Stealth_CR2 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3184), putative

Species:

Leishmania major

UniProt:

Q4QER2_LEIMA

TriTrypDb:

LmjF.16.1060 , LMJLV39_160016500 , LMJSD75_160016100

Length:

978

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 120

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 32

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

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Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	10
GO:0016020	membrane	2	20
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	27

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Expansion

Sequence features

Q4QER2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QER2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	35
GO:0016740	transferase activity	2	35
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	16

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.393
CLV_C14_Caspase3-7	307	311	PF00656	0.450
CLV_C14_Caspase3-7	506	510	PF00656	0.347
CLV_C14_Caspase3-7	959	963	PF00656	0.372
CLV_NRD_NRD_1	210	212	PF00675	0.617
CLV_NRD_NRD_1	257	259	PF00675	0.567
CLV_NRD_NRD_1	263	265	PF00675	0.709
CLV_NRD_NRD_1	604	606	PF00675	0.708
CLV_NRD_NRD_1	835	837	PF00675	0.679
CLV_NRD_NRD_1	845	847	PF00675	0.714

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYY7	Trypanosomatidae	36%	100%
A0A3Q8IAD3	Leishmania donovani	91%	100%
A0A3Q8IAF8	Leishmania donovani	56%	100%
A0A3Q8IAK8	Leishmania donovani	53%	100%
A0A3Q8IJ32	Leishmania donovani	53%	100%
A0A3S5H6Y1	Leishmania donovani	52%	100%
A0A3S7WTZ8	Leishmania donovani	51%	95%
A0A3S7WU13	Leishmania donovani	53%	100%
A0A422NAR5	Trypanosoma rangeli	38%	100%
A4H8M5	Leishmania braziliensis	48%	100%

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