Tyrosyl or methionyl-tRNA synthetase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosyl or methionyl-tRNA synthetase-like protein

Species:

Leishmania major

UniProt:

Q4QEQ4_LEIMA

TriTrypDb:

LmjF.16.1130 , LMJLV39_160017500 , LMJSD75_160017100

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEQ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0005488	binding	1	12
GO:0016874	ligase activity	2	12
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.475
CLV_NRD_NRD_1	102	104	PF00675	0.373
CLV_NRD_NRD_1	71	73	PF00675	0.271
CLV_PCSK_SKI1_1	104	108	PF00082	0.301
CLV_PCSK_SKI1_1	119	123	PF00082	0.356
CLV_PCSK_SKI1_1	136	140	PF00082	0.457
CLV_PCSK_SKI1_1	43	47	PF00082	0.271
CLV_PCSK_SKI1_1	61	65	PF00082	0.271
DEG_APCC_DBOX_1	42	50	PF00400	0.471
DOC_ANK_TNKS_1	148	155	PF00023	0.402
DOC_MAPK_gen_1	103	110	PF00069	0.539
DOC_MAPK_MEF2A_6	103	110	PF00069	0.513
DOC_PP1_RVXF_1	117	123	PF00149	0.543
DOC_PP2B_LxvP_1	108	111	PF13499	0.471
DOC_USP7_UBL2_3	135	139	PF12436	0.468
LIG_14-3-3_CanoR_1	149	156	PF00244	0.494
LIG_14-3-3_CterR_2	178	180	PF00244	0.510
LIG_BIR_II_1	1	5	PF00653	0.388
LIG_deltaCOP1_diTrp_1	155	163	PF00928	0.340
LIG_FHA_2	86	92	PF00498	0.519
LIG_KLC1_Yacidic_2	21	26	PF13176	0.513
LIG_LIR_Nem_3	126	132	PF02991	0.460
LIG_MAD2	10	18	PF02301	0.513
LIG_SH2_SRC	129	132	PF00017	0.494
LIG_SH2_STAT5	24	27	PF00017	0.471
LIG_SH3_3	125	131	PF00018	0.441
LIG_SH3_3	89	95	PF00018	0.560
LIG_SUMO_SIM_par_1	10	15	PF11976	0.538
LIG_SUMO_SIM_par_1	104	109	PF11976	0.512
LIG_UBA3_1	45	54	PF00899	0.481
MOD_CK2_1	35	41	PF00069	0.573
MOD_CK2_1	84	90	PF00069	0.515
MOD_GlcNHglycan	150	153	PF01048	0.462
MOD_GlcNHglycan	165	168	PF01048	0.372
MOD_GlcNHglycan	46	49	PF01048	0.271
MOD_GlcNHglycan	78	81	PF01048	0.364
MOD_GlcNHglycan	96	99	PF01048	0.351
MOD_NEK2_1	12	17	PF00069	0.586
MOD_NEK2_1	163	168	PF00069	0.421
MOD_NEK2_1	84	89	PF00069	0.483
MOD_PKA_2	148	154	PF00069	0.480
MOD_SUMO_for_1	53	56	PF00179	0.538
MOD_SUMO_rev_2	97	106	PF00179	0.503
TRG_ENDOCYTIC_2	129	132	PF00928	0.494
TRG_NLS_MonoExtN_4	131	138	PF00514	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I419	Leptomonas seymouri	91%	74%
A0A0S4IPY2	Bodo saltans	57%	79%
A0A1X0NZC6	Trypanosomatidae	63%	73%
A0A3S5H6Y3	Leishmania donovani	98%	100%
A0A422MWG6	Trypanosoma rangeli	57%	74%
A4H8N9	Leishmania braziliensis	94%	100%
A4HX10	Leishmania infantum	98%	76%
C9ZVZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	81%
E9AQS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
V5BI34	Trypanosoma cruzi	58%	74%