LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania major
UniProt:
Q4QER9_LEIMA
TriTrypDb:
LmjF.16.1005 * , LMJLV39_000017800 , LMJLV39_160016300 , LMJSD75_160015800
Length:
926

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 125
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 37
NetGPI no yes: 0, no: 37
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 27
GO:0016020 membrane 2 19

Expansion

Sequence features

Q4QER9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QER9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 36
GO:0016740 transferase activity 2 36
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 334 338 PF00656 0.514
CLV_C14_Caspase3-7 915 919 PF00656 0.358
CLV_MEL_PAP_1 185 191 PF00089 0.615
CLV_NRD_NRD_1 177 179 PF00675 0.675
CLV_NRD_NRD_1 208 210 PF00675 0.600
CLV_NRD_NRD_1 213 215 PF00675 0.623
CLV_NRD_NRD_1 293 295 PF00675 0.677
CLV_NRD_NRD_1 34 36 PF00675 0.760
CLV_NRD_NRD_1 50 52 PF00675 0.709
CLV_NRD_NRD_1 523 525 PF00675 0.671
CLV_NRD_NRD_1 526 528 PF00675 0.639
CLV_NRD_NRD_1 561 563 PF00675 0.595
CLV_NRD_NRD_1 599 601 PF00675 0.693
CLV_NRD_NRD_1 677 679 PF00675 0.630
CLV_NRD_NRD_1 805 807 PF00675 0.708
CLV_PCSK_FUR_1 524 528 PF00082 0.638
CLV_PCSK_FUR_1 597 601 PF00082 0.657
CLV_PCSK_KEX2_1 151 153 PF00082 0.665
CLV_PCSK_KEX2_1 176 178 PF00082 0.663
CLV_PCSK_KEX2_1 213 215 PF00082 0.559
CLV_PCSK_KEX2_1 293 295 PF00082 0.696
CLV_PCSK_KEX2_1 34 36 PF00082 0.760
CLV_PCSK_KEX2_1 481 483 PF00082 0.595
CLV_PCSK_KEX2_1 50 52 PF00082 0.714
CLV_PCSK_KEX2_1 523 525 PF00082 0.671
CLV_PCSK_KEX2_1 526 528 PF00082 0.597
CLV_PCSK_KEX2_1 599 601 PF00082 0.686
CLV_PCSK_KEX2_1 677 679 PF00082 0.630
CLV_PCSK_KEX2_1 805 807 PF00082 0.708
CLV_PCSK_PC1ET2_1 151 153 PF00082 0.649
CLV_PCSK_PC1ET2_1 481 483 PF00082 0.588
CLV_PCSK_PC7_1 172 178 PF00082 0.521
CLV_PCSK_PC7_1 209 215 PF00082 0.505
CLV_PCSK_SKI1_1 124 128 PF00082 0.678
CLV_PCSK_SKI1_1 178 182 PF00082 0.638
CLV_PCSK_SKI1_1 340 344 PF00082 0.701
CLV_PCSK_SKI1_1 394 398 PF00082 0.616
CLV_PCSK_SKI1_1 448 452 PF00082 0.684
CLV_PCSK_SKI1_1 527 531 PF00082 0.662
CLV_PCSK_SKI1_1 565 569 PF00082 0.546
CLV_PCSK_SKI1_1 677 681 PF00082 0.665
CLV_PCSK_SKI1_1 767 771 PF00082 0.699
CLV_PCSK_SKI1_1 851 855 PF00082 0.673
DEG_APCC_DBOX_1 151 159 PF00400 0.437
DEG_APCC_DBOX_1 306 314 PF00400 0.491
DEG_SCF_FBW7_2 43 49 PF00400 0.473
DEG_SPOP_SBC_1 244 248 PF00917 0.471
DOC_CKS1_1 234 239 PF01111 0.468
DOC_CKS1_1 43 48 PF01111 0.472
DOC_CKS1_1 684 689 PF01111 0.471
DOC_CYCLIN_yCln2_LP_2 567 573 PF00134 0.345
DOC_CYCLIN_yCln2_LP_2 70 76 PF00134 0.465
DOC_CYCLIN_yCln2_LP_2 905 911 PF00134 0.355
DOC_MAPK_DCC_7 166 175 PF00069 0.349
DOC_MAPK_DCC_7 652 661 PF00069 0.416
DOC_MAPK_gen_1 318 327 PF00069 0.421
DOC_MAPK_gen_1 392 401 PF00069 0.405
DOC_MAPK_gen_1 560 569 PF00069 0.455
DOC_MAPK_gen_1 652 661 PF00069 0.440
DOC_MAPK_HePTP_8 680 692 PF00069 0.466
DOC_MAPK_MEF2A_6 166 175 PF00069 0.369
DOC_MAPK_MEF2A_6 394 403 PF00069 0.403
DOC_MAPK_MEF2A_6 562 571 PF00069 0.456
DOC_MAPK_MEF2A_6 683 692 PF00069 0.465
DOC_MAPK_MEF2A_6 748 755 PF00069 0.510
DOC_PP2B_LxvP_1 567 570 PF13499 0.456
DOC_PP2B_LxvP_1 70 73 PF13499 0.483
DOC_PP2B_LxvP_1 854 857 PF13499 0.426
DOC_PP4_FxxP_1 234 237 PF00568 0.463
DOC_PP4_FxxP_1 684 687 PF00568 0.421
DOC_USP7_MATH_1 222 226 PF00917 0.405
DOC_USP7_MATH_1 245 249 PF00917 0.575
DOC_USP7_MATH_1 354 358 PF00917 0.512
DOC_USP7_MATH_1 491 495 PF00917 0.386
DOC_USP7_MATH_1 514 518 PF00917 0.517
DOC_USP7_MATH_1 629 633 PF00917 0.415
DOC_USP7_MATH_1 66 70 PF00917 0.489
DOC_USP7_MATH_1 843 847 PF00917 0.472
DOC_USP7_MATH_1 898 902 PF00917 0.494
DOC_WW_Pin1_4 144 149 PF00397 0.482
DOC_WW_Pin1_4 233 238 PF00397 0.533
DOC_WW_Pin1_4 325 330 PF00397 0.399
DOC_WW_Pin1_4 39 44 PF00397 0.488
DOC_WW_Pin1_4 582 587 PF00397 0.457
DOC_WW_Pin1_4 605 610 PF00397 0.540
DOC_WW_Pin1_4 683 688 PF00397 0.469
DOC_WW_Pin1_4 78 83 PF00397 0.499
LIG_14-3-3_CanoR_1 124 132 PF00244 0.490
LIG_14-3-3_CanoR_1 176 181 PF00244 0.504
LIG_14-3-3_CanoR_1 307 311 PF00244 0.470
LIG_14-3-3_CanoR_1 363 368 PF00244 0.410
LIG_14-3-3_CanoR_1 378 382 PF00244 0.348
LIG_14-3-3_CanoR_1 394 400 PF00244 0.382
LIG_14-3-3_CanoR_1 482 492 PF00244 0.447
LIG_14-3-3_CanoR_1 50 58 PF00244 0.504
LIG_14-3-3_CanoR_1 526 536 PF00244 0.331
LIG_14-3-3_CanoR_1 600 609 PF00244 0.473
LIG_14-3-3_CanoR_1 752 756 PF00244 0.505
LIG_14-3-3_CanoR_1 773 781 PF00244 0.413
LIG_14-3-3_CanoR_1 92 100 PF00244 0.505
LIG_14-3-3_CanoR_1 922 926 PF00244 0.490
LIG_Actin_WH2_2 348 365 PF00022 0.542
LIG_Actin_WH2_2 466 483 PF00022 0.362
LIG_BRCT_BRCA1_1 584 588 PF00533 0.372
LIG_BRCT_BRCA1_1 710 714 PF00533 0.511
LIG_eIF4E_1 468 474 PF01652 0.398
LIG_FAT_LD_1 257 265 PF03623 0.339
LIG_FHA_1 121 127 PF00498 0.539
LIG_FHA_1 177 183 PF00498 0.390
LIG_FHA_1 190 196 PF00498 0.475
LIG_FHA_1 224 230 PF00498 0.336
LIG_FHA_1 279 285 PF00498 0.369
LIG_FHA_1 301 307 PF00498 0.566
LIG_FHA_1 414 420 PF00498 0.358
LIG_FHA_1 456 462 PF00498 0.371
LIG_FHA_1 53 59 PF00498 0.481
LIG_FHA_1 608 614 PF00498 0.488
LIG_FHA_1 79 85 PF00498 0.472
LIG_FHA_1 858 864 PF00498 0.414
LIG_FHA_1 904 910 PF00498 0.397
LIG_FHA_2 104 110 PF00498 0.489
LIG_FHA_2 179 185 PF00498 0.379
LIG_FHA_2 278 284 PF00498 0.416
LIG_FHA_2 332 338 PF00498 0.513
LIG_FHA_2 473 479 PF00498 0.329
LIG_FHA_2 544 550 PF00498 0.293
LIG_FHA_2 642 648 PF00498 0.401
LIG_FHA_2 760 766 PF00498 0.452
LIG_FHA_2 93 99 PF00498 0.475
LIG_LIR_Apic_2 233 237 PF02991 0.439
LIG_LIR_Apic_2 906 910 PF02991 0.381
LIG_LIR_Apic_2 920 926 PF02991 0.429
LIG_LIR_Gen_1 193 204 PF02991 0.394
LIG_LIR_Gen_1 475 483 PF02991 0.333
LIG_LIR_Gen_1 633 643 PF02991 0.376
LIG_LIR_Gen_1 912 921 PF02991 0.491
LIG_LIR_LC3C_4 877 882 PF02991 0.477
LIG_LIR_Nem_3 193 199 PF02991 0.367
LIG_LIR_Nem_3 475 480 PF02991 0.368
LIG_LIR_Nem_3 538 544 PF02991 0.306
LIG_LIR_Nem_3 566 571 PF02991 0.334
LIG_LIR_Nem_3 585 591 PF02991 0.445
LIG_LIR_Nem_3 633 639 PF02991 0.363
LIG_LIR_Nem_3 686 692 PF02991 0.458
LIG_LIR_Nem_3 711 717 PF02991 0.409
LIG_LIR_Nem_3 864 869 PF02991 0.449
LIG_MAD2 124 132 PF02301 0.459
LIG_MAD2 773 781 PF02301 0.448
LIG_MYND_1 167 171 PF01753 0.465
LIG_NRBOX 181 187 PF00104 0.311
LIG_PTB_Apo_2 401 408 PF02174 0.376
LIG_PTB_Apo_2 654 661 PF02174 0.388
LIG_PTB_Phospho_1 401 407 PF10480 0.378
LIG_PTB_Phospho_1 654 660 PF10480 0.429
LIG_REV1ctd_RIR_1 541 551 PF16727 0.319
LIG_SH2_CRK 196 200 PF00017 0.407
LIG_SH2_GRB2like 402 405 PF00017 0.494
LIG_SH2_GRB2like 660 663 PF00017 0.433
LIG_SH2_SRC 689 692 PF00017 0.458
LIG_SH2_SRC 728 731 PF00017 0.507
LIG_SH2_STAP1 528 532 PF00017 0.408
LIG_SH2_STAP1 548 552 PF00017 0.225
LIG_SH2_STAT3 785 788 PF00017 0.500
LIG_SH2_STAT5 228 231 PF00017 0.444
LIG_SH2_STAT5 407 410 PF00017 0.365
LIG_SH2_STAT5 468 471 PF00017 0.432
LIG_SH2_STAT5 536 539 PF00017 0.336
LIG_SH2_STAT5 591 594 PF00017 0.378
LIG_SH2_STAT5 660 663 PF00017 0.429
LIG_SH2_STAT5 689 692 PF00017 0.454
LIG_SH3_1 131 137 PF00018 0.440
LIG_SH3_1 238 244 PF00018 0.494
LIG_SH3_2 522 527 PF14604 0.375
LIG_SH3_3 131 137 PF00018 0.534
LIG_SH3_3 150 156 PF00018 0.518
LIG_SH3_3 161 167 PF00018 0.475
LIG_SH3_3 22 28 PF00018 0.538
LIG_SH3_3 238 244 PF00018 0.556
LIG_SH3_3 250 256 PF00018 0.620
LIG_SH3_3 40 46 PF00018 0.504
LIG_SH3_3 519 525 PF00018 0.397
LIG_SH3_3 70 76 PF00018 0.471
LIG_SH3_3 79 85 PF00018 0.472
LIG_SH3_3 812 818 PF00018 0.430
LIG_SUMO_SIM_anti_2 460 467 PF11976 0.388
LIG_SUMO_SIM_anti_2 877 883 PF11976 0.449
LIG_SUMO_SIM_par_1 218 227 PF11976 0.359
LIG_SUMO_SIM_par_1 323 328 PF11976 0.422
LIG_SUMO_SIM_par_1 859 865 PF11976 0.437
LIG_SUMO_SIM_par_1 877 883 PF11976 0.316
LIG_TRAF2_1 704 707 PF00917 0.451
LIG_TRAF2_1 727 730 PF00917 0.491
LIG_TYR_ITIM 194 199 PF00017 0.572
LIG_WRC_WIRS_1 195 200 PF05994 0.467
MOD_CDK_SPK_2 233 238 PF00069 0.530
MOD_CDK_SPK_2 39 44 PF00069 0.580
MOD_CDK_SPK_2 582 587 PF00069 0.464
MOD_CDK_SPxxK_3 144 151 PF00069 0.562
MOD_CK1_1 309 315 PF00069 0.527
MOD_CK1_1 357 363 PF00069 0.611
MOD_CK1_1 53 59 PF00069 0.631
MOD_CK1_1 624 630 PF00069 0.439
MOD_CK1_1 65 71 PF00069 0.572
MOD_CK1_1 93 99 PF00069 0.631
MOD_CK2_1 103 109 PF00069 0.599
MOD_CK2_1 178 184 PF00069 0.471
MOD_CK2_1 543 549 PF00069 0.320
MOD_CK2_1 641 647 PF00069 0.494
MOD_CK2_1 665 671 PF00069 0.565
MOD_CK2_1 724 730 PF00069 0.451
MOD_CK2_1 759 765 PF00069 0.610
MOD_CK2_1 796 802 PF00069 0.599
MOD_CK2_1 92 98 PF00069 0.607
MOD_GlcNHglycan 3 6 PF01048 0.581
MOD_GlcNHglycan 357 360 PF01048 0.597
MOD_GlcNHglycan 485 488 PF01048 0.639
MOD_GlcNHglycan 626 629 PF01048 0.420
MOD_GlcNHglycan 64 67 PF01048 0.600
MOD_GlcNHglycan 668 671 PF01048 0.533
MOD_GlcNHglycan 697 700 PF01048 0.670
MOD_GlcNHglycan 775 778 PF01048 0.504
MOD_GlcNHglycan 8 11 PF01048 0.618
MOD_GlcNHglycan 845 848 PF01048 0.594
MOD_GlcNHglycan 95 98 PF01048 0.659
MOD_GSK3_1 120 127 PF00069 0.599
MOD_GSK3_1 243 250 PF00069 0.637
MOD_GSK3_1 422 429 PF00069 0.441
MOD_GSK3_1 472 479 PF00069 0.371
MOD_GSK3_1 49 56 PF00069 0.629
MOD_GSK3_1 601 608 PF00069 0.594
MOD_GSK3_1 61 68 PF00069 0.573
MOD_LATS_1 361 367 PF00433 0.464
MOD_LATS_1 90 96 PF00433 0.567
MOD_N-GLC_1 199 204 PF02516 0.509
MOD_N-GLC_1 394 399 PF02516 0.450
MOD_N-GLC_1 483 488 PF02516 0.609
MOD_N-GLC_1 61 66 PF02516 0.595
MOD_N-GLC_1 641 646 PF02516 0.455
MOD_NEK2_1 108 113 PF00069 0.628
MOD_NEK2_1 260 265 PF00069 0.477
MOD_NEK2_1 271 276 PF00069 0.691
MOD_NEK2_1 306 311 PF00069 0.465
MOD_NEK2_1 355 360 PF00069 0.613
MOD_NEK2_1 362 367 PF00069 0.532
MOD_NEK2_1 476 481 PF00069 0.464
MOD_NEK2_1 543 548 PF00069 0.494
MOD_NEK2_1 595 600 PF00069 0.537
MOD_NEK2_1 735 740 PF00069 0.420
MOD_NEK2_1 903 908 PF00069 0.463
MOD_NEK2_2 759 764 PF00069 0.511
MOD_PIKK_1 271 277 PF00454 0.653
MOD_PIKK_1 450 456 PF00454 0.398
MOD_PIKK_1 607 613 PF00454 0.490
MOD_PK_1 796 802 PF00069 0.687
MOD_PKA_1 176 182 PF00069 0.416
MOD_PKA_1 50 56 PF00069 0.634
MOD_PKA_2 176 182 PF00069 0.615
MOD_PKA_2 278 284 PF00069 0.616
MOD_PKA_2 300 306 PF00069 0.564
MOD_PKA_2 355 361 PF00069 0.558
MOD_PKA_2 362 368 PF00069 0.429
MOD_PKA_2 377 383 PF00069 0.443
MOD_PKA_2 49 55 PF00069 0.742
MOD_PKA_2 694 700 PF00069 0.599
MOD_PKA_2 751 757 PF00069 0.583
MOD_PKB_1 176 184 PF00069 0.349
MOD_PKB_1 392 400 PF00069 0.494
MOD_Plk_1 223 229 PF00069 0.464
MOD_Plk_1 394 400 PF00069 0.495
MOD_Plk_1 641 647 PF00069 0.462
MOD_Plk_2-3 300 306 PF00069 0.696
MOD_Plk_2-3 787 793 PF00069 0.620
MOD_Plk_4 194 200 PF00069 0.461
MOD_Plk_4 224 230 PF00069 0.456
MOD_Plk_4 331 337 PF00069 0.573
MOD_Plk_4 422 428 PF00069 0.441
MOD_Plk_4 472 478 PF00069 0.387
MOD_Plk_4 516 522 PF00069 0.468
MOD_Plk_4 621 627 PF00069 0.413
MOD_ProDKin_1 144 150 PF00069 0.583
MOD_ProDKin_1 233 239 PF00069 0.666
MOD_ProDKin_1 325 331 PF00069 0.473
MOD_ProDKin_1 39 45 PF00069 0.593
MOD_ProDKin_1 582 588 PF00069 0.547
MOD_ProDKin_1 605 611 PF00069 0.660
MOD_ProDKin_1 683 689 PF00069 0.567
MOD_ProDKin_1 78 84 PF00069 0.609
TRG_DiLeu_BaEn_1 165 170 PF01217 0.566
TRG_DiLeu_BaEn_1 900 905 PF01217 0.482
TRG_ENDOCYTIC_2 196 199 PF00928 0.503
TRG_ENDOCYTIC_2 573 576 PF00928 0.398
TRG_ENDOCYTIC_2 660 663 PF00928 0.516
TRG_ENDOCYTIC_2 689 692 PF00928 0.566
TRG_ENDOCYTIC_2 914 917 PF00928 0.438
TRG_ER_diArg_1 175 178 PF00400 0.447
TRG_ER_diArg_1 212 214 PF00400 0.399
TRG_ER_diArg_1 321 324 PF00400 0.527
TRG_ER_diArg_1 33 35 PF00400 0.708
TRG_ER_diArg_1 391 394 PF00400 0.484
TRG_ER_diArg_1 522 524 PF00400 0.534
TRG_ER_diArg_1 525 527 PF00400 0.446
TRG_ER_diArg_1 557 560 PF00400 0.408
TRG_ER_diArg_1 597 600 PF00400 0.555
TRG_ER_diArg_1 676 678 PF00400 0.510
TRG_ER_diArg_1 828 831 PF00400 0.553

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NYY7 Trypanosomatidae 43% 100%
A0A3Q8IAD3 Leishmania donovani 54% 95%
A0A3Q8IAF8 Leishmania donovani 79% 96%
A0A3Q8IAK8 Leishmania donovani 83% 95%
A0A3Q8IJ32 Leishmania donovani 76% 100%
A0A3S5H6Y1 Leishmania donovani 87% 98%
A0A3S7WTZ8 Leishmania donovani 63% 90%
A0A3S7WU13 Leishmania donovani 76% 99%
A0A422NAR5 Trypanosoma rangeli 44% 100%
A4H8M5 Leishmania braziliensis 67% 100%
A4H8M7 Leishmania braziliensis 71% 100%
A4H8N0 Leishmania braziliensis 50% 100%
A4H8N1 Leishmania braziliensis 51% 95%
A4HWZ5 Leishmania infantum 76% 99%
A4HWZ6 Leishmania infantum 86% 100%
A4HWZ8 Leishmania infantum 85% 100%
A4HX00 Leishmania infantum 63% 90%
A4HX01 Leishmania infantum 55% 100%
A4HX05 Leishmania infantum 81% 96%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 99%
E9AGP0 Leishmania infantum 92% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 94%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 97%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 100%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 95%
Q4QER2 Leishmania major 54% 100%
Q4QER3 Leishmania major 65% 100%
Q4QER4 Leishmania major 97% 100%
Q4QER5 Leishmania major 80% 100%
Q4QER6 Leishmania major 80% 100%
Q4QER7 Leishmania major 90% 100%
Q4QER8 Leishmania major 91% 100%
Q4QES0 Leishmania major 79% 100%
V5ANJ8 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS