LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania major
UniProt:
Q4QER7_LEIMA
TriTrypDb:
LmjF.16.1015 , LMJLV39_000018700 , LMJLV39_160016300 , LMJSD75_160015800
Length:
858

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 125
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 38
NetGPI no yes: 0, no: 38
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 27
GO:0016020 membrane 2 19

Expansion

Sequence features

Q4QER7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QER7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 37
GO:0016740 transferase activity 2 37
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 266 270 PF00656 0.448
CLV_C14_Caspase3-7 847 851 PF00656 0.399
CLV_MEL_PAP_1 136 142 PF00089 0.502
CLV_NRD_NRD_1 128 130 PF00675 0.605
CLV_NRD_NRD_1 159 161 PF00675 0.489
CLV_NRD_NRD_1 455 457 PF00675 0.614
CLV_NRD_NRD_1 458 460 PF00675 0.546
CLV_NRD_NRD_1 493 495 PF00675 0.608
CLV_NRD_NRD_1 531 533 PF00675 0.617
CLV_NRD_NRD_1 609 611 PF00675 0.509
CLV_NRD_NRD_1 737 739 PF00675 0.636
CLV_NRD_NRD_1 92 94 PF00675 0.615
CLV_PCSK_FUR_1 456 460 PF00082 0.535
CLV_PCSK_FUR_1 529 533 PF00082 0.545
CLV_PCSK_KEX2_1 127 129 PF00082 0.570
CLV_PCSK_KEX2_1 413 415 PF00082 0.539
CLV_PCSK_KEX2_1 455 457 PF00082 0.614
CLV_PCSK_KEX2_1 458 460 PF00082 0.490
CLV_PCSK_KEX2_1 531 533 PF00082 0.585
CLV_PCSK_KEX2_1 609 611 PF00082 0.509
CLV_PCSK_KEX2_1 737 739 PF00082 0.636
CLV_PCSK_KEX2_1 92 94 PF00082 0.607
CLV_PCSK_PC1ET2_1 413 415 PF00082 0.534
CLV_PCSK_SKI1_1 129 133 PF00082 0.532
CLV_PCSK_SKI1_1 272 276 PF00082 0.663
CLV_PCSK_SKI1_1 326 330 PF00082 0.585
CLV_PCSK_SKI1_1 380 384 PF00082 0.600
CLV_PCSK_SKI1_1 459 463 PF00082 0.574
CLV_PCSK_SKI1_1 497 501 PF00082 0.562
CLV_PCSK_SKI1_1 609 613 PF00082 0.577
CLV_PCSK_SKI1_1 699 703 PF00082 0.600
CLV_PCSK_SKI1_1 783 787 PF00082 0.597
CLV_PCSK_SKI1_1 84 88 PF00082 0.604
DEG_APCC_DBOX_1 238 246 PF00400 0.437
DEG_Nend_UBRbox_1 1 4 PF02207 0.558
DEG_SPOP_SBC_1 41 45 PF00917 0.525
DEG_SPOP_SBC_1 65 69 PF00917 0.598
DOC_CDC14_PxL_1 165 173 PF14671 0.381
DOC_CKS1_1 616 621 PF01111 0.629
DOC_CYCLIN_yCln2_LP_2 499 505 PF00134 0.342
DOC_CYCLIN_yCln2_LP_2 837 843 PF00134 0.426
DOC_MAPK_DCC_7 584 593 PF00069 0.493
DOC_MAPK_gen_1 250 259 PF00069 0.373
DOC_MAPK_gen_1 324 333 PF00069 0.385
DOC_MAPK_gen_1 492 501 PF00069 0.419
DOC_MAPK_gen_1 584 593 PF00069 0.547
DOC_MAPK_HePTP_8 612 624 PF00069 0.561
DOC_MAPK_MEF2A_6 326 335 PF00069 0.385
DOC_MAPK_MEF2A_6 494 503 PF00069 0.419
DOC_MAPK_MEF2A_6 615 624 PF00069 0.559
DOC_MAPK_MEF2A_6 680 687 PF00069 0.619
DOC_PP2B_LxvP_1 499 502 PF13499 0.419
DOC_PP2B_LxvP_1 75 78 PF13499 0.565
DOC_PP2B_LxvP_1 786 789 PF13499 0.486
DOC_PP4_FxxP_1 616 619 PF00568 0.524
DOC_USP7_MATH_1 188 192 PF00917 0.469
DOC_USP7_MATH_1 286 290 PF00917 0.411
DOC_USP7_MATH_1 423 427 PF00917 0.465
DOC_USP7_MATH_1 446 450 PF00917 0.563
DOC_USP7_MATH_1 561 565 PF00917 0.493
DOC_USP7_MATH_1 58 62 PF00917 0.568
DOC_USP7_MATH_1 775 779 PF00917 0.589
DOC_USP7_MATH_1 830 834 PF00917 0.615
DOC_WW_Pin1_4 129 134 PF00397 0.589
DOC_WW_Pin1_4 194 199 PF00397 0.466
DOC_WW_Pin1_4 257 262 PF00397 0.360
DOC_WW_Pin1_4 514 519 PF00397 0.504
DOC_WW_Pin1_4 537 542 PF00397 0.685
DOC_WW_Pin1_4 54 59 PF00397 0.596
DOC_WW_Pin1_4 61 66 PF00397 0.607
DOC_WW_Pin1_4 615 620 PF00397 0.629
LIG_14-3-3_CanoR_1 127 132 PF00244 0.640
LIG_14-3-3_CanoR_1 160 166 PF00244 0.526
LIG_14-3-3_CanoR_1 239 243 PF00244 0.403
LIG_14-3-3_CanoR_1 27 33 PF00244 0.607
LIG_14-3-3_CanoR_1 295 300 PF00244 0.378
LIG_14-3-3_CanoR_1 310 314 PF00244 0.318
LIG_14-3-3_CanoR_1 326 332 PF00244 0.360
LIG_14-3-3_CanoR_1 414 424 PF00244 0.627
LIG_14-3-3_CanoR_1 458 468 PF00244 0.396
LIG_14-3-3_CanoR_1 532 541 PF00244 0.564
LIG_14-3-3_CanoR_1 60 64 PF00244 0.599
LIG_14-3-3_CanoR_1 684 688 PF00244 0.629
LIG_14-3-3_CanoR_1 705 713 PF00244 0.517
LIG_14-3-3_CanoR_1 854 858 PF00244 0.581
LIG_14-3-3_CanoR_1 92 100 PF00244 0.582
LIG_Actin_WH2_2 280 297 PF00022 0.459
LIG_Actin_WH2_2 398 415 PF00022 0.416
LIG_BRCT_BRCA1_1 516 520 PF00533 0.430
LIG_BRCT_BRCA1_1 642 646 PF00533 0.626
LIG_eIF4E_1 400 406 PF01652 0.489
LIG_FHA_1 141 147 PF00498 0.592
LIG_FHA_1 233 239 PF00498 0.464
LIG_FHA_1 346 352 PF00498 0.316
LIG_FHA_1 35 41 PF00498 0.618
LIG_FHA_1 388 394 PF00498 0.453
LIG_FHA_1 540 546 PF00498 0.610
LIG_FHA_1 66 72 PF00498 0.691
LIG_FHA_1 790 796 PF00498 0.472
LIG_FHA_1 836 842 PF00498 0.495
LIG_FHA_2 130 136 PF00498 0.474
LIG_FHA_2 176 182 PF00498 0.434
LIG_FHA_2 264 270 PF00498 0.448
LIG_FHA_2 3 9 PF00498 0.573
LIG_FHA_2 405 411 PF00498 0.599
LIG_FHA_2 41 47 PF00498 0.537
LIG_FHA_2 476 482 PF00498 0.306
LIG_FHA_2 51 57 PF00498 0.548
LIG_FHA_2 574 580 PF00498 0.473
LIG_Integrin_RGD_1 13 15 PF01839 0.574
LIG_LIR_Apic_2 164 169 PF02991 0.646
LIG_LIR_Apic_2 838 842 PF02991 0.473
LIG_LIR_Apic_2 852 858 PF02991 0.500
LIG_LIR_Gen_1 144 155 PF02991 0.486
LIG_LIR_Gen_1 407 415 PF02991 0.376
LIG_LIR_Gen_1 565 575 PF02991 0.461
LIG_LIR_Gen_1 844 853 PF02991 0.574
LIG_LIR_LC3C_4 809 814 PF02991 0.575
LIG_LIR_Nem_3 144 150 PF02991 0.444
LIG_LIR_Nem_3 407 412 PF02991 0.424
LIG_LIR_Nem_3 470 476 PF02991 0.304
LIG_LIR_Nem_3 498 503 PF02991 0.327
LIG_LIR_Nem_3 517 523 PF02991 0.549
LIG_LIR_Nem_3 565 571 PF02991 0.443
LIG_LIR_Nem_3 618 624 PF02991 0.549
LIG_LIR_Nem_3 643 649 PF02991 0.468
LIG_LIR_Nem_3 796 801 PF02991 0.517
LIG_LIR_Nem_3 80 86 PF02991 0.607
LIG_MAD2 705 713 PF02301 0.541
LIG_MYND_1 118 122 PF01753 0.573
LIG_PTB_Apo_2 173 180 PF02174 0.562
LIG_PTB_Apo_2 333 340 PF02174 0.360
LIG_PTB_Apo_2 586 593 PF02174 0.480
LIG_PTB_Phospho_1 173 179 PF10480 0.414
LIG_PTB_Phospho_1 333 339 PF10480 0.360
LIG_PTB_Phospho_1 586 592 PF10480 0.511
LIG_REV1ctd_RIR_1 473 483 PF16727 0.316
LIG_SH2_CRK 147 151 PF00017 0.497
LIG_SH2_CRK 209 213 PF00017 0.438
LIG_SH2_CRK 83 87 PF00017 0.588
LIG_SH2_GRB2like 209 212 PF00017 0.414
LIG_SH2_GRB2like 334 337 PF00017 0.453
LIG_SH2_GRB2like 592 595 PF00017 0.515
LIG_SH2_SRC 108 111 PF00017 0.589
LIG_SH2_SRC 621 624 PF00017 0.546
LIG_SH2_SRC 660 663 PF00017 0.555
LIG_SH2_STAP1 460 464 PF00017 0.449
LIG_SH2_STAP1 480 484 PF00017 0.222
LIG_SH2_STAT3 717 720 PF00017 0.608
LIG_SH2_STAT5 204 207 PF00017 0.428
LIG_SH2_STAT5 339 342 PF00017 0.342
LIG_SH2_STAT5 400 403 PF00017 0.532
LIG_SH2_STAT5 468 471 PF00017 0.333
LIG_SH2_STAT5 523 526 PF00017 0.438
LIG_SH2_STAT5 592 595 PF00017 0.510
LIG_SH2_STAT5 621 624 PF00017 0.560
LIG_SH3_2 454 459 PF14604 0.449
LIG_SH3_3 112 118 PF00018 0.600
LIG_SH3_3 451 457 PF00018 0.465
LIG_SH3_3 71 77 PF00018 0.704
LIG_SH3_3 744 750 PF00018 0.512
LIG_SUMO_SIM_anti_2 37 46 PF11976 0.651
LIG_SUMO_SIM_anti_2 392 399 PF11976 0.519
LIG_SUMO_SIM_anti_2 809 815 PF11976 0.503
LIG_SUMO_SIM_par_1 255 260 PF11976 0.384
LIG_SUMO_SIM_par_1 48 53 PF11976 0.587
LIG_SUMO_SIM_par_1 791 797 PF11976 0.492
LIG_SUMO_SIM_par_1 809 815 PF11976 0.361
LIG_TRAF2_1 636 639 PF00917 0.558
LIG_TRAF2_1 659 662 PF00917 0.544
LIG_TYR_ITIM 145 150 PF00017 0.566
LIG_TYR_ITSM 79 86 PF00017 0.588
LIG_WRC_WIRS_1 146 151 PF05994 0.486
MOD_CDC14_SPxK_1 57 60 PF00782 0.558
MOD_CDK_SPK_2 514 519 PF00069 0.453
MOD_CDK_SPxK_1 54 60 PF00069 0.558
MOD_CK1_1 241 247 PF00069 0.398
MOD_CK1_1 289 295 PF00069 0.428
MOD_CK1_1 34 40 PF00069 0.552
MOD_CK1_1 556 562 PF00069 0.440
MOD_CK1_1 61 67 PF00069 0.634
MOD_CK2_1 129 135 PF00069 0.506
MOD_CK2_1 175 181 PF00069 0.445
MOD_CK2_1 2 8 PF00069 0.559
MOD_CK2_1 40 46 PF00069 0.552
MOD_CK2_1 475 481 PF00069 0.306
MOD_CK2_1 50 56 PF00069 0.571
MOD_CK2_1 573 579 PF00069 0.496
MOD_CK2_1 597 603 PF00069 0.568
MOD_CK2_1 656 662 PF00069 0.463
MOD_CK2_1 728 734 PF00069 0.574
MOD_GlcNHglycan 2 5 PF01048 0.609
MOD_GlcNHglycan 289 292 PF01048 0.605
MOD_GlcNHglycan 33 36 PF01048 0.560
MOD_GlcNHglycan 417 420 PF01048 0.642
MOD_GlcNHglycan 558 561 PF01048 0.431
MOD_GlcNHglycan 600 603 PF01048 0.517
MOD_GlcNHglycan 629 632 PF01048 0.686
MOD_GlcNHglycan 707 710 PF01048 0.498
MOD_GlcNHglycan 71 74 PF01048 0.625
MOD_GlcNHglycan 777 780 PF01048 0.596
MOD_GSK3_1 188 195 PF00069 0.488
MOD_GSK3_1 22 29 PF00069 0.641
MOD_GSK3_1 354 361 PF00069 0.383
MOD_GSK3_1 404 411 PF00069 0.371
MOD_GSK3_1 48 55 PF00069 0.636
MOD_GSK3_1 533 540 PF00069 0.608
MOD_GSK3_1 59 66 PF00069 0.622
MOD_LATS_1 293 299 PF00433 0.360
MOD_N-GLC_1 150 155 PF02516 0.531
MOD_N-GLC_1 175 180 PF02516 0.564
MOD_N-GLC_1 23 28 PF02516 0.571
MOD_N-GLC_1 326 331 PF02516 0.560
MOD_N-GLC_1 415 420 PF02516 0.637
MOD_N-GLC_1 573 578 PF02516 0.456
MOD_NEK2_1 101 106 PF00069 0.712
MOD_NEK2_1 218 223 PF00069 0.529
MOD_NEK2_1 238 243 PF00069 0.345
MOD_NEK2_1 287 292 PF00069 0.413
MOD_NEK2_1 294 299 PF00069 0.391
MOD_NEK2_1 408 413 PF00069 0.462
MOD_NEK2_1 475 480 PF00069 0.412
MOD_NEK2_1 50 55 PF00069 0.634
MOD_NEK2_1 527 532 PF00069 0.554
MOD_NEK2_1 667 672 PF00069 0.420
MOD_NEK2_1 835 840 PF00069 0.497
MOD_PIKK_1 382 388 PF00454 0.396
MOD_PIKK_1 539 545 PF00454 0.488
MOD_PIKK_1 86 92 PF00454 0.602
MOD_PK_1 728 734 PF00069 0.683
MOD_PKA_1 127 133 PF00069 0.425
MOD_PKA_2 127 133 PF00069 0.644
MOD_PKA_2 232 238 PF00069 0.435
MOD_PKA_2 26 32 PF00069 0.760
MOD_PKA_2 287 293 PF00069 0.384
MOD_PKA_2 294 300 PF00069 0.337
MOD_PKA_2 309 315 PF00069 0.349
MOD_PKA_2 59 65 PF00069 0.590
MOD_PKA_2 626 632 PF00069 0.616
MOD_PKA_2 683 689 PF00069 0.549
MOD_PKA_2 91 97 PF00069 0.562
MOD_PKB_1 324 332 PF00069 0.378
MOD_Plk_1 175 181 PF00069 0.487
MOD_Plk_1 23 29 PF00069 0.569
MOD_Plk_1 326 332 PF00069 0.378
MOD_Plk_1 573 579 PF00069 0.465
MOD_Plk_2-3 175 181 PF00069 0.438
MOD_Plk_2-3 232 238 PF00069 0.542
MOD_Plk_2-3 719 725 PF00069 0.630
MOD_Plk_4 145 151 PF00069 0.482
MOD_Plk_4 161 167 PF00069 0.496
MOD_Plk_4 188 194 PF00069 0.493
MOD_Plk_4 263 269 PF00069 0.418
MOD_Plk_4 354 360 PF00069 0.378
MOD_Plk_4 404 410 PF00069 0.388
MOD_Plk_4 448 454 PF00069 0.466
MOD_Plk_4 553 559 PF00069 0.431
MOD_ProDKin_1 129 135 PF00069 0.586
MOD_ProDKin_1 194 200 PF00069 0.459
MOD_ProDKin_1 257 263 PF00069 0.360
MOD_ProDKin_1 514 520 PF00069 0.502
MOD_ProDKin_1 537 543 PF00069 0.680
MOD_ProDKin_1 54 60 PF00069 0.600
MOD_ProDKin_1 61 67 PF00069 0.608
MOD_ProDKin_1 615 621 PF00069 0.628
MOD_TYR_CSK 104 112 PF07714 0.576
TRG_DiLeu_BaEn_1 116 121 PF01217 0.574
TRG_DiLeu_BaEn_1 832 837 PF01217 0.500
TRG_DiLeu_BaEn_4 116 122 PF01217 0.556
TRG_DiLeu_BaLyEn_6 45 50 PF01217 0.531
TRG_ENDOCYTIC_2 147 150 PF00928 0.516
TRG_ENDOCYTIC_2 209 212 PF00928 0.467
TRG_ENDOCYTIC_2 505 508 PF00928 0.345
TRG_ENDOCYTIC_2 592 595 PF00928 0.515
TRG_ENDOCYTIC_2 621 624 PF00928 0.561
TRG_ENDOCYTIC_2 83 86 PF00928 0.616
TRG_ENDOCYTIC_2 846 849 PF00928 0.437
TRG_ER_diArg_1 126 129 PF00400 0.455
TRG_ER_diArg_1 253 256 PF00400 0.384
TRG_ER_diArg_1 323 326 PF00400 0.385
TRG_ER_diArg_1 454 456 PF00400 0.568
TRG_ER_diArg_1 457 459 PF00400 0.488
TRG_ER_diArg_1 489 492 PF00400 0.371
TRG_ER_diArg_1 529 532 PF00400 0.550
TRG_ER_diArg_1 608 610 PF00400 0.505
TRG_ER_diArg_1 760 763 PF00400 0.550

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q7 Leptomonas seymouri 47% 100%
A0A1X0NYY7 Trypanosomatidae 44% 100%
A0A3Q8IAD3 Leishmania donovani 55% 88%
A0A3Q8IAF8 Leishmania donovani 75% 89%
A0A3Q8IAK8 Leishmania donovani 82% 88%
A0A3Q8IJ32 Leishmania donovani 83% 100%
A0A3S5H6Y1 Leishmania donovani 81% 91%
A0A3S7WTZ8 Leishmania donovani 62% 83%
A0A3S7WU13 Leishmania donovani 82% 91%
A0A422NAR5 Trypanosoma rangeli 43% 100%
A4H8M5 Leishmania braziliensis 69% 95%
A4H8M7 Leishmania braziliensis 73% 93%
A4H8N0 Leishmania braziliensis 48% 100%
A4H8N1 Leishmania braziliensis 50% 88%
A4HWZ5 Leishmania infantum 83% 91%
A4HWZ6 Leishmania infantum 79% 94%
A4HWZ8 Leishmania infantum 81% 94%
A4HX00 Leishmania infantum 62% 83%
A4HX01 Leishmania infantum 55% 100%
A4HX05 Leishmania infantum 77% 89%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 92%
E9AGP0 Leishmania infantum 92% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 99%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 87%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 92%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 90%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 100%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 88%
Q4QER2 Leishmania major 55% 100%
Q4QER3 Leishmania major 65% 100%
Q4QER4 Leishmania major 95% 100%
Q4QER5 Leishmania major 91% 99%
Q4QER6 Leishmania major 91% 99%
Q4QER8 Leishmania major 90% 90%
Q4QER9 Leishmania major 90% 93%
Q4QES0 Leishmania major 89% 100%
V5ANJ8 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS