Polyketide_cyc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Polyketide cyclase / dehydrase and lipid transport, putative

Species:

Leishmania major

UniProt:

Q4QEQ6_LEIMA

TriTrypDb:

LmjF.16.1110 , LMJLV39_160017200 , LMJSD75_160016800

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEQ6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	8
GO:0006743	ubiquinone metabolic process	5	8
GO:0006744	ubiquinone biosynthetic process	6	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	8
GO:0015980	energy derivation by oxidation of organic compounds	4	8
GO:0042180	cellular ketone metabolic process	3	8
GO:0042181	ketone biosynthetic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044281	small molecule metabolic process	2	8
GO:0044283	small molecule biosynthetic process	3	8
GO:0045333	cellular respiration	5	8
GO:0071704	organic substance metabolic process	2	8
GO:1901576	organic substance biosynthetic process	3	8
GO:1901661	quinone metabolic process	4	8
GO:1901663	quinone biosynthetic process	5	8

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0048038	quinone binding	2	8
GO:0048039	ubiquinone binding	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.660
CLV_C14_Caspase3-7	195	199	PF00656	0.347
CLV_C14_Caspase3-7	258	262	PF00656	0.197
CLV_C14_Caspase3-7	88	92	PF00656	0.597
CLV_NRD_NRD_1	164	166	PF00675	0.347
CLV_NRD_NRD_1	226	228	PF00675	0.436
CLV_NRD_NRD_1	279	281	PF00675	0.297
CLV_NRD_NRD_1	32	34	PF00675	0.753
CLV_NRD_NRD_1	347	349	PF00675	0.426
CLV_PCSK_KEX2_1	164	166	PF00082	0.288
CLV_PCSK_KEX2_1	291	293	PF00082	0.411
CLV_PCSK_KEX2_1	32	34	PF00082	0.715
CLV_PCSK_KEX2_1	347	349	PF00082	0.426
CLV_PCSK_KEX2_1	68	70	PF00082	0.535
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.411
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.535
CLV_PCSK_PC7_1	343	349	PF00082	0.423
CLV_PCSK_SKI1_1	102	106	PF00082	0.801
CLV_PCSK_SKI1_1	170	174	PF00082	0.230
CLV_PCSK_SKI1_1	292	296	PF00082	0.306
DEG_APCC_DBOX_1	291	299	PF00400	0.297
DEG_Nend_UBRbox_2	1	3	PF02207	0.562
DEG_SPOP_SBC_1	111	115	PF00917	0.581
DOC_AGCK_PIF_2	319	324	PF00069	0.297
DOC_MAPK_gen_1	167	175	PF00069	0.185
DOC_MAPK_MEF2A_6	310	318	PF00069	0.347
DOC_PP1_SILK_1	292	297	PF00149	0.347
DOC_PP2B_LxvP_1	173	176	PF13499	0.185
DOC_PP2B_LxvP_1	37	40	PF13499	0.576
DOC_PP4_FxxP_1	324	327	PF00568	0.256
DOC_USP7_MATH_1	103	107	PF00917	0.712
DOC_USP7_MATH_1	112	116	PF00917	0.591
DOC_USP7_MATH_1	186	190	PF00917	0.359
DOC_USP7_MATH_1	21	25	PF00917	0.651
DOC_USP7_MATH_1	255	259	PF00917	0.185
DOC_USP7_MATH_1	290	294	PF00917	0.347
DOC_USP7_MATH_1	49	53	PF00917	0.562
DOC_USP7_MATH_1	71	75	PF00917	0.479
DOC_USP7_MATH_2	135	141	PF00917	0.297
DOC_WW_Pin1_4	131	136	PF00397	0.312
DOC_WW_Pin1_4	175	180	PF00397	0.342
DOC_WW_Pin1_4	81	86	PF00397	0.566
DOC_WW_Pin1_4	93	98	PF00397	0.777
LIG_14-3-3_CanoR_1	220	224	PF00244	0.367
LIG_14-3-3_CanoR_1	250	256	PF00244	0.297
LIG_14-3-3_CanoR_1	280	288	PF00244	0.297
LIG_14-3-3_CanoR_1	69	77	PF00244	0.577
LIG_APCC_ABBA_1	122	127	PF00400	0.480
LIG_BRCT_BRCA1_1	320	324	PF00533	0.259
LIG_deltaCOP1_diTrp_1	301	304	PF00928	0.347
LIG_EVH1_1	37	41	PF00568	0.573
LIG_FHA_1	161	167	PF00498	0.446
LIG_FHA_1	201	207	PF00498	0.262
LIG_FHA_1	216	222	PF00498	0.241
LIG_FHA_1	283	289	PF00498	0.334
LIG_FHA_1	311	317	PF00498	0.360
LIG_FHA_2	185	191	PF00498	0.372
LIG_FHA_2	29	35	PF00498	0.628
LIG_LIR_Apic_2	321	327	PF02991	0.256
LIG_LIR_Apic_2	350	356	PF02991	0.365
LIG_LIR_Gen_1	136	145	PF02991	0.312
LIG_LIR_Gen_1	146	156	PF02991	0.256
LIG_LIR_Gen_1	207	217	PF02991	0.256
LIG_LIR_Nem_3	136	142	PF02991	0.288
LIG_LIR_Nem_3	146	151	PF02991	0.288
LIG_LIR_Nem_3	207	213	PF02991	0.256
LIG_LIR_Nem_3	301	307	PF02991	0.295
LIG_NRBOX	2	8	PF00104	0.560
LIG_PCNA_yPIPBox_3	272	281	PF02747	0.185
LIG_Pex14_2	318	322	PF04695	0.256
LIG_PTB_Apo_2	323	330	PF02174	0.347
LIG_PTB_Phospho_1	323	329	PF10480	0.347
LIG_Rb_pABgroove_1	228	236	PF01858	0.347
LIG_REV1ctd_RIR_1	210	218	PF16727	0.194
LIG_REV1ctd_RIR_1	276	285	PF16727	0.269
LIG_SH2_CRK	139	143	PF00017	0.256
LIG_SH2_CRK	353	357	PF00017	0.360
LIG_SH2_NCK_1	139	143	PF00017	0.347
LIG_SH2_STAP1	139	143	PF00017	0.304
LIG_SH2_STAP1	148	152	PF00017	0.220
LIG_SH2_STAP1	217	221	PF00017	0.256
LIG_SH2_STAT5	217	220	PF00017	0.256
LIG_SH3_3	14	20	PF00018	0.602
LIG_SH3_3	163	169	PF00018	0.389
LIG_SH3_3	173	179	PF00018	0.429
LIG_SH3_3	35	41	PF00018	0.594
LIG_SH3_3	358	364	PF00018	0.461
LIG_Sin3_3	57	64	PF02671	0.432
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.185
LIG_SUMO_SIM_anti_2	313	318	PF11976	0.360
LIG_WRC_WIRS_1	275	280	PF05994	0.297
LIG_WRC_WIRS_1	319	324	PF05994	0.288
MOD_CDK_SPK_2	81	86	PF00069	0.497
MOD_CK1_1	110	116	PF00069	0.628
MOD_CK1_1	12	18	PF00069	0.717
MOD_CK1_1	219	225	PF00069	0.347
MOD_CK1_1	249	255	PF00069	0.433
MOD_CK1_1	259	265	PF00069	0.272
MOD_CK1_1	78	84	PF00069	0.667
MOD_CK2_1	131	137	PF00069	0.347
MOD_CK2_1	184	190	PF00069	0.372
MOD_CK2_1	21	27	PF00069	0.720
MOD_CK2_1	28	34	PF00069	0.549
MOD_Cter_Amidation	225	228	PF01082	0.328
MOD_GlcNHglycan	109	112	PF01048	0.515
MOD_GlcNHglycan	11	14	PF01048	0.682
MOD_GlcNHglycan	148	151	PF01048	0.297
MOD_GlcNHglycan	17	20	PF01048	0.662
MOD_GlcNHglycan	252	255	PF01048	0.446
MOD_GlcNHglycan	263	266	PF01048	0.297
MOD_GlcNHglycan	269	272	PF01048	0.215
MOD_GlcNHglycan	356	359	PF01048	0.455
MOD_GlcNHglycan	73	76	PF01048	0.677
MOD_GlcNHglycan	77	80	PF01048	0.576
MOD_GSK3_1	107	114	PF00069	0.632
MOD_GSK3_1	127	134	PF00069	0.256
MOD_GSK3_1	155	162	PF00069	0.369
MOD_GSK3_1	180	187	PF00069	0.309
MOD_GSK3_1	200	207	PF00069	0.278
MOD_GSK3_1	215	222	PF00069	0.229
MOD_GSK3_1	245	252	PF00069	0.377
MOD_GSK3_1	255	262	PF00069	0.356
MOD_GSK3_1	71	78	PF00069	0.645
MOD_GSK3_1	9	16	PF00069	0.591
MOD_GSK3_1	98	105	PF00069	0.622
MOD_N-GLC_1	246	251	PF02516	0.297
MOD_N-GLC_1	50	55	PF02516	0.585
MOD_N-GLC_1	71	76	PF02516	0.614
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	202	207	PF00069	0.288
MOD_NEK2_1	274	279	PF00069	0.396
MOD_NEK2_1	28	33	PF00069	0.628
MOD_NEK2_1	77	82	PF00069	0.722
MOD_PIKK_1	103	109	PF00454	0.641
MOD_PKA_2	219	225	PF00069	0.367
MOD_PKA_2	249	255	PF00069	0.297
MOD_PKA_2	259	265	PF00069	0.227
MOD_PKA_2	28	34	PF00069	0.822
MOD_Plk_1	1	7	PF00069	0.628
MOD_Plk_1	50	56	PF00069	0.583
MOD_Plk_4	137	143	PF00069	0.382
MOD_Plk_4	219	225	PF00069	0.347
MOD_Plk_4	274	280	PF00069	0.367
MOD_Plk_4	348	354	PF00069	0.437
MOD_ProDKin_1	131	137	PF00069	0.256
MOD_ProDKin_1	175	181	PF00069	0.342
MOD_ProDKin_1	81	87	PF00069	0.563
MOD_ProDKin_1	93	99	PF00069	0.776
MOD_SUMO_rev_2	303	311	PF00179	0.297
MOD_SUMO_rev_2	321	327	PF00179	0.297
TRG_DiLeu_BaEn_1	2	7	PF01217	0.558
TRG_DiLeu_LyEn_5	2	7	PF01217	0.558
TRG_ENDOCYTIC_2	139	142	PF00928	0.256
TRG_ENDOCYTIC_2	148	151	PF00928	0.256
TRG_ENDOCYTIC_2	329	332	PF00928	0.347
TRG_ER_diArg_1	164	167	PF00400	0.347
TRG_Pf-PMV_PEXEL_1	296	301	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ5	Leptomonas seymouri	58%	67%
A0A1X0NYV9	Trypanosomatidae	36%	87%
A0A3S7WU24	Leishmania donovani	91%	99%
A4HX08	Leishmania infantum	91%	99%
C9ZVZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AQS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%