WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WW domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEQ3_LEIMA

TriTrypDb:

LmjF.16.1140 , LMJLV39_160017700 , LMJSD75_160017300

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005685	U1 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0071004	U2-type prespliceosome	5	2
GO:0071010	prespliceosome	4	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QEQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEQ3

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	549	553	PF00656	0.577
CLV_NRD_NRD_1	458	460	PF00675	0.363
CLV_NRD_NRD_1	78	80	PF00675	0.568
CLV_PCSK_KEX2_1	458	460	PF00082	0.444
CLV_PCSK_KEX2_1	635	637	PF00082	0.268
CLV_PCSK_KEX2_1	78	80	PF00082	0.568
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.268
CLV_PCSK_SKI1_1	28	32	PF00082	0.668
CLV_PCSK_SKI1_1	53	57	PF00082	0.551
DEG_Kelch_Keap1_1	154	159	PF01344	0.576
DEG_SPOP_SBC_1	333	337	PF00917	0.770
DEG_SPOP_SBC_1	355	359	PF00917	0.844
DOC_CKS1_1	138	143	PF01111	0.670
DOC_CKS1_1	238	243	PF01111	0.540
DOC_CKS1_1	479	484	PF01111	0.586
DOC_CKS1_1	590	595	PF01111	0.696
DOC_CKS1_1	94	99	PF01111	0.628
DOC_CYCLIN_RxL_1	102	110	PF00134	0.671
DOC_CYCLIN_RxL_1	415	427	PF00134	0.691
DOC_CYCLIN_RxL_1	75	84	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	607	613	PF00134	0.459
DOC_MAPK_DCC_7	299	309	PF00069	0.647
DOC_MAPK_MEF2A_6	301	309	PF00069	0.551
DOC_PP1_RVXF_1	51	58	PF00149	0.531
DOC_PP1_RVXF_1	76	83	PF00149	0.554
DOC_PP2B_LxvP_1	271	274	PF13499	0.784
DOC_PP2B_LxvP_1	607	610	PF13499	0.459
DOC_PP4_FxxP_1	272	275	PF00568	0.769
DOC_PP4_MxPP_1	352	355	PF00568	0.699
DOC_USP7_MATH_1	125	129	PF00917	0.559
DOC_USP7_MATH_1	252	256	PF00917	0.781
DOC_USP7_MATH_1	282	286	PF00917	0.770
DOC_USP7_MATH_1	291	295	PF00917	0.700
DOC_USP7_MATH_1	320	324	PF00917	0.676
DOC_USP7_MATH_1	370	374	PF00917	0.647
DOC_USP7_MATH_1	377	381	PF00917	0.465
DOC_USP7_MATH_1	475	479	PF00917	0.676
DOC_USP7_MATH_1	486	490	PF00917	0.710
DOC_USP7_MATH_1	49	53	PF00917	0.587
DOC_USP7_MATH_1	540	544	PF00917	0.594
DOC_WW_Pin1_4	137	142	PF00397	0.674
DOC_WW_Pin1_4	237	242	PF00397	0.526
DOC_WW_Pin1_4	335	340	PF00397	0.677
DOC_WW_Pin1_4	344	349	PF00397	0.662
DOC_WW_Pin1_4	356	361	PF00397	0.744
DOC_WW_Pin1_4	478	483	PF00397	0.629
DOC_WW_Pin1_4	532	537	PF00397	0.748
DOC_WW_Pin1_4	579	584	PF00397	0.636
DOC_WW_Pin1_4	589	594	PF00397	0.853
DOC_WW_Pin1_4	595	600	PF00397	0.792
DOC_WW_Pin1_4	93	98	PF00397	0.582
LIG_14-3-3_CanoR_1	15	22	PF00244	0.670
LIG_14-3-3_CanoR_1	28	37	PF00244	0.477
LIG_14-3-3_CanoR_1	301	305	PF00244	0.664
LIG_14-3-3_CanoR_1	410	414	PF00244	0.643
LIG_14-3-3_CanoR_1	458	462	PF00244	0.430
LIG_14-3-3_CanoR_1	511	517	PF00244	0.395
LIG_14-3-3_CanoR_1	574	579	PF00244	0.522
LIG_14-3-3_CanoR_1	81	90	PF00244	0.638
LIG_FHA_1	102	108	PF00498	0.402
LIG_FHA_1	183	189	PF00498	0.699
LIG_FHA_1	325	331	PF00498	0.800
LIG_FHA_1	356	362	PF00498	0.851
LIG_FHA_1	380	386	PF00498	0.610
LIG_FHA_1	458	464	PF00498	0.424
LIG_FHA_1	46	52	PF00498	0.641
LIG_FHA_1	513	519	PF00498	0.529
LIG_FHA_1	564	570	PF00498	0.440
LIG_FHA_1	580	586	PF00498	0.753
LIG_FHA_1	620	626	PF00498	0.527
LIG_FHA_1	82	88	PF00498	0.563
LIG_FHA_2	145	151	PF00498	0.653
LIG_FHA_2	15	21	PF00498	0.615
LIG_FHA_2	265	271	PF00498	0.694
LIG_FHA_2	29	35	PF00498	0.587
LIG_FHA_2	468	474	PF00498	0.459
LIG_FHA_2	523	529	PF00498	0.459
LIG_FHA_2	547	553	PF00498	0.579
LIG_FHA_2	94	100	PF00498	0.683
LIG_GBD_Chelix_1	29	37	PF00786	0.460
LIG_LIR_Apic_2	270	275	PF02991	0.773
LIG_LIR_Apic_2	411	416	PF02991	0.544
LIG_LIR_Apic_2	469	475	PF02991	0.369
LIG_LIR_Apic_2	524	530	PF02991	0.401
LIG_LIR_Apic_2	576	581	PF02991	0.453
LIG_LIR_Apic_2	631	637	PF02991	0.367
LIG_LIR_Gen_1	386	394	PF02991	0.570
LIG_LIR_Nem_3	159	165	PF02991	0.664
LIG_LIR_Nem_3	386	390	PF02991	0.592
LIG_Pex14_1	387	391	PF04695	0.454
LIG_SH2_GRB2like	517	520	PF00017	0.401
LIG_SH2_GRB2like	568	571	PF00017	0.453
LIG_SH2_GRB2like	624	627	PF00017	0.366
LIG_SH2_SRC	462	465	PF00017	0.453
LIG_SH2_SRC	517	520	PF00017	0.401
LIG_SH2_SRC	624	627	PF00017	0.366
LIG_SH2_STAT5	144	147	PF00017	0.571
LIG_SH2_STAT5	402	405	PF00017	0.507
LIG_SH2_STAT5	462	465	PF00017	0.366
LIG_SH2_STAT5	517	520	PF00017	0.401
LIG_SH2_STAT5	568	571	PF00017	0.444
LIG_SH2_STAT5	624	627	PF00017	0.401
LIG_SH2_STAT5	9	12	PF00017	0.557
LIG_SH3_2	416	421	PF14604	0.648
LIG_SH3_3	246	252	PF00018	0.734
LIG_SH3_3	257	263	PF00018	0.699
LIG_SH3_3	272	278	PF00018	0.777
LIG_SH3_3	302	308	PF00018	0.749
LIG_SH3_3	413	419	PF00018	0.644
LIG_SH3_3	476	482	PF00018	0.753
LIG_SH3_3	582	588	PF00018	0.853
LIG_SH3_3	591	597	PF00018	0.766
LIG_SH3_3	602	608	PF00018	0.579
LIG_SH3_3	91	97	PF00018	0.645
LIG_TRAF2_1	17	20	PF00917	0.580
MOD_CK1_1	154	160	PF00069	0.575
MOD_CK1_1	285	291	PF00069	0.713
MOD_CK1_1	347	353	PF00069	0.798
MOD_CK1_1	359	365	PF00069	0.685
MOD_CK1_1	467	473	PF00069	0.517
MOD_CK1_1	478	484	PF00069	0.691
MOD_CK1_1	490	496	PF00069	0.756
MOD_CK1_1	579	585	PF00069	0.782
MOD_CK2_1	14	20	PF00069	0.560
MOD_CK2_1	144	150	PF00069	0.602
MOD_CK2_1	264	270	PF00069	0.710
MOD_CK2_1	28	34	PF00069	0.548
MOD_CK2_1	320	326	PF00069	0.753
MOD_CK2_1	370	376	PF00069	0.724
MOD_CK2_1	467	473	PF00069	0.507
MOD_CK2_1	522	528	PF00069	0.459
MOD_DYRK1A_RPxSP_1	93	97	PF00069	0.609
MOD_GlcNHglycan	11	14	PF01048	0.582
MOD_GlcNHglycan	119	122	PF01048	0.739
MOD_GlcNHglycan	123	126	PF01048	0.736
MOD_GlcNHglycan	156	159	PF01048	0.640
MOD_GlcNHglycan	178	181	PF01048	0.594
MOD_GlcNHglycan	223	226	PF01048	0.706
MOD_GlcNHglycan	293	296	PF01048	0.736
MOD_GlcNHglycan	311	314	PF01048	0.780
MOD_GlcNHglycan	349	352	PF01048	0.778
MOD_GlcNHglycan	442	445	PF01048	0.684
MOD_GlcNHglycan	492	495	PF01048	0.819
MOD_GlcNHglycan	543	546	PF01048	0.871
MOD_GlcNHglycan	58	61	PF01048	0.726
MOD_GSK3_1	107	114	PF00069	0.714
MOD_GSK3_1	117	124	PF00069	0.675
MOD_GSK3_1	195	202	PF00069	0.634
MOD_GSK3_1	278	285	PF00069	0.700
MOD_GSK3_1	286	293	PF00069	0.668
MOD_GSK3_1	316	323	PF00069	0.763
MOD_GSK3_1	329	336	PF00069	0.592
MOD_GSK3_1	355	362	PF00069	0.790
MOD_GSK3_1	402	409	PF00069	0.528
MOD_GSK3_1	45	52	PF00069	0.610
MOD_GSK3_1	450	457	PF00069	0.507
MOD_GSK3_1	464	471	PF00069	0.242
MOD_GSK3_1	486	493	PF00069	0.781
MOD_GSK3_1	519	526	PF00069	0.389
MOD_GSK3_1	546	553	PF00069	0.602
MOD_GSK3_1	570	577	PF00069	0.453
MOD_GSK3_1	626	633	PF00069	0.371
MOD_N-GLC_1	219	224	PF02516	0.666
MOD_N-GLC_1	289	294	PF02516	0.719
MOD_N-GLC_1	486	491	PF02516	0.754
MOD_NEK2_1	107	112	PF00069	0.671
MOD_NEK2_1	221	226	PF00069	0.660
MOD_NEK2_1	309	314	PF00069	0.663
MOD_NEK2_1	324	329	PF00069	0.726
MOD_NEK2_1	378	383	PF00069	0.550
MOD_NEK2_1	56	61	PF00069	0.595
MOD_NEK2_1	72	77	PF00069	0.533
MOD_PIKK_1	282	288	PF00454	0.693
MOD_PKA_2	14	20	PF00069	0.673
MOD_PKA_2	154	160	PF00069	0.575
MOD_PKA_2	300	306	PF00069	0.649
MOD_PKA_2	409	415	PF00069	0.607
MOD_PKA_2	457	463	PF00069	0.410
MOD_PKA_2	573	579	PF00069	0.459
MOD_PKB_1	79	87	PF00069	0.569
MOD_Plk_1	219	225	PF00069	0.663
MOD_Plk_4	107	113	PF00069	0.619
MOD_Plk_4	195	201	PF00069	0.706
MOD_Plk_4	245	251	PF00069	0.820
MOD_Plk_4	320	326	PF00069	0.740
MOD_ProDKin_1	137	143	PF00069	0.670
MOD_ProDKin_1	237	243	PF00069	0.533
MOD_ProDKin_1	335	341	PF00069	0.680
MOD_ProDKin_1	344	350	PF00069	0.663
MOD_ProDKin_1	356	362	PF00069	0.742
MOD_ProDKin_1	478	484	PF00069	0.632
MOD_ProDKin_1	532	538	PF00069	0.748
MOD_ProDKin_1	579	585	PF00069	0.643
MOD_ProDKin_1	589	595	PF00069	0.857
MOD_ProDKin_1	93	99	PF00069	0.579
MOD_SUMO_rev_2	222	232	PF00179	0.621
TRG_ER_diArg_1	77	79	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ37	Leptomonas seymouri	49%	100%
A0A3Q8IJ47	Leishmania donovani	93%	99%
A0A3R7LE31	Trypanosoma rangeli	33%	98%
A4H8P0	Leishmania braziliensis	72%	100%
A4HX11	Leishmania infantum	93%	99%
C9ZVZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AQS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
V5BML0	Trypanosoma cruzi	36%	100%