LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania major
UniProt:
Q4QER8_LEIMA
TriTrypDb:
LmjF.16.1010 , LMJLV39_000017800 , LMJLV39_160016300 , LMJSD75_160015900
Length:
954

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 120
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 36
NetGPI no yes: 0, no: 36
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 10
GO:0016020 membrane 2 20
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 27

Expansion

Sequence features

Q4QER8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QER8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 35
GO:0016740 transferase activity 2 35
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 362 366 PF00656 0.508
CLV_C14_Caspase3-7 943 947 PF00656 0.359
CLV_MEL_PAP_1 233 239 PF00089 0.626
CLV_NRD_NRD_1 10 12 PF00675 0.471
CLV_NRD_NRD_1 101 103 PF00675 0.672
CLV_NRD_NRD_1 225 227 PF00675 0.687
CLV_NRD_NRD_1 256 258 PF00675 0.600
CLV_NRD_NRD_1 40 42 PF00675 0.521
CLV_NRD_NRD_1 551 553 PF00675 0.695
CLV_NRD_NRD_1 554 556 PF00675 0.636
CLV_NRD_NRD_1 589 591 PF00675 0.595
CLV_NRD_NRD_1 627 629 PF00675 0.691
CLV_NRD_NRD_1 705 707 PF00675 0.630
CLV_NRD_NRD_1 833 835 PF00675 0.709
CLV_PCSK_FUR_1 552 556 PF00082 0.648
CLV_PCSK_FUR_1 625 629 PF00082 0.653
CLV_PCSK_KEX2_1 101 103 PF00082 0.692
CLV_PCSK_KEX2_1 224 226 PF00082 0.678
CLV_PCSK_KEX2_1 39 41 PF00082 0.548
CLV_PCSK_KEX2_1 509 511 PF00082 0.595
CLV_PCSK_KEX2_1 551 553 PF00082 0.695
CLV_PCSK_KEX2_1 554 556 PF00082 0.593
CLV_PCSK_KEX2_1 627 629 PF00082 0.683
CLV_PCSK_KEX2_1 705 707 PF00082 0.630
CLV_PCSK_KEX2_1 833 835 PF00082 0.709
CLV_PCSK_PC1ET2_1 39 41 PF00082 0.483
CLV_PCSK_PC1ET2_1 509 511 PF00082 0.588
CLV_PCSK_PC7_1 36 42 PF00082 0.475
CLV_PCSK_SKI1_1 226 230 PF00082 0.648
CLV_PCSK_SKI1_1 368 372 PF00082 0.696
CLV_PCSK_SKI1_1 422 426 PF00082 0.616
CLV_PCSK_SKI1_1 476 480 PF00082 0.686
CLV_PCSK_SKI1_1 555 559 PF00082 0.659
CLV_PCSK_SKI1_1 593 597 PF00082 0.546
CLV_PCSK_SKI1_1 705 709 PF00082 0.666
CLV_PCSK_SKI1_1 795 799 PF00082 0.695
CLV_PCSK_SKI1_1 879 883 PF00082 0.671
DEG_APCC_DBOX_1 334 342 PF00400 0.484
DEG_Nend_Nbox_1 1 3 PF02207 0.640
DEG_SCF_FBW7_1 176 183 PF00400 0.462
DEG_SPOP_SBC_1 123 127 PF00917 0.473
DOC_CKS1_1 142 147 PF01111 0.485
DOC_CKS1_1 712 717 PF01111 0.471
DOC_CYCLIN_yCln2_LP_2 595 601 PF00134 0.345
DOC_CYCLIN_yCln2_LP_2 933 939 PF00134 0.347
DOC_MAPK_DCC_7 680 689 PF00069 0.414
DOC_MAPK_gen_1 346 355 PF00069 0.414
DOC_MAPK_gen_1 420 429 PF00069 0.405
DOC_MAPK_gen_1 588 597 PF00069 0.455
DOC_MAPK_gen_1 680 689 PF00069 0.439
DOC_MAPK_HePTP_8 708 720 PF00069 0.467
DOC_MAPK_MEF2A_6 16 25 PF00069 0.661
DOC_MAPK_MEF2A_6 422 431 PF00069 0.402
DOC_MAPK_MEF2A_6 590 599 PF00069 0.455
DOC_MAPK_MEF2A_6 711 720 PF00069 0.465
DOC_MAPK_MEF2A_6 776 783 PF00069 0.510
DOC_PP2B_LxvP_1 595 598 PF13499 0.455
DOC_PP2B_LxvP_1 882 885 PF13499 0.422
DOC_PP4_FxxP_1 712 715 PF00568 0.424
DOC_USP7_MATH_1 123 127 PF00917 0.482
DOC_USP7_MATH_1 134 138 PF00917 0.497
DOC_USP7_MATH_1 382 386 PF00917 0.494
DOC_USP7_MATH_1 519 523 PF00917 0.404
DOC_USP7_MATH_1 542 546 PF00917 0.517
DOC_USP7_MATH_1 657 661 PF00917 0.395
DOC_USP7_MATH_1 698 702 PF00917 0.318
DOC_USP7_MATH_1 871 875 PF00917 0.469
DOC_USP7_MATH_1 926 930 PF00917 0.473
DOC_USP7_UBL2_3 12 16 PF12436 0.699
DOC_WW_Pin1_4 106 111 PF00397 0.500
DOC_WW_Pin1_4 126 131 PF00397 0.467
DOC_WW_Pin1_4 135 140 PF00397 0.488
DOC_WW_Pin1_4 141 146 PF00397 0.506
DOC_WW_Pin1_4 151 156 PF00397 0.524
DOC_WW_Pin1_4 16 21 PF00397 0.647
DOC_WW_Pin1_4 176 181 PF00397 0.492
DOC_WW_Pin1_4 226 231 PF00397 0.471
DOC_WW_Pin1_4 353 358 PF00397 0.393
DOC_WW_Pin1_4 610 615 PF00397 0.458
DOC_WW_Pin1_4 633 638 PF00397 0.536
DOC_WW_Pin1_4 711 716 PF00397 0.471
LIG_14-3-3_CanoR_1 224 229 PF00244 0.515
LIG_14-3-3_CanoR_1 335 339 PF00244 0.466
LIG_14-3-3_CanoR_1 391 396 PF00244 0.407
LIG_14-3-3_CanoR_1 406 410 PF00244 0.351
LIG_14-3-3_CanoR_1 422 428 PF00244 0.382
LIG_14-3-3_CanoR_1 510 520 PF00244 0.462
LIG_14-3-3_CanoR_1 554 564 PF00244 0.331
LIG_14-3-3_CanoR_1 628 637 PF00244 0.468
LIG_14-3-3_CanoR_1 780 784 PF00244 0.503
LIG_14-3-3_CanoR_1 801 809 PF00244 0.409
LIG_14-3-3_CanoR_1 950 954 PF00244 0.481
LIG_Actin_WH2_2 376 393 PF00022 0.532
LIG_Actin_WH2_2 494 511 PF00022 0.360
LIG_BRCT_BRCA1_1 272 276 PF00533 0.319
LIG_BRCT_BRCA1_1 42 46 PF00533 0.598
LIG_BRCT_BRCA1_1 612 616 PF00533 0.374
LIG_BRCT_BRCA1_1 738 742 PF00533 0.511
LIG_eIF4E_1 496 502 PF01652 0.396
LIG_FHA_1 142 148 PF00498 0.540
LIG_FHA_1 152 158 PF00498 0.511
LIG_FHA_1 184 190 PF00498 0.501
LIG_FHA_1 238 244 PF00498 0.481
LIG_FHA_1 329 335 PF00498 0.555
LIG_FHA_1 442 448 PF00498 0.359
LIG_FHA_1 484 490 PF00498 0.373
LIG_FHA_1 636 642 PF00498 0.489
LIG_FHA_1 886 892 PF00498 0.415
LIG_FHA_1 932 938 PF00498 0.384
LIG_FHA_2 147 153 PF00498 0.507
LIG_FHA_2 227 233 PF00498 0.386
LIG_FHA_2 306 312 PF00498 0.397
LIG_FHA_2 360 366 PF00498 0.507
LIG_FHA_2 501 507 PF00498 0.329
LIG_FHA_2 572 578 PF00498 0.292
LIG_FHA_2 670 676 PF00498 0.404
LIG_FHA_2 788 794 PF00498 0.451
LIG_FHA_2 810 816 PF00498 0.419
LIG_FHA_2 83 89 PF00498 0.425
LIG_LIR_Apic_2 934 938 PF02991 0.373
LIG_LIR_Apic_2 948 954 PF02991 0.422
LIG_LIR_Gen_1 241 252 PF02991 0.397
LIG_LIR_Gen_1 503 511 PF02991 0.334
LIG_LIR_Gen_1 661 671 PF02991 0.376
LIG_LIR_Gen_1 940 949 PF02991 0.491
LIG_LIR_LC3C_4 905 910 PF02991 0.477
LIG_LIR_Nem_3 156 161 PF02991 0.473
LIG_LIR_Nem_3 241 247 PF02991 0.368
LIG_LIR_Nem_3 503 508 PF02991 0.368
LIG_LIR_Nem_3 594 599 PF02991 0.333
LIG_LIR_Nem_3 613 619 PF02991 0.446
LIG_LIR_Nem_3 661 667 PF02991 0.363
LIG_LIR_Nem_3 714 720 PF02991 0.457
LIG_LIR_Nem_3 739 745 PF02991 0.409
LIG_LIR_Nem_3 892 897 PF02991 0.451
LIG_LYPXL_S_1 157 161 PF13949 0.669
LIG_LYPXL_yS_3 158 161 PF13949 0.468
LIG_MAD2 801 809 PF02301 0.443
LIG_MYND_1 155 159 PF01753 0.477
LIG_MYND_1 215 219 PF01753 0.478
LIG_Pex14_2 90 94 PF04695 0.402
LIG_PTB_Apo_2 429 436 PF02174 0.373
LIG_PTB_Apo_2 682 689 PF02174 0.386
LIG_PTB_Phospho_1 429 435 PF10480 0.375
LIG_PTB_Phospho_1 682 688 PF10480 0.426
LIG_REV1ctd_RIR_1 569 579 PF16727 0.317
LIG_SH2_CRK 244 248 PF00017 0.407
LIG_SH2_GRB2like 287 290 PF00017 0.399
LIG_SH2_GRB2like 430 433 PF00017 0.487
LIG_SH2_GRB2like 688 691 PF00017 0.433
LIG_SH2_SRC 717 720 PF00017 0.455
LIG_SH2_SRC 756 759 PF00017 0.506
LIG_SH2_STAP1 556 560 PF00017 0.408
LIG_SH2_STAP1 576 580 PF00017 0.224
LIG_SH2_STAT3 256 259 PF00017 0.334
LIG_SH2_STAT3 813 816 PF00017 0.503
LIG_SH2_STAT5 435 438 PF00017 0.364
LIG_SH2_STAT5 47 50 PF00017 0.532
LIG_SH2_STAT5 496 499 PF00017 0.430
LIG_SH2_STAT5 564 567 PF00017 0.335
LIG_SH2_STAT5 619 622 PF00017 0.378
LIG_SH2_STAT5 65 68 PF00017 0.247
LIG_SH2_STAT5 688 691 PF00017 0.430
LIG_SH2_STAT5 717 720 PF00017 0.452
LIG_SH3_1 163 169 PF00018 0.471
LIG_SH3_2 550 555 PF14604 0.387
LIG_SH3_3 133 139 PF00018 0.502
LIG_SH3_3 163 169 PF00018 0.506
LIG_SH3_3 20 26 PF00018 0.781
LIG_SH3_3 209 215 PF00018 0.519
LIG_SH3_3 547 553 PF00018 0.408
LIG_SH3_3 840 846 PF00018 0.430
LIG_SUMO_SIM_anti_2 488 495 PF11976 0.388
LIG_SUMO_SIM_anti_2 52 58 PF11976 0.324
LIG_SUMO_SIM_anti_2 905 911 PF11976 0.449
LIG_SUMO_SIM_par_1 185 191 PF11976 0.412
LIG_SUMO_SIM_par_1 19 24 PF11976 0.643
LIG_SUMO_SIM_par_1 351 356 PF11976 0.416
LIG_SUMO_SIM_par_1 887 893 PF11976 0.438
LIG_SUMO_SIM_par_1 905 911 PF11976 0.315
LIG_TRAF2_1 732 735 PF00917 0.446
LIG_TRAF2_1 755 758 PF00917 0.493
LIG_TYR_ITIM 242 247 PF00017 0.476
LIG_TYR_ITIM 63 68 PF00017 0.251
LIG_TYR_ITSM 154 161 PF00017 0.464
LIG_WRC_WIRS_1 243 248 PF05994 0.399
MOD_CDK_SPK_2 610 615 PF00069 0.397
MOD_CK1_1 126 132 PF00069 0.515
MOD_CK1_1 337 343 PF00069 0.435
MOD_CK1_1 385 391 PF00069 0.490
MOD_CK1_1 652 658 PF00069 0.365
MOD_CK2_1 146 152 PF00069 0.511
MOD_CK2_1 226 232 PF00069 0.410
MOD_CK2_1 571 577 PF00069 0.292
MOD_CK2_1 669 675 PF00069 0.418
MOD_CK2_1 693 699 PF00069 0.473
MOD_CK2_1 752 758 PF00069 0.386
MOD_CK2_1 787 793 PF00069 0.504
MOD_CK2_1 809 815 PF00069 0.450
MOD_CK2_1 82 88 PF00069 0.428
MOD_CK2_1 824 830 PF00069 0.491
MOD_Cter_Amidation 37 40 PF01082 0.559
MOD_GlcNHglycan 284 287 PF01048 0.592
MOD_GlcNHglycan 33 36 PF01048 0.451
MOD_GlcNHglycan 385 388 PF01048 0.674
MOD_GlcNHglycan 51 54 PF01048 0.320
MOD_GlcNHglycan 513 516 PF01048 0.724
MOD_GlcNHglycan 6 9 PF01048 0.454
MOD_GlcNHglycan 654 657 PF01048 0.560
MOD_GlcNHglycan 696 699 PF01048 0.647
MOD_GlcNHglycan 725 728 PF01048 0.739
MOD_GlcNHglycan 803 806 PF01048 0.619
MOD_GlcNHglycan 873 876 PF01048 0.690
MOD_GSK3_1 106 113 PF00069 0.510
MOD_GSK3_1 121 128 PF00069 0.497
MOD_GSK3_1 130 137 PF00069 0.482
MOD_GSK3_1 176 183 PF00069 0.507
MOD_GSK3_1 27 34 PF00069 0.657
MOD_GSK3_1 450 457 PF00069 0.379
MOD_GSK3_1 500 507 PF00069 0.330
MOD_GSK3_1 629 636 PF00069 0.481
MOD_GSK3_1 694 701 PF00069 0.359
MOD_LATS_1 389 395 PF00433 0.393
MOD_N-GLC_1 247 252 PF02516 0.630
MOD_N-GLC_1 422 427 PF02516 0.586
MOD_N-GLC_1 511 516 PF02516 0.703
MOD_N-GLC_1 669 674 PF02516 0.593
MOD_NEK2_1 2 7 PF00069 0.657
MOD_NEK2_1 276 281 PF00069 0.397
MOD_NEK2_1 298 303 PF00069 0.503
MOD_NEK2_1 334 339 PF00069 0.390
MOD_NEK2_1 383 388 PF00069 0.484
MOD_NEK2_1 390 395 PF00069 0.442
MOD_NEK2_1 504 509 PF00069 0.393
MOD_NEK2_1 571 576 PF00069 0.417
MOD_NEK2_1 623 628 PF00069 0.445
MOD_NEK2_1 72 77 PF00069 0.518
MOD_NEK2_1 763 768 PF00069 0.362
MOD_NEK2_1 931 936 PF00069 0.372
MOD_NEK2_2 787 792 PF00069 0.434
MOD_PIKK_1 168 174 PF00454 0.489
MOD_PIKK_1 478 484 PF00454 0.348
MOD_PIKK_1 635 641 PF00454 0.415
MOD_PK_1 824 830 PF00069 0.554
MOD_PKA_1 224 230 PF00069 0.372
MOD_PKA_1 40 46 PF00069 0.615
MOD_PKA_2 224 230 PF00069 0.518
MOD_PKA_2 328 334 PF00069 0.455
MOD_PKA_2 383 389 PF00069 0.447
MOD_PKA_2 390 396 PF00069 0.368
MOD_PKA_2 40 46 PF00069 0.622
MOD_PKA_2 405 411 PF00069 0.382
MOD_PKA_2 722 728 PF00069 0.492
MOD_PKA_2 779 785 PF00069 0.480
MOD_PKB_1 420 428 PF00069 0.419
MOD_Plk_1 422 428 PF00069 0.420
MOD_Plk_1 669 675 PF00069 0.396
MOD_Plk_1 72 78 PF00069 0.406
MOD_Plk_2-3 328 334 PF00069 0.551
MOD_Plk_2-3 815 821 PF00069 0.510
MOD_Plk_4 153 159 PF00069 0.466
MOD_Plk_4 242 248 PF00069 0.395
MOD_Plk_4 276 282 PF00069 0.421
MOD_Plk_4 359 365 PF00069 0.466
MOD_Plk_4 450 456 PF00069 0.378
MOD_Plk_4 500 506 PF00069 0.342
MOD_Plk_4 544 550 PF00069 0.398
MOD_Plk_4 649 655 PF00069 0.352
MOD_ProDKin_1 106 112 PF00069 0.502
MOD_ProDKin_1 126 132 PF00069 0.463
MOD_ProDKin_1 135 141 PF00069 0.485
MOD_ProDKin_1 151 157 PF00069 0.526
MOD_ProDKin_1 16 22 PF00069 0.646
MOD_ProDKin_1 176 182 PF00069 0.492
MOD_ProDKin_1 226 232 PF00069 0.469
MOD_ProDKin_1 353 359 PF00069 0.395
MOD_ProDKin_1 610 616 PF00069 0.456
MOD_ProDKin_1 633 639 PF00069 0.533
MOD_ProDKin_1 711 717 PF00069 0.470
MOD_SUMO_for_1 164 167 PF00179 0.469
MOD_SUMO_rev_2 97 107 PF00179 0.424
TRG_DiLeu_BaEn_1 213 218 PF01217 0.485
TRG_DiLeu_BaEn_1 928 933 PF01217 0.376
TRG_DiLeu_BaEn_4 213 219 PF01217 0.471
TRG_ENDOCYTIC_2 158 161 PF00928 0.468
TRG_ENDOCYTIC_2 244 247 PF00928 0.423
TRG_ENDOCYTIC_2 601 604 PF00928 0.348
TRG_ENDOCYTIC_2 65 68 PF00928 0.310
TRG_ENDOCYTIC_2 688 691 PF00928 0.433
TRG_ENDOCYTIC_2 717 720 PF00928 0.466
TRG_ENDOCYTIC_2 942 945 PF00928 0.376
TRG_ER_diArg_1 223 226 PF00400 0.396
TRG_ER_diArg_1 349 352 PF00400 0.435
TRG_ER_diArg_1 419 422 PF00400 0.409
TRG_ER_diArg_1 550 552 PF00400 0.456
TRG_ER_diArg_1 553 555 PF00400 0.398
TRG_ER_diArg_1 585 588 PF00400 0.355
TRG_ER_diArg_1 625 628 PF00400 0.456
TRG_ER_diArg_1 704 706 PF00400 0.427
TRG_ER_diArg_1 856 859 PF00400 0.457
TRG_NLS_MonoExtN_4 36 43 PF00514 0.656

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NYY7 Trypanosomatidae 44% 100%
A0A3Q8IAD3 Leishmania donovani 55% 98%
A0A3Q8IAF8 Leishmania donovani 77% 99%
A0A3Q8IAK8 Leishmania donovani 86% 98%
A0A3Q8IJ32 Leishmania donovani 76% 100%
A0A3S5H6Y1 Leishmania donovani 76% 100%
A0A3S7WTZ8 Leishmania donovani 62% 93%
A0A3S7WU13 Leishmania donovani 76% 100%
A0A422NAR5 Trypanosoma rangeli 45% 100%
A4H8M5 Leishmania braziliensis 67% 100%
A4H8M7 Leishmania braziliensis 72% 100%
A4H8N0 Leishmania braziliensis 50% 100%
A4H8N1 Leishmania braziliensis 52% 98%
A4HWZ5 Leishmania infantum 76% 100%
A4HWZ6 Leishmania infantum 69% 100%
A4HWZ8 Leishmania infantum 88% 100%
A4HX00 Leishmania infantum 62% 93%
A4HX01 Leishmania infantum 55% 100%
A4HX05 Leishmania infantum 79% 99%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 69% 96%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 100%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 97%
Q4QER2 Leishmania major 55% 100%
Q4QER3 Leishmania major 65% 100%
Q4QER4 Leishmania major 100% 100%
Q4QER5 Leishmania major 81% 100%
Q4QER6 Leishmania major 80% 100%
Q4QER7 Leishmania major 90% 100%
Q4QER9 Leishmania major 91% 100%
Q4QES0 Leishmania major 80% 100%
V5ANJ8 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS