Alpha-type protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QER0_LEIMA

TriTrypDb:

LmjF.16.1070 , LMJLV39_160016700 , LMJSD75_160016300

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QER0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QER0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.701
CLV_NRD_NRD_1	105	107	PF00675	0.424
CLV_NRD_NRD_1	201	203	PF00675	0.546
CLV_NRD_NRD_1	260	262	PF00675	0.473
CLV_NRD_NRD_1	403	405	PF00675	0.469
CLV_NRD_NRD_1	456	458	PF00675	0.625
CLV_PCSK_KEX2_1	105	107	PF00082	0.428
CLV_PCSK_KEX2_1	201	203	PF00082	0.546
CLV_PCSK_KEX2_1	403	405	PF00082	0.469
CLV_PCSK_KEX2_1	456	458	PF00082	0.654
CLV_PCSK_SKI1_1	215	219	PF00082	0.380
CLV_PCSK_SKI1_1	431	435	PF00082	0.575
CLV_PCSK_SKI1_1	496	500	PF00082	0.583
CLV_PCSK_SKI1_1	503	507	PF00082	0.580
DEG_APCC_DBOX_1	221	229	PF00400	0.573
DEG_SCF_FBW7_2	13	20	PF00400	0.570
DEG_SCF_TRCP1_1	168	174	PF00400	0.678
DEG_SPOP_SBC_1	196	200	PF00917	0.752
DOC_MAPK_gen_1	144	152	PF00069	0.594
DOC_MAPK_gen_1	407	417	PF00069	0.491
DOC_MAPK_MEF2A_6	119	126	PF00069	0.633
DOC_MAPK_MEF2A_6	410	419	PF00069	0.480
DOC_PP4_FxxP_1	87	90	PF00568	0.611
DOC_USP7_MATH_1	180	184	PF00917	0.762
DOC_USP7_MATH_1	196	200	PF00917	0.699
DOC_USP7_MATH_1	2	6	PF00917	0.723
DOC_USP7_MATH_1	318	322	PF00917	0.659
DOC_WW_Pin1_4	13	18	PF00397	0.621
DOC_WW_Pin1_4	192	197	PF00397	0.754
DOC_WW_Pin1_4	203	208	PF00397	0.768
DOC_WW_Pin1_4	382	387	PF00397	0.634
DOC_WW_Pin1_4	390	395	PF00397	0.584
LIG_14-3-3_CanoR_1	209	217	PF00244	0.722
LIG_14-3-3_CanoR_1	222	226	PF00244	0.643
LIG_14-3-3_CanoR_1	407	413	PF00244	0.690
LIG_14-3-3_CanoR_1	45	52	PF00244	0.666
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BRCT_BRCA1_1	83	87	PF00533	0.687
LIG_CSL_BTD_1	87	90	PF09270	0.631
LIG_FHA_1	253	259	PF00498	0.604
LIG_FHA_1	301	307	PF00498	0.680
LIG_FHA_1	414	420	PF00498	0.412
LIG_FHA_2	156	162	PF00498	0.690
LIG_FHA_2	355	361	PF00498	0.622
LIG_FHA_2	55	61	PF00498	0.629
LIG_FHA_2	77	83	PF00498	0.691
LIG_Integrin_RGD_1	468	470	PF01839	0.800
LIG_LIR_Apic_2	84	90	PF02991	0.625
LIG_LIR_Gen_1	329	340	PF02991	0.605
LIG_LIR_Gen_1	504	514	PF02991	0.368
LIG_LIR_Nem_3	230	236	PF02991	0.556
LIG_LIR_Nem_3	247	252	PF02991	0.653
LIG_LIR_Nem_3	321	326	PF02991	0.656
LIG_LIR_Nem_3	329	335	PF02991	0.570
LIG_LIR_Nem_3	338	343	PF02991	0.497
LIG_LIR_Nem_3	484	490	PF02991	0.535
LIG_LIR_Nem_3	68	74	PF02991	0.609
LIG_Pex14_2	73	77	PF04695	0.636
LIG_SH2_CRK	249	253	PF00017	0.619
LIG_SH2_CRK	332	336	PF00017	0.607
LIG_SH2_CRK	409	413	PF00017	0.437
LIG_SH2_CRK	430	434	PF00017	0.444
LIG_SH2_CRK	71	75	PF00017	0.669
LIG_SH2_SRC	166	169	PF00017	0.708
LIG_SH2_SRC	436	439	PF00017	0.403
LIG_SH2_SRC	81	84	PF00017	0.697
LIG_SH2_STAP1	241	245	PF00017	0.561
LIG_SH2_STAT3	263	266	PF00017	0.526
LIG_SH2_STAT5	102	105	PF00017	0.724
LIG_SH2_STAT5	234	237	PF00017	0.558
LIG_SH2_STAT5	263	266	PF00017	0.526
LIG_SH2_STAT5	436	439	PF00017	0.414
LIG_SH3_3	21	27	PF00018	0.712
LIG_SH3_3	303	309	PF00018	0.723
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.622
LIG_SUMO_SIM_par_1	278	284	PF11976	0.622
LIG_TRAF2_1	357	360	PF00917	0.729
LIG_TRFH_1	508	512	PF08558	0.401
LIG_TYR_ITIM	330	335	PF00017	0.590
LIG_TYR_ITIM	428	433	PF00017	0.543
LIG_UBA3_1	142	147	PF00899	0.622
LIG_UBA3_1	494	503	PF00899	0.474
MOD_CDK_SPK_2	13	18	PF00069	0.658
MOD_CDK_SPxK_1	203	209	PF00069	0.648
MOD_CK1_1	129	135	PF00069	0.594
MOD_CK1_1	191	197	PF00069	0.738
MOD_CK1_1	211	217	PF00069	0.733
MOD_CK1_1	224	230	PF00069	0.691
MOD_CK1_1	441	447	PF00069	0.469
MOD_CK1_1	5	11	PF00069	0.702
MOD_CK2_1	354	360	PF00069	0.624
MOD_CK2_1	54	60	PF00069	0.610
MOD_CMANNOS	389	392	PF00535	0.506
MOD_Cter_Amidation	259	262	PF01082	0.391
MOD_Cter_Amidation	454	457	PF01082	0.745
MOD_GlcNHglycan	167	171	PF01048	0.500
MOD_GlcNHglycan	177	180	PF01048	0.463
MOD_GlcNHglycan	240	244	PF01048	0.401
MOD_GlcNHglycan	332	335	PF01048	0.441
MOD_GlcNHglycan	394	397	PF01048	0.405
MOD_GlcNHglycan	478	481	PF01048	0.704
MOD_GlcNHglycan	60	65	PF01048	0.564
MOD_GlcNHglycan	68	71	PF01048	0.556
MOD_GlcNHglycan	74	77	PF01048	0.544
MOD_GSK3_1	1	8	PF00069	0.667
MOD_GSK3_1	171	178	PF00069	0.758
MOD_GSK3_1	187	194	PF00069	0.664
MOD_GSK3_1	217	224	PF00069	0.673
MOD_GSK3_1	244	251	PF00069	0.654
MOD_GSK3_1	72	79	PF00069	0.680
MOD_N-GLC_1	109	114	PF02516	0.439
MOD_N-GLC_1	126	131	PF02516	0.374
MOD_N-GLC_1	187	192	PF02516	0.519
MOD_N-GLC_1	28	33	PF02516	0.516
MOD_N-GLC_1	318	323	PF02516	0.512
MOD_N-GLC_1	330	335	PF02516	0.359
MOD_NEK2_1	1	6	PF00069	0.728
MOD_NEK2_1	115	120	PF00069	0.647
MOD_NEK2_1	126	131	PF00069	0.614
MOD_NEK2_1	143	148	PF00069	0.577
MOD_NEK2_1	155	160	PF00069	0.578
MOD_NEK2_1	171	176	PF00069	0.687
MOD_NEK2_1	189	194	PF00069	0.578
MOD_NEK2_1	217	222	PF00069	0.690
MOD_NEK2_1	494	499	PF00069	0.396
MOD_PIKK_1	2	8	PF00454	0.693
MOD_PIKK_1	81	87	PF00454	0.769
MOD_PK_1	254	260	PF00069	0.598
MOD_PKA_2	143	149	PF00069	0.608
MOD_PKA_2	208	214	PF00069	0.733
MOD_PKA_2	221	227	PF00069	0.646
MOD_PKA_2	476	482	PF00069	0.477
MOD_PKA_2	65	71	PF00069	0.696
MOD_Plk_1	109	115	PF00069	0.626
MOD_Plk_1	155	161	PF00069	0.681
MOD_Plk_1	171	177	PF00069	0.775
MOD_Plk_1	239	245	PF00069	0.547
MOD_Plk_1	318	324	PF00069	0.710
MOD_Plk_1	330	336	PF00069	0.560
MOD_Plk_4	254	260	PF00069	0.674
MOD_Plk_4	83	89	PF00069	0.658
MOD_ProDKin_1	13	19	PF00069	0.618
MOD_ProDKin_1	192	198	PF00069	0.756
MOD_ProDKin_1	203	209	PF00069	0.765
MOD_ProDKin_1	382	388	PF00069	0.630
MOD_ProDKin_1	390	396	PF00069	0.576
MOD_SUMO_for_1	17	20	PF00179	0.576
MOD_SUMO_for_1	367	370	PF00179	0.596
TRG_DiLeu_BaEn_1	231	236	PF01217	0.564
TRG_DiLeu_BaEn_1	275	280	PF01217	0.603
TRG_ENDOCYTIC_2	233	236	PF00928	0.549
TRG_ENDOCYTIC_2	249	252	PF00928	0.560
TRG_ENDOCYTIC_2	332	335	PF00928	0.587
TRG_ENDOCYTIC_2	409	412	PF00928	0.562
TRG_ENDOCYTIC_2	430	433	PF00928	0.407
TRG_ENDOCYTIC_2	71	74	PF00928	0.671
TRG_ER_diArg_1	104	106	PF00400	0.699
TRG_ER_diArg_1	201	203	PF00400	0.735
TRG_ER_diArg_1	397	400	PF00400	0.629
TRG_ER_diArg_1	403	405	PF00400	0.666
TRG_ER_diArg_1	44	47	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	296	301	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM4	Leptomonas seymouri	67%	100%
A0A0S4KPP2	Bodo saltans	32%	100%
A0A1X0NYW7	Trypanosomatidae	42%	100%
A0A3S7WU15	Leishmania donovani	95%	100%
A0A422NAT9	Trypanosoma rangeli	43%	100%
A4H8N3	Leishmania braziliensis	80%	100%
A4HX03	Leishmania infantum	95%	100%
C9ZW04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AQR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BD08	Trypanosoma cruzi	40%	100%