Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEQ7_LEIMA

TriTrypDb:

LmjF.16.1100 , LMJLV39_160017100 , LMJSD75_160016700

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.699
CLV_NRD_NRD_1	109	111	PF00675	0.638
CLV_NRD_NRD_1	14	16	PF00675	0.580
CLV_NRD_NRD_1	203	205	PF00675	0.629
CLV_NRD_NRD_1	22	24	PF00675	0.642
CLV_NRD_NRD_1	294	296	PF00675	0.748
CLV_NRD_NRD_1	421	423	PF00675	0.662
CLV_NRD_NRD_1	449	451	PF00675	0.654
CLV_NRD_NRD_1	479	481	PF00675	0.665
CLV_PCSK_FUR_1	201	205	PF00082	0.628
CLV_PCSK_KEX2_1	13	15	PF00082	0.668
CLV_PCSK_KEX2_1	203	205	PF00082	0.629
CLV_PCSK_KEX2_1	22	24	PF00082	0.542
CLV_PCSK_KEX2_1	421	423	PF00082	0.662
CLV_PCSK_KEX2_1	449	451	PF00082	0.654
CLV_PCSK_KEX2_1	469	471	PF00082	0.368
CLV_PCSK_KEX2_1	473	475	PF00082	0.605
CLV_PCSK_KEX2_1	479	481	PF00082	0.530
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.668
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.637
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.605
CLV_PCSK_SKI1_1	102	106	PF00082	0.580
CLV_PCSK_SKI1_1	368	372	PF00082	0.798
DEG_APCC_DBOX_1	75	83	PF00400	0.651
DOC_CKS1_1	369	374	PF01111	0.785
DOC_CKS1_1	376	381	PF01111	0.692
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.653
DOC_MAPK_gen_1	71	79	PF00069	0.599
DOC_MAPK_MEF2A_6	280	287	PF00069	0.434
DOC_MAPK_RevD_3	283	296	PF00069	0.484
DOC_PP4_FxxP_1	405	408	PF00568	0.709
DOC_USP7_MATH_1	129	133	PF00917	0.711
DOC_USP7_MATH_1	153	157	PF00917	0.770
DOC_USP7_MATH_1	312	316	PF00917	0.595
DOC_USP7_MATH_1	335	339	PF00917	0.718
DOC_USP7_UBL2_3	167	171	PF12436	0.714
DOC_USP7_UBL2_3	469	473	PF12436	0.643
DOC_WW_Pin1_4	325	330	PF00397	0.775
DOC_WW_Pin1_4	368	373	PF00397	0.801
DOC_WW_Pin1_4	375	380	PF00397	0.694
DOC_WW_Pin1_4	404	409	PF00397	0.765
LIG_14-3-3_CanoR_1	125	129	PF00244	0.653
LIG_BIR_III_4	39	43	PF00653	0.677
LIG_BRCT_BRCA1_1	390	394	PF00533	0.712
LIG_CtBP_PxDLS_1	351	355	PF00389	0.750
LIG_eIF4E_1	100	106	PF01652	0.638
LIG_FHA_1	369	375	PF00498	0.786
LIG_FHA_1	376	382	PF00498	0.690
LIG_FHA_1	408	414	PF00498	0.702
LIG_FHA_1	518	524	PF00498	0.660
LIG_FHA_2	125	131	PF00498	0.668
LIG_FHA_2	140	146	PF00498	0.601
LIG_FHA_2	44	50	PF00498	0.728
LIG_FHA_2	482	488	PF00498	0.651
LIG_FHA_2	7	13	PF00498	0.678
LIG_LIR_Apic_2	126	131	PF02991	0.653
LIG_LIR_Apic_2	135	140	PF02991	0.616
LIG_LIR_Apic_2	149	153	PF02991	0.627
LIG_LIR_Apic_2	402	408	PF02991	0.705
LIG_LIR_Nem_3	132	137	PF02991	0.730
LIG_LIR_Nem_3	263	268	PF02991	0.573
LIG_LIR_Nem_3	29	34	PF02991	0.678
LIG_LIR_Nem_3	392	398	PF02991	0.694
LIG_MYND_1	379	383	PF01753	0.777
LIG_Pex14_1	401	405	PF04695	0.702
LIG_Pex14_2	459	463	PF04695	0.481
LIG_SH2_CRK	61	65	PF00017	0.696
LIG_SH2_SRC	137	140	PF00017	0.697
LIG_SH2_SRC	61	64	PF00017	0.695
LIG_SH2_STAP1	100	104	PF00017	0.638
LIG_SH2_STAP1	265	269	PF00017	0.573
LIG_SH2_STAT3	268	271	PF00017	0.572
LIG_SH2_STAT5	123	126	PF00017	0.705
LIG_SH2_STAT5	162	165	PF00017	0.728
LIG_SH2_STAT5	220	223	PF00017	0.615
LIG_SH3_3	114	120	PF00018	0.679
LIG_SH3_3	284	290	PF00018	0.635
LIG_SH3_3	323	329	PF00018	0.663
LIG_SH3_3	338	344	PF00018	0.567
LIG_SH3_3	366	372	PF00018	0.754
LIG_SH3_3	373	379	PF00018	0.699
LIG_SH3_3	383	389	PF00018	0.535
LIG_TRAF2_1	241	244	PF00917	0.654
LIG_TRAF2_1	269	272	PF00917	0.571
LIG_TRAF2_1	304	307	PF00917	0.762
LIG_TRAF2_1	536	539	PF00917	0.602
LIG_TRAF2_1	67	70	PF00917	0.657
MOD_CDK_SPxxK_3	368	375	PF00069	0.787
MOD_CK1_1	132	138	PF00069	0.732
MOD_CK1_1	328	334	PF00069	0.759
MOD_CK1_1	407	413	PF00069	0.673
MOD_CK1_1	550	556	PF00069	0.678
MOD_CK2_1	220	226	PF00069	0.618
MOD_CK2_1	312	318	PF00069	0.592
MOD_CK2_1	43	49	PF00069	0.730
MOD_CK2_1	533	539	PF00069	0.605
MOD_CK2_1	6	12	PF00069	0.684
MOD_CK2_1	64	70	PF00069	0.663
MOD_DYRK1A_RPxSP_1	325	329	PF00069	0.774
MOD_DYRK1A_RPxSP_1	368	372	PF00069	0.784
MOD_DYRK1A_RPxSP_1	375	379	PF00069	0.693
MOD_GlcNHglycan	159	162	PF01048	0.744
MOD_GlcNHglycan	298	301	PF01048	0.755
MOD_GlcNHglycan	314	317	PF01048	0.537
MOD_GlcNHglycan	337	340	PF01048	0.756
MOD_GlcNHglycan	365	368	PF01048	0.568
MOD_GlcNHglycan	550	553	PF01048	0.670
MOD_GSK3_1	119	126	PF00069	0.646
MOD_GSK3_1	153	160	PF00069	0.751
MOD_GSK3_1	325	332	PF00069	0.780
MOD_GSK3_1	350	357	PF00069	0.747
MOD_GSK3_1	84	91	PF00069	0.646
MOD_N-GLC_1	413	418	PF02516	0.704
MOD_N-GLC_1	517	522	PF02516	0.608
MOD_N-GLC_1	6	11	PF02516	0.473
MOD_NEK2_1	106	111	PF00069	0.640
MOD_NEK2_1	124	129	PF00069	0.462
MOD_NEK2_1	26	31	PF00069	0.665
MOD_NEK2_1	363	368	PF00069	0.571
MOD_NEK2_1	428	433	PF00069	0.408
MOD_NEK2_1	459	464	PF00069	0.643
MOD_NEK2_1	500	505	PF00069	0.390
MOD_NEK2_1	547	552	PF00069	0.646
MOD_PIKK_1	267	273	PF00454	0.570
MOD_PIKK_1	354	360	PF00454	0.771
MOD_PIKK_1	381	387	PF00454	0.772
MOD_PIKK_1	428	434	PF00454	0.485
MOD_PIKK_1	437	443	PF00454	0.595
MOD_PIKK_1	481	487	PF00454	0.653
MOD_PIKK_1	517	523	PF00454	0.608
MOD_PKA_2	124	130	PF00069	0.650
MOD_PKA_2	234	240	PF00069	0.661
MOD_PKA_2	32	38	PF00069	0.657
MOD_PKA_2	436	442	PF00069	0.573
MOD_PKA_2	88	94	PF00069	0.649
MOD_Plk_1	428	434	PF00069	0.426
MOD_Plk_1	517	523	PF00069	0.662
MOD_Plk_1	6	12	PF00069	0.468
MOD_Plk_4	119	125	PF00069	0.700
MOD_Plk_4	220	226	PF00069	0.618
MOD_Plk_4	27	33	PF00069	0.673
MOD_Plk_4	350	356	PF00069	0.709
MOD_ProDKin_1	325	331	PF00069	0.776
MOD_ProDKin_1	368	374	PF00069	0.802
MOD_ProDKin_1	375	381	PF00069	0.693
MOD_ProDKin_1	404	410	PF00069	0.763
MOD_SUMO_for_1	44	47	PF00179	0.534
TRG_DiLeu_BaEn_1	101	106	PF01217	0.636
TRG_DiLeu_BaEn_4	49	55	PF01217	0.732
TRG_DiLeu_BaEn_4	540	546	PF01217	0.613
TRG_ENDOCYTIC_2	31	34	PF00928	0.694
TRG_ENDOCYTIC_2	61	64	PF00928	0.695
TRG_ER_diArg_1	201	204	PF00400	0.632
TRG_ER_diArg_1	21	23	PF00400	0.658
TRG_ER_diArg_1	228	231	PF00400	0.659
TRG_ER_diArg_1	283	286	PF00400	0.652
TRG_ER_diArg_1	448	450	PF00400	0.652
TRG_ER_diArg_1	71	74	PF00400	0.650
TRG_ER_diArg_1	76	79	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICK9	Leishmania donovani	92%	100%
A4HX07	Leishmania infantum	92%	100%
E9AQR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%