LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania major
UniProt:
Q4QER4_LEIMA
TriTrypDb:
LmjF.16.1040 , LMJLV39_000017800 * , LMJLV39_160016300 * , LMJSD75_160015900 *
Length:
690

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 125
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 41
NetGPI no yes: 0, no: 41
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 28
GO:0016020 membrane 2 20

Expansion

Sequence features

Q4QER4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QER4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 38
GO:0016740 transferase activity 2 38
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 679 683 PF00656 0.401
CLV_C14_Caspase3-7 98 102 PF00656 0.604
CLV_NRD_NRD_1 287 289 PF00675 0.628
CLV_NRD_NRD_1 290 292 PF00675 0.552
CLV_NRD_NRD_1 325 327 PF00675 0.609
CLV_NRD_NRD_1 363 365 PF00675 0.621
CLV_NRD_NRD_1 441 443 PF00675 0.499
CLV_NRD_NRD_1 569 571 PF00675 0.643
CLV_PCSK_FUR_1 288 292 PF00082 0.541
CLV_PCSK_FUR_1 361 365 PF00082 0.547
CLV_PCSK_KEX2_1 245 247 PF00082 0.540
CLV_PCSK_KEX2_1 287 289 PF00082 0.570
CLV_PCSK_KEX2_1 290 292 PF00082 0.491
CLV_PCSK_KEX2_1 363 365 PF00082 0.586
CLV_PCSK_KEX2_1 441 443 PF00082 0.499
CLV_PCSK_KEX2_1 569 571 PF00082 0.643
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.534
CLV_PCSK_SKI1_1 104 108 PF00082 0.613
CLV_PCSK_SKI1_1 158 162 PF00082 0.542
CLV_PCSK_SKI1_1 212 216 PF00082 0.599
CLV_PCSK_SKI1_1 291 295 PF00082 0.609
CLV_PCSK_SKI1_1 329 333 PF00082 0.562
CLV_PCSK_SKI1_1 441 445 PF00082 0.577
CLV_PCSK_SKI1_1 531 535 PF00082 0.610
CLV_PCSK_SKI1_1 615 619 PF00082 0.589
DEG_APCC_DBOX_1 70 78 PF00400 0.615
DEG_Nend_UBRbox_3 1 3 PF02207 0.494
DOC_CKS1_1 448 453 PF01111 0.632
DOC_CYCLIN_yCln2_LP_2 331 337 PF00134 0.343
DOC_CYCLIN_yCln2_LP_2 669 675 PF00134 0.410
DOC_MAPK_DCC_7 416 425 PF00069 0.480
DOC_MAPK_gen_1 156 165 PF00069 0.527
DOC_MAPK_gen_1 324 333 PF00069 0.419
DOC_MAPK_gen_1 416 425 PF00069 0.543
DOC_MAPK_gen_1 82 91 PF00069 0.540
DOC_MAPK_HePTP_8 444 456 PF00069 0.556
DOC_MAPK_MEF2A_6 158 167 PF00069 0.527
DOC_MAPK_MEF2A_6 326 335 PF00069 0.419
DOC_MAPK_MEF2A_6 447 456 PF00069 0.555
DOC_MAPK_MEF2A_6 512 519 PF00069 0.624
DOC_PP2B_LxvP_1 331 334 PF13499 0.420
DOC_PP2B_LxvP_1 618 621 PF13499 0.478
DOC_PP4_FxxP_1 448 451 PF00568 0.527
DOC_USP7_MATH_1 118 122 PF00917 0.673
DOC_USP7_MATH_1 204 208 PF00917 0.387
DOC_USP7_MATH_1 255 259 PF00917 0.420
DOC_USP7_MATH_1 278 282 PF00917 0.482
DOC_USP7_MATH_1 393 397 PF00917 0.486
DOC_USP7_MATH_1 434 438 PF00917 0.353
DOC_USP7_MATH_1 607 611 PF00917 0.585
DOC_USP7_MATH_1 662 666 PF00917 0.575
DOC_WW_Pin1_4 346 351 PF00397 0.513
DOC_WW_Pin1_4 369 374 PF00397 0.615
DOC_WW_Pin1_4 447 452 PF00397 0.630
DOC_WW_Pin1_4 89 94 PF00397 0.513
LIG_14-3-3_CanoR_1 127 132 PF00244 0.499
LIG_14-3-3_CanoR_1 142 146 PF00244 0.455
LIG_14-3-3_CanoR_1 158 164 PF00244 0.500
LIG_14-3-3_CanoR_1 246 256 PF00244 0.630
LIG_14-3-3_CanoR_1 290 300 PF00244 0.394
LIG_14-3-3_CanoR_1 364 373 PF00244 0.557
LIG_14-3-3_CanoR_1 516 520 PF00244 0.633
LIG_14-3-3_CanoR_1 537 545 PF00244 0.562
LIG_14-3-3_CanoR_1 686 690 PF00244 0.593
LIG_14-3-3_CanoR_1 71 75 PF00244 0.551
LIG_Actin_WH2_2 112 129 PF00022 0.642
LIG_Actin_WH2_2 230 247 PF00022 0.417
LIG_BRCT_BRCA1_1 348 352 PF00533 0.434
LIG_BRCT_BRCA1_1 474 478 PF00533 0.627
LIG_BRCT_BRCA1_1 8 12 PF00533 0.518
LIG_eIF4E_1 232 238 PF01652 0.489
LIG_FHA_1 178 184 PF00498 0.432
LIG_FHA_1 220 226 PF00498 0.447
LIG_FHA_1 372 378 PF00498 0.643
LIG_FHA_1 622 628 PF00498 0.468
LIG_FHA_1 65 71 PF00498 0.708
LIG_FHA_1 668 674 PF00498 0.470
LIG_FHA_2 237 243 PF00498 0.602
LIG_FHA_2 308 314 PF00498 0.304
LIG_FHA_2 406 412 PF00498 0.470
LIG_FHA_2 42 48 PF00498 0.495
LIG_FHA_2 524 530 PF00498 0.539
LIG_FHA_2 96 102 PF00498 0.604
LIG_LIR_Apic_2 670 674 PF02991 0.464
LIG_LIR_Apic_2 684 690 PF02991 0.514
LIG_LIR_Gen_1 239 247 PF02991 0.375
LIG_LIR_Gen_1 397 407 PF02991 0.458
LIG_LIR_Gen_1 676 685 PF02991 0.575
LIG_LIR_LC3C_4 641 646 PF02991 0.568
LIG_LIR_Nem_3 239 244 PF02991 0.419
LIG_LIR_Nem_3 302 308 PF02991 0.302
LIG_LIR_Nem_3 330 335 PF02991 0.325
LIG_LIR_Nem_3 349 355 PF02991 0.573
LIG_LIR_Nem_3 397 403 PF02991 0.441
LIG_LIR_Nem_3 450 456 PF02991 0.546
LIG_LIR_Nem_3 475 481 PF02991 0.469
LIG_LIR_Nem_3 628 633 PF02991 0.529
LIG_MAD2 537 545 PF02301 0.576
LIG_PTB_Apo_2 165 172 PF02174 0.478
LIG_PTB_Apo_2 418 425 PF02174 0.475
LIG_PTB_Phospho_1 165 171 PF10480 0.484
LIG_PTB_Phospho_1 418 424 PF10480 0.503
LIG_REV1ctd_RIR_1 305 315 PF16727 0.312
LIG_SH2_GRB2like 166 169 PF00017 0.619
LIG_SH2_GRB2like 23 26 PF00017 0.528
LIG_SH2_GRB2like 424 427 PF00017 0.508
LIG_SH2_SRC 453 456 PF00017 0.542
LIG_SH2_SRC 492 495 PF00017 0.542
LIG_SH2_STAP1 292 296 PF00017 0.448
LIG_SH2_STAP1 312 316 PF00017 0.223
LIG_SH2_STAT3 549 552 PF00017 0.595
LIG_SH2_STAT5 171 174 PF00017 0.417
LIG_SH2_STAT5 232 235 PF00017 0.537
LIG_SH2_STAT5 300 303 PF00017 0.334
LIG_SH2_STAT5 355 358 PF00017 0.452
LIG_SH2_STAT5 424 427 PF00017 0.503
LIG_SH2_STAT5 453 456 PF00017 0.561
LIG_SH3_2 286 291 PF14604 0.447
LIG_SH3_3 283 289 PF00018 0.466
LIG_SH3_3 576 582 PF00018 0.522
LIG_SUMO_SIM_anti_2 224 231 PF11976 0.527
LIG_SUMO_SIM_anti_2 641 647 PF11976 0.503
LIG_SUMO_SIM_par_1 623 629 PF11976 0.492
LIG_SUMO_SIM_par_1 641 647 PF11976 0.510
LIG_SUMO_SIM_par_1 87 92 PF11976 0.540
LIG_TRAF2_1 468 471 PF00917 0.634
LIG_TRAF2_1 491 494 PF00917 0.534
MOD_CDK_SPK_2 346 351 PF00069 0.461
MOD_CK1_1 121 127 PF00069 0.643
MOD_CK1_1 388 394 PF00069 0.438
MOD_CK1_1 73 79 PF00069 0.546
MOD_CK2_1 307 313 PF00069 0.304
MOD_CK2_1 405 411 PF00069 0.491
MOD_CK2_1 429 435 PF00069 0.563
MOD_CK2_1 488 494 PF00069 0.458
MOD_CK2_1 523 529 PF00069 0.604
MOD_CK2_1 560 566 PF00069 0.576
MOD_GlcNHglycan 121 124 PF01048 0.595
MOD_GlcNHglycan 20 23 PF01048 0.691
MOD_GlcNHglycan 205 209 PF01048 0.569
MOD_GlcNHglycan 249 252 PF01048 0.650
MOD_GlcNHglycan 390 393 PF01048 0.418
MOD_GlcNHglycan 432 435 PF01048 0.517
MOD_GlcNHglycan 461 464 PF01048 0.590
MOD_GlcNHglycan 539 542 PF01048 0.572
MOD_GlcNHglycan 609 612 PF01048 0.593
MOD_GSK3_1 186 193 PF00069 0.451
MOD_GSK3_1 236 243 PF00069 0.368
MOD_GSK3_1 365 372 PF00069 0.603
MOD_GSK3_1 430 437 PF00069 0.390
MOD_LATS_1 125 131 PF00433 0.480
MOD_N-GLC_1 158 163 PF02516 0.502
MOD_N-GLC_1 247 252 PF02516 0.639
MOD_N-GLC_1 405 410 PF02516 0.454
MOD_NEK2_1 119 124 PF00069 0.642
MOD_NEK2_1 12 17 PF00069 0.576
MOD_NEK2_1 126 131 PF00069 0.517
MOD_NEK2_1 240 245 PF00069 0.456
MOD_NEK2_1 307 312 PF00069 0.412
MOD_NEK2_1 34 39 PF00069 0.645
MOD_NEK2_1 359 364 PF00069 0.562
MOD_NEK2_1 499 504 PF00069 0.417
MOD_NEK2_1 667 672 PF00069 0.451
MOD_NEK2_1 70 75 PF00069 0.486
MOD_NEK2_2 523 528 PF00069 0.515
MOD_PIKK_1 214 220 PF00454 0.391
MOD_PIKK_1 371 377 PF00454 0.520
MOD_PK_1 560 566 PF00069 0.563
MOD_PKA_2 119 125 PF00069 0.570
MOD_PKA_2 126 132 PF00069 0.446
MOD_PKA_2 141 147 PF00069 0.496
MOD_PKA_2 458 464 PF00069 0.622
MOD_PKA_2 515 521 PF00069 0.554
MOD_PKA_2 64 70 PF00069 0.591
MOD_PKB_1 156 164 PF00069 0.517
MOD_Plk_1 158 164 PF00069 0.523
MOD_Plk_1 405 411 PF00069 0.454
MOD_Plk_2-3 551 557 PF00069 0.629
MOD_Plk_2-3 64 70 PF00069 0.686
MOD_Plk_4 12 18 PF00069 0.599
MOD_Plk_4 186 192 PF00069 0.446
MOD_Plk_4 236 242 PF00069 0.385
MOD_Plk_4 280 286 PF00069 0.468
MOD_Plk_4 385 391 PF00069 0.440
MOD_Plk_4 95 101 PF00069 0.587
MOD_ProDKin_1 346 352 PF00069 0.510
MOD_ProDKin_1 369 375 PF00069 0.613
MOD_ProDKin_1 447 453 PF00069 0.629
MOD_ProDKin_1 89 95 PF00069 0.521
TRG_DiLeu_BaEn_1 664 669 PF01217 0.446
TRG_ENDOCYTIC_2 337 340 PF00928 0.342
TRG_ENDOCYTIC_2 424 427 PF00928 0.513
TRG_ENDOCYTIC_2 453 456 PF00928 0.557
TRG_ENDOCYTIC_2 678 681 PF00928 0.438
TRG_ER_diArg_1 155 158 PF00400 0.513
TRG_ER_diArg_1 286 288 PF00400 0.541
TRG_ER_diArg_1 289 291 PF00400 0.493
TRG_ER_diArg_1 321 324 PF00400 0.371
TRG_ER_diArg_1 361 364 PF00400 0.551
TRG_ER_diArg_1 440 442 PF00400 0.497
TRG_ER_diArg_1 592 595 PF00400 0.552
TRG_ER_diArg_1 85 88 PF00400 0.569

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q7 Leptomonas seymouri 47% 100%
A0A1X0NYY7 Trypanosomatidae 45% 87%
A0A3Q8IAD3 Leishmania donovani 57% 71%
A0A3Q8IAF8 Leishmania donovani 87% 72%
A0A3Q8IAK8 Leishmania donovani 89% 71%
A0A3Q8IJ32 Leishmania donovani 79% 83%
A0A3S5H6Y1 Leishmania donovani 85% 73%
A0A3S7WTZ8 Leishmania donovani 67% 67%
A0A3S7WU13 Leishmania donovani 79% 73%
A0A422NAR5 Trypanosoma rangeli 47% 87%
A4H8M5 Leishmania braziliensis 81% 76%
A4H8M6 Leishmania braziliensis 77% 100%
A4H8M7 Leishmania braziliensis 75% 75%
A4H8N0 Leishmania braziliensis 50% 88%
A4H8N1 Leishmania braziliensis 55% 71%
A4HWZ5 Leishmania infantum 79% 73%
A4HWZ6 Leishmania infantum 84% 76%
A4HWZ8 Leishmania infantum 92% 75%
A4HX00 Leishmania infantum 67% 67%
A4HX01 Leishmania infantum 57% 88%
A4HX05 Leishmania infantum 88% 72%
A4HZW0 Leishmania infantum 30% 73%
A4I0N5 Leishmania infantum 32% 88%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 74%
E9AGP0 Leishmania infantum 92% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 80%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 70%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 74%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 73%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 70%
Q4QER2 Leishmania major 57% 100%
Q4QER3 Leishmania major 71% 100%
Q4QER5 Leishmania major 84% 81%
Q4QER6 Leishmania major 84% 81%
Q4QER7 Leishmania major 95% 80%
Q4QER8 Leishmania major 100% 72%
Q4QER9 Leishmania major 97% 75%
Q4QES0 Leishmania major 84% 85%
V5ANJ8 Trypanosoma cruzi 47% 86%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS