454	0.525
MOD_PIKK_1	344	350	PF00454	0.634
MOD_PIKK_1	401	407	PF00454	0.483
MOD_PIKK_1	408	414	PF00454	0.393
MOD_PIKK_1	615	621	PF00454	0.539
MOD_PIKK_1	627	633	PF00454	0.494
MOD_PK_1	232	238	PF00069	0.553
MOD_PK_1	91	97	PF00069	0.360
MOD_PKA_1	179	185	PF00069	0.483
MOD_PKA_1	212	218	PF00069	0.514
MOD_PKA_1	362	368	PF00069	0.502
MOD_PKA_2	160	166	PF00069	0.628
MOD_PKA_2	179	185	PF00069	0.566
MOD_PKA_2	212	218	PF00069	0.514
MOD_PKA_2	297	303	PF00069	0.494
MOD_PKA_2	314	320	PF00069	0.528
MOD_PKA_2	362	368	PF00069	0.502
MOD_PKA_2	378	384	PF00069	0.554
MOD_PKA_2	406	412	PF00069	0.640
MOD_PKA_2	424	430	PF00069	0.321
MOD_PKA_2	441	447	PF00069	0.554
MOD_PKA_2	471	477	PF00069	0.501
MOD_PKA_2	680	686	PF00069	0.613
MOD_PKB_1	311	319	PF00069	0.482
MOD_Plk_1	232	238	PF00069	0.668
MOD_Plk_1	261	267	PF00069	0.527
MOD_Plk_1	33	39	PF00069	0.477
MOD_Plk_1	55	61	PF00069	0.429
MOD_Plk_1	627	633	PF00069	0.575
MOD_Plk_2-3	181	187	PF00069	0.608
MOD_Plk_2-3	214	220	PF00069	0.514
MOD_Plk_2-3	441	447	PF00069	0.480
MOD_Plk_4	33	39	PF00069	0.570
MOD_Plk_4	45	51	PF00069	0.444
MOD_Plk_4	471	477	PF00069	0.558
MOD_Plk_4	705	711	PF00069	0.465
MOD_SUMO_for_1	586	589	PF00179	0.419
MOD_SUMO_for_1	67	70	PF00179	0.451
MOD_SUMO_rev_2	29	36	PF00179	0.455
MOD_SUMO_rev_2	484	492	PF00179	0.446
TRG_DiLeu_BaEn_1	120	125	PF01217	0.350
TRG_DiLeu_BaEn_1	23	28	PF01217	0.621
TRG_DiLeu_BaEn_2	470	476	PF01217	0.404
TRG_DiLeu_BaEn_3	33	39	PF01217	0.483
TRG_DiLeu_BaEn_4	157	163	PF01217	0.468
TRG_DiLeu_BaEn_4	187	193	PF01217	0.543
TRG_DiLeu_BaEn_4	440	446	PF01217	0.544
TRG_DiLeu_BaEn_4	570	576	PF01217	0.487
TRG_DiLeu_BaEn_4	588	594	PF01217	0.499
TRG_DiLeu_BaEn_4	83	89	PF01217	0.599
TRG_DiLeu_BaLyEn_6	673	678	PF01217	0.552
TRG_ENDOCYTIC_2	71	74	PF00928	0.464
TRG_ER_diArg_1	178	180	PF00400	0.500
TRG_ER_diArg_1	285	288	PF00400	0.492
TRG_ER_diArg_1	450	452	PF00400	0.561
TRG_ER_diArg_1	506	508	PF00400	0.447
TRG_ER_diArg_1	689	691	PF00400	0.501
TRG_NES_CRM1_1	591	605	PF08389	0.408
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	627	631	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JQ17	Bodo saltans	33%	83%
A0A3R7LSL7	Trypanosoma rangeli	41%	78%
A4H8M2	Leishmania braziliensis	87%	88%
A4HWZ3	Leishmania infantum	97%	75%
C9ZW08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	78%
E9AQQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5B8F4	Trypanosoma cruzi	40%	78%