Ubiquitin-fold modifier 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin fold modifier protein, putative

Species:

Leishmania major

UniProt:

Q4QER1_LEIMA

TriTrypDb:

LmjF.16.1065 , LMJLV39_160016600 , LMJSD75_160016200

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QER1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QER1

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071569	protein ufmylation	7	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1990564	protein polyufmylation	8	2
GO:1990592	protein K69-linked ufmylation	9	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.433
CLV_NRD_NRD_1	106	108	PF00675	0.506
CLV_NRD_NRD_1	121	123	PF00675	0.529
CLV_NRD_NRD_1	133	135	PF00675	0.491
CLV_PCSK_KEX2_1	106	108	PF00082	0.506
CLV_PCSK_KEX2_1	133	135	PF00082	0.491
CLV_PCSK_SKI1_1	126	130	PF00082	0.510
CLV_PCSK_SKI1_1	156	160	PF00082	0.233
DOC_ANK_TNKS_1	112	119	PF00023	0.544
DOC_MAPK_MEF2A_6	231	240	PF00069	0.440
DOC_PP1_RVXF_1	150	156	PF00149	0.233
DOC_USP7_MATH_1	139	143	PF00917	0.514
DOC_USP7_MATH_1	146	150	PF00917	0.462
DOC_WW_Pin1_4	41	46	PF00397	0.495
DOC_WW_Pin1_4	78	83	PF00397	0.488
LIG_14-3-3_CanoR_1	133	137	PF00244	0.498
LIG_14-3-3_CanoR_1	14	19	PF00244	0.451
LIG_14-3-3_CanoR_1	156	166	PF00244	0.433
LIG_14-3-3_CanoR_1	63	68	PF00244	0.459
LIG_14-3-3_CanoR_1	75	81	PF00244	0.474
LIG_14-3-3_CanoR_1	91	100	PF00244	0.514
LIG_BRCT_BRCA1_1	163	167	PF00533	0.433
LIG_BRCT_BRCA1_1	67	71	PF00533	0.453
LIG_DLG_GKlike_1	14	21	PF00625	0.452
LIG_FHA_1	127	133	PF00498	0.502
LIG_FHA_1	152	158	PF00498	0.433
LIG_FHA_1	177	183	PF00498	0.433
LIG_FHA_2	198	204	PF00498	0.433
LIG_LIR_Gen_1	127	136	PF02991	0.499
LIG_LIR_Nem_3	127	131	PF02991	0.503
LIG_LIR_Nem_3	154	158	PF02991	0.433
LIG_LIR_Nem_3	164	170	PF02991	0.433
LIG_LIR_Nem_3	17	23	PF02991	0.445
LIG_LIR_Nem_3	215	220	PF02991	0.433
LIG_LIR_Nem_3	68	74	PF02991	0.459
LIG_Pex14_2	67	71	PF04695	0.453
LIG_Rb_pABgroove_1	98	106	PF01858	0.507
LIG_REV1ctd_RIR_1	71	79	PF16727	0.472
LIG_SH2_SRC	20	23	PF00017	0.443
LIG_SH2_STAT5	20	23	PF00017	0.443
LIG_SH2_STAT5	39	42	PF00017	0.504
LIG_SH2_STAT5	6	9	PF00017	0.454
LIG_SH2_STAT5	72	75	PF00017	0.471
LIG_SH3_3	142	148	PF00018	0.497
LIG_SH3_3	25	31	PF00018	0.441
LIG_SH3_3	5	11	PF00018	0.445
LIG_SUMO_SIM_par_1	168	175	PF11976	0.433
LIG_TRAF2_1	185	188	PF00917	0.433
MOD_CDK_SPK_2	78	83	PF00069	0.488
MOD_CDK_SPxxK_3	78	85	PF00069	0.497
MOD_CK1_1	161	167	PF00069	0.233
MOD_CK1_1	193	199	PF00069	0.233
MOD_CK1_1	35	41	PF00069	0.496
MOD_CK2_1	105	111	PF00069	0.512
MOD_CK2_1	168	174	PF00069	0.233
MOD_GlcNHglycan	107	110	PF01048	0.514
MOD_GlcNHglycan	136	139	PF01048	0.507
MOD_GlcNHglycan	141	144	PF01048	0.519
MOD_GlcNHglycan	148	151	PF01048	0.433
MOD_GlcNHglycan	59	62	PF01048	0.457
MOD_GSK3_1	10	17	PF00069	0.444
MOD_GSK3_1	157	164	PF00069	0.233
MOD_GSK3_1	193	200	PF00069	0.233
MOD_GSK3_1	35	42	PF00069	0.496
MOD_GSK3_1	45	52	PF00069	0.500
MOD_GSK3_1	74	81	PF00069	0.475
MOD_N-GLC_1	139	144	PF02516	0.514
MOD_NEK2_1	197	202	PF00069	0.233
MOD_NEK2_1	240	245	PF00069	0.449
MOD_NEK2_1	74	79	PF00069	0.473
MOD_PIKK_1	161	167	PF00454	0.233
MOD_PIKK_1	65	71	PF00454	0.452
MOD_PK_1	168	174	PF00069	0.233
MOD_PKA_2	105	111	PF00069	0.512
MOD_PKA_2	132	138	PF00069	0.496
MOD_PKA_2	74	80	PF00069	0.475
MOD_Plk_4	127	133	PF00069	0.502
MOD_Plk_4	212	218	PF00069	0.233
MOD_Plk_4	49	55	PF00069	0.490
MOD_ProDKin_1	41	47	PF00069	0.496
MOD_ProDKin_1	78	84	PF00069	0.492
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.233
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.447
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.443
TRG_ENDOCYTIC_2	20	23	PF00928	0.443
TRG_ENDOCYTIC_2	6	9	PF00928	0.454
TRG_ER_diArg_1	132	134	PF00400	0.495
TRG_ER_diArg_1	241	244	PF00400	0.452
TRG_ER_diArg_1	82	85	PF00400	0.518
TRG_NLS_Bipartite_1	106	126	PF00514	0.529
TRG_NLS_MonoExtC_3	121	126	PF00514	0.526
TRG_NLS_MonoExtN_4	120	126	PF00514	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A8D888	ARTSF	62%	100%
A8DYH2	DROME	57%	100%
A8Q8M5	BRUMA	59%	100%
B0G186	DICDI	58%	100%
B0WK43	CULQU	60%	100%
B3DL37	XENTR	57%	100%
B4GBR1	DROPE	57%	100%
B4JVK9	DROGR	57%	100%
B4KSR4	DROMO	57%	100%
B4LP65	DROVI	57%	100%
B5E0K3	DROPS	57%	100%
B5LVL2	COLLI	59%	100%
B9ENM6	SALSA	58%	100%
C1BJ98	OSMMO	58%	100%
P34661	CAEEL	56%	100%
P61960	HUMAN	57%	100%
P61961	MOUSE	57%	100%
Q09JK2	ARGMO	55%	100%
Q176V0	AEDAE	59%	100%
Q2KJG2	BOVIN	58%	100%
Q4N927	THEPA	57%	100%
Q4R4I2	MACFA	57%	100%
Q5BJP3	RAT	58%	100%
Q5PU89	CHLIN	61%	100%
Q5R4N5	PONAB	57%	100%
Q5RJW4	XENLA	57%	100%
Q5ZMK7	CHICK	58%	100%
Q61E22	CAEBR	56%	100%
Q7PXE2	ANOGA	60%	100%
Q803Y4	DANRE	56%	100%
Q94DM8	ORYSJ	61%	100%
Q94EY2	CHLRE	64%	100%
Q9CA23	ARATH	60%	100%