Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEQ9_LEIMA

TriTrypDb:

LmjF.16.1080 , LMJLV39_160016800 , LMJSD75_160016400

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.629
CLV_C14_Caspase3-7	32	36	PF00656	0.559
CLV_C14_Caspase3-7	381	385	PF00656	0.708
CLV_C14_Caspase3-7	386	390	PF00656	0.671
CLV_C14_Caspase3-7	427	431	PF00656	0.697
CLV_C14_Caspase3-7	439	443	PF00656	0.615
CLV_NRD_NRD_1	173	175	PF00675	0.693
CLV_NRD_NRD_1	285	287	PF00675	0.711
CLV_NRD_NRD_1	303	305	PF00675	0.531
CLV_NRD_NRD_1	501	503	PF00675	0.662
CLV_NRD_NRD_1	58	60	PF00675	0.690
CLV_NRD_NRD_1	623	625	PF00675	0.582
CLV_PCSK_FUR_1	270	274	PF00082	0.721
CLV_PCSK_FUR_1	55	59	PF00082	0.689
CLV_PCSK_KEX2_1	173	175	PF00082	0.693
CLV_PCSK_KEX2_1	272	274	PF00082	0.666
CLV_PCSK_KEX2_1	285	287	PF00082	0.711
CLV_PCSK_KEX2_1	303	305	PF00082	0.531
CLV_PCSK_KEX2_1	57	59	PF00082	0.692
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.728
CLV_PCSK_SKI1_1	158	162	PF00082	0.654
CLV_PCSK_SKI1_1	534	538	PF00082	0.661
DEG_SCF_TRCP1_1	615	621	PF00400	0.647
DEG_SCF_TRCP1_1	88	93	PF00400	0.560
DOC_ANK_TNKS_1	573	580	PF00023	0.649
DOC_MAPK_DCC_7	118	126	PF00069	0.637
DOC_MAPK_gen_1	335	345	PF00069	0.734
DOC_PP2B_LxvP_1	448	451	PF13499	0.719
DOC_PP2B_LxvP_1	587	590	PF13499	0.629
DOC_USP7_MATH_1	114	118	PF00917	0.835
DOC_USP7_MATH_1	132	136	PF00917	0.542
DOC_USP7_MATH_1	184	188	PF00917	0.594
DOC_USP7_MATH_1	254	258	PF00917	0.706
DOC_USP7_MATH_1	284	288	PF00917	0.722
DOC_USP7_MATH_1	460	464	PF00917	0.659
DOC_USP7_UBL2_3	76	80	PF12436	0.597
DOC_WW_Pin1_4	117	122	PF00397	0.760
DOC_WW_Pin1_4	130	135	PF00397	0.663
DOC_WW_Pin1_4	588	593	PF00397	0.679
LIG_14-3-3_CanoR_1	107	115	PF00244	0.690
LIG_14-3-3_CanoR_1	173	183	PF00244	0.695
LIG_14-3-3_CanoR_1	20	26	PF00244	0.575
LIG_14-3-3_CanoR_1	206	213	PF00244	0.569
LIG_14-3-3_CanoR_1	285	295	PF00244	0.721
LIG_14-3-3_CanoR_1	3	8	PF00244	0.654
LIG_14-3-3_CanoR_1	465	469	PF00244	0.695
LIG_14-3-3_CanoR_1	490	498	PF00244	0.597
LIG_14-3-3_CanoR_1	539	545	PF00244	0.719
LIG_14-3-3_CanoR_1	580	590	PF00244	0.624
LIG_14-3-3_CanoR_1	606	613	PF00244	0.664
LIG_14-3-3_CterR_2	637	640	PF00244	0.619
LIG_Actin_WH2_2	112	127	PF00022	0.597
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_deltaCOP1_diTrp_1	188	200	PF00928	0.585
LIG_deltaCOP1_diTrp_1	393	401	PF00928	0.668
LIG_FHA_1	108	114	PF00498	0.593
LIG_FHA_1	483	489	PF00498	0.742
LIG_FHA_1	548	554	PF00498	0.688
LIG_FHA_1	557	563	PF00498	0.539
LIG_FHA_1	582	588	PF00498	0.577
LIG_FHA_2	221	227	PF00498	0.582
LIG_FHA_2	264	270	PF00498	0.741
LIG_FHA_2	30	36	PF00498	0.566
LIG_GSK3_LRP6_1	588	594	PF00069	0.634
LIG_Integrin_isoDGR_2	368	370	PF01839	0.603
LIG_Integrin_isoDGR_2	622	624	PF01839	0.655
LIG_LIR_Apic_2	135	141	PF02991	0.680
LIG_LIR_Apic_2	177	183	PF02991	0.613
LIG_LIR_Apic_2	444	450	PF02991	0.609
LIG_LIR_Nem_3	71	77	PF02991	0.681
LIG_SH2_CRK	180	184	PF00017	0.596
LIG_SH2_GRB2like	418	421	PF00017	0.669
LIG_SH2_STAT3	264	267	PF00017	0.692
LIG_SH2_STAT5	447	450	PF00017	0.614
LIG_SH3_1	163	169	PF00018	0.668
LIG_SH3_1	233	239	PF00018	0.821
LIG_SH3_1	447	453	PF00018	0.659
LIG_SH3_1	96	102	PF00018	0.697
LIG_SH3_2	11	16	PF14604	0.569
LIG_SH3_2	632	637	PF14604	0.690
LIG_SH3_3	163	169	PF00018	0.717
LIG_SH3_3	228	234	PF00018	0.815
LIG_SH3_3	28	34	PF00018	0.654
LIG_SH3_3	342	348	PF00018	0.593
LIG_SH3_3	447	453	PF00018	0.731
LIG_SH3_3	470	476	PF00018	0.777
LIG_SH3_3	5	11	PF00018	0.775
LIG_SH3_3	550	556	PF00018	0.693
LIG_SH3_3	570	576	PF00018	0.635
LIG_SH3_3	583	589	PF00018	0.620
LIG_SH3_3	629	635	PF00018	0.694
LIG_SH3_3	96	102	PF00018	0.697
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.594
LIG_SUMO_SIM_par_1	109	117	PF11976	0.590
LIG_TRFH_1	180	184	PF08558	0.668
MOD_CK1_1	117	123	PF00069	0.799
MOD_CK1_1	2	8	PF00069	0.657
MOD_CK1_1	219	225	PF00069	0.641
MOD_CK1_1	247	253	PF00069	0.694
MOD_CK1_1	287	293	PF00069	0.806
MOD_CK1_1	29	35	PF00069	0.656
MOD_CK1_1	443	449	PF00069	0.761
MOD_CK1_1	497	503	PF00069	0.673
MOD_CK1_1	546	552	PF00069	0.736
MOD_CK1_1	591	597	PF00069	0.707
MOD_CK1_1	616	622	PF00069	0.641
MOD_CK2_1	184	190	PF00069	0.692
MOD_CK2_1	199	205	PF00069	0.533
MOD_CK2_1	263	269	PF00069	0.662
MOD_CK2_1	322	328	PF00069	0.580
MOD_CK2_1	605	611	PF00069	0.740
MOD_Cter_Amidation	171	174	PF01082	0.688
MOD_Cter_Amidation	521	524	PF01082	0.587
MOD_Cter_Amidation	622	625	PF01082	0.654
MOD_GlcNHglycan	134	137	PF01048	0.757
MOD_GlcNHglycan	197	200	PF01048	0.826
MOD_GlcNHglycan	201	204	PF01048	0.774
MOD_GlcNHglycan	261	264	PF01048	0.783
MOD_GlcNHglycan	304	307	PF01048	0.736
MOD_GlcNHglycan	312	315	PF01048	0.648
MOD_GlcNHglycan	324	327	PF01048	0.506
MOD_GlcNHglycan	35	38	PF01048	0.609
MOD_GlcNHglycan	356	359	PF01048	0.630
MOD_GlcNHglycan	362	365	PF01048	0.641
MOD_GlcNHglycan	491	494	PF01048	0.596
MOD_GlcNHglycan	565	568	PF01048	0.635
MOD_GlcNHglycan	614	618	PF01048	0.699
MOD_GlcNHglycan	88	91	PF01048	0.752
MOD_GSK3_1	195	202	PF00069	0.661
MOD_GSK3_1	216	223	PF00069	0.609
MOD_GSK3_1	255	262	PF00069	0.760
MOD_GSK3_1	29	36	PF00069	0.722
MOD_GSK3_1	460	467	PF00069	0.740
MOD_GSK3_1	489	496	PF00069	0.650
MOD_GSK3_1	498	505	PF00069	0.670
MOD_GSK3_1	540	547	PF00069	0.702
MOD_GSK3_1	86	93	PF00069	0.700
MOD_LATS_1	156	162	PF00433	0.654
MOD_N-GLC_1	255	260	PF02516	0.736
MOD_N-GLC_1	42	47	PF02516	0.521
MOD_N-GLC_1	537	542	PF02516	0.708
MOD_N-GLC_1	547	552	PF02516	0.583
MOD_NEK2_1	464	469	PF00069	0.710
MOD_NEK2_1	498	503	PF00069	0.654
MOD_NEK2_1	537	542	PF00069	0.660
MOD_NEK2_1	613	618	PF00069	0.650
MOD_PIKK_1	247	253	PF00454	0.707
MOD_PIKK_1	263	269	PF00454	0.641
MOD_PIKK_1	474	480	PF00454	0.693
MOD_PIKK_1	502	508	PF00454	0.736
MOD_PIKK_1	594	600	PF00454	0.675
MOD_PIKK_1	605	611	PF00454	0.599
MOD_PKA_1	173	179	PF00069	0.666
MOD_PKA_1	285	291	PF00069	0.674
MOD_PKA_1	502	508	PF00069	0.637
MOD_PKA_1	523	529	PF00069	0.693
MOD_PKA_2	106	112	PF00069	0.691
MOD_PKA_2	173	179	PF00069	0.732
MOD_PKA_2	2	8	PF00069	0.654
MOD_PKA_2	205	211	PF00069	0.601
MOD_PKA_2	21	27	PF00069	0.580
MOD_PKA_2	284	290	PF00069	0.822
MOD_PKA_2	302	308	PF00069	0.579
MOD_PKA_2	464	470	PF00069	0.695
MOD_PKA_2	482	488	PF00069	0.745
MOD_PKA_2	489	495	PF00069	0.666
MOD_PKA_2	538	544	PF00069	0.594
MOD_PKA_2	605	611	PF00069	0.692
MOD_Plk_1	219	225	PF00069	0.600
MOD_Plk_1	244	250	PF00069	0.603
MOD_Plk_1	42	48	PF00069	0.521
MOD_Plk_1	493	499	PF00069	0.646
MOD_Plk_2-3	205	211	PF00069	0.649
MOD_Plk_2-3	220	226	PF00069	0.533
MOD_Plk_4	192	198	PF00069	0.594
MOD_Plk_4	26	32	PF00069	0.634
MOD_Plk_4	443	449	PF00069	0.589
MOD_Plk_4	540	546	PF00069	0.704
MOD_Plk_4	549	555	PF00069	0.595
MOD_Plk_4	596	602	PF00069	0.549
MOD_ProDKin_1	117	123	PF00069	0.756
MOD_ProDKin_1	130	136	PF00069	0.663
MOD_ProDKin_1	588	594	PF00069	0.682
TRG_DiLeu_BaEn_1	42	47	PF01217	0.570
TRG_ER_diArg_1	284	286	PF00400	0.698
TRG_ER_diArg_1	56	59	PF00400	0.687
TRG_NES_CRM1_1	561	572	PF08389	0.553
TRG_NLS_MonoExtC_3	522	527	PF00514	0.616
TRG_NLS_MonoExtN_4	521	528	PF00514	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDQ3	Leishmania donovani	85%	100%
A4H8N4	Leishmania braziliensis	51%	100%
A4HX04	Leishmania infantum	84%	100%
E9AQR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%