LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania major
UniProt:
Q4QER6_LEIMA
TriTrypDb:
LmjF.16.1020 , LMJLV39_000018700 , LMJLV39_160016300 , LMJSD75_160015800
Length:
856

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 125
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 38
NetGPI no yes: 0, no: 38
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 27
GO:0016020 membrane 2 19

Expansion

Sequence features

Q4QER6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QER6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 37
GO:0016740 transferase activity 2 37
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 266 270 PF00656 0.448
CLV_C14_Caspase3-7 433 437 PF00656 0.393
CLV_C14_Caspase3-7 845 849 PF00656 0.401
CLV_MEL_PAP_1 136 142 PF00089 0.503
CLV_NRD_NRD_1 128 130 PF00675 0.608
CLV_NRD_NRD_1 159 161 PF00675 0.489
CLV_NRD_NRD_1 453 455 PF00675 0.626
CLV_NRD_NRD_1 456 458 PF00675 0.557
CLV_NRD_NRD_1 491 493 PF00675 0.608
CLV_NRD_NRD_1 529 531 PF00675 0.611
CLV_NRD_NRD_1 607 609 PF00675 0.504
CLV_NRD_NRD_1 735 737 PF00675 0.641
CLV_NRD_NRD_1 92 94 PF00675 0.607
CLV_PCSK_FUR_1 454 458 PF00082 0.548
CLV_PCSK_FUR_1 527 531 PF00082 0.551
CLV_PCSK_KEX2_1 127 129 PF00082 0.570
CLV_PCSK_KEX2_1 453 455 PF00082 0.626
CLV_PCSK_KEX2_1 456 458 PF00082 0.501
CLV_PCSK_KEX2_1 490 492 PF00082 0.565
CLV_PCSK_KEX2_1 529 531 PF00082 0.579
CLV_PCSK_KEX2_1 607 609 PF00082 0.504
CLV_PCSK_KEX2_1 735 737 PF00082 0.641
CLV_PCSK_KEX2_1 92 94 PF00082 0.599
CLV_PCSK_SKI1_1 129 133 PF00082 0.530
CLV_PCSK_SKI1_1 272 276 PF00082 0.663
CLV_PCSK_SKI1_1 326 330 PF00082 0.585
CLV_PCSK_SKI1_1 363 367 PF00082 0.526
CLV_PCSK_SKI1_1 368 372 PF00082 0.473
CLV_PCSK_SKI1_1 457 461 PF00082 0.579
CLV_PCSK_SKI1_1 607 611 PF00082 0.573
CLV_PCSK_SKI1_1 697 701 PF00082 0.611
CLV_PCSK_SKI1_1 781 785 PF00082 0.602
CLV_PCSK_SKI1_1 84 88 PF00082 0.600
DEG_APCC_DBOX_1 238 246 PF00400 0.437
DEG_Nend_UBRbox_1 1 4 PF02207 0.577
DEG_SPOP_SBC_1 41 45 PF00917 0.557
DEG_SPOP_SBC_1 65 69 PF00917 0.594
DOC_CDC14_PxL_1 165 173 PF14671 0.391
DOC_CKS1_1 614 619 PF01111 0.627
DOC_CYCLIN_yCln2_LP_2 497 503 PF00134 0.342
DOC_CYCLIN_yCln2_LP_2 835 841 PF00134 0.431
DOC_MAPK_DCC_7 582 591 PF00069 0.489
DOC_MAPK_gen_1 250 259 PF00069 0.373
DOC_MAPK_gen_1 324 333 PF00069 0.385
DOC_MAPK_gen_1 490 501 PF00069 0.419
DOC_MAPK_gen_1 582 591 PF00069 0.543
DOC_MAPK_HePTP_8 610 622 PF00069 0.559
DOC_MAPK_MEF2A_6 326 335 PF00069 0.385
DOC_MAPK_MEF2A_6 492 501 PF00069 0.419
DOC_MAPK_MEF2A_6 613 622 PF00069 0.557
DOC_MAPK_MEF2A_6 678 685 PF00069 0.622
DOC_PP2B_LxvP_1 497 500 PF13499 0.419
DOC_PP2B_LxvP_1 75 78 PF13499 0.570
DOC_PP2B_LxvP_1 784 787 PF13499 0.489
DOC_PP4_FxxP_1 614 617 PF00568 0.523
DOC_USP7_MATH_1 188 192 PF00917 0.516
DOC_USP7_MATH_1 286 290 PF00917 0.411
DOC_USP7_MATH_1 483 487 PF00917 0.281
DOC_USP7_MATH_1 58 62 PF00917 0.620
DOC_USP7_MATH_1 773 777 PF00917 0.595
DOC_USP7_MATH_1 828 832 PF00917 0.620
DOC_WW_Pin1_4 129 134 PF00397 0.587
DOC_WW_Pin1_4 194 199 PF00397 0.508
DOC_WW_Pin1_4 257 262 PF00397 0.360
DOC_WW_Pin1_4 370 375 PF00397 0.389
DOC_WW_Pin1_4 512 517 PF00397 0.501
DOC_WW_Pin1_4 535 540 PF00397 0.676
DOC_WW_Pin1_4 54 59 PF00397 0.641
DOC_WW_Pin1_4 61 66 PF00397 0.631
DOC_WW_Pin1_4 613 618 PF00397 0.627
LIG_14-3-3_CanoR_1 127 132 PF00244 0.639
LIG_14-3-3_CanoR_1 160 166 PF00244 0.524
LIG_14-3-3_CanoR_1 239 243 PF00244 0.403
LIG_14-3-3_CanoR_1 27 33 PF00244 0.623
LIG_14-3-3_CanoR_1 295 300 PF00244 0.378
LIG_14-3-3_CanoR_1 310 314 PF00244 0.318
LIG_14-3-3_CanoR_1 326 332 PF00244 0.360
LIG_14-3-3_CanoR_1 384 392 PF00244 0.576
LIG_14-3-3_CanoR_1 408 415 PF00244 0.587
LIG_14-3-3_CanoR_1 456 465 PF00244 0.396
LIG_14-3-3_CanoR_1 490 495 PF00244 0.336
LIG_14-3-3_CanoR_1 530 539 PF00244 0.556
LIG_14-3-3_CanoR_1 60 64 PF00244 0.623
LIG_14-3-3_CanoR_1 682 686 PF00244 0.633
LIG_14-3-3_CanoR_1 703 711 PF00244 0.547
LIG_14-3-3_CanoR_1 852 856 PF00244 0.608
LIG_14-3-3_CanoR_1 92 100 PF00244 0.589
LIG_Actin_WH2_2 280 297 PF00022 0.459
LIG_BRCT_BRCA1_1 514 518 PF00533 0.426
LIG_BRCT_BRCA1_1 640 644 PF00533 0.624
LIG_FHA_1 141 147 PF00498 0.593
LIG_FHA_1 233 239 PF00498 0.464
LIG_FHA_1 346 352 PF00498 0.316
LIG_FHA_1 35 41 PF00498 0.589
LIG_FHA_1 538 544 PF00498 0.603
LIG_FHA_1 66 72 PF00498 0.688
LIG_FHA_1 788 794 PF00498 0.473
LIG_FHA_1 834 840 PF00498 0.503
LIG_FHA_2 130 136 PF00498 0.471
LIG_FHA_2 176 182 PF00498 0.472
LIG_FHA_2 264 270 PF00498 0.448
LIG_FHA_2 3 9 PF00498 0.601
LIG_FHA_2 376 382 PF00498 0.576
LIG_FHA_2 41 47 PF00498 0.557
LIG_FHA_2 51 57 PF00498 0.571
LIG_FHA_2 572 578 PF00498 0.470
LIG_FHA_2 690 696 PF00498 0.541
LIG_Integrin_RGD_1 13 15 PF01839 0.612
LIG_LIR_Apic_2 164 169 PF02991 0.649
LIG_LIR_Apic_2 836 840 PF02991 0.481
LIG_LIR_Apic_2 850 856 PF02991 0.522
LIG_LIR_Gen_1 144 155 PF02991 0.484
LIG_LIR_Gen_1 386 396 PF02991 0.392
LIG_LIR_Gen_1 436 447 PF02991 0.425
LIG_LIR_Gen_1 563 573 PF02991 0.455
LIG_LIR_Gen_1 842 851 PF02991 0.577
LIG_LIR_LC3C_4 807 812 PF02991 0.577
LIG_LIR_Nem_3 144 150 PF02991 0.441
LIG_LIR_Nem_3 436 442 PF02991 0.413
LIG_LIR_Nem_3 481 487 PF02991 0.373
LIG_LIR_Nem_3 496 501 PF02991 0.327
LIG_LIR_Nem_3 515 521 PF02991 0.544
LIG_LIR_Nem_3 563 569 PF02991 0.438
LIG_LIR_Nem_3 616 622 PF02991 0.547
LIG_LIR_Nem_3 641 647 PF02991 0.466
LIG_LIR_Nem_3 794 799 PF02991 0.518
LIG_LIR_Nem_3 80 86 PF02991 0.604
LIG_MAD2 703 711 PF02301 0.571
LIG_MYND_1 118 122 PF01753 0.573
LIG_PTB_Apo_2 173 180 PF02174 0.588
LIG_PTB_Apo_2 333 340 PF02174 0.360
LIG_PTB_Apo_2 584 591 PF02174 0.476
LIG_PTB_Phospho_1 173 179 PF10480 0.441
LIG_PTB_Phospho_1 333 339 PF10480 0.360
LIG_PTB_Phospho_1 584 590 PF10480 0.507
LIG_SH2_CRK 147 151 PF00017 0.493
LIG_SH2_CRK 209 213 PF00017 0.438
LIG_SH2_CRK 484 488 PF00017 0.344
LIG_SH2_CRK 83 87 PF00017 0.581
LIG_SH2_GRB2like 209 212 PF00017 0.415
LIG_SH2_GRB2like 334 337 PF00017 0.453
LIG_SH2_GRB2like 590 593 PF00017 0.514
LIG_SH2_NCK_1 439 443 PF00017 0.444
LIG_SH2_SRC 108 111 PF00017 0.577
LIG_SH2_SRC 439 442 PF00017 0.439
LIG_SH2_SRC 619 622 PF00017 0.544
LIG_SH2_SRC 658 661 PF00017 0.553
LIG_SH2_STAP1 458 462 PF00017 0.449
LIG_SH2_STAP1 478 482 PF00017 0.222
LIG_SH2_STAT3 715 718 PF00017 0.609
LIG_SH2_STAT5 204 207 PF00017 0.431
LIG_SH2_STAT5 339 342 PF00017 0.342
LIG_SH2_STAT5 401 404 PF00017 0.573
LIG_SH2_STAT5 498 501 PF00017 0.354
LIG_SH2_STAT5 521 524 PF00017 0.436
LIG_SH2_STAT5 590 593 PF00017 0.509
LIG_SH2_STAT5 619 622 PF00017 0.558
LIG_SH3_3 112 118 PF00018 0.609
LIG_SH3_3 419 425 PF00018 0.456
LIG_SH3_3 71 77 PF00018 0.703
LIG_SH3_3 742 748 PF00018 0.516
LIG_SH3_CIN85_PxpxPR_1 448 453 PF14604 0.525
LIG_SUMO_SIM_anti_2 37 46 PF11976 0.548
LIG_SUMO_SIM_anti_2 807 813 PF11976 0.504
LIG_SUMO_SIM_par_1 255 260 PF11976 0.384
LIG_SUMO_SIM_par_1 427 433 PF11976 0.413
LIG_SUMO_SIM_par_1 48 53 PF11976 0.558
LIG_SUMO_SIM_par_1 789 795 PF11976 0.493
LIG_SUMO_SIM_par_1 807 813 PF11976 0.362
LIG_TRAF2_1 634 637 PF00917 0.557
LIG_TRAF2_1 657 660 PF00917 0.542
LIG_TYR_ITIM 145 150 PF00017 0.563
LIG_TYR_ITIM 482 487 PF00017 0.350
LIG_TYR_ITSM 79 86 PF00017 0.584
LIG_WRC_WIRS_1 146 151 PF05994 0.482
MOD_CDC14_SPxK_1 57 60 PF00782 0.582
MOD_CDK_SPK_2 512 517 PF00069 0.449
MOD_CDK_SPxK_1 54 60 PF00069 0.597
MOD_CK1_1 241 247 PF00069 0.398
MOD_CK1_1 289 295 PF00069 0.428
MOD_CK1_1 34 40 PF00069 0.627
MOD_CK1_1 375 381 PF00069 0.473
MOD_CK1_1 61 67 PF00069 0.639
MOD_CK2_1 129 135 PF00069 0.504
MOD_CK2_1 175 181 PF00069 0.474
MOD_CK2_1 2 8 PF00069 0.596
MOD_CK2_1 375 381 PF00069 0.572
MOD_CK2_1 40 46 PF00069 0.561
MOD_CK2_1 50 56 PF00069 0.576
MOD_CK2_1 571 577 PF00069 0.492
MOD_CK2_1 595 601 PF00069 0.562
MOD_CK2_1 654 660 PF00069 0.461
MOD_CK2_1 689 695 PF00069 0.577
MOD_CK2_1 726 732 PF00069 0.575
MOD_GlcNHglycan 2 5 PF01048 0.691
MOD_GlcNHglycan 289 292 PF01048 0.605
MOD_GlcNHglycan 33 36 PF01048 0.651
MOD_GlcNHglycan 374 377 PF01048 0.636
MOD_GlcNHglycan 410 413 PF01048 0.526
MOD_GlcNHglycan 419 422 PF01048 0.607
MOD_GlcNHglycan 598 601 PF01048 0.512
MOD_GlcNHglycan 627 630 PF01048 0.658
MOD_GlcNHglycan 705 708 PF01048 0.533
MOD_GlcNHglycan 71 74 PF01048 0.622
MOD_GlcNHglycan 775 778 PF01048 0.607
MOD_GSK3_1 188 195 PF00069 0.530
MOD_GSK3_1 22 29 PF00069 0.698
MOD_GSK3_1 354 361 PF00069 0.387
MOD_GSK3_1 442 449 PF00069 0.677
MOD_GSK3_1 48 55 PF00069 0.637
MOD_GSK3_1 531 538 PF00069 0.600
MOD_GSK3_1 59 66 PF00069 0.637
MOD_LATS_1 293 299 PF00433 0.360
MOD_LATS_1 455 461 PF00433 0.398
MOD_LATS_1 488 494 PF00433 0.276
MOD_N-GLC_1 150 155 PF02516 0.527
MOD_N-GLC_1 175 180 PF02516 0.592
MOD_N-GLC_1 23 28 PF02516 0.602
MOD_N-GLC_1 326 331 PF02516 0.560
MOD_N-GLC_1 571 576 PF02516 0.453
MOD_NEK2_1 101 106 PF00069 0.675
MOD_NEK2_1 218 223 PF00069 0.530
MOD_NEK2_1 238 243 PF00069 0.345
MOD_NEK2_1 287 292 PF00069 0.413
MOD_NEK2_1 294 299 PF00069 0.391
MOD_NEK2_1 473 478 PF00069 0.412
MOD_NEK2_1 50 55 PF00069 0.612
MOD_NEK2_1 525 530 PF00069 0.562
MOD_NEK2_1 665 670 PF00069 0.426
MOD_NEK2_1 833 838 PF00069 0.507
MOD_NEK2_2 483 488 PF00069 0.299
MOD_NEK2_2 689 694 PF00069 0.515
MOD_PIKK_1 537 543 PF00454 0.480
MOD_PIKK_1 86 92 PF00454 0.604
MOD_PK_1 490 496 PF00069 0.255
MOD_PK_1 726 732 PF00069 0.684
MOD_PKA_1 127 133 PF00069 0.424
MOD_PKA_1 490 496 PF00069 0.265
MOD_PKA_2 127 133 PF00069 0.643
MOD_PKA_2 232 238 PF00069 0.435
MOD_PKA_2 26 32 PF00069 0.674
MOD_PKA_2 287 293 PF00069 0.384
MOD_PKA_2 294 300 PF00069 0.337
MOD_PKA_2 309 315 PF00069 0.349
MOD_PKA_2 383 389 PF00069 0.397
MOD_PKA_2 490 496 PF00069 0.327
MOD_PKA_2 59 65 PF00069 0.601
MOD_PKA_2 624 630 PF00069 0.619
MOD_PKA_2 681 687 PF00069 0.553
MOD_PKA_2 91 97 PF00069 0.572
MOD_PKB_1 324 332 PF00069 0.378
MOD_Plk_1 175 181 PF00069 0.516
MOD_Plk_1 23 29 PF00069 0.629
MOD_Plk_1 326 332 PF00069 0.378
MOD_Plk_1 571 577 PF00069 0.460
MOD_Plk_2-3 175 181 PF00069 0.467
MOD_Plk_2-3 232 238 PF00069 0.542
MOD_Plk_2-3 717 723 PF00069 0.629
MOD_Plk_4 145 151 PF00069 0.479
MOD_Plk_4 161 167 PF00069 0.496
MOD_Plk_4 188 194 PF00069 0.535
MOD_Plk_4 263 269 PF00069 0.418
MOD_Plk_4 354 360 PF00069 0.381
MOD_ProDKin_1 129 135 PF00069 0.584
MOD_ProDKin_1 194 200 PF00069 0.497
MOD_ProDKin_1 257 263 PF00069 0.360
MOD_ProDKin_1 370 376 PF00069 0.392
MOD_ProDKin_1 512 518 PF00069 0.499
MOD_ProDKin_1 535 541 PF00069 0.672
MOD_ProDKin_1 54 60 PF00069 0.645
MOD_ProDKin_1 61 67 PF00069 0.633
MOD_ProDKin_1 613 619 PF00069 0.626
MOD_TYR_CSK 104 112 PF07714 0.561
TRG_DiLeu_BaEn_1 116 121 PF01217 0.580
TRG_DiLeu_BaEn_1 830 835 PF01217 0.505
TRG_DiLeu_BaEn_4 116 122 PF01217 0.561
TRG_DiLeu_BaLyEn_6 45 50 PF01217 0.548
TRG_ENDOCYTIC_2 147 150 PF00928 0.511
TRG_ENDOCYTIC_2 209 212 PF00928 0.468
TRG_ENDOCYTIC_2 439 442 PF00928 0.431
TRG_ENDOCYTIC_2 484 487 PF00928 0.345
TRG_ENDOCYTIC_2 498 501 PF00928 0.339
TRG_ENDOCYTIC_2 503 506 PF00928 0.345
TRG_ENDOCYTIC_2 590 593 PF00928 0.514
TRG_ENDOCYTIC_2 619 622 PF00928 0.559
TRG_ENDOCYTIC_2 83 86 PF00928 0.610
TRG_ENDOCYTIC_2 844 847 PF00928 0.439
TRG_ER_diArg_1 126 129 PF00400 0.457
TRG_ER_diArg_1 253 256 PF00400 0.384
TRG_ER_diArg_1 323 326 PF00400 0.385
TRG_ER_diArg_1 452 454 PF00400 0.575
TRG_ER_diArg_1 456 458 PF00400 0.474
TRG_ER_diArg_1 490 492 PF00400 0.360
TRG_ER_diArg_1 527 530 PF00400 0.559
TRG_ER_diArg_1 606 608 PF00400 0.503
TRG_ER_diArg_1 758 761 PF00400 0.550
TRG_Pf-PMV_PEXEL_1 363 367 PF00026 0.494

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q7 Leptomonas seymouri 46% 100%
A0A1X0NYY7 Trypanosomatidae 43% 100%
A0A3Q8IAD3 Leishmania donovani 54% 88%
A0A3Q8IAF8 Leishmania donovani 72% 89%
A0A3Q8IAK8 Leishmania donovani 78% 88%
A0A3Q8IJ32 Leishmania donovani 91% 100%
A0A3S5H6Y1 Leishmania donovani 73% 91%
A0A3S7WTZ8 Leishmania donovani 63% 83%
A0A3S7WU13 Leishmania donovani 89% 91%
A0A422NAR5 Trypanosoma rangeli 44% 100%
A4H8M5 Leishmania braziliensis 64% 95%
A4H8M7 Leishmania braziliensis 77% 93%
A4H8N0 Leishmania braziliensis 50% 100%
A4H8N1 Leishmania braziliensis 53% 88%
A4HWZ5 Leishmania infantum 89% 91%
A4HWZ6 Leishmania infantum 70% 94%
A4HWZ8 Leishmania infantum 74% 93%
A4HX00 Leishmania infantum 63% 83%
A4HX01 Leishmania infantum 54% 100%
A4HX05 Leishmania infantum 70% 89%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 92%
E9AGP0 Leishmania infantum 82% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 86%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 92%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 90%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 84%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 87%
Q4QER2 Leishmania major 55% 100%
Q4QER3 Leishmania major 65% 100%
Q4QER4 Leishmania major 84% 100%
Q4QER5 Leishmania major 100% 100%
Q4QER7 Leishmania major 91% 100%
Q4QER8 Leishmania major 80% 90%
Q4QER9 Leishmania major 80% 92%
Q4QES0 Leishmania major 96% 100%
V5ANJ8 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS