LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania major
UniProt:
Q4QES0_LEIMA
TriTrypDb:
LmjF.16.1000 , LMJLV39_000018700 , LMJLV39_160016300 , LMJSD75_160015800
Length:
812

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 125
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 39
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 27
GO:0016020 membrane 2 19

Expansion

Sequence features

Q4QES0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QES0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 38
GO:0016740 transferase activity 2 38
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 222 226 PF00656 0.444
CLV_C14_Caspase3-7 389 393 PF00656 0.378
CLV_C14_Caspase3-7 41 45 PF00656 0.482
CLV_C14_Caspase3-7 801 805 PF00656 0.394
CLV_MEL_PAP_1 92 98 PF00089 0.493
CLV_NRD_NRD_1 115 117 PF00675 0.475
CLV_NRD_NRD_1 409 411 PF00675 0.611
CLV_NRD_NRD_1 412 414 PF00675 0.564
CLV_NRD_NRD_1 447 449 PF00675 0.608
CLV_NRD_NRD_1 48 50 PF00675 0.593
CLV_NRD_NRD_1 485 487 PF00675 0.611
CLV_NRD_NRD_1 563 565 PF00675 0.501
CLV_NRD_NRD_1 691 693 PF00675 0.640
CLV_NRD_NRD_1 84 86 PF00675 0.601
CLV_PCSK_FUR_1 410 414 PF00082 0.555
CLV_PCSK_FUR_1 483 487 PF00082 0.553
CLV_PCSK_KEX2_1 409 411 PF00082 0.611
CLV_PCSK_KEX2_1 412 414 PF00082 0.509
CLV_PCSK_KEX2_1 446 448 PF00082 0.564
CLV_PCSK_KEX2_1 48 50 PF00082 0.586
CLV_PCSK_KEX2_1 485 487 PF00082 0.581
CLV_PCSK_KEX2_1 563 565 PF00082 0.501
CLV_PCSK_KEX2_1 691 693 PF00082 0.640
CLV_PCSK_KEX2_1 83 85 PF00082 0.562
CLV_PCSK_SKI1_1 228 232 PF00082 0.663
CLV_PCSK_SKI1_1 282 286 PF00082 0.585
CLV_PCSK_SKI1_1 319 323 PF00082 0.546
CLV_PCSK_SKI1_1 324 328 PF00082 0.475
CLV_PCSK_SKI1_1 4 8 PF00082 0.531
CLV_PCSK_SKI1_1 413 417 PF00082 0.581
CLV_PCSK_SKI1_1 563 567 PF00082 0.574
CLV_PCSK_SKI1_1 653 657 PF00082 0.604
CLV_PCSK_SKI1_1 737 741 PF00082 0.595
CLV_PCSK_SKI1_1 85 89 PF00082 0.520
DEG_APCC_DBOX_1 194 202 PF00400 0.437
DEG_Nend_UBRbox_2 1 3 PF02207 0.532
DOC_CDC14_PxL_1 121 129 PF14671 0.370
DOC_CKS1_1 570 575 PF01111 0.626
DOC_CYCLIN_yCln2_LP_2 453 459 PF00134 0.343
DOC_CYCLIN_yCln2_LP_2 791 797 PF00134 0.408
DOC_MAPK_DCC_7 538 547 PF00069 0.486
DOC_MAPK_gen_1 206 215 PF00069 0.372
DOC_MAPK_gen_1 280 289 PF00069 0.385
DOC_MAPK_gen_1 446 457 PF00069 0.419
DOC_MAPK_gen_1 538 547 PF00069 0.545
DOC_MAPK_HePTP_8 566 578 PF00069 0.560
DOC_MAPK_MEF2A_6 282 291 PF00069 0.385
DOC_MAPK_MEF2A_6 448 457 PF00069 0.419
DOC_MAPK_MEF2A_6 569 578 PF00069 0.559
DOC_MAPK_MEF2A_6 634 641 PF00069 0.624
DOC_PP2B_LxvP_1 453 456 PF13499 0.419
DOC_PP2B_LxvP_1 740 743 PF13499 0.486
DOC_PP4_FxxP_1 570 573 PF00568 0.522
DOC_USP7_MATH_1 144 148 PF00917 0.451
DOC_USP7_MATH_1 242 246 PF00917 0.410
DOC_USP7_MATH_1 439 443 PF00917 0.280
DOC_USP7_MATH_1 729 733 PF00917 0.591
DOC_USP7_MATH_1 784 788 PF00917 0.608
DOC_WW_Pin1_4 14 19 PF00397 0.594
DOC_WW_Pin1_4 150 155 PF00397 0.458
DOC_WW_Pin1_4 213 218 PF00397 0.358
DOC_WW_Pin1_4 326 331 PF00397 0.386
DOC_WW_Pin1_4 468 473 PF00397 0.501
DOC_WW_Pin1_4 491 496 PF00397 0.675
DOC_WW_Pin1_4 569 574 PF00397 0.627
DOC_WW_Pin1_4 85 90 PF00397 0.580
LIG_14-3-3_CanoR_1 116 122 PF00244 0.511
LIG_14-3-3_CanoR_1 195 199 PF00244 0.400
LIG_14-3-3_CanoR_1 251 256 PF00244 0.377
LIG_14-3-3_CanoR_1 266 270 PF00244 0.322
LIG_14-3-3_CanoR_1 282 288 PF00244 0.361
LIG_14-3-3_CanoR_1 340 348 PF00244 0.576
LIG_14-3-3_CanoR_1 364 371 PF00244 0.578
LIG_14-3-3_CanoR_1 4 12 PF00244 0.582
LIG_14-3-3_CanoR_1 412 421 PF00244 0.397
LIG_14-3-3_CanoR_1 446 451 PF00244 0.335
LIG_14-3-3_CanoR_1 48 56 PF00244 0.579
LIG_14-3-3_CanoR_1 486 495 PF00244 0.551
LIG_14-3-3_CanoR_1 638 642 PF00244 0.636
LIG_14-3-3_CanoR_1 659 667 PF00244 0.508
LIG_14-3-3_CanoR_1 808 812 PF00244 0.561
LIG_14-3-3_CanoR_1 83 88 PF00244 0.633
LIG_Actin_WH2_2 236 253 PF00022 0.459
LIG_BRCT_BRCA1_1 470 474 PF00533 0.426
LIG_BRCT_BRCA1_1 596 600 PF00533 0.624
LIG_FHA_1 189 195 PF00498 0.465
LIG_FHA_1 302 308 PF00498 0.315
LIG_FHA_1 494 500 PF00498 0.605
LIG_FHA_1 744 750 PF00498 0.473
LIG_FHA_1 790 796 PF00498 0.478
LIG_FHA_1 97 103 PF00498 0.586
LIG_FHA_2 132 138 PF00498 0.426
LIG_FHA_2 21 27 PF00498 0.525
LIG_FHA_2 220 226 PF00498 0.444
LIG_FHA_2 332 338 PF00498 0.582
LIG_FHA_2 528 534 PF00498 0.474
LIG_FHA_2 646 652 PF00498 0.539
LIG_FHA_2 668 674 PF00498 0.527
LIG_FHA_2 86 92 PF00498 0.464
LIG_LIR_Apic_2 120 125 PF02991 0.635
LIG_LIR_Apic_2 792 796 PF02991 0.454
LIG_LIR_Apic_2 806 812 PF02991 0.489
LIG_LIR_Gen_1 100 111 PF02991 0.478
LIG_LIR_Gen_1 342 352 PF02991 0.391
LIG_LIR_Gen_1 392 403 PF02991 0.418
LIG_LIR_Gen_1 519 529 PF02991 0.456
LIG_LIR_Gen_1 798 807 PF02991 0.572
LIG_LIR_LC3C_4 763 768 PF02991 0.578
LIG_LIR_Nem_3 100 106 PF02991 0.434
LIG_LIR_Nem_3 392 398 PF02991 0.402
LIG_LIR_Nem_3 437 443 PF02991 0.374
LIG_LIR_Nem_3 452 457 PF02991 0.327
LIG_LIR_Nem_3 471 477 PF02991 0.543
LIG_LIR_Nem_3 519 525 PF02991 0.443
LIG_LIR_Nem_3 572 578 PF02991 0.549
LIG_LIR_Nem_3 597 603 PF02991 0.467
LIG_LIR_Nem_3 750 755 PF02991 0.518
LIG_MAD2 659 667 PF02301 0.528
LIG_MYND_1 74 78 PF01753 0.554
LIG_PTB_Apo_2 129 136 PF02174 0.549
LIG_PTB_Apo_2 289 296 PF02174 0.361
LIG_PTB_Apo_2 540 547 PF02174 0.478
LIG_PTB_Phospho_1 129 135 PF10480 0.401
LIG_PTB_Phospho_1 289 295 PF10480 0.361
LIG_PTB_Phospho_1 540 546 PF10480 0.511
LIG_SH2_CRK 103 107 PF00017 0.487
LIG_SH2_CRK 165 169 PF00017 0.437
LIG_SH2_CRK 440 444 PF00017 0.348
LIG_SH2_GRB2like 165 168 PF00017 0.414
LIG_SH2_GRB2like 290 293 PF00017 0.454
LIG_SH2_GRB2like 546 549 PF00017 0.514
LIG_SH2_NCK_1 395 399 PF00017 0.443
LIG_SH2_SRC 395 398 PF00017 0.436
LIG_SH2_SRC 575 578 PF00017 0.545
LIG_SH2_SRC 614 617 PF00017 0.555
LIG_SH2_SRC 64 67 PF00017 0.527
LIG_SH2_STAP1 414 418 PF00017 0.450
LIG_SH2_STAP1 434 438 PF00017 0.223
LIG_SH2_STAT3 671 674 PF00017 0.604
LIG_SH2_STAT5 160 163 PF00017 0.424
LIG_SH2_STAT5 295 298 PF00017 0.343
LIG_SH2_STAT5 357 360 PF00017 0.563
LIG_SH2_STAT5 454 457 PF00017 0.353
LIG_SH2_STAT5 477 480 PF00017 0.436
LIG_SH2_STAT5 546 549 PF00017 0.510
LIG_SH2_STAT5 575 578 PF00017 0.558
LIG_SH3_3 375 381 PF00018 0.460
LIG_SH3_3 68 74 PF00018 0.575
LIG_SH3_3 698 704 PF00018 0.512
LIG_SH3_CIN85_PxpxPR_1 404 409 PF14604 0.515
LIG_SUMO_SIM_anti_2 38 45 PF11976 0.482
LIG_SUMO_SIM_anti_2 763 769 PF11976 0.505
LIG_SUMO_SIM_par_1 211 216 PF11976 0.383
LIG_SUMO_SIM_par_1 383 389 PF11976 0.405
LIG_SUMO_SIM_par_1 745 751 PF11976 0.493
LIG_SUMO_SIM_par_1 763 769 PF11976 0.363
LIG_TRAF2_1 590 593 PF00917 0.553
LIG_TRAF2_1 613 616 PF00917 0.544
LIG_TYR_ITIM 101 106 PF00017 0.552
LIG_TYR_ITIM 438 443 PF00017 0.354
LIG_WRC_WIRS_1 102 107 PF05994 0.477
MOD_CDK_SPK_2 468 473 PF00069 0.449
MOD_CK1_1 16 22 PF00069 0.608
MOD_CK1_1 197 203 PF00069 0.397
MOD_CK1_1 245 251 PF00069 0.427
MOD_CK1_1 331 337 PF00069 0.475
MOD_CK1_1 38 44 PF00069 0.524
MOD_CK2_1 131 137 PF00069 0.433
MOD_CK2_1 20 26 PF00069 0.524
MOD_CK2_1 331 337 PF00069 0.575
MOD_CK2_1 527 533 PF00069 0.495
MOD_CK2_1 551 557 PF00069 0.563
MOD_CK2_1 610 616 PF00069 0.463
MOD_CK2_1 645 651 PF00069 0.577
MOD_CK2_1 667 673 PF00069 0.565
MOD_CK2_1 682 688 PF00069 0.577
MOD_CK2_1 85 91 PF00069 0.497
MOD_GlcNHglycan 245 248 PF01048 0.604
MOD_GlcNHglycan 330 333 PF01048 0.640
MOD_GlcNHglycan 366 369 PF01048 0.515
MOD_GlcNHglycan 375 378 PF01048 0.605
MOD_GlcNHglycan 554 557 PF01048 0.509
MOD_GlcNHglycan 583 586 PF01048 0.653
MOD_GlcNHglycan 661 664 PF01048 0.488
MOD_GlcNHglycan 731 734 PF01048 0.599
MOD_GSK3_1 144 151 PF00069 0.479
MOD_GSK3_1 16 23 PF00069 0.608
MOD_GSK3_1 310 317 PF00069 0.387
MOD_GSK3_1 38 45 PF00069 0.527
MOD_GSK3_1 398 405 PF00069 0.675
MOD_GSK3_1 487 494 PF00069 0.597
MOD_LATS_1 249 255 PF00433 0.359
MOD_LATS_1 411 417 PF00433 0.406
MOD_LATS_1 444 450 PF00433 0.275
MOD_N-GLC_1 106 111 PF02516 0.523
MOD_N-GLC_1 131 136 PF02516 0.552
MOD_N-GLC_1 282 287 PF02516 0.561
MOD_N-GLC_1 527 532 PF02516 0.456
MOD_NEK2_1 174 179 PF00069 0.526
MOD_NEK2_1 194 199 PF00069 0.344
MOD_NEK2_1 243 248 PF00069 0.413
MOD_NEK2_1 250 255 PF00069 0.388
MOD_NEK2_1 429 434 PF00069 0.413
MOD_NEK2_1 481 486 PF00069 0.562
MOD_NEK2_1 621 626 PF00069 0.421
MOD_NEK2_1 789 794 PF00069 0.481
MOD_NEK2_2 439 444 PF00069 0.298
MOD_NEK2_2 645 650 PF00069 0.518
MOD_PIKK_1 42 48 PF00454 0.549
MOD_PIKK_1 493 499 PF00454 0.485
MOD_PK_1 446 452 PF00069 0.255
MOD_PK_1 682 688 PF00069 0.687
MOD_PKA_1 446 452 PF00069 0.265
MOD_PKA_1 83 89 PF00069 0.418
MOD_PKA_2 188 194 PF00069 0.433
MOD_PKA_2 243 249 PF00069 0.383
MOD_PKA_2 250 256 PF00069 0.337
MOD_PKA_2 265 271 PF00069 0.355
MOD_PKA_2 339 345 PF00069 0.399
MOD_PKA_2 446 452 PF00069 0.326
MOD_PKA_2 47 53 PF00069 0.548
MOD_PKA_2 580 586 PF00069 0.617
MOD_PKA_2 637 643 PF00069 0.556
MOD_PKA_2 83 89 PF00069 0.637
MOD_PKB_1 280 288 PF00069 0.380
MOD_Plk_1 131 137 PF00069 0.475
MOD_Plk_1 282 288 PF00069 0.380
MOD_Plk_1 527 533 PF00069 0.457
MOD_Plk_2-3 131 137 PF00069 0.427
MOD_Plk_2-3 188 194 PF00069 0.535
MOD_Plk_2-3 673 679 PF00069 0.633
MOD_Plk_4 101 107 PF00069 0.472
MOD_Plk_4 117 123 PF00069 0.481
MOD_Plk_4 144 150 PF00069 0.484
MOD_Plk_4 219 225 PF00069 0.417
MOD_Plk_4 310 316 PF00069 0.381
MOD_ProDKin_1 14 20 PF00069 0.596
MOD_ProDKin_1 150 156 PF00069 0.450
MOD_ProDKin_1 213 219 PF00069 0.358
MOD_ProDKin_1 326 332 PF00069 0.391
MOD_ProDKin_1 468 474 PF00069 0.499
MOD_ProDKin_1 491 497 PF00069 0.671
MOD_ProDKin_1 569 575 PF00069 0.625
MOD_ProDKin_1 85 91 PF00069 0.576
MOD_TYR_CSK 60 68 PF07714 0.521
TRG_DiLeu_BaEn_1 72 77 PF01217 0.554
TRG_DiLeu_BaEn_1 786 791 PF01217 0.492
TRG_DiLeu_BaEn_4 72 78 PF01217 0.538
TRG_ENDOCYTIC_2 103 106 PF00928 0.506
TRG_ENDOCYTIC_2 165 168 PF00928 0.465
TRG_ENDOCYTIC_2 395 398 PF00928 0.422
TRG_ENDOCYTIC_2 440 443 PF00928 0.348
TRG_ENDOCYTIC_2 454 457 PF00928 0.339
TRG_ENDOCYTIC_2 459 462 PF00928 0.344
TRG_ENDOCYTIC_2 546 549 PF00928 0.514
TRG_ENDOCYTIC_2 575 578 PF00928 0.560
TRG_ENDOCYTIC_2 800 803 PF00928 0.434
TRG_ER_diArg_1 209 212 PF00400 0.383
TRG_ER_diArg_1 279 282 PF00400 0.385
TRG_ER_diArg_1 408 410 PF00400 0.559
TRG_ER_diArg_1 412 414 PF00400 0.482
TRG_ER_diArg_1 446 448 PF00400 0.361
TRG_ER_diArg_1 483 486 PF00400 0.561
TRG_ER_diArg_1 562 564 PF00400 0.499
TRG_ER_diArg_1 714 717 PF00400 0.552
TRG_ER_diArg_1 82 85 PF00400 0.451
TRG_Pf-PMV_PEXEL_1 319 323 PF00026 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q7 Leptomonas seymouri 46% 100%
A0A1X0NYY7 Trypanosomatidae 43% 100%
A0A3Q8IAD3 Leishmania donovani 54% 83%
A0A3Q8IAF8 Leishmania donovani 72% 84%
A0A3Q8IAK8 Leishmania donovani 78% 83%
A0A3Q8IJ32 Leishmania donovani 89% 98%
A0A3S5H6Y1 Leishmania donovani 76% 86%
A0A3S7WTZ8 Leishmania donovani 62% 79%
A0A3S7WU13 Leishmania donovani 90% 86%
A0A422NAR5 Trypanosoma rangeli 44% 100%
A4H8M5 Leishmania braziliensis 70% 90%
A4H8M6 Leishmania braziliensis 83% 100%
A4H8M7 Leishmania braziliensis 81% 88%
A4H8N0 Leishmania braziliensis 50% 100%
A4H8N1 Leishmania braziliensis 53% 83%
A4HWZ5 Leishmania infantum 91% 86%
A4HWZ6 Leishmania infantum 73% 89%
A4HWZ8 Leishmania infantum 76% 89%
A4HX00 Leishmania infantum 62% 79%
A4HX01 Leishmania infantum 54% 100%
A4HX05 Leishmania infantum 71% 84%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 87%
E9AGP0 Leishmania infantum 81% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 94%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 82%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 87%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 85%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 80%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 83%
Q4QER2 Leishmania major 55% 100%
Q4QER3 Leishmania major 65% 100%
Q4QER4 Leishmania major 84% 100%
Q4QER5 Leishmania major 96% 100%
Q4QER6 Leishmania major 96% 100%
Q4QER7 Leishmania major 89% 100%
Q4QER8 Leishmania major 80% 100%
Q4QER9 Leishmania major 79% 100%
V5ANJ8 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS